Storage conditions
The drug requires storage at a temperature not exceeding 30°C. Children must not have access to it.
To buy Nucleo ampoules, you need to place an order on our website. We have been delivering medicines from Europe to Russia for a long time, so you can trust us.
2000 people received this medicine to combat lumbodynia, shingles, diabetic neuropathy, cervicalgia, myopathy, carpal tunnel syndrome. They were watched by specialists. 1853 patients reported a significant improvement in their health. They no longer needed painkillers. 100 people combined this drug with medications to cope with concomitant pathologies. This combination did not lead to any negative effects. Scientists have proven that Nucleo helps defeat any pathologies resulting from damage to the peripheral nervous system.
Pharmacodynamics of the drug
Pathology of the peripheral nervous system (PNS) is one of the most common reasons for visiting a neurologist. PNS dysfunctions occupy a leading place among the causes of long-term disability in patients.
The peripheral nervous system is an internal mechanism of the body that connects the central nervous system (brain and spinal cord) with other organs. The PNS has not received natural powerful defense mechanisms, unlike the central nervous system, which is protected by the bone skeleton and the blood-brain barrier, which makes the PNS very vulnerable to external mechanical damage, as well as to the effects of negative factors.
There are two types of neurons involved in the peripheral nervous system:
- Sensitive sensory neurons that transmit impulses to the central nervous system;
- Sensitive motor neurons that transmit impulses from the central nervous system.
To date, more than 100 factors have been identified that have a negative impact on neurons and contribute to disruption of their function (impulse conduction), among which are:
- Toxins;
- Diseases of various nature;
- Viral and bacterial infections of the body;
- Medications;
- Unfavorable environmental conditions;
- Mechanical injuries.
There are four types of reactions of nerve fibers to damaging factors, most of which Nucleo CMF Forte is able to stop, restoring the sensitivity of the nerve process:
- Reaction of Wallerian degeneration (to the intersection of the nerve process);
- Axonopathy, consisting of degeneration or atrophy of the nerve fiber (the least studied pathology of the PNS);
- Partial demyelination (segmental myelinopathy - damage to the myelin sheaths with preservation of the nerve itself);
- Neuronopathy is a primary disorder of the neuron body.
In modern medical practice, treatment of PNS pathologies mainly comes down to relieving the symptomatic complex without eliminating the causes, which makes treatment ineffective and lengthy.
Nucleo CMF Forte is a unique drug due to its composition. Pyrimidine nucleotides, used as the basis for the innovative pyrimidine complex, play a leading role in the restoration of many morphological structures (elements) of the peripheral nervous system and normalize the transmission of impulses to and from the central nervous system.
Pyrimidine nucleotides in the innovative drug:
- Cytidine 5-monophosphate (CMP) is a nucleotide involved in the synthesis of complex lipid complexes that form the neuronal membrane. This nucleotide is the main structural component of the myelin sheath (the electrically insulating sheath that covers axons). Damage to the myelin sheath in some diseases leads to impaired coordination and balance. CMP is the precursor of the basic nucleic acids RNA and DNA, which play a major role in cellular metabolism;
- Uridine-5-triphosphate (UTP), a nucleotide in the composition of the drug, complements the action of CMP, and also, acting as a coenzyme, stimulates the synthesis of glycolipids of myelin sheaths.
Thus, the drug Nucleo CMF Forte promotes the rapid regeneration of nerve fibers and their myelin sheaths after damage to the PNS nerves.
A few words about the correct dosage
Despite the attached instructions, be sure to consult your doctor before starting to use the drug “Nucleo CMF Forte” (you can find out analogues further). Do not self-medicate or prescribe this medicine to your children under any circumstances.
However, there are general recommendations for maintaining dosages. The maximum daily dose of the drug in tablets is two pieces. You shouldn't take this anymore. The course of treatment is selected individually, but usually it lasts at least ten days.
But small children and elderly people are allowed to use this drug only in the form of injections. But in some cases, doctors allow the use of tablets for children. In this case, they will have to be crushed.
Compound
1 capsule contains cytidine-5-monophosphate disodium 5 mg, uridine-5-trisodium phosphate, uridine-5-diphosphate disodium, uridine-5-monophosphate disodium in total 63 mg (corresponding to 1.33 0 mg of pure uridine). Excipients: citric acid, Na citrate dihydrate, Mg stearate, Aerosil 200, mannitol. 1 ampoule with lyophilized powder contains cytidine-5-monophosphate disodium 10 mg, uridine-5-trisodium phosphate, uridine-5-diphosphate disodium, uridine-5-monophosphate disodium only 6 mg (corresponding to 2.660 mg of pure uridine). Excipients: mannitol; solvent: water, Na chloride.
When is Nucleo CMF prescribed?
Instructions for use describe the diseases for which the drug can be prescribed. The medication has proven itself in the treatment of neuropathy. Also, tablets can be prescribed for neuralgia, plexitis and neuritis. The medicine is widely used to eliminate vertebrogenic pain and Bell's palsy.
The medication can only be prescribed by a specialist. The medicine is available in tablets and ampoules. The product has a safe composition. It can be taken by children and adults. The drug combines well with other types of medications. During the treatment period, it is possible to operate vehicles or other mechanisms that require increased attention.
The drug "Nucleo CMF" is available in pharmacies only by prescription. The instructions must be studied by the patient before starting treatment.
Side effects and contraindications
It is worth noting that the official instructions say absolutely nothing about contraindications, which indicates the maximum safety of the drug. In addition, no side effects were observed in patients during special medical studies. Therefore, the drug is well tolerated by all categories of patients.
By the way, another factor indicating the safety of the drug is the ability to use the drug by pregnant and lactating women. However, in this case, consultations with a gynecologist and neurologist are simply mandatory.
While undergoing treatment, you can drive a vehicle, as the medicine does not have a negative effect on activities associated with increased concentration.
Reviews and recommendations from doctors
The drug Nucleo CMF Forte, reviews of which position it as an effective remedy in the treatment of PNS pathologies, is a unique drug that has no contraindications, side effects and does not interact with other drugs used in complex therapy.
Nucleo CMF Forte capsules, reviews of which can be found in various sources, have the following effects:
- Active regeneration of nerve fiber sheaths;
- Restoring the conductivity of nerve fibers, normalizing the correct conduction of impulses;
- Restoration of muscle trophism (cell nutrition processes that contribute to the preservation of the structure and function of organs and tissues);
- Improving mobility and sensitivity of the damaged area;
- Reducing pain, symptoms of inflammatory processes in affected tissues, and numbness.
The effectiveness of the drug has been proven by practical observations and retrospective studies. The majority of patients receiving Nucleo CMF Forte therapy noted an improvement in the dynamics of recovery, a rapid return to a normal lifestyle, and a significant improvement in the quality of life.
Directions for use and dosage
The drug in the form of capsules is prescribed to adults and children over 5 years of age in a dosage of 1-2 capsules per day with a course of treatment of at least 10 days to achieve a noticeable therapeutic effect.
Nucleo CMF forte ampoules have undoubted advantages in the treatment of PNS pathologies. With invasive therapy (injection), the drug enters directly into the blood, while the effect of active substances when taken in capsules slows down due to the duration of absorption in the gastrointestinal tract. Nucleo CMF Forte ampoules are prescribed to children from 2 years of age, as well as to elderly people. The Nucleo CMF Forte complex in ampoules contains 1 ampoule of drug powder and 1 ampoule of injection solution. The course lasts from 3 to 6 days, then the course is continued by taking the drug in capsules.
Nucleo C.m.f. Forte (Nucleo Cmp Forte)
Release form, composition and packaging
• caps. blister, no. 30
• Cytidine-5-monophosphate disodium salt 5 mg • Uridine 1.33 mg
Other ingredients: anhydrous citric acid, sodium citrate, magnesium stearate, anhydrous colloidal silicon dioxide, mannitol (E421).
No. UA/3396/01/01 from 01.09.2010 to 01.09.2015
• lyophile d/r-ra d/in. 61 mg amp., with solution. in amp. 2 ml, no. 3
• Cytidine-5-monophosphate disodium salt 10 mg • Uridine 2.66 mg
Other ingredients: mannitol (E421), water for injection, sodium chloride.
No. UA/3396/02/01 from 01.09.2010 to 01.09.2015
pharmachologic effect
Pharmacodynamics. Nucleo C.M.F. Forte contains nucleotides: cytidine monophosphate (CMP), uridine triphosphate (UTP), which are widely used to treat diseases of the central nervous system.
From a biochemical point of view, the effect of these components is as follows.
CMP takes part in the synthesis of a complex of lipids that form the neuronal membrane, mainly sphingomyelin, the main component of the myelin sheath. CMP is also a precursor of nucleic acids (DNA and RNA), which, in turn, are the main elements of cellular metabolism (for example, in protein synthesis).
UTP acts as a coenzyme in the synthesis of glycolipids, neuronal structures and the myelin sheath, complementing the action of CMP. In addition, UTP acts as an energy source during muscle contraction.
CMP and UTP are involved in the synthesis of phospholipids and glycolipids, which mainly make up the myelin sheath and other nerve structures. This results in intense metabolic activity that promotes the process of regeneration of the myelin sheath, regulating demyelination in peripheral nerve injuries. Thus, the combination of the actions of CMP and UTP promotes the regeneration of the myelin sheath, the correct conduction of nervous stimulation and the restoration of muscle trophism.
Pharmacokinetics. Nucleo C.M.F. Forte contains physiological products. Classical pharmacokinetic studies are not possible due to the difficulty of quantifying exogenous and endogenous components. It is also impossible to carry out analysis using a radioactively labeled product due to the high radiological load.
Dosage
Nucleo C.M.F. Forte capsules are taken orally.
Adults: 1–2 capsules 2 times a day; children over 5 years of age: 1 capsule 2 times a day.
Capsules Nucleo C.M.F. Forte can be taken before or after meals.
The recommended duration of treatment is at least 10 days. If necessary, taking capsules can be extended for 20 days.
Nucleo C.M.F. Forte is a lyophilized powder for the preparation of solution for injection - for intramuscular administration. Before administration, the solvent must be added to the ampoule with lyophilized powder.
Adults, including elderly patients, and adolescents over 14 years of age: 1 injection of Nucleo C.M.F. Forte is administered once a day.
Children aged 2–14 years are recommended to receive 1 injection of Nucleo C.M.F. Forte every 2 days. The recommended course of treatment is 3 or 6 days. Next, treatment is continued using Nucleo C.M.F. Forte capsules.
Overdose
Given the low toxicity of the drug, an overdose is unlikely even if the therapeutic dose is accidentally exceeded.
Drug interactions
not installed.
Side effects
not described. Persons with hypersensitivity may experience allergic reactions. If an adverse reaction occurs due to the use of the drug, consult a doctor.
Storage conditions and periods
at a temperature not exceeding 30 °C.
Indications
neuropathy of osteoarticular (sciatica, radiculitis), metabolic (alcoholic, diabetic polyneuropathy), infectious origin (shingles) and Bell's palsy. Neuralgia of the facial, trigeminal nerve, intercostal neuralgia, lumbago.
Contraindications
known allergic reactions to individual components of the drug.
special instructions
Use during pregnancy and lactation. The use of the drug during pregnancy and lactation is possible if, in the opinion of the doctor, the expected positive effect for the mother exceeds the potential risk for the fetus/child.
Children. The drug is used in children over 2 years of age.
The ability to influence reaction speed when driving vehicles or working with other mechanisms. Nucleo C.M.F. Forte does not affect the ability to drive vehicles or operate complex machinery.
