Adapalene cream. Instructions for use for wrinkles, acne, dry skin, rosacea, rosacea. Price, reviews

Adapalene is known as a substance that helps get rid of juvenile acne (acne) and comedones. But recently it has been actively used in cosmetology as an anti-aging skin product. The impetus for this development of events was given by the program “Health” with Elena Malysheva on Channel One. Part of the broadcast was devoted to the topic of using Adapalene anti-wrinkle cream. The drug belongs to the group of dermatological products and was not declared as anti-aging. Therefore, before using it for an indirect purpose, you must carefully read the instructions and weigh the pros and cons.

Release form: adapalene

Indications for use

The product is used for various skin problems. The main indications are acne and wrinkles. The active components of the drug promote proper keratinization of epithelial cells, which prevents the development of inflammatory reactions and protects against clogging of pores.

Stimulation of cells leads to normalization of keratinization processes. The process leads to increased tightness and elasticity of the upper layer of skin. Therefore, the product is effective against wrinkles.

The drug helps in the fight against nasolabial folds, pigmentation, atrophy of the skin and muscles. The product prevents premature skin aging, prevents the formation of comedones, fights inflammation and acne.

Effect:

• skin rejuvenation;
• reduction of fat content, which allows you to regulate and normalize the processes of sebum production;
• restoration of tightness and elasticity;
• elimination of minor defects, facial wrinkles, blackheads, acne;
• getting rid of pigmentation;
• preventing the formation of free radicals, which prevents the development of excessive dryness and prevents the appearance of wrinkles;
• elimination of inflammatory reactions;
• restoration of natural complexion.

It can be used as an independent product or as part of care products - masks, emulsions, creams.

Preparations based on adapalene

On sale you can find the following gels and creams with adapalene used for acne:

• Adaklin;
• Adolen;
• Differin;
• Klenzit;
• Effezel.

Adaklin is a cream based on a synthetic retinoid. It has a similar composition as Adapalene gel. The principle of action and treatment regimen for the drug is the same.

Adolen is available in gel form and is no different in composition and mechanism of action from the previous product.

The main active ingredient of Differin is the same synthetic retinoid. Available in the form of cream and gel. The first of them has a greasy and thick consistency, intended for more sensitive skin, the second has the ability to be absorbed much faster and does not leave any traces behind.

In addition to the retinoid, Klenzit contains clindamycin. Thanks to the second component, the drug has an antibacterial effect, allowing you to quickly stop the inflammatory process in the dermis and suppress the growth of pathogenic microorganisms. The average duration of treatment with the combination medication is 1 month.

Effezel contains adapalene and benzoyl peroxide. The active components have a synergistic effect, that is, they enhance each other’s therapeutic effect. The product exhibits antimicrobial activity, quickly relieves inflammation, and significantly reduces sebum production. The gel is prescribed for acne and papulopustular rash.

Chemical composition

Anti-wrinkle cream Adapalene is a synthesized (artificial) vitamin A substitute, but its properties differ.

The chemical composition of the product includes:

• carbomer;
• propylene glycol;
• methylparaben;
• disodium edetate;
• poloxamer;
• phenoxyethanol;
• purified water;
• sodium hydroxide.

The product has an anti-inflammatory effect, stimulates keratinization processes, eliminating various skin problems. The active substances act on the receptors involved in the processing of retinoic acid and do not bind to proteins. This selective action prevents the adhesion of follicles to keratinocytes.

This leads to exfoliation of the top layer of skin (keratinized epithelium) and accelerates regeneration processes. In this case, the process leads to increased sensitivity of the skin to ultraviolet radiation. Accelerated keratinization of epithelial cells further leads to stimulation of regeneration processes and cell renewal, which, in turn, promotes skin rejuvenation and the elimination of wrinkles.

Composition and release form

Adapalene is produced by many foreign and domestic pharmaceutical factories. In our country, the drug mainly produced by VELFARM in the Republic of San Marino is sold. It is available in the form of 0.1% cream or gel, packaged in 15 or 30 g in aluminum tubes. The secondary packaging is a cardboard box with instructions for use inside.

The active ingredient of the cream is adapalene from the clinical-pharmacological group of synthetic retinoids. And the auxiliary composition is represented by the following components:

• propylene glycol;
• sodium hydroxide;
• methyl 4-hydroxybenzoate;
• disodium edetate;
• glycol ether;
• purified water;
• poloxamer.

The cream is white, thick, without foreign inclusions with a slight specific odor. Thanks to the auxiliary components, it is easily absorbed and does not leave a greasy shine. The active ingredient is gradually released from the base, providing a long-lasting therapeutic effect.

Adapalene cream is most often used to treat chronic acne that is prone to recurrence. And the gel of the same name is used for its exacerbations. It is less thick, so it penetrates faster into inflamed sebaceous glands and skin pores.

Gel is a product with a higher concentration of the active ingredient

Pharmacological properties

Adapalene is a new generation synthetic retinoid, a derivative of naphthoic acid. It is able to normalize the processes of skin keratinization and ensure stable structural and functional transformation of cells. Adapalene selectively binds to specific receptors, stimulating keratinocyte differentiation. It is also characterized by a pronounced comedolytic, anti-inflammatory effect.

Adapalene exhibits pronounced therapeutic effects:

• prevents the formation of acne and comedones, eliminates existing rashes;
• increases skin elasticity;
• removes dead skin cells and gently exfoliates them;
• activates subcutaneous blood circulation;
• accelerates lymph flow and metabolic processes;
• stimulates the formation of young and healthy cells;
• helps cleanse the skin of tissue breakdown products and toxins;
• optimizes the production of sebaceous secretions.

After a course of using the drug, the skin condition improves significantly. There is also an acceleration of blood and lymph circulation in the deepest dermal layers. Pigment spots, scars, scars, and marks from squeezing out pimples become less noticeable.

The product is effective in the treatment of acne

Pharmadynamics

The medication has some pharmacodynamic properties associated with the action of the main substance. In this case, pharmacodynamics depend on the dosage form taken.

The therapeutic effect of the drug is observed after 7-14 days of treatment. However, the drug exhibits persistent effectiveness after 8-12 weeks of therapy.

Analogues of Adapalene - which one to choose?

In case of individual intolerance to adapalene, the drug can be replaced with local retinoids containing other active ingredients, which include:

• Retinoic ointment;
• Retasol;
• Tazorac.

Retinoic ointment is a cheap analogue of the above mentioned retinoid. It contains isotretinoin, known in pharmacology as 13-cis-retinoic acid. The active substance has anti-acne and anti-inflammatory effects. Ointment is prescribed for acne vulgaris, papulopustular rash and rosacea. To obtain a therapeutic effect, the product is applied morning and evening to clean skin. The duration of use is from 1 to 3 months, depending on the severity of the dermatological disease. The drug cannot be used simultaneously with tetracycline antibiotics and glucocorticosteroids due to a possible decrease in the therapeutic effect.

Retasol is available in the form of a solution, the main active component of which is isotretinoin. In addition to its anti-inflammatory effect, the drug has a drying effect due to the alcohol content. For this reason, the solution is not recommended for people with particularly sensitive skin. It has the same indications for use as retinoic ointment.

Tazorac is an effective drug prescribed for acne. The active substance of the drug tazarotene is a third-generation retinoid, which is prescribed for both acne vulgaris and rosacea. The duration of treatment with the cream is 8-12 weeks. Today it is one of the most expensive retinoids for external use.

Pharmacokinetics

The medication has low absorption capacity. According to clinical studies, with daily use of the cream at a concentration of 0.1%, the level of substances in the body was found in minimal quantities. Metabolites are excreted primarily by the liver.

Clinical studies on animals have confirmed the minimal risk of oncogenicity of the drug when interacting with ultraviolet irradiation or sunlight. No genotoxic effects or mutagenic properties of the cream were detected. Also, the drug does not have a negative effect on the reproductive system.

Application

The product is used according to indications. The dosage depends on the severity of the pathological process.

Recommendations for use:

1. Before applying the product, it is necessary to cleanse the skin of dirt and makeup.
2. You should steam your face a little with a warm towel.
3. The product is applied to dry skin. In this case, it is necessary to apply with massage circular movements.
4. After using the drug, you must additionally use any moisturizer.

The duration of use depends on the degree and depth of wrinkles. On average, the duration of the course is 3 months.

For adults

Adapalene cream can be used at any age, starting from 12 years. The dosage in adults is 1 time per day. The medication can be used as a cosmetic care product and used as a mask or peeling for wrinkles. Use the product as a mask once a week.

In this case, the product is applied in a thin layer to the problem area for 40-50 minutes, after which the residue is washed off with warm water. The course of application is 2-3 months. Excessive peeling may occur during treatment. Which goes away on its own. During this period, it is prohibited to use aggressive cosmetic substances and remove the stratum corneum yourself.

For pregnant

During pregnancy, the product is applied only with the permission of the attending physician, taking into account the potential benefits/risks for the health of the unborn child and mother. However, according to clinical trials, the cream or gel does not have a toxic (teratogenic) effect. The dosage is standard - once a day. Used for 3-10 weeks.

For the elderly

No dosage adjustment is required in old age. The drug is applied in a thin layer once a day. The therapeutic effect is observed after 1-2 weeks.

How to do peeling using Adapalene at home

To rejuvenate the skin, Adapalene gel can be used at home. Peeling is recommended to exfoliate the stratum corneum. In the absence of contraindications, the sequence of actions is as follows:

1. Cleanse your face thoroughly of decorative and caring cosmetics.
2. Apply a thick layer of gel to the skin, avoiding contact with the mucous membranes of the eyes and mouth.
3. Leave the anti-aging composition on your face for 2 hours, then wash thoroughly with warm water.
4. 1-2 days after visible peeling appears, use a nourishing, moisturizing cream.
5. Mechanical methods of removing dead skin cells from the surface of the face remain prohibited.

On the first day after home peeling, the skin turns red and swells. After another couple of days, it begins to peel off intensively. During rehabilitation, it is important to avoid exposure of the dermis to direct sunlight, poisonous and toxic substances. It is prohibited to apply foundation cosmetics to the face, use alcohol-containing solutions and local antiseptics. The procedure is allowed to be repeated once a month - no more often. The course of treatment is 3–4 months.

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Contraindications

The main limitation to prescribing the medication is individual intolerance to the components included in the composition. At the same time, there is a thinning of the skin and the development of excessive dryness, which leads to additional problems.

Additional contraindications:

• seborrheic dermatitis - using cream can only worsen the problem;
• children under 12 years of age - not applicable due to incompletely formed skin;
• eczema – when applying the product, the healing process slows down.

Adapalene anti-wrinkle cream should not be used for eczema.
There are no data on the use of the drug in children under 12 years of age.
There is no need to use a cream/gel to eliminate wrinkles. It is also recommended to refrain from using the medication for persons prone to developing allergic reactions.

Advantages and disadvantages of the product

The benefits of Adapalene include:

• effective in removing small and medium expression wrinkles;
• prevention of early development of age-related changes;
• evens out facial tone, lightens skin;
• smoothing out scars;
• affordability.

The main disadvantage of the cream is the intense drying of the skin. In rare cases, an allergic reaction and negative effects may develop. The latter manifest themselves in the form of irritation, rashes, itching and redness.

Side effects

Anti-wrinkle cream can occasionally lead to various side effects. The degree of manifestation and symptoms depend on the dosage form of Adapalene.

Thus, when using the cream, the development of erythema and peeling was noted. Excessive dryness of the skin, persistent itching, burning sensation. Very rarely, the product led to dermatitis, acne, swelling, changes in skin color, and eczema.

Side effects (for gel):

• burning sensation;
• redness;
• erythema;
• persistent itching;
• excessive dryness;
• sunburn;
• acne.

The development of negative reactions is possible in the first month of using the drug, after which the severity and symptoms noticeably decrease. According to clinical studies, adverse reactions disappear after cessation of therapy. If undesirable effects develop, it is recommended to temporarily discontinue use of the drug and consult a doctor for advice.

Drug interactions

The drug is approved for joint use of other drugs related to antibiotics, benzoyl peroxide. The effectiveness of the cream decreases with the simultaneous use of various applications during the same period of time and on the same area of ​​skin. To achieve therapeutic results, it is recommended to use medications at different periods of time.

This will avoid the development of irritation and other undesirable manifestations. Due to the high local irritant activity of the drug, it is recommended to refrain from using other agents that have a similar effect. This group includes: abrasive soaps, various detergents, cosmetics and perfumes, especially those containing ethanol.

The cream is prescribed with extreme caution in combination with drugs containing sulfur, salicylic acid, and resorcinol. If you have recently used such medications, it is recommended that you refrain from taking the medication until all signs of irritation have disappeared.

Drug compatibility

Adapalene gel enhances its therapeutic effect when used simultaneously with clindamycin, an antibiotic of the lincosamide group. The drug also has good compatibility with benzoyl peroxide.

It is not recommended to use the retinoid simultaneously with products that have a drying effect. These include sulfur, alcohol, salicylic acid and resorcinol.

The drug is incompatible with other retinoids, as it can provoke hypervitaminosis A.

special instructions

Adapalene, an anti-wrinkle cream, is not recommended for use in the presence of erythema and other damage to the skin until complete healing. When applying the composition to the area affected by erythema, increased negative reactions in the form of irritation may occur.

It is also not recommended to prescribe the drug if you have sunburn, as the drug increases the skin's sensitivity to ultraviolet radiation. It is recommended to wait until the wounds have completely healed.

In this case, it is necessary to avoid contact with sunlight and ultraviolet radiation. If you need to stay in the sun, you should stop taking the product the day before the expected date. To avoid the development of reactions, it is necessary to treat the skin with special sunscreens and wear sunglasses.

It should be remembered that the medicine can cause various negative manifestations when exposed to unfavorable environmental factors - temperature changes, wind, cold. When applying the composition, it is necessary to avoid direct contact of the cream with the eyes, lips or mucous membranes. In case of accidental contact, it is recommended to rinse the affected area with warm water.

The gel is recommended for use by persons with normal skin type, as well as those with increased oil content. The cream is intended for dry and sensitive facial skin.

If there is no therapeutic effect after 8-12 weeks of treatment, you should consult a specialist for advice.

Reviews of those who used Adapalene

Ekaterina, 48 years old, St. Petersburg: “I decided to try the medicine after watching Elena Malysheva’s program “Live Healthy.” Reviews from doctors are positive, and users note a good anti-aging effect. I wanted to tighten the skin around my mouth and remove deep nasolabial folds. Adapalene tightens the dermis through intense drying. I have oily skin, so the drying properties of the product were beneficial. It’s inexpensive and effective.”

Anna, 30 years old, Vladivostok: “I will not advertise the drug. It dries out the skin a lot, so I recommend using it with caution and only for people with oily skin. I have a sensitive, mixed type. After the first application it stung strongly, after a day irritation, itching and redness appeared. Because of the peeling, I couldn’t go outside, I couldn’t apply cosmetics to mask the defects.”

Marina, 50 years old, Moscow: “I used Adapalene as a peeling agent. There were no side effects. After 2 months, a real positive result appeared: a healthy blush, crow’s feet in the corners of the eyes became smaller, the tone evened out. I think this is one of the best anti-aging creams for home care."

Analogs

Adapalene is used only if indicated. However, the drug often causes allergic reactions or hypersensitivity effects, and therefore can be replaced with other medications. In this case, the selection of an analogue should be carried out by a dermatologist or cosmetologist.

Self-replacement can lead to the development of negative reactions on the skin.

Before using Adapalene anti-wrinkle cream, or its analogues, you should consult a dermatologist and carefully study the instructions for use of the product.

Features of the impact

The effect of Adapalene is similar to peeling, which removes the upper keratinized layer of the epidermis. This stimulates cell regeneration, collagen production, and the result is a visual reduction in the depth of wrinkles and skin tightening. A lasting effect is observed after 3-4 procedures. Adapalene cream, used for wrinkles or acne, may cause local irritation. Therefore, during the period of its use, it is recommended not to use scrubs, medicated soaps, or cleansers based on ethyl alcohol. You cannot use other drying or irritating agents in parallel with Adapalene.

Adapalene is not absorbed into the blood through the skin

The product does not have any negative effects on human internal organs, since it is practically not absorbed into the blood through the skin. Testing on rats has shown that Adapaleno can cause thyroid cancer and adrenal tumors. But the animals were fed doses several times higher than the maximum permissible for humans. When used externally, no carcinogenic effects were detected. This is only possible with a significant overdose, but for this the drug must be ingested in a very large quantity. And since Adapelene is not absorbed into the blood, the possibility of an overdose is extremely low.