Biltricide - instructions for use, composition, indications, side effects, analogues and price

The drug Biltricide 600 is intended to combat various parasites, including flukes and tapeworms. But, given the presence of praziquantel in its composition (a toxic substance), the medication should be used only after consultation with a specialist.

The drug Biltricide 600 is intended to combat various parasites, including flukes and tapeworms.

Pharmacodynamics and pharmacokinetics

The principle of action is aimed at increasing the permeability of cell membranes of parasites for calcium ions. The active component leads to a generalized reduction in the muscle tissue of helminths , which causes persistent paralysis and subsequent death of the parasite. The main substance is praziquantel . Biltricide affects Chinese, Siberian, liver and cat flukes, broad tapeworms, dwarf tapeworms , Menson's intestinal schistosomes, giant flukes, and lung flukes.

Side effects of Biltricide

The drug does not belong to the category of preventive, it should be taken only after a diagnosis has been established. Undesirable consequences of treatment can manifest themselves as the body’s reaction to the medication itself, due to intoxication after the death of parasites, or as symptoms of infection. The active substance may cause undesirable symptoms from the following systems:

• digestive (nausea, vomiting, diarrhea);
• central nervous (dizziness, drowsiness, retardation of consciousness);
• the body as a whole (asthenia, hyperthermia, increased sweating);
• musculoskeletal (myalgia);
• cardiovascular (arrhythmia);
• immune - allergic manifestations (urticaria).

Contraindications

Instructions for use of Biltricide do not recommend prescribing the medication for intolerance to praziquantel, for cysticericosis of the eyes , during breastfeeding, in the first trimester of pregnancy, and for children under four years of age.

In hepatosplenic forms of schistosomiasis and in cases of severe pathology of the hepatic system, praziquantel is prescribed with caution, assessing the risks and consequences.

6 Interaction with other medications

When taking Dexamethasone, the plasma concentration of Praziquantel decreases. Rifampicin is a cytochrome P450 inducer. Its use together with Praziquantel is strictly contraindicated. When taking a standard dose of Biltricide for several days after taking Rifampicin, the drug in question is not detected in the blood plasma.

If the patient is forced to take Rifampicin (for example, against the background of long-term combination therapy for the tuberculosis process in the body), then if he develops schistosomiasis and other invasions that require Praziquantel, it is necessary to decide on prescribing another drug that would be active against these pathogens. On the contrary, if it is necessary to take Praziquantel, then Rifampicin should be discontinued 4 weeks before such therapy. The day after you stop taking Praziquantel, you can resume taking Rifampicin if the need remains.

Taking Chloroquine also leads to a decrease in the concentration of Biltricide in plasma. The mechanism of such negative interaction is not completely clear today.

The simultaneous use of antiepileptic drugs (for example, Phenytoin, Phenobarbital, Carbamazepine, etc.) leads to the fact that the concentration of Biltricide may decrease slightly. And the combination of drugs such as Cimetidine, Ketoconazole, Erythromycin leads to an increase in the concentration of the active component of this drug in plasma. All these nuances, naturally, must be taken into account when choosing Praziquantel in various situations. These aspects once again confirm that self-medication of helminthic infestations with Biltricide is dangerous. It may not only fail to lead to the desired therapeutic effect, but also contribute to the further progression of helminthic infestation and various systemic disorders in the body.

Ethanol during active anthelmintic therapy with Praziquantel is strictly prohibited. Violation of this prohibition leads to pathological changes in the liver tissue, since numerous metabolites of this drug are formed in it. Their interaction with ethyl alcohol and its breakdown products is hazardous to health. Alcohol, in particular, can cause persistent and severe damage to the nervous system and a decrease in intellectual abilities.

Studies have shown that drinking grapefruit juice simultaneously with taking Biltricid leads to an increase in its concentration in the blood plasma.

Biltricide, instructions for use (Method and dosage)

Treatment is carried out after mandatory consultation with the treating doctor; self-medication is unacceptable.

How to take Biltricid?

Before or during meals, without chewing, with the required amount of water or any liquid. When taken once, the tablet is best taken in the evening. When taking multiple doses, the recommended break between doses of the medication should be at least 4-6 hours.

The dose is selected individually for each individual and depends on the severity of the disease.

The dosage of Biltricide in the treatment of schistosomiasis is calculated according to the scheme of 40 mg per 1 kg (single dose, or ½ of the calculated dose twice).

Treatment regimen for opisthorchiasis : three doses of a total dose calculated according to the regimen of 75 mg per 1 kg.

Biltricide price

Moscow pharmacies sell the drug in the price range from 400 to 500 rubles. Depending on the location of the pharmacy, the cost of tablets is as follows:

special instructions

The use of Biltricide does not require the mandatory prescription of laxative medications.

In patients with hepatosplenic schistosomiasis and liver pathology, a slowdown in the metabolism of praziquantel is observed (inpatient treatment is required).

In patients with schistosomiasis of the brain , no reactions were identified that may require limited use of the drug.

Patients with trematodiasis and schistosomiasis must be treated in a hospital.

Short-term therapy with praziquantel requires cessation of breastfeeding for all days of treatment and the next 2 days.

The drug affects driving and concentration.

Monitoring the effectiveness of treatment

If a patient has suffered a disease such as opisthorchiasis, then he must be checked for parasites every quarter.

Thus, the patient controls the condition of the body and when the helminths return, they can begin a new stage of treatment. Biltricide is most suitable for this. It instantly acts on the worms, destroying them and without causing severe harm to the body.

Pinworms, Giardia, tapeworm, helminths, tapeworm. The list goes on for a long time, but how long are you going to tolerate parasites in your body?

But parasites are the main cause of most diseases, from skin problems to cancer. But parasitologist Sergei Rykov assures that it is easy to cleanse your body even at home, you just need to drink.

You should not delay treatment, as damage to internal organs may become a contraindication to treatment of the disease.

Before starting treatment, the doctor must tell almost every patient about Biltricide. Study the medical history and, after receiving all previously taken tests, draw up a treatment plan.

Any doctor must make sure that the drug is suitable for anthelmintic therapy and will not cause any harm to the body. Reviews of Biltricid say that if any reaction occurs after taking the first tablet, the medicine is discontinued and an attempt is made to replace it with another. Usually the drug is well tolerated by all patients, only in rare cases intolerance to individual components is observed.

Indications for use of Biltricide 600

Recommended for use in the following pathologies:

• neurocysticercosis;
• cestodosis;
• trematodes;
• opisthorchiasis;
• schistosomiasis, genitourinary and intestinal;
• cysticercosis;
• taeniasis caused by pork tapeworms;
• metagonimiasis;
• paragonimiasis;
• fasciolopsidosis;
• fascioliasis.

Biltricide 600 is used to eliminate opisthorchiasis.

Pharmacological properties of Biltricide 600

The medicinal properties of the drug are determined by its pharmacokinetics and pharmacodynamics.

The drug Biltricide 600 is active against pork/bovine tapeworms.

Pharmacodynamics

The drug is active against helminths, tapeworms, pork/bovine tapeworms, fasciolopsis and other parasites. Its active substance increases the degree of permeability of their cell membranes to calcium ions, provoking generalized muscle contraction of organisms. In addition, the medication suppresses the ability of helminths to capture glucose, reducing the concentration of glycogen and activating the release of lactic acid. In this case, the parasites die. In addition, the drug allows you to fight cestodes and trematodes.

Pharmacokinetics

Praziquantel is quickly absorbed by the gastrointestinal tract. Cmax of the substance is gained in 1-2 hours.

T½ varies from 1 to 2.5 hours.

The main route of drug elimination is the kidneys. About 80% of the dosage is eliminated in the first 4 days, and about 90% of the MS is eliminated within 1 day.

The main route of drug elimination is the kidneys.

Analogs

"Azinox"

Ekokhimtekh LLC, Russia Price 350 rub.

Azinox is an anthelmintic that helps fight many parasites, including tapeworm. The manufacturer offers this product in the form of tablets coated with a special coating.

Pros:

• Wide spectrum of action
• Effectiveness of the product against many parasites
• Good absorption and tolerability

Minuses:

• The drug is not approved in children
• There are side effects.

"Vermox"

Gedeon Richter, JSC, Romania Price 140 rub.

Vermox is a broad-spectrum anthelmintic. The active ingredient of the drug is mebendazole. Available in tablet form. Prescribed for diseases caused by intestinal parasites.

Pros:

• Wide spectrum of action
• Fairly low cost

Minuses:

• Effective against enterobiasis and trichuriasis; for other ailments the drug has a lesser effect
• A considerable number of side effects and contraindications.

"Pirantel"

Pharmatechnology, LLC, Republic of Belarus Price 40 rub.

An anthelmintic drug is used for nematodes. Prescribed for ascariasis, enterobiasis, hookworm disease, opisthorchiasis. The medicine is available in the form of tablets and suspensions for oral use.

Pros:

• Well tolerated by patients
• Fairly reasonable price

Minuses:

• Lots of side effects
• The drug is contraindicated in patients with impaired liver and kidney function.