Pharmacodynamics and pharmacokinetics
Pharmacodynamics
Nicodin is a choleretic agent. It has choleretic, cholekinetic, anti-inflammatory and bactericidal effects. The latter is due to the action of the formaldehyde part of the molecule, which is cleaved off during metabolism . Nicotinamide has the properties of vitamin PP and enhances the secretion of bile. Used in the complex treatment of cholecystitis , liver dysfunction and gastroenteritis . Effective in the treatment of enteritis caused by Escherichia coli. To enhance the antibacterial effect for cholecystitis, it is used simultaneously with antibiotics .
Pharmacokinetics
No data available.
Storage
This drug should be stored at temperatures up to 25 degrees in a place that is dry, fairly cool, and dark. In addition, the medicine should be kept away from children and their pets.
Attention! In order to purchase this drug there is no need to show a prescription from your doctor.
If all recommendations are followed, this medicine can be stored for four years. An expired drug should not be used further, because such a product will not have a therapeutic effect; rather, on the contrary, it will harm the already affected body.
Reviews
The goal of treating functional disorders of the biliary tract is to restore the flow of bile through the biliary ducts. If it is necessary to increase bile secretion in the hypertensive type of dyskinesia and at the same time provide an anti-inflammatory effect, then the choice is made in favor of synthetic drugs, which include Nikodin - a true choleretic (increases the secretion of bile), which also combines an anti-inflammatory effect. It also increases the secretion of bile. For cholecystitis, it is prescribed in the phase of exacerbation or subsiding exacerbation in a course of 3 weeks. There are very few reviews about the drug, this is due to the fact that it has not been produced for the last 15 years. A few reviews note its effectiveness and relatively good tolerability:
“For a very long time it was prescribed for exacerbation of cholecystitis. After 5 days the pain went away. In general, I took it for 2 weeks, and then switched to choleretic herbs.”
“I have always taken it before during a spring exacerbation of cholecystitis along with choleretic herbs and against the background of a diet . Within a week my condition improved significantly.”
“It helped well, but rashes and itching .”
“Periodically I was saved by this remedy, but after disappearing from pharmacies I began to take equally effective drugs.”
Side effects
The instructions for the medicine say that during treatment the patient may experience such manifestations as:
- Itching, swelling, hives, cough, runny nose, sore throat, redness of the skin, as well as any other manifestations of allergies;
- Manifestation of abdominal pain with anacid gastritis (diseases that develop due to insufficiency of acid in the gastric juice);
- Flatulence, bloating, as well as constipation or diarrhea;
- Pain in the right hypochondrium.
If the use of Nicodin in patients with anacid gastritis provokes an increase in dyspepsia, then there is no need to discontinue the drug. In this case, diluted hydrochloric acid should be used to relieve pain.
Cases of overdose have not yet been observed, however, doctors do not exclude the possibility of its occurrence.
If you take a medicine in a dosage that exceeds the maximum permissible, it is imperative to rinse the stomach using laxatives, as well as carry out symptomatic treatment.
Overdose
Episodes of Nikodin overdose have not been recorded in medical practice, but this nuance does not exclude the manifestation of a negative reaction of the body when the dosage of the drug is exceeded. The risk of side effects increases in the presence of contraindications and hypersensitivity to elements from the tablets.
Symptoms of overdose in this case can arise from various internal systems and in the form of various pathological conditions.
An overdose can provoke the following symptoms:
- signs of an allergic reaction (runny nose, sneezing, dry cough, skin rashes, redness and itching of certain areas of the skin, nasal congestion, sore throat, etc.);
- constipation or diarrhea (symptoms may occur in combination with flatulence, bloating and pain in the digestive system);
- increased symptoms of the existing disease (sharp pain in the right hypochondrium may occur).
Contraindications
The drug is not prescribed for hypersensitivity to the main substance or other components of the drug. In addition, it is not advisable to give the medicine to children under 10 years of age.
For gastritis or cholestasis, the drug can only be prescribed with caution in a reduced dosage.
During pregnancy
During pregnancy you should not use any drugs. The medicine Nikodin is no exception.
However, if the attending physician has given his consent, the drug can be taken, but the dosage prescribed by the doctor must be strictly observed and the attending physician must be regularly visited to monitor the patient’s condition.
In addition, it is also not advisable to take this drug during breastfeeding. If an appointment is still necessary, then the girl should exclude the method of natural feeding of the baby.
Characteristics of the drug
Paracodin is a dihydrocodeine-based semisynthetic opioid analgesic prescribed for pain or severe shortness of breath, or as an antitussive, alone or in combination with paracetamol (acetaminophen) or aspirin.
Country of origin: Germany. Composition. 5 ml of syrup (1 teaspoon) contains 12 mg of dihydrocodeine tartrate, 60.5 mg of liquid marshmallow extract and 90.7 mg of liquid grindelia extract.
Active ingredient: Dihydrocodeine. Typically available in tablets, solutions, elixirs and other oral forms, dihydrocodeine is also available in some countries as an injection solution for deep subcutaneous and intramuscular administration. As with codeine, intravenous administration should be avoided as it can lead to anaphylaxis and life-threatening pulmonary edema.
It was first described in 1911 and approved for medical use in 1948. Dihydrocodeine was developed during the search for more effective cough medications, especially to help reduce the spread of tuberculosis, whooping cough, and pneumonia between 1895 and 1915. Its chemical composition is similar to codeine. Dihydrocodeine is twice as strong as codeine.
Indications for use
Codeine and drugs containing it are prescribed to eliminate unproductive paroxysmal cough in emphysema, bronchopneumonia, and bronchitis. The drug is also indicated for use to eliminate and reduce the severity of pain in complex therapy with drugs from the group of non-narcotic analgesics:
- for headaches, toothaches;
- for neuralgia, injuries;
- for renal and hepatic colic;
- for pain associated with cancer.
As part of Bekhterev's mixture, Codeine is taken as an effective sedative. Diarrhea is also an indication for taking the drug.
The main advantages of drops
Nicoden Silver has a number of advantages compared to nicotine replacement therapy. According to research results, the first results from using the drug appear already on the third day after the start of the course of treatment. The product has a number of distinctive features:
- According to the manufacturer, the effectiveness of using drops is 99%. According to other data, it is slightly less - 96%, which is also not bad.
- Low cost of the entire course of treatment with the drug. A full course of getting rid of nicotine addiction costs the same as 10 packs of cigarettes.
- General positive changes in the body. Thanks to nicoden silver, smokers' health improves even before they quit smoking.
- Ease of use. There is no need to carry drops with you all the time.
- Safe product. Real reviews left by customers in the comments on the official Nicoden Silver website indicate that the product is completely safe. There are no strict contraindications, no side effects have been noticed.
How it works: mechanism of action of the drug
The truth is that there is no special secret in the drug Nicoden Silver. It’s surprising that the drops were launched into production quite recently. The principle of operation of the solution is simple and is divided into obvious and non-obvious factors:
- Obvious ones. Lebanese mint extract has long been used to stabilize the nervous system. Smokers are prone to stress during the quitting period, thanks to this component you will be protected from stress. Also obvious is the effect of extract from a crab shell. The Maltese freshwater crab has long been used in folk medicine in Young Europe as a remedy for smoking.
- The effect of silver ions and white mistletoe extract is not so noticeable to the thrower. However, without these substances, quitting smoking will not be so easy. Even water is purified by silver ions; compared to tap water, a smoker’s lungs are much dirtier. General strengthening of the body and cleansing of harmful substances gives vigor and self-confidence on the path to quitting smoking.
What the statistics show
According to the World Health Organization, 9% of the world's population die annually from diseases caused by smoking or passive inhalation of cigarette smoke. In just two decades of the 21st century, addiction has caused more deaths than during any previous war. The harm of smoking is confirmed by the following statistics:
- 98% of people with lung cancer are smokers.
- 75% of patients in pulmonary clinics suffer from cravings for cigarettes.
- 50% of pregnancies end in miscarriage in women who smoke.
- 5% of cases of fetal death are recorded in pregnant women who smoke.
- 60% of smokers admit that they cannot independently overcome the physical and psychological dependence on smoking.
Nicoden Silver drops help to get rid of a bad habit and stop the negative effects of tobacco smoke on the body of both the former smoker and his family members.
Analogs
Today, this drug is being replaced by one of the analogues listed below, which include such drugs.
A drug | Description |
Bilizoirn | This drug is used to treat cholangitis, cholecystitis, urinary tract infections, gastroenteritis, and cholelithiasis. |
Isochol | This drug is used to treat the same diseases as the first analogue. |
Bilamide | Used to treat gastroenteritis, cholecystitis, urinary tract infections, hepatocholecystitis. |
In addition, among analogues one can also highlight Nikoform, Bilocid, Felozan, Holpitd.
All these analogues contain the same active substance as the original. In addition, the drugs have similar therapeutic effects. Medicines have a bacteriostatic as well as bactericidal effect.
What's included
The main component of Nicodin (Nikoden) Silver drops are silver ions. Once in the blood, they quickly spread throughout the body, providing an antiseptic effect and reducing cravings for nicotine. If smoking has caused the development of a pathological process, leukocytes transfer silver to the site of the disease, where the ions penetrate under the membrane of the affected cells, blocking their division.
An auxiliary ingredient of Nicoden Silver, mistletoe extract, cleanses internal organs from the destructive effects of tar and nicotine breakdown products. The complex effect of natural components helps you quit cigarettes in just one course of taking Nicoden Silver.
What are the results of taking
The results of medical statistics indicate the high effectiveness of Nicoden Silver. Thus, the effectiveness of the fight against smoking can be characterized in the following figures:
- The craving for smoking completely disappeared in 95% of people.
- 89% of former smokers felt disgusted by the smell of cigarette smoke.
- Mild, painless cessation of cigarettes was noted by 85% of people.
In reviews, former smokers indicate that after taking a course of Nicoden Silver, their complexion improved, shortness of breath disappeared, and vitality increased.
Review of smoking drops Nikodin Silver with reviews and cost
- Author: admin
- 10.09.2017
- Potency Products
- leave a comment
Nicoden Silver is a herbal preparation created to quickly get rid of an obsessive habit. The advertised anti-smoking drops "Nikoden" - a beautiful scam or real help? Let's look into a difficult issue.
Special instructions:
For anacid gastritis, simultaneous intake of diluted HCl, gastric juice or acidin-pepsin is recommended.
Before using Nicodin, consult your doctor!
Lech photo video: 01/16/2010 / 19:28 | where in Moscow can you buy the drug NIKODIN? it is not available in pharmacies |
Ksenia: 01/20/2010 / 14:36 | maybe Vicodin? I mean...:)) |
Shvetik: 01/22/2010 / 03:13 | Most likely you can only buy it illegally... |
special instructions
During the period of use, you should refrain from drinking ethanol, and also be careful when driving vehicles and engaging in activities that require increased concentration and speed of psychomotor reactions. Safety of use during pregnancy has not been studied
The safety of use during pregnancy has not been studied.
Children under 2 years of age are more sensitive to the effects of opioid analgesics, and paradoxical reactions may occur at this age.
The drug reduces salivation, which can contribute to the development of caries and oral diseases.
Drug interactions
Codeine enhances the effect of ethanol on the speed of psychomotor reactions.
In combination with ethanol, muscle relaxants and central nervous system depressants, the sedative effect, suppression of the respiratory center and central nervous system depression are enhanced,
Combination with other opioid analgesics increases the risk of depression of the central nervous system, respiration, and decreased blood pressure.
Codeine enhances the effect of neuroleptics, anxiolytics, barbiturates, antihypertensives and drugs for general anesthesia.
The drug is taken with caution with MAO inhibitors, due to the risk of overexcitation or inhibition with the occurrence of hypertensive and hypotensive crises