"Krinon" is a gestagenic agent used in gynecology. This medicine is actively used in relation to those women who have decided to undergo IVF. It is also used for uterine bleeding and postmenopause. Today we will find out what the price of “Krinon” is, a drug that is a real salvation for many women, as well as how to use it correctly. We’ll also find out what women themselves think about him.
In what cases can it be prescribed?
The medicine "Krinon", instructions for use of which must be included in the packaging, can be used in the following cases:
- Hormone therapy in postmenopause.
- Secondary amenorrhea (absence of menstruation).
- Uterine bleeding associated with a lack of the hormone progesterone.
- Maintaining the luteal phase - the period that begins after ovulation and lasts until the next menstruation appears, while using additional methods of reproduction.
Price
Vaginal gel is a medicine of a high price category. The price of Krinon gel in package No. 15 ranges from 2100 to 2570 rubles. The price of 1 applicator is from 160 to 190 rubles.
You need to store a cardboard pack with disposable applicators in a cool place, the maximum temperature is not higher than + 25 C. Do not freeze vaginal gel: violation of the temperature regime can change the properties of the drug.
The shelf life of the progesterone-based composition is 36 months. Once opened, use the disposable applicator immediately.
In what form is it produced?
The medicine "Krinon", the instructions for use of which are quite clear, is a vaginal gel. Its composition is as follows:
- The main substance is progesterone.
- Auxiliary components – glycerol, carbomer, liquid paraffin, sorbic acid, palm oil glyceride, sodium hydroxide, polycarbophil, water.
The gel is packaged in special disposable plastic containers.
Release form
To reduce the risk of infection and increase comfort during the procedure, the manufacturer offers Crinon gel 8% in convenient packaging. A soft plastic applicator with a long handle contains a homogeneous mass with a specific odor, the color is almost white or white, and the consistency is soft.
A cardboard box contains 15 disposable applicators in paper packaging or a foil shell with an ionized layer, the weight of the gel in each device is 1.125 g. The box contains instructions describing the composition and rules for application. The drug is made in the UK. To purchase vaginal gel you need a prescription from a gynecologist.
Dosage
"Krinon" (gel) is prescribed to girls and women in the following quantities as prescribed:
- As a substitute for hormone therapy in postmenopause - 1 dose (90 mg) 2 times a week.
- To maintain the luteal phase - 1 applicator daily, starting from the day of embryo transfer. And when the long-awaited pregnancy occurs, you need to continue to administer the medicine intravaginally for up to 12 weeks.
- For uterine bleeding resulting from progesterone deficiency, with secondary amenorrhea, 1 dose is prescribed every other day, from the 15th to the 25th day of the menstrual cycle. If necessary, the gynecologist can either reduce or increase the dose of this drug.
Possible side effects
During treatment, local and systemic reactions are possible:
- headache,
- drowsiness,
- breast tenderness,
- discomfort in the abdominal area.
Unpleasant manifestations rarely occur:
- itching and irritation in the vagina,
- bleeding during the intermenstrual period,
- allergic reactions, skin rashes.
Most women tolerate the effects of progesterone well when the gel is administered intravaginally. Reviews about Crinone are often positive; doctors rarely record complaints about intolerance to the drug. Most negative reactions occur due to individual sensitivity to the main component. Dosage adjustment or discontinuation of a progesterone-containing drug is carried out as directed by a gynecologist or reproductive specialist.
Rules for using the drug
The use of Krinon, a medicine that solves serious problems, is not difficult. For ease of use and compliance with hygiene rules, this drug is packaged in disposable containers, which must be used as follows:
- Take the plastic device with the medicine and shake it.
- Holding the applicator by the upper end of the container, remove the cap by turning it sharply.
- The product can be administered in two positions: sitting or lying down with bent legs.
- The applicator should be inserted slowly.
- In order for the medicine to completely enter the vagina, it is necessary to squeeze the container.
Features of application:
Crinon is a topical drug used intravaginally. It is administered at a dosage of 90 mg every day before going to bed.
Note! The dosage may differ from the stated one, since the doctor, when prescribing the drug, is based on the data obtained as a result of a hormone analysis.
The method of use depends on the form.
- gel
- Shake the plastic applicator vigorously (just like a mercury thermometer) so that the liquid moves to the bottom.
- Twist the cap or tear it off along the perforations.
- Insert the end of the applicator as deep as possible into the vagina. Move slowly, without causing yourself discomfort.
- Squeeze the container sharply to force the liquid inside.
Reference! It is more convenient to administer Crinon in a lying position, with your knees bent or sitting on the toilet.
- candles
Candles are introduced in the standard manner. The main task is to push the medication deep enough into the vagina.
- side effects
Many drugs that affect hormone production have a number of side effects. Crinon is no exception. Most often, women who underwent such therapy complained of such unpleasant symptoms as:
- attacks of headache;
- increased fatigue;
- drowsiness in the middle of the day;
- chest pain;
- abdominal pain;
- bloody discharge between periods;
- irritation on the mucous tissues of the external genitalia;
- skin rash (in case of intolerance to one or more components).
There have been no cases of overdose with Crinon in medical practice.
- contraindications
The drug is contraindicated for the following ailments:
- bleeding from the vagina of unknown etiology;
- oncological diseases of the mammary glands or genital organs;
- circulatory disorders in the brain;
- frozen pregnancy;
- lactation period;
- intolerance to one or more components of the drug.
Restrictions
Krinon gel, the instructions for use of which clearly indicate situations in which the drug can be prescribed, has the following contraindications:
- Malignant formations in the breast, uterus, vagina.
- Incomplete abortion.
- Cerebrovascular accident.
- Breast-feeding.
- Vaginal bleeding that appears for unknown reasons.
- Acute porphyria (pigment metabolism disorder - a hereditary disease).
- Hypersensitivity to the drug.
- Acute thrombosis and thrombophlebitis.
With caution, this drug should be used for renal failure, heart failure, arterial hypertension, diabetes mellitus, epilepsy, migraine, depression, bronchial asthma.
The need to use medication for artificial conception
Gel "Krinon" for IVF (in vitro fertilization) is often prescribed by gynecologists. With such artificial conception, the woman’s body does not have time to quickly react to changes. And it turns out that the membrane that envelops the uterus cannot accept a fertilized egg. As a result, spontaneous miscarriages occur in the early stages. Doctors have solved this problem, and in order to reduce the risk of miscarriage, they prescribe Crinon gel. Progesterone, which is the active element of this drug, enters the mucous membranes and helps the endometrium prepare for implantation of the fertilized egg. And this is done quite successfully.
Pharmacological properties
When pregnancy occurs naturally, the body begins to produce hormones that provide:
- preparing the endometrium to receive a fertilized egg;
- fixation of the egg in the uterine cavity;
- full-fledged implantation and provision of the embryo until the moment when the woman’s own body “comes to its senses” and rearranges its work to carry the pregnancy.
Important! If during a physiological pregnancy the processes necessary for a further successful outcome occur under the influence of natural factors immediately after fertilization, then an artificial pregnancy must be provided with conditions for the acceptance of the embryo and its development.
Thanks to him:
- the uterine mucosa (endometrium) passes from the proliferative to the secretory phase;
- the excitability and tone of the uterus and fallopian tubes decreases;
- ovulation is suppressed;
- the production of gonadotropic and some other hormones slows down;
- The body's hormonal system is adjusted to bear an artificially implanted embryo.
Did you know? It is a mistake to consider progesterone a sex hormone
In fact, it is the matrix of all sex and steroid hormones, and it is this “progenitor” function that determines its importance and exclusivity for the body.
What to do if the gel leaks?
If a woman uses this remedy every day, then, of course, the medicine accumulates in the vagina. Some girls may experience clear or white discharge even after 5-6 days after use. This is not scary, because it indicates that a special progesterone carrier is coming out of the vagina. And it is transported because the hormone itself has already moved from the medication to the uterus. This is how the medicine “Krinon” works. Discharge may bother a woman, but in reality there is no need to worry. Although, to be more sure, it is still better to consult your doctor.
Crinon: reviews
I found out about the drug when the doctor prescribed me a transfer. I accepted it with fear. When the doctor told me about the drug, I wasn’t particularly worried, but when I got home, I was seized by an inexplicable panic. But then I pulled myself together and got down to business. The procedure for administering the gel itself is fundamentally different from the use of all other medications. First you need to squeeze it out, and then take everything that is not absorbed back out. I was very lucky that I found an excellent and professional doctor who explained in great detail how to use the drug.
Oksana
After the examination, I was informed that I had a deficiency of an important hormone, which was causing my cycle to go wrong and periodically causing DUBs. On the doctor's recommendation, I started taking these applicators. I was more than pleased with the result. Now my body works like a clock.
Valeria
While undergoing a routine examination before giving birth, I learned that I had a progesterone deficiency. At first I was prescribed Utrozhestan, but it did not suit me. Then he was replaced by Crinon. But I was unable to recover quickly, all because of acute pain in my chest. As the doctors explained, all this is a consequence of progesterone deficiency. But she continued to take Crinon and was gradually able to cope with this problem.
Olesya
Doubts of the fair sex
Many women have a completely logical question: is it necessary to lie down for some time after Crinon, a drug that makes many girls’ dreams of becoming mothers come true? The answer will be simple and clear: no. The uniqueness of this medication is that its components quickly attach to the walls of the vagina, and therefore there is no need to lie down, even for half a minute, after inserting the gel.
Also, some women do not know, and therefore doubt the question of whether it is possible or not to have sexual intercourse during treatment with the drug "Krinon". Gynecologists clearly advise women to get closer to their partners. Sexual activity will in no way interfere with the transport of progesterone to the uterus. Therefore, this gel should in no way interfere with your sex life.
Women's opinions
The medication "Krinon" receives only favorable reviews from girls who have used it. So, users of this medicine note that it is easy to use, there is nothing supernatural or complicated. This is a mobile device that can be used in any situation, wherever the girl is: at work, visiting, on a train or on a plane. Women also note that the procedure for introducing this gel is absolutely painless, unlike progesterone injections that were previously prescribed to people. And of course, the effect of this medication is amazing: those women who decided to undergo IVF note that an important factor in the onset of their pregnancy is the use of Crinon gel. Also, for many girls who previously had problems with menstruation, their periods became regular. Such positive reviews about this medication indicate only one thing: the medicine really brings an effect, because it is no coincidence that many gynecologists prescribe it.
special instructions
- Women should be aware that the product contains sorbic acid, which can cause contact dermatitis. This happens extremely rarely, but patients should still be aware of it.
- If a girl uses this medication for a long time, then she must undergo gynecological examinations in order to exclude the possibility of endometrial hyperplasia.
- Women who experience depression while using Crinon gel should interrupt treatment if the blues and despondency increase.
- If a girl has diabetes, then treatment with this medication should be strictly under the supervision of a doctor. The fact is that the components of the drug can reduce glucose tolerance. It is for this reason that diabetic women using the gel need to be monitored.
