Release form and composition
Dosage form of Pentaflucin - granules for the preparation of a solution for oral administration: a mixture of granules of cylindrical, round or irregular shape, from yellow-green to white with a creamy tint and white (in polymer-coated paper bags; in a cardboard pack there are 5 or 10 bags) .
Content of active substances in 1 sachet (5000 mg):
- Paracetamol – 500 mg;
- Ascorbic acid (vitamin C) – 200 mg;
- Calcium gluconate – 200 mg;
- Diphenhydramine (diphenhydramine hydrochloride) – 20 mg;
- Rutin (rutoside) – 20 mg.
Auxiliary components: polyvinylpyrrolidone (povidone), sugar (sucrose), soluble saccharin (sodium saccharinate), citric acid.
Pentaflucin price, where to buy
You can buy it in many pharmacies in Moscow. The price of Pentaflucin in granules 5 g No. 10 sachets ranges from 109 rubles. up to 178 rub.
- Online pharmacies in RussiaRussia
ZdravCity
- Pentaflucin granules for intravenous injection solution.
approx. 5g 10 pcs. JSC Uralbiopharm 233 rub. order
Contraindications
- Severe renal and/or liver failure;
- Blood diseases with a tendency to bleeding and hemorrhage;
- Hereditary deficiency of the enzyme glucose-6-phosphate dehydrogenase (G6PD);
- Hyperoxaluria, nephrourolithiasis (calcium), nephrolithiasis;
- Thrombophilia (propensity to form blood clots);
- Sucrose-isomaltose deficiency, glucose-galactose malabsorption, congenital fructose intolerance;
- Period of pregnancy, breastfeeding (lactation);
- Children and adolescents under 18 years of age (no clinical trial data);
- Hypersensitivity to any of the components of Pentaflucin.
Take the drug with caution in case of constitutional hyperbilirubinemia (Gilbert's syndrome).
If it is necessary to use the drug during lactation, breastfeeding must be interrupted for the entire duration of therapy.
Side effects
If you follow the recommended dosage regimen, in rare cases the following side effects are possible due to the action of the active components of Pentaflucin:
- Complex of active ingredients: skin allergic reactions, constipation, nausea, vomiting;
- Paracetamol: changes in the peripheral blood pattern (leukopenia, thrombocytopenia, agranulocytosis), nephrotoxic and hepatotoxic effects (long-term use in high doses);
- Diphenhydramine: impaired coordination of movements and speed of psychomotor reactions, drowsiness, insomnia, irritability, euphoria, dizziness, tremor;
- Rutoside: flushing, diarrhea.
If you observe any adverse reactions, their aggravation, or the manifestation of other previously unnoticeable effects, you should immediately inform your doctor.
Symptoms of an overdose of Pentaflucin are: stomach pain, nausea, vomiting; After a few days, signs of liver damage are diagnosed; in some cases, severe liver failure, encephalopathy and coma may develop.
To treat the condition at home, the patient should rinse the stomach, take adsorbents (activated carbon) and immediately consult a doctor. Further symptomatic therapy (injections of acetylcysteine and methionine) is recommended.
Analogs
Level 4 ATC code matches:
Aflubin
Kofex
TeraFlu Bro
Suprima-Broncho
Sinupret
Bronchostop
Doctor Mom
Tonsilgon N
Tonsipret
Insti
Imupret
Antigrippin-Maximum
Antigrippin-ANVI
Atma
Viburkol
Travisil
Rinicold Broncho
Umkalor
Stodal
AnviMax
Coldrex Max Gripp , Coldflu , Antigrippin have a similar effect.
special instructions
It is not recommended to combine Pentaflucin with alcoholic beverages to avoid toxic liver damage.
During therapy, care should be taken when driving vehicles and engaging in other potentially hazardous activities that require rapid psychomotor reactions and increased concentration.
Patients with diabetes should take into account that the drug contains sugar, 1 sachet contains 0.33 XE.
Reviews
The drug is used for symptomatic treatment of respiratory diseases . Everyone who has taken this drug notes its effectiveness, availability and low cost.
“It helps! Inexpensive and effective"
“It helps well and quickly with colds, quickly relieves the condition”
“Pentaflucin is an effective, efficient and inexpensive remedy”
“...an effective drug for the initial signs of a cold”
One of the disadvantages of the drug is its side effect - drowsiness. This is understandable because it contains diphenhydramine . Please note that there is Pentaflucin daily (without diphenhydramine), devoid of this undesirable effect.
Drug interactions
The presence of active ingredients in the drug with a wide range of pharmacological activity causes possible drug interactions between Pentaflucin and other drugs/substances.
Paracetamol:
- Uricosuric drugs – reduces their effectiveness;
- Anticoagulants – reduces the synthesis of procoagulant factors in the liver (the use of paracetamol in additional high doses increases the effect);
- Inducers of microsomal oxidation in the liver (tricyclic antidepressants, barbiturates, rifampicin, phenytoin, phenylbutazone), hepatotoxic substances/drugs, ethanol - increase the production of hydroxylated active metabolites, causing the possibility of developing severe intoxications even with a slight overdose of paracetamol;
- Barbiturates (in case of prolonged use) - reduce the effectiveness of paracetamol;
- Ethanol – promotes the development of acute pancreatitis;
- Nonsteroidal anti-inflammatory drugs (NSAIDs) – with long-term combined use, the risk of developing analgesic nephropathy, renal papillary necrosis, and end-stage chronic renal failure increases;
- Diflunisal - increases the likelihood of developing hepatotoxicity due to an increase in plasma concentration of paracetamol by 50%;
- Myelotoxic drugs/drugs – increase the manifestations of hematotoxicity.
Diphenhydramine (diphenhydramine hydrochloride):
- Drugs that depress the central nervous system (CNS) and ethanol - diphenhydramine hydrochloride potentiates their effect;
- MAO inhibitors (monoamine oxidase) - enhance its anticholinergic effect.
Ascorbic acid (vitamin C):
- Benzylpenicillin and tetracyclines - their concentration in the blood increases;
- Ethinyl estradiol, including that included in oral contraceptives - at a dose of 1000 mg per day, vitamin C increases its bioavailability;
- Heparin and indirect anticoagulants – their effectiveness decreases;
- Iron preparations – their absorption in the stomach improves, ferric iron is converted into divalent iron;
- Deferoxamine – may increase iron excretion;
- Acetylsalicylic acid - its excretion in urine decreases and the excretion of vitamin C increases, absorption of ascorbic acid decreases by 30%;
- Short-acting salicylates and sulfonamides - the excretion of acids by the kidneys slows down, the excretion of drugs with an alkaline reaction (including alkaloids) increases, the concentration of oral contraceptives in the blood decreases, and the risk of developing crystalluria increases;
- Isoprenaline – chronotropic effect decreases;
- Barbiturates and primidone increase the urinary excretion of ascorbic acid.
Calcium gluconate:
- Quinidine is likely to increase its toxicity and slow down intraventricular conduction of the heart;
- Tetracycline antibiotics: form insoluble complexes with calcium gluconate, which reduces the antibacterial effect;
- Tetracyclines, digoxin, oral iron preparations - absorption is reduced (the interval between doses should be at least 2 hours);
- Thiazide diuretics - may increase hypercalcemia and reduce the effect of calcitonin in hypercalcemia;
- Phenytoin – its bioavailability decreases;
- Carbonates, salicylates, sulfates are pharmaceutically incompatible with calcium gluconate, since they form insoluble or sparingly soluble calcium salts;
- Blockers of slow calcium channels - the therapeutic effect is reduced.
Interaction of the active components of Pentaflucin: ascorbic acid enhances the pharmacological effect of rutin (rutoside).
Acetylsalicylic acid, fresh juices, alkaline drinks, oral contraceptives - reduce the absorption and absorption of the drug.
What can be replaced?
Pentaflucin has many analogues both in composition and pharmacological action, but we will consider the most similar and effective:
Fervex is a combination drug with an anti-inflammatory effect and is also capable of having an antipyretic effect due to the presence of paracetamol in the composition. Contains pheniramine maleate. Available in the form of a water-soluble powder with the addition of vitamin C. It is the most popular medicine for colds and flu.The drug is not recommended for children under 15 years of age. For patients under 15 years of age, there is an adapted version of Fervex, designed specifically for children's bodies. With long-term use, it can cause severe adverse reactions from all body systems, including the development of diabetes mellitus and hypoglycemic coma.
- Antigrippin is an effervescent tablet for preparing a drinking solution. Available in different flavors (cranberry, strawberry and blackberry). Prescribed as a symptomatic treatment for acute respiratory viral infections and acute respiratory infections.
It contains paracetamol, which helps fight fever, muscle pain, headaches, and even sore throat. In addition to paracetamol, the composition contains ascorbic acid and chlorphenamine. One of the most affordable antiviral medications. Permitted from 15 years of age.
Coldact Flu Plus - long-acting capsules to combat cold symptoms, including swelling of the nasal mucosa and lacrimation. It is used both as an antipyretic and as an analgesic.
Thanks to its long-lasting effect and capsule form, it is the most convenient analogue. The effect of Koldakt lasts more than 8 hours. Patients under 12 years of age are prohibited from admission. In most cases, the drug is well tolerated and does not cause side effects.
- Rinzasip is a powder containing vitamin C and intended for preparing a solution with the taste of lemon, orange, blackcurrant, cranberry and honey. It is administered orally. Eliminates symptoms of respiratory diseases and has anti-allergic effects, eliminating itching, redness in the eyes and lacrimation.
Contains caffeine, paracetamol, phenylephrine hydrochloride and pheniramine maleate. Caffeine reduces drowsiness during a cold and has a psychostimulating effect, increasing performance. Contraindicated for persons under 15 years of age.
Rinikold - tablets that have antipyretic, analgesic, antihistamine and psychostimulant effects. Prescribed for colds that are accompanied by high fever, chills, headache, runny or stuffy nose, as well as muscle and joint pain. Increases performance and fights fatigue and drowsiness.Consists of caffeine, paracetamol, phenylephrine and chlorpheniramine. Each substance is responsible for certain actions, and with parallel interaction they complement each other and prolong the effect. Prohibited for children under 6 years of age. Virtually no adverse reactions.
