Magnesium-Diasporal granules for suspension. 300mg/5g sachets No. 20

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Manufacturers: Protina Pharmazeutische Gmbh

Active ingredients

• Magnesium citrate

Disease class

• Magnesium deficiency

Clinical and pharmacological group

• Not indicated. See instructions

Pharmacological action

• Replenishes magnesium deficiency

Pharmacological group

• Macro- and microelements

Composition and release form

The official international name of this medication is Magnesium diasporal 300. The drug is produced by a leading German pharmaceutical company.

Unlike analogues intended for use in cases of magnesium deficiency, this product has a specific release form - it is a yellowish powdery granular mixture used in the preparation of an oral solution. The granules are packaged in sachets weighing 5 g.

One cardboard box can contain 20 or 50 of these mini-packages, connected with an easy-to-tear seam. Each 5 g sachet contains a whole complex of substances, among which, in addition to magnesium citrate (1830 mg, corresponding to 295.7 mg of magnesium), it is worth noting riboflavin, sucrose, and sodium bicarbonate.

Magnesium diasporal

Magnesium Diasporal 300, the price of which exceeds the cost of analogues, is an officially registered medicine. This is not a dietary supplement. The drug belongs to the pharmacotherapeutic group A.12.CC Magnesium preparations.

Selling Features

You can purchase the medicine in stationary pharmacy chains or online pharmacies. However, every user should know that today the sale of medicines through the World Wide Web is prohibited.

You can find and buy Magnesium Diasporal 300 without leaving your home using services that provide exclusively search and booking services. But the delivery of the drug itself, according to the law, cannot be carried out by third-party companies, so you will have to pick up the medicine from the pharmacy yourself.

This restriction does not apply to cosmetic products, dietary supplements, vitamin-mineral complexes and other products that do not belong to the category of medicines. They can be sold online and delivered to the buyer.

Thus, it is possible to reserve Magnesium Diasporal 300 through an online resource and receive the drug at a conveniently located pharmacy, but it is impossible to legally order it along with home delivery. Also, you should not turn to shady companies, since in this case there can be no talk of any guarantees of quality and health safety.

The cost of a package with 20 sachets is in the range of 825 - 1,022 rubles. Each pack contains an annotation for the drug from the manufacturer.

Mechanism of action

The pharmacological properties of the drug directly depend on the participation of magnesium in biochemical reactions. It is an essential element present in all cells and tissues. This substance must be contained in the body in a certain amount in order to maintain the functionality of cells, participate in metabolism, and promote the production and maintenance of energy reserves.

Thanks to magnesium ions, which are calcium antagonists, increased neuronal excitability is eliminated, neuromuscular impulse transmission is normalized, and the course of enzymatic reactions is stabilized. Magnesium citrate is easily absorbed and tolerated by patients, and extremely rarely causes allergic reactions.

An adult's daily requirement for magnesium is about 300 mg. Almost the same amount is contained in 1 mini-pack of Magnesium Diasporal 300, which, when entering the body, stimulates the production of choline and cholinesterase, and takes part in other enzymatic processes.

Magnesium citrate is necessary primarily for energy supply to muscle tissue. In fact, this component directly performs the function of a membrane protector, helping to stabilize the level of phospholipids in the cell membrane.

Magnesium citrate prevents the appearance of excess calcium deposits. In order to regulate muscle excitability and prevent the flow of calcium ions through presynaptic membrane barriers in the central nervous system, the concentration of neurotransmitters decreases.

The pharmacokinetic properties of magnesium directly depend on the amount in which it enters the body. The main part of the substance is absorbed into the bloodstream through the walls of the small intestine, and its volume will be proportional to serum magnesium levels in the blood.

In patients suffering from malabsorption syndrome, as well as in people who abuse foods high in vegetable or animal fats, the absorption of magnesium is minimal.

Magnesium Diasporal 300, absorbed into the blood, is excreted from the body through the urinary system, sweat glands and bile. The part of the medication that is not absorbed into the blood enters the colon and has a slight laxative effect.

The rate of filtration and excretion of magnesium by the kidneys is related to the level of this substance in the plasma and the significance of the glomerular blood purification process. Normal serum contains approximately 1% magnesium citrate, which equals 0.8–1 mmol/l. No more than 50% of the specified amount reacts with albumin.

Pharmacokinetics

Magnesium is slowly and incompletely absorbed in the gastrointestinal tract; with malabsorption syndrome and consumption of foods rich in fat, magnesium absorption is reduced. The unabsorbed portion of magnesium is excreted through the intestines.

Blood serum contains about 1% of absorbed magnesium (0.8-1.0 mmol/l). Approximately 45% of magnesium is bound to intracellular proteins and macroenergetic phosphates and deposited in skeletal muscles, kidneys, liver and myocardium. The remaining part is deposited in bone tissue; in small quantities - in tissue fluid and red blood cells.

Magnesium ions penetrate the blood-brain barrier and the placental barrier.

Absorbed magnesium is eliminated by the kidneys, and only a small part is excreted in the bile and sweat glands. Partially resorbed in the renal tubules. The rate of excretion by the kidneys is proportional to plasma concentration and glomerular filtration rate.

Indications for use

Magnesium is involved in many biological processes and is responsible for several hundred chemical reactions. For example, adenosine triphosphate, which is an important chemical compound for ensuring uninterrupted nutrition of cells, consists of 30% magnesium salts.

Since a kind of balance is established between the concentration of magnesium in the blood serum and its content in bone and muscle tissue, it is not advisable to draw a conclusion about the existing deficiency of this substance in the body based on the result of a laboratory analysis alone.

A lack of magnesium can be judged by the presence of corresponding symptoms indicating disorders of neuromuscular conduction:

Magnesium Diasporal 300 (the price of the drug is indicated above) is recommended for use in the presence of a confirmed magnesium deficiency, which is manifested by one or more of the symptoms indicated in the table. If after a month of using the drug no improvement has occurred, further use of the medication does not make sense.

Description of possible adverse reactions

Reviews from doctors and patients indicate that the drug rarely causes any side effects. On the other hand, the instructions confirm the possibility of complications. Most often, the medicine causes disorders of the digestive tract. Some patients report nausea, abdominal pain, flatulence, and diarrhea.

With increased sensitivity, allergic reactions may develop. Therapy in some cases is associated with the appearance of skin rash, swelling, redness, itching, and urticaria. If there is any deterioration, you should contact your doctor - he will decide to discontinue the drug, if necessary.

Contraindications

The necessity of magnesium for the functioning of the body has been confirmed by many laboratory studies. However, it would be wrong to consider drugs based on this substance to be completely safe. They, like a number of other medications, have contraindications.

An absolute ban on the use of Magnesium Diasporal 300 occurs in the following cases:

• with increased individual sensitivity to magnesium citrate;
• in severe forms of renal failure and creatinine clearance less than 30 ml/min;
• with atrioventricular block;
• with myasthenia;
• with an excess of magnesium in the blood serum.

For persons suffering from diabetes, Magnesium Diasporal 300 is contraindicated due to the presence of sucrose in its composition. Also, this drug is not prescribed to children under 12 years of age. The product must be used as recommended and under the supervision of a physician.

The drug "Magnesium Diasporal" (300): instructions for use

Magnesium is a beneficial element for the body. But too much of this substance can negatively affect the functioning of the nervous and cardiovascular systems. Therefore, before starting therapy, you should definitely consult your doctor.

The contents of one sachet of Magnesium Diasporol (300 mg) should be dissolved in 150 ml of water (for this purpose, you can use chilled tea or fruit juice). The daily dose for adults and adolescents over 12 years of age is 1 sachet. The course of treatment lasts 30 days, although in some cases the doctor may decide to extend the therapy.

Side effects

The drug can provoke adverse reactions in the body. Taking Magnesium Diasporal 300 sometimes leads to temporary disorders of the central nervous system, which appears as weakness, loss of strength, and apathy.

Such side effects usually occur as a result of prolonged or uncontrolled use of the drug. It is recommended to suspend further use of Magnesium Diasporal 300, and it will be possible to resume taking the drug in a lower dosage after stabilization of health.

Sometimes patients develop allergies to magnesium-containing medications. In this case, we are talking about the reaction of the immune system to the main or auxiliary components. Most often, the allergy manifests itself as a skin rash, mild itching and swelling. After discontinuation of the drug, the symptoms go away on their own.

In the first days of using Magnesium Diasporal 300, some patients, judging by reviews, observe changes in the gastrointestinal tract, expressed by diarrhea, flatulence, nausea, and abdominal pain.

Such undesirable reactions to the drug, although they bring temporary discomfort, are still not a reason for a categorical refusal to use it. If it is necessary to select an analogue, the patient should consult a doctor.

Similar drugs:

• Magne B6 Oral tablets
• Magnesium plus B6 (MAGNESIUM PLUS B6) Oral tablets
• Magne B6 forte Oral tablets
• Asparcam Solution for infusion
• Magvit (MAGVIT) Capsule
• Magne B6 Oral solution
• Panangin Solution for infusion
• Magnerot Oral tablets
• Potassium aspartate and magnesium aspartate Solution for infusion
• Asparcam Oral tablets

** The Drug Directory is intended for informational purposes only. For more complete information, please refer to the manufacturer's instructions. Do not self-medicate; Before starting to use the drug Magnesium-Diasporal 300, you should consult a doctor. EUROLAB is not responsible for the consequences caused by the use of information posted on the portal. Any information on the site does not replace medical advice and cannot serve as a guarantee of the positive effect of the drug.

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** Attention! The information presented in this medication guide is intended for medical professionals and should not be used as a basis for self-medication. The description of the drug Magnesium-Diasporal 300 is provided for informational purposes and is not intended for prescribing treatment without the participation of a doctor. Patients need to consult a specialist!

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Overdose

If for a long time the amount of magnesium entering the body exceeds the daily requirement for this substance, the patient may experience symptoms of an overdose.

The maximum allowable amount of magnesium is considered to be 310-420 mg. In pregnant and lactating women, as well as people involved in professional sports who experience regular physical activity, the need for any microelements increases by 20-25%.

With a course of magnesium intake, the full functioning of the kidneys is of great importance. In the case of a slight excess of a substance entering the body orally, no symptoms appear in a person with healthy kidneys.

In case of overdose, which leads to an increase in serum magnesium levels, the following symptoms and complications occur:

• gagging;
• nausea;
• drop in blood pressure;
• bradycardia;
• CNS depression;
• dulling of reflexes;
• lack of urination;
• breathing problems, up to complete stop;
• coma;
• death.

  

Thus, an excess of magnesium can be fatal if the necessary actions are not taken in a timely manner.

Rescue therapy involves:

• intravenous administration of calcium, a magnesium antagonist, which partially neutralizes its effect;
• subcutaneous and intramuscular injections of a cholinesterase inhibitor;
• drip injection of sodium chloride 0.9% to cleanse the blood.

Patients with a history of renal failure undergo urgent hemodialysis.

Directions for use and doses

Magnesium Diasporal 300 in granules is used orally. The drug, about the price of which there is often indignation, is diluted with water and the resulting liquid solution is drunk. 1 sachet contains the recommended dose of magnesium for adult patients, so there is no need to divide its contents over several days of treatment.

Before use, granules from 1 sachet are dissolved in 100 ml of drinking water, non-hot tea or juice. The average course duration is 1 month. If necessary, after 2-3 months, taking the drug can be repeated with the permission of the doctor. As soon as the level of magnesium in the blood reaches normal values, further use of the drug should be discontinued.

Cost and analogues of medicine

If necessary, the doctor can always select an analogue. The medicine "Magnesium Diasporol" can be replaced by any of the drugs in the "Magne" line ("Magne Express", "Magne Positive", "Magne B6", etc.). These products contain not only magnesium, but vitamin B6, as well as some additional components. The list of analogues includes such products as “Magnistad”, “Magvik” and “Magnetrans”.

When considering the options, one cannot help but pay attention to the price of the drug. A package of 50 bags will cost approximately 700 rubles.

special instructions

The medication must be used strictly according to the instructions. You cannot increase the dosage recommended by the manufacturer without permission. However, in some cases, adjustment of the therapeutic dose is allowed in consultation with the doctor.

The dosage is calculated based on the established daily norms: the human body should receive about 300 mg of magnesium daily (the specified amount of requirement also includes those substances contained in food products).

However, systematic consumption of alcoholic beverages, strong coffee, tea, laxatives, and increased physical activity increase this need.

Magnesium Diasporal 300 (the price of the drug deserves special attention) is not advisable for persons with genetic disorders accompanied by fructose intolerance, glucose-galactose malabsorption or sucrose-isomaltose deficiency.

Restrictions also apply to patients who are prescribed a salt-free diet, since 1 package of this medication contains about 40 mg of sodium.

If a patient has a magnesium and calcium deficiency at the same time, it is impossible to replenish the missing substances with the parallel use of such drugs. First, you need to undergo a course of treatment with Magnesium Diasporal 300, and then start taking medications and dietary supplements with a high calcium content.

Precautionary measures

Magnesium Diasporal 300 does not affect the reaction speed and quality of control of various mechanisms and vehicles. The drug has no effect on psychomotor functions and does not change the patient’s cognitive behavior.

For patients with moderate renal failure, the drug is prescribed in a minimal dosage due to the risk of developing hypermagnesemia. At the same time, pregnant and lactating women can use this medicine as prescribed by specialists.

Numerous clinical experiments confirm the absence of a direct relationship between taking the medication and the development of intrauterine defects of the fetus, but the use of Magnesium Diasporal 300 is recommended only if the potential benefit to the health of the mother outweighs the risk to the development of the unborn child.

The active substance passes into breast milk through the bloodstream, therefore, in order to avoid oversaturation of the child’s body with magnesium, lactation must be suspended before starting treatment.

In what cases is the drug prescribed to patients?

For what disorders do doctors recommend taking the drug Diasporal Magnesium? Indications for use are as follows:

• Conditions that are associated with magnesium deficiency. They are accompanied by sleep disturbances, increased irritability and constant anxiety, increased fatigue, and spasms of the calf muscles.
• The drug is included in the treatment regimen for hypertensive crisis.
• Indications include heart attacks, angina pectoris, cardiac arrhythmias.
• Magnesium is used for cholecystitis and cholangitis.
• Indications include seizures and poisoning.
• The drug is recommended to be taken if a person’s diet is unbalanced (magnesium does not enter the body with food in normal quantities).
• Magnesium is essential for pregnant women. It is often included in the treatment regimen for gestosis and eclampsia.
• The medicine is taken to strengthen the body in cases of chronic alcoholism, constant stress and depression, dental caries, diabetes, during menopause and premenstrual syndrome, against the background of constant use of laxatives and hormonal drugs.

Drug interactions

You can combine Magnesium Diasporal 300 with other medications, but if you plan to take other medications at the same time, you must inform your doctor about this. For example, the effect of muscle relaxants increases when combined with magnesium salts. Aminoglycosides, diuretics, and antacids act in the opposite way: they remove magnesium from the body, causing its deficiency.

If it is necessary to undergo complex treatment, incompatible medications can be used, but subject to a 3-hour interval between taking each of them.

This will avoid their interaction and will not interfere with full absorption. Magnesium preparations have a weakening effect on indirect anticoagulants, while calcium salts and phosphates reduce its absorption in the gastrointestinal tract.

The drug "Magnesium Diasporal": reviews

When studying information, you should pay attention not only to official data, but also to reviews. The drug "Magnesium Diasporal" is popular - doctors often prescribe it for the treatment and prevention of various diseases. Side effects rarely develop, because magnesium is a natural substance for the body.

Patients say that during therapy, positive changes are observed - muscle cramps disappear, sleep quality improves, and it becomes easier to cope with stress. The price of the drug can be considered overpriced, because some analogues are cheaper. On the other hand, this product is considered to be of higher quality and safer.

Analogs

Based on its chemical formula and principle of action, Magnesium Diasporal 300 can hardly be called a unique drug. It is distinguished from other drugs in this group by its release form and relatively high cost. In case of intolerance to the medication, you can find a full-fledged replacement and continue therapy.

Magnelis B6 Forte

This remedy is a combination product of magnesium citrate and vitamin B6. The drug is available in the form of tablets, each of which contains 618 mg of magnesium, corresponding to 100 mg of easily digestible magnesium. 1 package of Magnelis B6 Forte contains 60 tablets.

The main indication for its use is magnesium deficiency, which is the cause of various functional disorders:

• muscle spasms;
• tachycardia;
• depression.

  

It has the same restrictions on use as other magnesium-containing products. Unlike Magnesium Diasporal 300, which is recommended to be taken once a day, Magnelis B6 Forte is used daily, 3-4 tablets. In this case, the dosage can be increased or decreased according to indications. The average price of a medicine in pharmacies is 550-600 rubles.

Magnerot

The main component of this drug is not magnesium citrate, but orotic acid, which has almost the same structure as most vitamins. Magnerot is prescribed to patients not only to replenish magnesium reserves in the body, but also as a compound that increases the bioavailability of metals.

The medication is produced in tablet form with a dosage of 500 mg of magnesium orotate. Most often, the medicine is prescribed to people suffering from heart disease. Magnerot is prescribed to patients who have had a heart attack, for coronary artery disease and chronic myocardial failure, arrhythmia, and atherosclerotic vascular lesions.

The standard regimen for using Magnerot is 2 tablets three times a day. 1 package contains 50 tablets and costs more than 650 rubles. Magnerot is an expensive drug. To complete the recommended 30-day course of treatment, you will have to spend about 2,500 rubles. Another disadvantage of the drug is the presence of additional contraindications, in comparison with Magnesium Diasporal 300 (liver cirrhosis and urolithiasis).

Magne Express

Magnesium Diasporal 300, the price of which is within 1000 rubles, loses according to this criterion: the cost of a Magne Express package with 20 sachets is approximately 500-550 rubles.

This drug is a complex of pyridoxine hydrochloride and magnesium citrate. Both components enhance each other’s action, helping to restore the balance of important microelements in the body.

Magne Express is sold in sachets of granules for oral use. Unlike Magnesium Diasporal 300, they do not need to be diluted in water, but simply dissolved. You should take 2 sachets per day with meals. By the way, the granules have a pleasant taste and aroma of exotic fruits.

Magnesium preparations, such as Magnesium Diasporal 300 and analogues, are intended to eliminate health problems caused by a deficiency of this substance. The prices of medications, their composition and mechanism of action may vary, so before using medications, you should always seek the advice of a qualified doctor.