Sedalgin Plus - 13 reviews, instructions for use

To date, pharmaceutical companies have developed many drugs that have powerful analgesic and antipyretic effects. “Sedalgin Plus” is considered the most popular and inexpensive. Before using the medicine for treatment, you must read the description of the drug.

pharmachologic effect

The medication has anti-inflammatory, analgesic and antipyretic effects.

Metamizole sodium has a mild anti-inflammatory effect and has an analgesic effect. The mechanism of action is based on the ability of the pyrazolone derivative to inhibit the process of prostaglandin synthesis through inhibition of cyclooxygenase.

Caffeine has a stimulating effect on the nervous system, activating the vasomotor center, cerebral cortex and respiratory center. The active component reduces the severity of feelings of fatigue and drowsiness, increases physical and mental performance. Caffeine enhances the therapeutic effect of non-narcotic analgesics, increasing their bioavailability and increasing the permeability of histohematic barriers.

Thiamine has a beneficial effect on nerve-reflex conductivity and improves metabolism. Also known as vitamin B1.

Pharmacodynamics and pharmacokinetics

The indicators depend on the components that make up the medication.

Metamizole Na is completely absorbed from the digestive tract in a fairly short period of time. The maximum concentration is recorded 1-1.5 hours after administration. The active component binds to plasma proteins and is metabolized in the hepatic system. with bile , 90% through the renal system. The half-life is approximately 10 hours.

Caffeine is almost completely absorbed from the digestive tract. The maximum level of the active component is observed after 30-40 minutes. Caffeine can pass into breast milk and cross the blood-brain barrier . Metabolites are excreted unchanged through the renal system.

For thiamine, after oral administration, absorption reaches high levels and occurs in the lumen of the small intestine. Digestive enzymes release thiamine hydrochloride from its bound state before absorption. The level of thiamine in the blood is quite low. Only free thiamine can be found in plasma, and its phosphorus esters are found in blood cells: leukocytes and erythrocytes . 40% of thiamine can be found in internal organs, and more than 50% in striated muscles. The phosphorylation process takes place in the liver tissue. Thiamine diphosphate has coenzyme activity and is the most active phosphorus ester. Accumulates in the kidneys, heart muscle, liver tissue, spleen, and brain. It is excreted through the renal system, partly through the intestines.

Instructions for use

Sedalgin tablets are taken orally after meals. The drug should not be chewed and should be washed down with plenty of still water. If it is necessary to achieve a quick effect, the tablets are crushed to a powder state and stirred in half a glass of water. The occurrence of any side effects should be grounds for stopping treatment and a reason to consult a doctor.

Dosage

According to the instructions, the number of tablets taken depends on the age of the patient. Daily doses of the drug are:

for adults and children over 16 years of age, the average therapeutic dosage should not exceed 3 tablets per day, which must be taken at regular intervals;
the maximum daily dose for adults is no more than 6 tablets;
for children from 12 to 16 years old, the recommended dose is 0.5 or 1 tablet 2-3 times a day;
The maximum daily dosage for children is 4 tablets.

Duration of admission

The use of the medicine in the maximum permissible medicinal dosage is allowed only for two days. The duration of use of the medicine for the purpose of pain relief should not exceed five days, when using Sedalgin Plus as an antipyretic drug - no more than three days. If the symptoms do not disappear after completing the full course of symptomatic treatment or their intensity begins to increase, you should consult a doctor.

Indications for use

What is Sedalgin Plus prescribed for? Mainly for pain with:

dysmenorrhea;
neuralgia;
migraine;
polyneuropathy;
plexite;
inflammatory diseases of the musculoskeletal system;
degenerative pathology of muscle tissue;
toothache;
radicular syndrome;
after surgical interventions.

What are Sedalgin plus tablets?

Today, combination painkillers are widely used, which are more effective than analogues consisting of one active component. One of these medications is Sedalgin Plus. Thanks to its complex and well-combined composition, the medicine not only eliminates pain, but also has an antipyretic and anti-inflammatory effect.

What do they help with?

According to the instructions for the tablets, Sedalgin is a drug from the group of non-narcotic analgesics-antipyretics. Based on these data, we can conclude that the medicine will be effective when it is necessary to urgently relieve pain of various etiologies. Considering that the composition does not contain strong narcotic enzymes, the medication will only help with moderate or mild pain.

Contraindications

thrombocytopenia;
anemia;
leukopenia;
individual hypersensitivity;
pronounced atherosclerotic changes ;
hepatic porphyria;
breast-feeding;
suspicion of acute surgical pathology;
intolerance to NSAIDs;
ulcerative pathology of the gastrointestinal tract;
sleep disorders;
carrying a pregnancy ;
pathological excitability;
pathology of the hepatic system;
bronchial asthma;
glaucoma;
simultaneous treatment with MAO inhibitors;
hypertonic disease;
kidney diseases.

The combined agent is prescribed with caution for:

achalasia;
IHD;
arrhythmias;
stenosis of the pyloric part of the digestive system;
hyperplastic changes in prostate tissue;
bronchospastic reactions;
hyperthyroidism;
heart failure (congestive);
taking medications that depress the functioning of the nervous system;
gastroesophageal reflux.

Exceeding the daily dose

An overdose of the described drug may be accompanied by other unpleasant symptoms. In case of accidental ingestion of a large number of tablets, the following were recorded:

severe headaches;
tinnitus;
Read also: Jess, 3 mg+0.02 mg, film-coated tablets, 28 pcs.
feeling of fear, anxiety;
migraine;
nausea, vomiting;
dyspeptic pain;
tremor, mental excitability;
convulsions;
dysuria;
dehydration.

In case of overdose, you must immediately contact a medical facility. There is no specific antidote. First aid is based on gastric lavage and taking enterosorbent.

Side effects

Hematopoietic system:

purpura;
leukopenia;
thrombocytopenia (decreased platelet );
hemolytic form of anemia;
agranulocytosis.

Digestive tract:

jaundice;
vomit;
loss of appetite;
cholestasis;
nausea.

Nervous system:

increased excitability;
dizziness;
insomnia.

The cardiovascular system:

rhythm disturbances;
feeling of rapid heartbeat.

Allergic responses:

redness;
itchy skin;
anaphylactic shock;
Quincke's edema;
bronchospasm.

If other negative reactions occur, the patient should consult a doctor and stop taking Sedalgin Plus.

Who should not take the medicine?

"Sedalgin Plus" has quite a lot of contraindications. First of all, those patients who have been diagnosed with intolerance to the active components are not allowed to take it. In addition, the use of the drug is not recommended for the following pathologies:

problems with the gastrointestinal system;
dysfunction of hematopoiesis;
renal, liver failure;
myocardial infarction;
atherosclerosis of large vessels;
ischemia of the brain and heart;
hypertension;
high intraocular pressure;
anemia.

During pregnancy, the use of the medicine is possible only after consultation with a doctor, weighing the possible risks for the fetus and benefits for the mother.

Since the drug passes into breast milk, its use during lactation is prohibited.

Taking the medicine by children under 12 years of age is strictly prohibited.

Overdose

Manifests itself as rashes on the skin. Less commonly recorded are tremors of the limbs , anaphylactic shock, hallucinations , and a clinical picture similar to Meniere's disease. Significantly exceeding recommended dosages can lead to loss of consciousness and serious changes in the heart, nervous system, and blood. It is necessary to cleanse the stomach and intestines of drug residues, prescribe sorbents , and carry out syndromic treatment. A specific antidote for Sedalgin Plus has not been developed. When hemorrhagic gastritis , the stomach is washed with a cold solution of NA chloride (0.9%) and antacids are administered. If necessary, oxygenation is provided and ventilation of the lungs is supported. For epileptic seizures, Phenytoin and Diazepam are administered intravenously. It is important to maintain the level of fluids and salts at the required level.

Overdose

The analgesic drug is sold from pharmacies without a prescription, which is often abused by patients without following the recommendations from the instructions. Exceeding the dosage given by the manufacturer can lead to serious side effects and even calling an ambulance. If you accidentally take an extra pill and notice unpleasant symptoms, consult your doctor immediately.

Is it possible to increase the daily dose on your own?

When joint pain, migraine, or toothache occurs, health workers prescribe painkillers in a dosage that corresponds to the patient’s age, diagnosis and recommended by the manufacturer of the tablets. Doubling or tripling the dose of the drug will not give a quick effect, but will only contribute to the appearance of harmful side effects. If the standard daily dosage does not give the expected effect, do not take additional tablets; it is better to ask your doctor to replace Sedalgin Plus with an analogue.

Which is the best printer-scanner-copier for the home?
A very quick cake for tea
Tomatoes in gelatin for the winter recipes with photos without sterilization

Taking Sedalgin Plus while consuming caffeine-containing products

Do not take tablets with alcohol-containing drinks, caffeine or strong tea. It is not recommended to consume these drinks after taking the pill. The justification for the recommendations is simple. Coffee, strong tea and some other products contain caffeine, which is already included in Sedalgina Plus in normal daily dosages. This combination of products and tablets can lead to overdose symptoms and worsen the patient's condition.

Symptoms of drug poisoning

Negative reactions may occur in the cardiovascular, nervous or respiratory systems. The main symptoms of overdose are:

nausea, possibly vomiting blood;
motor or nervous excitement;
pain in the epigastric region;
tachycardia;
increase or decrease in urine volume;
heart rhythm disturbance;
confusion, speech;
hyperthermia;
migraine;
dehydration of the body;
limb spasms;
increased tactile sensitivity of the skin;
epileptic seizures;
tinnitus;
dizziness;
nervous tic.

Treatment of overdose

If you accidentally took a double dose of tablets and feel unwell, you should immediately consult a doctor or call an ambulance. Providing first aid to the victim consists of the following activities:

The patient undergoes gastric lavage, after which sorbents are prescribed: activated carbon, Enterosgel or others.
If symptoms of hemorrhagic gastritis occur, gastric lavage is done with sodium chloride solution and antacids are administered.
If there is difficulty breathing, the victim is prescribed oxygenation or provided with artificial ventilation of the lungs using a machine.
For epileptic seizures, an injection of Diazepam is given intravenously, and Phenytoin or Phenobarbital is additionally prescribed.
In all cases, after poisoning, the balance of fluid and salt in the body is constantly monitored until it is completely restored.

Interaction

Metamizole sodium can enhance the toxic effect of other medications. Medicines that increase the toxicity of Sedalgin Plus and disrupt the metabolism of its components:

Allopurinol;
antidepressants (tricyclics);
oral contraceptives.

Inducers of microsomal enzymes (Butadione, barbiturates) weaken the effect of the drug. Metamizole sodium can reduce the level of Cyclosporine in the blood. The analgesic effect of Sedalgin Plus is enhanced when taking tranquilizers and other sedatives.

Price Sedalgin plus

You can purchase Sedalgin tablets online or buy them at a pharmacy. The cost of the medicine depends on pricing in your region and the volume of the package. Approximate prices for the Moscow region are shown in the table: