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Manufacturers: Titan Laboratories Pvt. Ltd
Active ingredients
- Tamsulosin
Disease class
- Prostatic hyperplasia
Clinical and pharmacological group
- Not indicated. See instructions
Pharmacological action
- Antidysuric
- Alpha adrenolytic
Pharmacological group
- Alpha blockers
Pharmacological group
The drug Tamsulosin is a selective and competitive blocker of postsynaptic alpha1A-adrenergic receptors localized in the smooth muscle layer of the prostate gland, prostatic urethra and bladder neck. The drug also blocks alpha1D adrenergic receptors in the body of the bladder. In this regard, the smooth muscles of the prostate, the prostatic part of the urethra, and the bladder neck relax, and the outflow of urine improves and the severity of symptoms of irritation and obstruction of the urinary tract in benign forms of prostatic hyperplasia decreases.
Tamsulosin is rapidly absorbed into the gastrointestinal tract. Bioavailability is almost 100%. The maximum concentration in the blood serum is observed 6 hours after taking the capsules. The ability to create bonds with serum proteins is 99%. Tamsulosin undergoes slow hepatic metabolism to produce metabolic products with less activity. Most of the concentration of tamsulosin in the blood serum is present in unchanged form. The half-life of tamsulosin hydrochloride is 10 hours with a single dose and 13 hours with multiple doses. Excreted by the kidneys. When creatinine clearance is less than 10 ml/min, caution is required when prescribing therapeutic dosages of the drug.
Indications for use
Before starting the drug use of Tamsulosin, it is strongly recommended to visit your doctor to draw up an adequate treatment regimen and exclude possible contraindications to the use of the drug.
for adults
For adult patients, Tamsulosin is prescribed to eliminate the functional manifestations of benign prostatic hyperplasia.
for children
In pediatric practice, the use of the drug Tamsulosin is strictly contraindicated.
for pregnant women and during lactation
Women during pregnancy and breastfeeding are prohibited from taking Tamsulosin due to the lack of clinical need.
Reviews from real customers
Reviews about this drug are mostly positive, as side effects have rarely been reported. Patients note that they felt relief after only a relatively high price and frequent absence in pharmacies, which is why they have to turn to analogues.
Vladimir, 35 years old, Arkhangelsk: The detailed instructions say that you need to take the drug one capsule in the morning, but the doctor prescribed it at night. After the first dose, a strong diuretic effect began, I even had to get up an hour earlier. I decided not to drink anything at all 2 hours before bed, but the effect was the same. My sleep has improved significantly, although I always slept poorly before. The medicine helps.
Vyacheslav, 60 years old, Moscow: I started using Tamsulosin after the advice of my doctor, before that I suffered terribly with this problem. There were no effects in the first week, so I was quite skeptical about the medicine, but I waited another week and everything changed dramatically. There were no side effects, I feel great, everything helped. The price is, of course, high.
Oleg, 65 years old, Voronezh: I suffer from this problem constantly and for a long time. Doctors prescribed surgery. But before that, I used Tamsulosin all the time and, I think, it was thanks to it that there was no need for surgical intervention for so long. It's a shame that they are expensive, but they are almost impossible to find.
Applications and dosages
The product should be taken orally at the same time every day with plain water. Tamsulosin capsules should not be broken or chewed.
for adults
Adult patients should take Tamsulosin 1 capsule once a day.
for children
The drug is contraindicated for children and adolescents under 18 years of age.
for pregnant women and during lactation
Since Tamsulosin is intended for the treatment of pathological conditions of the prostate gland, taking the medication in pregnant and lactating women is inappropriate.
Instructions for use
Tamsulosin Retard
Tamsulosin Retard affects the metabolic process in the prostate gland, so BPH is treated with its help. This disease is better known as prostate adenoma or prostate adenoma. During the development of the disease, nodules form in the prostate, which subsequently compress the urethra. The disease differs significantly from gland cancer in its benign nature.
Tamsulosin Teva is available in the form of film-coated tablets or capsules. The package can contain 30 or 90 pieces. The active substance in the drug is tamsulosin hydrochloride.
This is an alpha blocker in the form of white crystals that blocks harmful substances in the prostate gland, bladder neck and prostate. The substance is completely eliminated from the body, absorption becomes less after food intake, but stabilizes with repeated doses of the drug at the same time. That is why you need to take the drug one tablet or capsule at the same time after breakfast, lunch or dinner. The drug is swallowed whole, without biting or chewing. In general, concomitant diseases do not require dosage adjustment, but it is advisable to consult a doctor first.
Tamsulosin interacts well with a number of other drugs. It is not advisable to take it with alpha adenoblockers, since their combined interaction reduces the effect of use. The concentration of tamsulosin in the blood increases when used together with cimetidine. Diclofenac and its analogues increase the rate of elimination of the drug from the body, but it is not concentrated in the blood plasma. Medicines for the treatment of heart and kidney failure, anesthetics, drugs for the treatment of inexcitability, various antidepressants and other blockers can increase the decrease in blood pressure.
The effect of treatment becomes noticeable after 2-3 weeks and remains relevant for a long time. After starting the course, it becomes easy to empty the bladder, the patient’s difficulty urinating is reduced and its volume is reduced, and all the symptoms of BPH are reduced to a minimum. Thus, the moment of catheterization or surgical intervention is significantly delayed.
The product is available with a doctor's prescription and is not addictive. The combined use of alcohol and medication is not recommended. The drug is not intended for the treatment of children, so the drug should be kept out of their reach. The medication can be used for 3 years from the date of manufacture, as is always written on the packaging. The average price is 550 rubles.
Side effects
The main side effects associated with the use of the drug Tamsulosin are:
- diarrhea or constipation;
- tachycardia;
- orthostatic hypotension;
- asthenia;
- hives;
- rhinitis;
- chest pain;
- nausea and vomiting;
- angioedema;
- back pain;
- skin rash;
- retrograde ejaculation;
- small pupil syndrome during cataract surgery;
- decreased sex drive;
- itching;
- priapism.
Contraindications and important tips
The drug Tamsulosin is not used in case of hypersensitivity to one of the components of the drug. To make sure there is no allergic reaction to the ingredients in the composition, consult your doctor. It is not allowed to use for orthostatic hypotension (when pressure drops sharply during ascent) and for severe renal failure. In the latter case, an appointment is still possible, but only with the permission of the attending physician.
Orthostatic hypotension
The drug is prohibited for orthostatic hypotension, because dizziness is often noted among the adverse reactions. At the first manifestation of these symptoms, you should immediately lie down until the condition improves. In more rare cases, the following symptoms were recorded: headache, fainting and sleep disturbances. In addition, in rare cases the following pathologies have been recorded:
- Cardiovascular system: tachycardia (rapid heartbeat) and pain in the thoracic region;
- Respiratory organs: rhinitis (inflammation of the nasal mucosa - runny nose);
- Digestive system: constipation, nausea and vomiting;
- Skin: hives, rash and itching;
- Genitourinary system: retrograde ejaculation (ejaculation into the bladder) and priapism (painful erection);
- Those who plan to get rid of cataracts through surgery should not take the drug, since the drug can subsequently cause small pupil syndrome.
The manufacturer strongly advises that before taking the drug, conduct a full examination to exclude a number of other diseases with identical symptoms. During treatment, the prostate gland must be checked regularly. Since the drug Tamsulosin can cause drowsiness, blurred vision and fainting, drivers and those who work in enterprises that require maximum concentration need to take the course of treatment especially carefully.
There have been no cases of drug overdose, but experts do not exclude the possibility of acute hypotension. In this case, you should take a horizontal position and carry out all the necessary actions to maintain the functioning of the cardiovascular system (restoring normal heart function and blood pressure). After this, it is necessary to rinse the stomach with activated carbon or other similar medications.
If this does not help, additionally take vasoconstrictors and medications that will increase blood circulation. Since Tamsulosin capsules are intended only for males, their effect on pregnancy and lactation is unknown. Treatment with this drug in women is contraindicated.
Interaction with other drugs
The combination of the drug with cimetidine leads to an increase in the plasma concentration of tamsulosin, while the combination with furosemide leads to the opposite effect.
Simultaneous use of the drug with warfarin or diclofenac may accelerate the elimination of tamsulosin from the body.
Alpha1-adrenergic receptor blockers, other antihypertensive medications and anesthetics may enhance the hypotensive effect of tamsulosin.
special instructions
If symptoms of orthostatic hypotension (weakness or dizziness) appear, you must take a sitting or lying position until they disappear completely.
Before starting to use Tamsulosin, all possible pathologies that could lead to benign prostatic hyperplasia should be excluded.
Due to the possible development of drowsiness, dizziness, fainting and blurred vision during the treatment period, it is recommended to refrain from driving a car or other vehicles, as well as from performing other activities that require reaction speed and attentiveness.
Tamsulosin overdose, symptoms and treatment
Acute overdose of tamsulosin has not been described. Theoretically, after an overdose, there is a risk of developing acute arterial hypotension, which may require additional cardiotropic therapy. If the symptoms are not eliminated, you should replenish the blood volume by prescribing electrolyte solutions, or administer vasoconstrictor drugs. To prevent further absorption of tamsulosin, gastric lavage should be performed, activated charcoal and an osmotic laxative should be prescribed.
List of pharmacies where you can buy Tamsulosin:
- Moscow
- Saint Petersburg
Analogs
In case of intolerance to the components of the drug Tamsulosin or in case of emergency replacement of the drug, it is necessary to resort to the selection of an effective analogue. On the modern market of pharmacological medicines, there are several worthy substitutes for Tamsulosin.
Omnic
The drug Omnic is a direct structural analogue of Tamsulosin. Indications and contraindications for use are absolutely similar. This drug has identical effectiveness and can replace Tamsulosin in the treatment of benign prostatic hyperplasia without disrupting the therapeutic process.
Doxazosin
Tablet alpha1-adrenergic receptor blocker. Contains 2 mg doxazosin mesylate. The drug is used for benign prostatic hyperplasia, as well as as a single drug or as an element of complex treatment of arterial hypertension. Doxazosin is contraindicated in women who are breastfeeding and pregnant, children under 18 years of age, and patients with intolerance to substances contained in the tablets.
Alfirum
The product is available in the form of modified-release tablets. The active substance is alfuzosin hydrochloride. The indication for the use of Alfirum is the symptomatic treatment of benign prostatic hyperplasia. Contraindications: chronic renal failure, liver failure, orthostatic hypotension, children under 18 years of age, hypersensitivity and combination with other alpha-adrenergic receptor blockers.
Setegis
Alpha1-adrenergic receptor blocker in tablet form containing terazosin hydrochloride. Indications for the use of Setegis are the symptomatic treatment of urinary problems directly related to benign prostatic hyperplasia, and the treatment of arterial hypertension (as monotherapy and as a component of combination therapy). Setegis is contraindicated for use in children and adolescents under 18 years of age, pregnant and lactating women, and patients suffering from intolerance or hypersensitivity to the current medication or other alpha-adrenergic blockers.
Composition and release form
The manufacturers of the drug claim that the main active ingredients of Tamsulosin are absorbed from the gastrointestinal tract by 100%. Numerous studies have shown that absorption efficiency increases if the patient takes the capsule immediately after eating.
The level of absorption of the medicine is completely proportional to the time that has passed since the use of the medicine. In other words, the highest concentration of active substances in the blood plasma is observed only six hours after the patient has taken 400 mg of the drug. The international name (INN) of this drug is indicated in the marketing documentation as Tamsulosin.
After six days of treatment, the equilibrium concentration of the drug components increases to 70%. The desired effect from the completed course becomes noticeable only after 14 days. An amazing fact is that the medicine undergoes any chemical changes quite slowly. Tamsulosin is broken down into individual enzymes in the patient’s liver, resulting in the formation of pharmacologically active metabolites that can maintain high selectivity for human adrenergic receptors for a long time.
The universal drug Tamsulosin is a powerful selective inhibitor of alpha-adrenergic receptors, due to which it is often prescribed to the male half of the population for the effective treatment of benign prostate hypertension. This medication can be taken in three forms:
- capsules for oral use that quickly dissolve in the gastrointestinal environment. They are packaged in blisters of 10 pieces. A cardboard package may contain from 1 to 10 such plates.
- Powerful white tablets , characterized by a prolonged principle of action. Manufacturers package this medicine in convenient blister packs, which include 10 pills. One cardboard box contains 3 blisters.
- Bright green capsules of prolonged action, which are filled with a special substance with a creamy structure. The medicine is packaged in high-quality jars made of durable polyethylene, as well as in blister packs.
Regardless of the form of release, each type contains a universal component - tamsulosin hydrochloride (at a concentration of 400 mg). But the chemical composition of both capsules and tablets has its own significant differences:
- Enteric capsules contain the following components: microcrystalline cellulose, talc, methacrylic acid, triethyl citrate, ethyl acrylate copolymer, purified water.
- For tablets, pharmacists use a completely different composition: red iron oxide, hypromellose, anhydrous colloidal silicon dioxide, microcrystalline cellulose, magnesium stearate, carbomer.
- Extended-release capsules are made from the following components: polyethylene glycol, universal methacrylic acid copolymer, sucrose, ethylcellulose, hypromellose. Shell composition: proprietary blue dye, titanium dioxide, gelatin, yellow iron oxide.
