Aldecin is an effective drug against common nasal diseases

Pharmacodynamics and pharmacokinetics

The active ingredient is beclomethasone . The aerosol is effectively used in the treatment of bronchial asthma (basic therapy).

Aldecine has antiallergic and moderate anti-inflammatory effects. Beclomethasone enhances the production of the A2 phospholipase inhibitor - annexin (lipocortin), inhibits the production of inflammatory mediators, reduces the release of arachidonic acid , and has an inhibitory effect on the synthesis of arachidonic acid metabolic products - prostaglandins and endoperoxides.

The anti-inflammatory effect is due to inhibition of the formation of chemotaxis , the formation of a slow allergic reaction slows down.

Belomethasone improves mucociliary transport , reduces the number of mast cells in the bronchial mucosa, reduces bronchial hyperreactivity, and reduces the secretion of mucus produced by the bronchial glands.

Aldecine has a positive effect on functional indicators of external respiration. The drug allows you to restore the patient's response to the effects of bronchodilators, which significantly reduces the frequency of their use.

The drug increases the number of active beta-adrenergic receptors and does not have a resorptive effect when used in inhalation.

The use of the drug Aldecin in therapeutic doses does not lead to the development of systemic side effects that occur when using glucocorticosteroids. The therapeutic effect develops gradually; the drug does not relieve bronchospasm .

Pharmacological action of Aldecin

Beclomethasone dipropionate is a glucocorticosteroid, which is an active component in Aldecin, has antiallergic, anti-inflammatory and immunosuppressive effects. This active substance of the drug provokes inhibition of the release of inflammatory mediators from mast cells. As a result, swelling of the mucous membrane decreases, and secretion production is also significantly reduced. Aldecine also has a beneficial effect on mucociliary clearance, that is, it helps improve the functioning of the ciliated epithelium, which takes part in the process of mucus removal.

Aldecin spray also has an effect on the bronchi, relaxing their smooth muscles and reducing hyperreactivity. Most oral glucocorticosteroids have a systemic effect on the adrenal cortex, but this drug, unlike them, almost does not cause such effects. In addition, Aldecin helps restore the patient's response to various medications that expand the bronchial muscles.

Contraindications

Aldecine is contraindicated in non-asthmatic bronchitis, acute bronchospasm, beclomethasone intolerance, and status asthmaticus.

Contraindications also include: tuberculosis, nosebleeds, age under 6 years.

For glaucoma , liver cirrhosis, breastfeeding , osteoporosis , hypothyroidism , pregnancy , systemic diseases (viral, parasitic, fungal, bacterial infections) prescribe with caution.

Aldecin nasal spray

Instructions for medical use of the drug

Description of pharmacological action

Beclomethasone dipropionate - GCS, has anti-inflammatory, antiallergic and immunosuppressive effects.

Indications for use

Allergic rhinitis (seasonal or year-round); Vasomotor rhinitis; Nasal polyposis (as part of combination therapy).

Release form

spray for nasal use dosed 50 mcg/dose; aerosol can (can) PE with a dosing valve 8 g, cardboard box (box) 1.

Pharmacodynamics

Beclomethasone dipropionate - GCS, has anti-inflammatory, antiallergic and immunosuppressive effects. Inhibits the release of inflammatory mediators from mast cells, increases the production of lipomodulin, which is an inhibitor of phospholipase A, reduces the release of arachidonic acid, inhibits the synthesis of arachidonic acid metabolic products - cyclic endoperoxides, PGs. Reduces swelling and secretion of glands of the nasal mucosa, improves mucociliary transport. It has virtually no mineralocorticoid activity and no resorptive effect after inhalation administration.

Pharmacokinetics

Absorption is low; when administered by inhalation in recommended doses, it does not have clinically significant systemic activity. After inhalation, it is possible to swallow part of the administered dose with saliva. Most of the drug that enters the gastrointestinal tract is inactivated by the “first pass” effect through the liver. Plasma protein binding - 87%. T1/2 - 15h. The main part of the drug (35–76%) is excreted within 96 hours in the feces, mainly in the form of polar metabolites, 10–15% by the kidneys.

Use during pregnancy

Aldecine can be used in pregnant and lactating women only if the possible benefit of treatment for the woman justifies the potential risk to the fetus or newborn. Newborn children of women who received corticosteroids during pregnancy should be examined to identify a possible decrease in adrenal function.

Contraindications for use

Hypersensitivity to any of the components of the drug; tuberculosis (including latent) of the respiratory system; systemic infections (bacterial, fungal, viral, including infection caused by Herpes simplex, with eye damage); recent surgery or trauma to the nose; bleeding diathesis; frequent nosebleeds; children under 6 years of age (the safety and effectiveness of the drug have not been established). With caution: concomitant infectious disease requiring antibiotics; arterial hypertension; recent myocardial infarction; ulceration of the nasal septum; glaucoma; amoebiasis; severe liver failure; hypothyroidism; pregnancy; lactation period.

Side effects

Allergic reactions (urticaria, itching, angioedema, redness of the skin), nasopharyngeal infections caused by fungal flora, rhinorrhea, nosebleeds, burning sensation or irritation of the nasal mucosa, dry nose, sneezing, impaired sense of smell, increased eye pressure, glaucoma, disorder appetite, dyspepsia, nausea, diarrhea, headache, dizziness, arterial hypertension, difficulty breathing. When using nasal corticosteroids in large doses for a long time, cases of perforation of the nasal septum have been reported. Side effects characteristic of systemic corticosteroids may also appear during treatment with Aldecin if the drug is used in doses higher than recommended, or the patient is hypersensitive to corticosteroids, or has recently received therapy with systemic corticosteroids. If such symptoms and side effects develop, Aldecin should be discontinued, gradually reducing the dose.

Directions for use and doses

Intranasally, in the form of inhalations. Adults and adolescents over 12 years of age: the recommended dose is 1-2 inhalations into each half of the nose 4 times a day, depending on the severity of symptoms. Children from 6 to 11 years old: the recommended dose is 1-2 inhalations into each half of the nose 2 times a day, depending on the severity of symptoms. The maximum daily dose should not exceed 16 inhalations (0.8 mg) in adults and 8 inhalations (0.4 mg) in children aged 6 to 11 years. Once the therapeutic effect is achieved, the drug is discontinued, gradually reducing the dose. A guide for patients on proper inhalation Before using the nasal spray for the first time, it is necessary to “calibrate” it by pressing the dosing device 6-7 times. After “calibration”, a stereotypical supply of the medicinal substance is established. If the spray has not been used for 14 days or longer, then re-calibration is necessary before using again. Before inhalation, the nasal passages should be cleared. Shake the bottle vigorously. Insert the nasal applicator, holding it in a vertical position, into the nostril - towards the inner corner of the eye. In this case, the second nostril should be closed by pressing it with a finger, and the head should be slightly tilted forward. Do not spray the spray directly onto the nasal septum! Then you should take a deep breath through your nose while simultaneously pressing the spray and exhale through your mouth. Inhalation into the second nostril is performed in a similar way. To receive a single dose of 100 mcg, patients must inhale twice as described above.

Overdose

Symptoms: When used in very high doses, systemic effects of GCS may be observed, including suppression of adrenal function and symptoms of hypercortisolism. Treatment: if such symptoms appear, the dose should be reduced.

Interactions with other drugs

No clinically significant types of interaction of inhaled corticosteroids with other drugs have been identified. Phenobarbital, phenytoin, rifampicin and other inducers of microsomal oxidation reduce effectiveness. Methandrostenolone, estrogens, beta2-agonists, theophylline and orally administered corticosteroids enhance the effect. Increases the effect of beta-agonists.

Special instructions for use

Do not pierce the bottle nozzle with a needle or wire. It is necessary to protect the eyes from contact with the drug. The therapeutic effect of Aldecin, unlike local vasoconstrictors for the treatment of rhinitis, does not appear immediately when administered intranasally. Relief from rhinitis symptoms usually becomes noticeable within a few days of starting treatment. Patients who may have a decrease in immunity during GCS therapy should be warned about the danger of contact with certain infections (for example, chickenpox, measles) and the need to consult a doctor in case of such contact. This is of particular importance for children. Because the drug slows wound healing, patients who have recently had trauma or surgery to the nose should not use Aldecine Nasal Spray until the wounds have completely healed.

Storage conditions

List B.: At a temperature not exceeding 25 °C. (do not freeze).

Best before date

36 months

ATX classification:

R Respiratory system

R03 Drugs for the treatment of bronchial asthma

R03B Other drugs for inhalation use for the treatment of bronchial asthma

R03BA Glucocorticoids

R03BA01 Beclometasone

Side effects

Irritation in the throat, hoarseness, sneezing , cough, paradoxical bronchospasm , oral candidiasis, allergies, eosinophilic pneumonia .

With long-term use of the drug in increased quantities, systemic side effects develop, adrenal insufficiency , leukocytosis, increased intraocular pressure, dizziness, headaches, eosinopenia, cataracts , lymphopenia.

With a single dose of high doses of Aldecin, a decrease in the function of the hypothalamic-pituitary and adrenal systems is recorded.

The systems are restored on their own after 2 days.

Interaction with other drugs

It is known that Aldecin has the ability to enhance the effect of any medications belonging to the category of beta-adrenergic stimulants, which, in turn, increase the anti-inflammatory effect of Aldecin.

The effectiveness of Aldecin may be slightly reduced if it is used together with certain types of tricyclic antidepressants, as well as drugs such as:

• phenytoin;
• rifampicin;
• phenobarbital;
• glutethimide.

There are also drugs that enhance and make the effect of Aldecin more pronounced. These include:

• estrogens;
• xanthines;
• glucocorticosteroids for oral use;
• Methandrostenolone.

Instructions for use of Aldecin (Method and dosage)

Aerosol

Used by inhalation.

For adults:

• Mild bronchial asthma: 100 mcg 3 times a day.
• For severe bronchial asthma, 200 mcg is prescribed 3 times a day. The maximum daily dose is 1 mg.

Children from 6 to 12 years old can use a maximum of 0.5 mg per day.

Upon completion of inhalation, it is recommended to rinse the mouth with running water.

Aldecin spray, instructions for use

From the age of six, you can use one or two injections in each nostril twice a day.

Composition, release form and analogues

1 dose of Aldecin contains 50 mcg of beclomethasone dipropionate as an active ingredient and the following auxiliary components:

• Dispersed cellulose;
• Propylene glycol;
• Sodium citrate dihydrate;
• Glycerol;
• Polysorbate 80;
• Citric acid monohydrate;
• Purified water.

Aldecin spray is available in the form of aerosol cans with a metering valve, a nasal applicator and a special mouthpiece. One bottle contains 8.5 g of the drug, which is equivalent to 200 doses. One cardboard package contains 1 aerosol can.

Among Adeltsin's analogues, the following drugs can be distinguished:

• Beclazon;
• Beclazon Eco;
• Beclazon Easy Breathing;
• Beclazon Eco Easy Breathing;
• Beclomethasone;
• Beclomethasone dipropionate;
• Beclomethasone Orion Pharma;
• Beklomet Easyhaler;
• Beclospira;
• Becotide;
• Rinoclenil;
• Klenil;
• Klenil UDV;
• Plibekot;
• Nasobek.

Interaction

Aldecine allows you to restore the patient's response to the use of beta-agonists , which significantly reduces the frequency of their use.

There are no significant drug interactions between inhaled glucocorticosteroids and other medications.

Inducers of microsomal oxidation ( rifampicin , phenobarbital, phenytoin) reduce the effectiveness of beclomethasone.

Estrogens, methandrostenolone , theophylline, beta2-adrenergic stimulants enhance the effect of the drug Aldecin.

Diseases for which Aldecin is prescribed

The action of the drug Aldecin is effective for the following diseases and symptoms:

• bronchial asthma is a hormone-dependent, severe and childhood form of the disease;
• obstructive bronchitis, including chronic;
• rhinitis – vasomotor, seasonal, allergic;
• nasal polyposis.

Aldecin inhalations are indicated for the treatment of bronchial asthma if long-term therapy is necessary, if there are contraindications for use or if bronchodilators - drugs that relax the walls of the bronchi - are ineffective. The benefits of the drug are most noticeable during inflammatory processes of the respiratory system.

Bronchodilators

The action of the main substance of the composition is aimed at slowing down allergic processes, relieving inflammation, reducing the number of mast cells in the bronchi and relaxing the smooth muscles of the latter, improving mucociliary transport, reducing the production of inflammatory exudate of the nasal cavity. With long-term use, it improves the effectiveness of bronchodilators.

When using an aerosol, a small amount of the product may enter the stomach. This is not dangerous - the drug Aldecin in this case is absorbed in the liver cells.

special instructions

Aldecine is not used to relieve acute attacks of bronchial asthma. Patients must be explained that the drug has a preventive effect, and that to achieve maximum effect, the drug must be used regularly, including in the absence of signs of asthma.

Regular use of the inhaler can improve respiratory function after just a week of treatment. The reason for the lack of effect may be the increased content of mucus and sputum in the respiratory system, as well as as a result of severe bronchospasm, which prevents beclomethasone from penetrating into the area of ​​action.

Before prescribing Aldecin, the doctor must instruct the patient about the aspects of proper use of the inhaler, which will subsequently provide a better therapeutic effect due to the complete penetration of the main substance into the lungs.

When transferring a patient from an oral glucocorticosteroid to Aldecin, regular peak flow measurements .

Washing after using the drug helps prevent damage to the nose and eyelid skin.

Indications for use of Aldecin

According to the instructions for Aldecin, this drug is intended for inhalation use in cases of bronchial asthma, including:

• Hormone-dependent form of the disease;
• Severe form of the disease in childhood;
• The need for maintenance therapy over a long period of time;
• Presence of contraindications for the use of bronchodilators;
• Ineffective use of bronchodilators;
• Ineffectiveness of combination therapy with cromoglycic acid and bronchodilators.

According to the instructions for Aldecin, this drug is also effective for the treatment of chronic obstructive bronchitis in cases of a pronounced inflammatory component.

Aldecine nasal is used in the treatment of seasonal or year-round allergic rhinitis, as well as in cases of vasomotor rhinitis. In addition, the drug is often used for nasal polyposis as part of complex therapy.

Aldecin's analogs

Level 4 ATX code matches:
Alvesco

Budenit Steri-Neb

Asmanex

Beclazon

Budesonide

Flixotide

Pulmicort

Analogs include the following drugs: Beclazon , Beclat , Glenbekar , Klenil .

Aldecin

Active substance:

Beclometasone*

Pharmgroup:

Glucocorticoids

Similar drugs:

• Dexamethasone Solution for intravenous and intramuscular administration
• Calcium gluconate Chewable tablets
• Pulmicort Suspension for inhalation
• Cetrine Oral tablets
• Sodium cromoglicate Substance-powder
• Diprospan Solution for injection
• Mometasone furoate Substance-powder
• L-cet Oral tablets
• Dexamethasone Solution for injection
• Adrenaline (Adrenaline) Solution for injection

** The Drug Directory is intended for informational purposes only. For more complete information, please refer to the manufacturer's instructions. Do not self-medicate; Before starting to use the drug Aldecin, you should consult a doctor. EUROLAB is not responsible for the consequences caused by the use of information posted on the portal. Any information on the site does not replace medical advice and cannot serve as a guarantee of the positive effect of the drug.

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** Attention! The information presented in this medication guide is intended for medical professionals and should not be used as a basis for self-medication. The description of the drug Aldecin is provided for informational purposes and is not intended for prescribing treatment without the participation of a doctor. Patients need to consult a specialist!

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