Does Citramon help with fever or not? Indications for use of "Citramon"

Compound

According to data provided on Wikipedia, traditionally Citramon tablets included 240 mg of acetylsalicylic acid (ASA), 180 mg of phenacetin , 30 mg of caffeine , 15 mg of cocoa, 20 mg of citric acid.
However, at present, the classic recipe for making the drug is not used due to the withdrawal of one of its active components, phenacetin, (this is due to the high nephrotoxicity of the substance ).

Numerous manufacturers produce medicines whose names contain the word “Citramon”, but they all have a slightly modified composition, in which Paracetamol is used an analgesic and antipyretic instead of phenacetin .

Tablets from different manufacturers maintain the same uniformity of active ingredients, but the concentration of each of them may differ.

In the composition of Citramon P, Citramon U and Citramon M, the active components (ASA, paracetamol and caffeine ), for example, are contained in the same concentration as in the original drug. But in Citramon-Forte their concentration is different: each tablet contains 320 mg of ASA, 240 mg of paracetamol and 40 mg of caffeine .

Citramon Borimed tablets contain 220 mg of ASA, 200 mg of paracetamol and 27 mg of caffeine . The concentration of these substances in Citramon-LekT tablets is, respectively, 240 mg, 180 mg and 27.5 mg.

But the main difference between Citramon Ultra and Citramon is the presence of a film shell, which makes the tablet easier to swallow, acts as a reliable barrier between the mucous membrane of the digestive canal and the active substances contained in the tablets (in particular, the shell protects the stomach from the aggressive effects of ASA) and accelerates the absorption of the drug.

Description

"Citramon" is considered a combination remedy. The drug has antipyretic and analgesic effects and is used to reduce the severity of these symptoms in various diseases.

"Citramon" is produced in tablet form for oral use. They have a round shape and a light brown tint. The structure of the drug includes several main active substances:

1. Paracetamol.
2. Aspirin.
3. Caffeine.

In addition, the medication includes additional components:

• lemon acid;
• calcium salt and stearic acid;
• starch;
• talc;
• ethoxylated sorbitans.

The tablets are placed in blisters of 10 pieces.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Citramon is a combined drug, the effect of which is determined by the properties of the components it contains ( non -narcotic analgesic , psychostimulant and NSAID).

ASA relieves fever and inflammation, relieves pain (especially if the pain is caused by an inflammatory process), has a moderate antiplatelet effect , prevents the formation of blood clots , and helps improve microcirculation in the area of ​​inflammation.

Paracetamol reduces the intensity of pain, reduces fever, and has a weak anti-inflammatory effect . The properties of this substance are associated with its influence on the thermoregulation center located in the hypothalamic region and a weakly expressed ability to inhibit the formation of Pg in peripheral tissues.

Caffeine has a direct stimulating effect on the central nervous system, which manifests itself in the form of increased excitation processes in the cerebral cortex, vasomotor and respiratory centers, increased motor activity and strengthened positive conditioned reflexes.

Stimulates mental activity, temporarily reducing or eliminating drowsiness and fatigue, and shortens reaction time. Reduces platelet aggregation .

Citramon tablets caffeine in low concentrations. Because of this, the substance has virtually no stimulating effect on the central nervous system, but improves cerebral vascular tone and helps accelerate blood flow.

The combination of ASA and paracetamol potentiates the analgesic effect of the drug. Both the analgesic and antipyretic effects of ASA and paracetamol are enhanced when these substances are used simultaneously with caffeine .

Pharmacokinetics

After oral administration, the components contained in the tablets are absorbed quickly and almost completely. caffeine helps to increase F (bioavailability) of ASA and paracetamol .

During absorption, it and ASA are intensively biotransformed with the formation of pharmacologically active metabolites. Salicylic acid is formed from ASA in the process of deacetylation in the liver and intestinal wall .

Under the influence of the hepatic isoenzyme CYP1A2, caffeine forms dimethylxanthines ( paraxanthine and theophylline ).

The maximum duration of all active components of Citramon is from 0.3 to 1 hour. In blood plasma, from 10 to 15% of paracetamol and approximately 80% of the taken dose of ASA are in an albumin state.

All components of the tablets easily penetrate into any fluids and tissues of the body (including easily crossing the placental barrier and entering breast milk). Minor concentrations of salicylates are found in brain tissue, while levels of caffeine and paracetamol are comparable to plasma levels.

With the development of acidosis, ASA turns into a non-ionized form, due to which its penetration into the tissues of the NS increases.

Metabolism of active substances occurs in the liver. ASA has 4 metabolites (gentisuronic and gentisic acids, salicylophenolic glucuronide, salicylurate). Paracetamol forms sulfate (80% of the total amount) and paracetamol glucuronide (both are pharmacologically inactive), as well as a potentially toxic substance - N-acetyl-benziminoquinone (about 17% of the total amount).

Caffeine metabolites are uridine derivatives, mono- and dimethylxanthines, mono- and dimethyluric acid, di- and trimethylallantoin.

Caffeine affects the pharmacokinetics of paracetamol , slightly increasing (up to 20-25%) the formation of N-acetyl-benziminoquinone.

Metabolites are excreted by the kidneys. About 5% of paracetamol, about 10% of caffeine and about 60% of salicylates are excreted unchanged.

The half-life of elimination is from 2 to 4.5 hours (all components of the drug are excreted at approximately the same rate). Increasing the dose of Citramon leads to a slower elimination of ASA compared to other substances by up to 15 hours.

In smokers, on the contrary, there is an accelerated elimination of caffeine in comparison with other components of the drug.

From low blood pressure

People often wonder whether medication lowers or increases blood pressure? The effect on blood pressure is carried out by caffeine, which is part of the drug - it increases tone, excites the nervous system and increases blood pressure readings.

Even with a small amount of this substance, such an effect can be achieved, but you need to be careful - it is not recommended to drink strong tea or coffee along with the medicine.

For low blood pressure, the use of the drug activates the nervous system and improves mental performance, while simultaneously reducing or completely eliminating pain. That is why the drug is one of the most popular among drugs used by hypotensive patients.

Indications for use of Citramon

What is Citramon P for?

When asked what Citramon P helps with, the manufacturer answers in the annotation for the drug that the use of tablets is advisable for relieving mild and moderate pain, as well as for alleviating the patient’s condition during febrile syndrome , which is accompanied by ARVI and influenza .

Citramon is effective for the head (including during migraine attacks), for joint and muscle pain, and algodismenorrhea .

What are Citramon-LekT tablets for?

Indications for the use of Citramon-LekT are the same as for other drugs based on ASA , paracetamol and caffeine , namely: pain syndrome due to algodismenorrhea , neuralgia , myalgia , arthralgia , headache and toothache , migraine .

The drug can also be used as a remedy for fever during acute respiratory viral and influenza .

Does Citramon help with toothache?

Toothache is one of the indications for using the drug. The effectiveness of Citramon is due to the properties of its constituent NSAIDs, non-narcotic analgesic and psychostimulant .

Strengthening each other's action, these components have a complex effect on the body, relieving any pain (including toothache), especially if it is associated with inflammation. During exacerbation of chronic pulpitis , against which the temperature often rises, Citramon not only helps relieve pain and reduce the severity of inflammation, but also has an antipyretic effect .

Pharmacological effects

Does Citramon help with fever or not? According to the annotation, the drug has several medicinal properties, which are due to the active ingredients:

1. Paracetamol has antipyretic and anti-inflammatory effects.
2. Acetylsalicylic acid has anti-inflammatory, as well as antipyretic and analgesic effects.
3. Caffeine enhances the activation of the brain and spinal cord, dilates capillaries.

After administration, the active substances are instantly absorbed into the blood. They are distributed throughout the tissues and penetrate the nervous system through the blood-brain barrier.

Contraindications

The instructions list the following contraindications for Citramon:

• complete or partial combination of recurrent nasal polyposis/paranasal sinuses , bronchial asthma and intolerance to NSAIDs or ASA (including a history);
• hypersensitivity to the components of the tablets;
• erosive and ulcerative lesions of the gastrointestinal tract in the acute phase;
• stomach or intestinal bleeding ;
• portal hypertension;
• hemophilia;
• hypoprothrombinemia;
• hemorrhagic diathesis;
• vitamin deficiency K;
• Severe ischemic heart disease;
• severe arterial hypertension ;
• renal failure;
• deficiency of the cytosolic enzyme G6PD;
• pregnancy (especially its first and last trimesters);
• lactation;
• increased excitability;
• glaucoma;
• dissecting aortic aneurysm;
• sleep disorders;
• surgical interventions accompanied by bleeding;
• childhood (in children under fifteen years of age with hyperthermia against the background of a viral infection, there is a high probability of developing Reye's syndrome );
• concomitant use of anticoagulants .

Relative contraindications are gout and existing liver pathologies .

Side effects

Side effects of Citramon:

• gastralgia , anorexia , nausea, formation of erosions and ulcerative elements on the mucous membrane of the digestive canal, gastric and intestinal bleeding;
• liver failure;
• hypersensitivity reactions (including the development of symptoms of the Fernand-Vidal triad );
• interstitial nephritis , nephrotic syndrome , necrotizing papillitis , with long-term use - renal failure ;
• anemia , thrombocytopenia , leukopenia ;
• acute fatty hepatosis , toxic hepatitis , acute hepatic encephalopathy ( Reye's syndrome );
• worsening heart failure , manifestation of its latent forms (with long-term use);
• dizziness, insomnia, agitation, anxiety, headache, tinnitus, hearing and vision impairment, aseptic meningitis ;
• increased blood pressure, arrhythmia , tachycardia ;
• development of tolerance and weak psychological dependence (with long-term use of high doses of the drug);
• drug-induced headache after discontinuation of Citramon (if the drug was used for a long time).

Experiments on animals also demonstrated the teratogenic effect of the drug on the fetus.

Citramon tablets: instructions for use

Preparations from different manufacturers have different compositions, and since they often contain active substances in different concentrations, you should read the instructions very carefully so as not to mistakenly exceed the permissible daily dose.

What all drugs have in common is that they can be used as an analgesic for a maximum of five days, and as an antipyretic for three days.

Instructions for use Citramon P and Citramon-LekT

Citramon P and Citramon-LekT can be taken from the age of fifteen. Take one tablet 2-4 times a day (during or after meals). The break between doses should be at least four hours. The average dose is 3-4 tablets per day.

Citramon for headaches (as well as in other cases when it is necessary to relieve severe pain) can be taken 2 pieces at once. The permissible upper limit of the daily dose is 8 tablets.

Treatment lasts from one week to ten days.

If necessary, the doctor may prescribe a different dose of the drug or select a different treatment regimen.

Instructions for use Citramon forte

Citramon-Forte is used in patients over sixteen years of age. The daily dose is 2-3 tablets. You need to take them one at a time, 2 or 3 times a day. To relieve an attack of acute pain, you should immediately take two tablets.

The permissible upper limit of the daily dose is 6 tablets.

Citramon-Darnitsa is taken according to a similar regimen (the only difference between the drug is the age limit - these tablets are prescribed from 15 years of age).

Instructions for use Citramon-Borimed

It is preferable to take Citramon-Borimed immediately after meals or between meals. The drug can be used in adults and adolescents over fifteen years of age. Take one tablet 2-3 times a day, maintaining intervals of at least 6-8 hours between doses. The highest single dose is 2 tablets, the daily dose is 4.

as an antipyretic at temperatures exceeding 38.5°C (if there is a tendency to febrile convulsions - at temperatures above 37.5°C). Single dose - 1-2 tablets.

Instructions for use of Citramon Ultra

Citramon Ultra is prescribed from the age of fifteen. Daily dose - 1-3 tablets. If necessary, you can take up to 6 tablets during the day.

Dosage

Considering that the medicine contains acetylsalicylic acid, which is not recommended to be taken on an empty stomach, Citramon is used only 20 minutes after a meal. You must take the medication with water. No other liquid should be consumed. The action of Citramon will begin 30-40 minutes after administration. The next tablet can be taken only after 8 hours.

We have already found out whether Citramon reduces temperature. The tablets are intended for oral administration, preferably after meals. The average pharmacological concentration of the active ingredient for adult patients and children over fifteen years of age varies from 1 to 3 tablets three times a day, depending on the severity of pain or fever.

The maximum daily dosage should not exceed 6 tablets. The medication is not intended for long-term therapy; the maximum duration of treatment should not exceed five days.

Overdose

A slight overdose manifests itself in the form of nausea, dizziness, increased pallor of the skin, gastralgia , vomiting, and ringing in the ears.

Symptoms of severe intoxication of the body: impaired circulation and breathing, anuria , anxiety, stupor, nausea, headache, hyperthermia , tremor , drowsiness, anxiety, sweating, collapse , bleeding, convulsions (with pathological increased tendon reflexes), coma .

If signs of overdose appear, taking the tablets should be stopped. To prevent the absorption of the drug in the digestive canal, the patient's stomach is washed, enterosorbents and a saline laxative are given.

If the plasma concentration of salicylates in a child exceeds 300 mg/l, and in an adult - 500 mg/l, it is advisable to carry out forced alkaline diuresis. To maintain urine pH at 7.5-8, alkalizing agents are administered.

Measures are taken to restore the bcc and acid-base balance.

In case of cerebral edema, mechanical ventilation with an oxygen-enriched mixture is prescribed in the mode of creating PEEP (positive end-expiratory pressure). Hyperventilation should be carried out in combination with the use of osmotic diuretics .

If there are signs of liver damage, N-acetylcysteine, which is a specific antidote to paracetamol, . The solution is used orally and injected into a vein. In total, the patient needs to administer seventeen doses: the first - 140 mg/kg, all subsequent doses - 70 mg/kg.

The most effective therapy is started in the first ten hours after the development of intoxication. If more than 36 hours have passed, treatment is ineffective.

When the prothrombin index (PTI) value increases to 1.5-3, the use of phytomenadione ( vitamin K ) in a dose of 1 to 10 mg is indicated. If the PTI exceeds 3.0, infusion of clotting factor concentrate or native plasma should be started.

Carrying out hemodialysis, using antihistamines , corticosteroids or acetazolamide (to alkalinize urine) during intoxication with Citramon is contraindicated.

These measures can provoke the development of acidemia and increase the toxic effect of ASA on the patient’s body.

General Negative Consequences

Citramon, due to its composition, can cause a large number of different side effects. Their occurrence is associated either with neglect of the rules for using tablets, or with the individual characteristics of the body and its reaction to individual components of the drug.

Adverse reactions

So, on the immune side, side effects from taking this medication may appear:

• anaphylaxis;
• allergic rhinitis;
• hypersensitivity reactions;
• nasal congestion;
• anaphylactic shock;
• bronchospasm (only in patients with individual intolerance to acetylsalicylic acid, or hypersensitivity to other NSAIDs).

Side effects of Citramon

Fortunately, such side effects occur extremely rarely in patients. Much more often the skin and gastrointestinal tract react to the medication. In this case, adverse reactions may occur:

• itching;
• skin rashes;
• erythema;
• hives;
• angioedema;
• Stevens-Johnson syndrome;
• nausea;
• vomiting;
• pain and discomfort in the epigastric zone;
• heartburn;
• abdominal pain;
• gastralgia.

Contraindications

Sometimes when taking the drug, cephalgia does not disappear, but, on the contrary, intensifies. Along with this, the patient begins to complain of sleep disturbances, dizziness, double vision, and tremors of the limbs. These symptoms may be accompanied by causeless anxiety, general weakness and malaise, ringing in the ears, etc. In these cases, the drug must be stopped and a more suitable analgesic or antipyretic drug must be selected.

Overdose

Symptoms of overdose can be divided into 2 groups:

• mild intoxication;
• severe intoxication.

A mild overdose is characterized by abdominal pain, nausea, vomiting, and ringing in the ears. As a rule, under such conditions, specific treatment is not required - you just need to stop taking the medication.

First aid for drug overdose

Severe intoxication is accompanied by drowsiness, convulsions, lethargy, bronchospasm, and breathing problems. With untimely intervention, the development of collapse is possible - a condition in which blood pressure drops to critical levels.

This is a dangerous deviation that threatens not only the health, but also the life of the patient, so action must be taken immediately. Resuscitation measures are possible at home, but for further treatment of severe intoxication the patient may be hospitalized in a hospital.

Treatment of this disorder should be carried out with constant monitoring of acid-base balance and electrolyte balance. Specific therapeutic measures using medications are carried out depending on the state of metabolic processes.

Possible harm of the drug

This medication must be taken with caution, even if the patient has no contraindications to its use. In no case should you exceed the maximum daily dosage or continue therapy longer than the permissible period. Otherwise, the medication may cause serious harm:

1. The drug increases blood pressure. Of course, the dose of caffeine in 1 tablet is not too high, but for a person suffering from hypertension, and even with a malignant course, this drug is strictly prohibited.

2. 
   The medicine thins the blood. Consequently, patients with low ESR levels are also strictly not recommended to take tablets due to the increased risk of bleeding.

3. ASA can cause an attack of bronchospasm. This side effect is often observed in patients with bronchial asthma or COPD. Even 1 tablet of Citramon can provoke an outbreak of the disease, so for such patients it is either not prescribed at all or is prescribed in minimal dosages for a short period of time. The medication intake is controlled by the attending physician.
4. Acetylsalicylic acid has a negative effect on the gastric mucosa. The medication is not prescribed to patients with ulcerative or duodenal ulcers, as well as patients with gastrointestinal bleeding. When systematically taking tablets on an empty stomach, ulcerative defects may form on the walls of the digestive organ with further development of bleeding or perforation.

As you can see, Citramon is by no means such a safe pain reliever and anti-inflammatory drug as many patients mistakenly believe it to be. All nuances regarding its use must be taken into account, otherwise even a highly qualified doctor cannot guarantee the safety of therapy.

Interaction

It is strictly forbidden to prescribe in combination with Citramon with:

• MAO inhibitors (when used simultaneously with caffeine , these drugs can lead to a dangerous increase in blood pressure );
• methotrexate at a dose exceeding 15 mg/week. (such a combination increases the hematological toxicity of methotrexate ).

Citramon also enhances the toxicity of barbiturates and valproic acid , the effects of opioid analgesics , oral hypoglycemic and sulfonamide agents , digoxin and triiodothyronine .

Phenytoin , ethanol , COCs, Rifampicin , tricyclic antidepressants , barbiturates , phenylbutazone increase the toxicity of paracetamol to the liver.

Macrolides ( Erythromycin , Clarithromycin ), interferon preparations , antimycotic agents ( Fluconazole , Ketoconazole ) slow down the metabolism of the active substances of Citramon tablets and lead to an increase in their concentration in plasma.

The use of the drug in combination with platelet , indirect anticoagulants and thrombolytic agents increases the risk of bleeding.

By inhibiting the synthesis of Pg in the kidneys, it weakens the effect of potassium-sparing and loop diuretics , as well as antihypertensive drugs from the group of ACE inhibitors.

GCS increase the toxicity of the components of the tablets on the gastric mucosa, increase the clearance of ASA and reduce its plasma concentration.

In combination with beta-adrenergic agonists ( Fenoterol , Salbutamol , salmeterol ) in high doses, the risk of developing hypokalemia ; with methylxanthines , the level of theophylline in plasma increases and the risk of its toxic effect increases; with Li salts, the plasma concentration of Li+ ions increases.

Due to the competitive excretion of uric acid in the nephron tubules, it weakens the effect of uricosuric drugs .

Peculiarities

Before treatment, you need to read the annotation for the drug, and also pay attention to certain nuances:

1. Long-term use of this medication requires regular laboratory monitoring of the functional state of the liver and kidneys.
2. Before surgery, patients should take the medication off as it reduces blood clotting.
3. People with allergies can use the product with extreme caution.
4. Long-term use of Citramon can cause a decrease in the excretion of uric acid from the body.
5. The active substances of the drug may interact with drugs from other pharmacological groups, so it is important to warn a specialist about their possible use.
6. "Citramon" does not have a direct effect on the functional state of the central nervous system.

The drug can be bought in pharmacies without a doctor's prescription. Before use, consultation with a specialist is required.

special instructions

Abuse of caffeine- products during treatment with Citramon can provoke overdose symptoms.

Elderly people, people suffering from gout , impaired renal and/or liver function with benign hyperbilirubinemia should be careful when taking tablets.

In patients with allergic complications ( allergic rhinitis , asthma, urticaria ), when they are combined with respiratory tract infections , as well as with increased sensitivity to NSAIDs during treatment, bronchospasm or asthma attacks are possible.

With long-term (more than five days in a row) use of Citramon, monitoring of the functional state of the liver and peripheral blood patterns is necessary.

Long-term use of tablets containing paracetamol in high cumulative doses in some cases can cause drug-induced nephropathy or irreversible renal failure .

Long-term use of painkillers to treat headaches often leads to chronic headaches .

Taking Citramon can distort laboratory test indicators such as: plasma concentration of uric acid, plasma concentration of heparin , plasma concentration of theophylline , blood sugar level, concentration of amino acids in the urine.

The drug may alter doping control tests in athletes. It complicates the diagnosis of “acute abdomen”.

In case of long-term treatment with Citramon, you should consult a doctor before taking Ibuprofen .

The use of drugs containing ASA during surgical interventions (including dental operations) increases the likelihood of the occurrence/intensification of bleeding.

The drug may affect the rate of neuromuscular transmission, and therefore during the period of treatment they should refrain from driving a vehicle or operating dangerous machinery.

The effect of the drug on blood pressure: do Citramon tablets increase or decrease blood pressure?

Headaches are a fairly common occurrence in people prone to changes in blood pressure . Therefore, questions naturally arise here: is it possible to take the medicine with high blood pressure, is the drug harmful for hypotensive patients, how are Citramon and blood pressure related?

The analgesic effect for headaches is provided primarily due to the presence of ASA and paracetamol .

The third component of the drug - caffeine - increases the flow of oxygen to tissues, stimulates blood circulation in the brain and increases blood pressure , thus helping to reduce the intensity of headaches and enhancing the effects of other components of Citramon.

High doses of caffeine provoke CNS depression . When taking small doses (as, for example, in Citramon), the stimulating effect predominates.

It should be noted that, while increasing blood pressure, which is reduced during hypotension , caffeine does not change normal blood pressure.

Limitations in use

In several pathological conditions of the body, the use of the drug is contraindicated for people, these include:

1. Gastric and intestinal bleeding.
2. Ulcerative diseases.
3. Hemorrhagic diathesis (a group of diseases characterized by an increased predisposition of the body to hemorrhages, which can appear independently, without any apparent reason, or after minor injuries).
4. Pregnancy in the 1st and 3rd trimester.
5. Hypoprothrombinemia (a disease manifested by a disorder of blood clotting. Caused by a deficiency of the coagulation factor prothrombin in the blood).
6. Lactation.
7. Arterial hypertension (a condition in which blood pressure is equal to or exceeds 140 mmHg).
8. Age up to 15 years.
9. Vitamin K deficiency in the body.
10. Increased excitability of the central nervous system.
11. Loss of sleep.

Before starting drug therapy, you must ensure that there are no restrictions. The drug is approved for use from the age of 15, and therefore “Citramon” helps children from this age against fever.

The medication should be taken with caution for the following problems:

1. Diseases of the liver and kidneys.
2. Chronic obstructive pulmonary disease (a progressive disease characterized by an inflammatory component, impaired bronchial obstruction at the level of the distal bronchi and structural changes in the lung tissue and blood vessels).
3. Cardiac ischemia (myocardial damage, which is caused by a deficiency or cessation of microcirculation of the heart muscle).
4. Cerebrovascular diseases (a brain disease that is caused by gradual progressive damage to brain tissue due to chronic disorders of blood microcirculation in the brain).
5. Peripheral arterial diseases.
6. Chronic heart diseases.
7. Epilepsy (a chronic neurological disease manifested in the body’s predisposition to the sudden onset of seizures).
8. Alcoholism.
9. Tobacco smoking.
10. Retirement age.

Analogs

Level 4 ATC code matches:
Acetylsalicylic acid

Aspirin-S

Citropak

Aspirin

Coficil-Plus

Farmadol

Askofen-P

Cefekon N

Aquacitramon

Upsarin UPSA

Citrapack

Alca Prim

Thrombopol

Citrapar

Analogs with the same composition of active ingredients: Citramon-Darnitsa, Citramon-Borimed, Citramon-Ultra, Citramon-LekT, Aquacitramon , Acepar , Askofen-P , Kofitsil-plus , Citrapar , Excedrin , Migrenol Extra .

Can children take Citramon?

The use of ASA-containing drugs for the treatment of ARVI in children (with or without hyperthermia

With some viral infections (particularly those caused by varicella zoster or influenza A or B ), there is a risk of developing acute hepatic encephalopathy ( Reye's syndrome ), which requires immediate medical attention. One of the signs of Reye's syndrome is prolonged vomiting.

Taking into account the above reasons, the use of tablets in patients under sixteen years of age is contraindicated.

Since the drug has a large number of side effects, it is better for children with a headache or toothache to choose safer remedies.

Alcohol compatibility

During treatment with Citramon, you should avoid drinking alcohol, since alcohol increases the likelihood of a toxic effect of paracetamol on the liver and ASA on the gastrointestinal tract.

The use of ethyl alcohol with ASA contributes to damage to the mucous membrane of the digestive canal. The synergism of alcohol and ASA also results in prolongation of bleeding time.

Citramon for hangover

Citramon for a hangover is not the most advantageous option, since the use of this drug allows you to relieve headaches only temporarily, but does not eliminate the main causes of poor health - imbalance of water and electrolytes, as well as intoxication.

The headache that accompanies hangover syndrome is associated with impaired venous outflow from the head, tissue swelling (in particular, swelling of the meninges ) and inhibition of the analgesic (antinociceptive) system, part of which is the action of serotonin and dopamine .

ASA partially unloads the membranes of the brain, caffeine stimulates metabolism in neurons and has an invigorating effect, cocoa reduces the relative deficiency of intracerebral serotonin and dopamine , citric acid reduces the severity of symptoms of alcohol intoxication.

However, the paracetamol puts a lot of strain on the liver, which, in combination with alcohol breakdown products, can aggravate hangover symptoms and damage the body.

For a hangover

Nausea, headache, and a whole list of negative symptoms are combined into one name - “hangover”. The medicine may help:

• deterioration of health;
• increased toxic effects.

The most well-known versions of this medicine contain 2 pain-relieving components, which are not recommended to be used in high concentrations in case of severe hangover:

1. Paracetamol has a harmful effect on the liver.
2. Acetylsalicylic acid increases the risk of bleeding.

When Citramon is combined with alcoholic drinks, a “mixture” is obtained that can seriously harm the body.

Citramon during pregnancy and lactation

Can pregnant women drink Citramon?

During pregnancy, you should avoid taking Citramon tablets, since the ASA they contain has a teratogenic effect .

The use of Citramon during pregnancy in the 1st trimester can cause cleft palate ; the use of the drug in the 3rd trimester leads to a deterioration in labor (suppression of Pg synthesis) and closure of the ductus arteriosus in the fetus. This in turn provokes hyperplasia of the pulmonary vessels and increased pressure in the vessels of the pulmonary (pulmonary) circulation.

Thus, the answer to questions like “Can I drink Citramon during pregnancy?” and “Can pregnant women take Citramon?” unambiguous - impossible.

Can a nursing mother take Citramon while breastfeeding?

The use of the drug during hepatitis B is contraindicated. The active components of the tablets and their metabolites are excreted into breast milk, which increases the likelihood of platelet dysfunction and bleeding in the baby.

Heat

As an antipyretic and analgesic, if a patient has a high temperature, the drug is used for a maximum of three days. A small dose supports the patient, improves tone with a general decrease in temperature.

The drug contains acetylsalicylic acid (antipyretic), so Citramon can be drunk at fever. However, it is important to follow the dosage. So, if Citramon helps adults with fever, how many tablets should they take per day?

You are allowed to take no more than 6 tablets per day. Acetylsalicylic acid is widely known as one of the representatives of the group of non-steroidal anti-inflammatory drugs.

It perfectly helps fight high temperatures, instantly returning them to normal values. So, using the drug at fever is more than justified. This has been scientifically proven. In addition, there is Citramon P. Does it help with fever as effectively as regular medication? Yes, they have the same effect on fever.

Reviews

Most people, despite the fact that the drug is considered potentially unsafe, leave good reviews about Citramon, calling it their savior from headaches (including migraine attacks ).

Although there are also those that mention the dangers of tablets for the liver and gastrointestinal tract, and also that with long-term use they cause a kind of addiction (patients can no longer do without Citramon for a long time and experience a constant need for it).

Based on all available reviews, the following conclusion can be drawn: the pills should be taken taking into account existing contraindications, as well as having previously compared the expected benefits from them and potential risks.

One or two tablets taken to relieve an attack of pain are not capable of harming the body; systematic, uncontrolled use, of course, threatens with very serious consequences.

Citramon price

The price of Citramon depends on which company produced the drug. So, for example, the price of Citramon P is from 14, and the price of Ciramon Ultra is from 70 rubles.

In Ukraine, a package of tablets can be purchased for 2.3-15.5 UAH.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

ZdravCity

• Citramon P tablets 20 pcs. Anzhero-Sudzhensky plant LLC Avexima Siberia
  74 rub. order
• Citramon P tablets 10 pcs. JSC "PFK Obnovlenye"

  47 RUR order

• Citramon p tablets 240mg+30mg+180mg 20pcs JSC Tatkhimfarmpreparaty

  67 RUR order

• Citramon P tablets 20 pcs. JSC Dalkhimfarm

  37 RUR order

• Citramon P tablets 20 pcs. AO Update PFK

  63 RUR order

Pharmacy Dialogue

• Citramon-P (tab. No. 10) FS.-Leksredstva

  8 rubles order

• Citramon-P (tab. No. 10) Uralbiopharm

  18 rub. order

• Citramon-P tablets No. 20Update PFK CJSC

  69 RUR order

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Pharmacy24

• Citramon-M No. 6 tablets PAT "Khimpharmzavod" Chervona Zirka", Kharkov, Ukraine
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• Citramon Fitofarm forte N12 capsules PRAT "Fitofarm", Ukraine

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• Citramon-M No. 10 tablets PAT "Khimpharmzavod" Chervona Zirka", Kharkov, Ukraine

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• Citramon Euro N10 tablets Mibe GmbH Arznam., Germany

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• Citramon-forte No. 100 tablets PAT "Lubnipharm", Ukraine

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PaniPharmacy

• Citramon In tablet Citramon In tablet. No. 6 Ukraine, Lubnyfarm PJSC

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• Citramon F tablets Citramon tablets. No. 6 Ukraine, Fitofarm ChAO

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• Citramon M tablets Citramon-M tablets. No. 10 Ukraine, Red Star JSC

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• Citramon tablets Citramon-Darnitsa tablets No. 6 Ukraine, Darnitsa ChAO

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• Citramon tablets Citramon-Darnitsa tablets No. 10 Ukraine, Darnitsa ChAO

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