Nasal drops "Ingaron": instructions for use, effectiveness, reviews

• November 19, 2018
• Other drugs
• Inna Makagon

During the cold season, the human body needs emergency help. It is provided by antiviral drugs. “Ingaron” is one of them. This medication effectively helps with the appearance and development of various colds, reduces the risk of complications, alleviates the course of the disease and shortens the treatment time.

In addition, it helps restore the normal functioning of the immune system, which means it increases resistance to various viruses in general. What reviews and instructions do Ingaron nasal drops have?

The drug contains an active component - interferon-gamma. Interferons stimulate cellular immunity and also make the body's cells resistant to viral invasion. The drug is effective at different stages of the disease, ensuring a speedy recovery both in the first days and at the peak of the disease, including pneumonia.

Compound

The main active substance of Ingaron is gamma interferon - this is a type of protein consisting of many amino acids. It is obtained by microbiological synthesis in a strain of Escherichia coli, and then purified as much as possible by column chromatography.

The interferon content in the drug is measured in international units (IU). One bottle can contain 100,000, 500,000, 1,000,000 or 2,000,000 IU.

In addition to the main active component, Ingaron contains an additional element - mannitol.

About the drug

Ingaron gained particular popularity after 2009, when the swine flu pandemic broke out, which, according to official data, killed more than 300 thousand people across the planet. The drug was created specifically for high protection of the population from an influenza pandemic.

It quickly stops coughing, reduces the likelihood of otitis media, shortens the duration of the disease and relieves its severity, but most importantly, the drug protects against the development of a serious influenza complication - pneumonia.

The body's production of interferons is the first defense of cells against viruses, which appear much earlier than antibodies and other protective immunity factors. Interferon gamma also stimulates the human immune system, activating cells that destroy viruses.

Interferon-gamma is the most important anti-inflammatory substance in the human body, capable of blocking the virus and human cells into which the virus has managed to penetrate at the DNA level. It makes healthy human cells immune to viruses. The duration of action of the drug is sufficient to protect the body and provide a therapeutic effect.

Ingaron is the only cytokine protein that significantly reduces the risk of allergic reactions and goes well with antibiotics and drugs for symptomatic treatment (Paracetamol, Ibufen, cough and sore throat remedies).

pharmachologic effect

"Ingaron" is a recombinant human interferon gamma, consisting of 144 amino acid residues (aa), lacking the first three aa. — Cys-Tyr-Cys replaced by Met. Molecular weight - 16.9 kDa. Obtained by microbiological synthesis in a recombinant strain of Escherichia coli

and purified by column chromatography.

The specific antiviral activity on cells (human fibroblasts) infected with the vesicular stomatitis virus is 2·107 U/mg protein.

Interferon gamma (immune interferon) is the most important pro-inflammatory cytokine, the producers of which in the human body are natural killer cells, CD4 Th1 cells and CD8 cytotoxic suppressor cells.

Macrophages, neutrophils, natural killer cells, and cytotoxic T lymphocytes have receptors for interferon gamma. Interferon gamma activates the effector functions of these cells, in particular their microbicidality, cytotoxicity, production of cytokines, superoxide and nitrooxide radicals, thereby causing the death of intracellular parasites.

Interferon gamma inhibits the B-cell response, IL-4, suppresses IgE production and CD23 antigen expression. It is an inducer of apoptosis of differentiated B cells, giving rise to autoreactive clones.

Cancels the suppressive effect of IL-4 on IL-2-dependent proliferation and generation of lymphokine-activated killer cells. Activates the production of proteins of the acute phase of inflammation, enhances the expression of genes C2 and C4 components of the complement system.

Unlike other interferons, it increases the expression of major histocompatibility complex (MHC) antigens of both classes 1 and 2 on different cells, and induces the expression of these molecules even on those cells that do not constitutively express them. This increases the efficiency of antigen presentation and the ability of T lymphocytes to recognize them.

Interferon gamma blocks the replication of viral DNA and RNA, the synthesis of viral proteins and the assembly of mature viral particles. Interferon gamma has a cytotoxic effect on virus-infected cells.

What is Ingaron

When cold weather sets in, viral infections often affect children and adults. To reduce the risk of the disease or to cope with it faster, doctors recommend using interferon drugs. They have a high level of biological activity, due to which they effectively fight harmful microorganisms. These medications include Ingaron, a recombinant drug that contains human interferon gamma, which combines immunomodulatory and antiviral effects.

The drug Ingaron is capable of destroying many different viruses. The active substance of the drug prevents them from attaching and introducing themselves into the body; it eliminates cells that have already been infected by the virus. The medicine with interferon gamma has a lot of positive qualities:

• complete exclusion of infection from entering the human body;
• viruses cannot adapt to Ingaron;
• the medicine has practically no toxins in its composition, therefore it is taken in large doses without risk to health;
• Ingaron is able to directly act on parasitic organisms throughout the entire period of illness;
• Interferon has the ability to accumulate in the human body, so the immune system is significantly strengthened.

Indications for use of the drug "Ingaron"

Lyophilisate for preparing a solution for intramuscular and subcutaneous administration.

Complex therapy:

1. chronic viral hepatitis C;
2. chronic viral hepatitis B;
3. HIV/AIDS infection;
4. pulmonary tuberculosis;
5. oncological diseases (as an immunomodulator - including in combination with chemotherapy);
6. urogenital chlamydia;
7. chronic prostatitis;
8. genital herpes virus infection and herpes zoster (Herpes zoster)
   - in monotherapy;
9. anogenital warts (human papillomavirus) - treatment and prevention of relapse of the disease.

Prevention of infectious complications in patients with chronic granulomatous disease.

Complex therapy for the prevention and treatment of influenza and avian influenza (H5N1 and H1N1).

Use of the drug

The drug Ingaron is available in the form of a white powder, which must be diluted in water for injection or saline before use. Manufacturer: Russian. One bottle can contain 100 or 500 thousand units of the drug. One package can contain one or five vials, as well as a pipette and water for injection.

At the same time, each package of the medicine comes with instructions for use, which should be read before use.

It is especially important to pay attention to indications and contraindications. If you have any doubts about whether to use this drug, it is better to first ask your doctor for advice.

It is also important to familiarize yourself with the recommended storage conditions for the medicine. The place where the drug is stored should be inaccessible to small children, and the temperature should be within 2–8 degrees

The shelf life of the medicine after the bottle has been opened does not exceed 10 days.

More to read:

If you cannot find Ingaron at the pharmacy, then you can use analogues. Such drugs include Viferon, Amiksin, Cycloferon. Despite the availability of these drugs, they cannot be called complete substitutes for interferon gamma. The medications listed above belong to the group of interferon inducers, that is, drugs that do not directly contain these substances, but stimulate their natural production in the human body.

Ingaron nasal drops can be used together with other medications that are indicated for the treatment of acute respiratory infections and influenza. However, there is a risk of unwanted effects, since each person’s body has its own individual characteristics, and in some cases there may be intolerance to the drug.

Adverse reactions occur especially often when this drug is used simultaneously with drugs such as:

• antithymocyte globulin;
• theophylline;
• strontium chloride.

Such phenomena also often occur when using drugs to treat cancer. Therefore, if the patient uses any of these medications, it is necessary to inform the doctor so that he can adjust the treatment regimen to prevent the development of unwanted reactions.

Treatment of a runny nose requires strict adherence to the dosage of the medication.

Reviews from doctors and patients who prescribed or used Ingaron for the treatment of ARVI and influenza confirm the effectiveness of this medicine. It has been proven effective not only in the treatment of the above diseases, but also in carrying out prevention in the autumn-spring period, when the incidence is highest.

Instructions for use of the drug "Ingaron"

The drug has the following instructions:

• For intramuscular injections, the contents of the bottle are dissolved in 2 ml of water for injection. The dose of the drug is determined individually.
• For the treatment of patients with chronic viral hepatitis B, chronic viral hepatitis C, as well as HIV infection/AIDS and pulmonary tuberculosis, the average daily dose for adults is 500 thousand IU. It is administered once a day, daily or every other day. The course of treatment ranges from 1 to 3 months; if necessary, the course of treatment is repeated after 1–2 months.
• To prevent infectious complications in patients with chronic granulomatous disease, the average daily dose for adults is usually 500 thousand IU. It is administered once a day, daily or every other day. The course consists of 5–15 injections; if necessary, the course is extended or repeated after 10–14 days.
• For the treatment of cancer, the average daily dose for adults is 500 thousand ME. It is administered once a day, every other day.
• For the treatment of genital herpes viral infection, herpes zoster and urogenital chlamydia, the average daily dose for adults is 500 thousand IU. It is administered once a day, subcutaneously, every other day. The course of treatment is 5 injections.
• For the treatment of chronic prostatitis, the daily dose is 100 thousand IU. It is administered 1 time per day subcutaneously, every other day. The course of treatment is 10 injections.
• For the treatment of anogenital warts, the daily dose is 100 thousand IU. It is administered 1 time per day subcutaneously, after cryodestruction, every other day. The course of treatment is 5 injections.
• Intranasally. The contents of the bottle are dissolved in 5 ml of water for injection.
• At the first signs of influenza, ARVI - 2 drops in each nasal passage, after toileting the nasal passages, 5 times a day for 5-7 days.
• For the prevention of ARVI and influenza upon contact with a patient and/or during hypothermia - 2-3 drops in each nasal passage every other day, 30 minutes before breakfast for 10 days. If necessary, preventive courses are repeated. For single contact, one instillation is sufficient.

After instillation, it is recommended to massage the wings of the nose with your fingers for several minutes to evenly distribute the drug in the nasal cavity.

Special Recommendations

There are no special recommendations for the use of the solution for subcutaneous and intramuscular administration of the drug "Ingaron". But if the patient has been prescribed an intranasal medication, then he should definitely know about the features of its use. This will contribute to an even greater therapeutic effect.

In order for the drug to envelop the entire nasal cavity, it is recommended to instill it in the “standing” position with the head slightly tilted back. To ensure uniform distribution of the drug in the nasal passages after instillation, the patient is recommended to massage the wings of the nose with light finger movements. It is advisable to carry out this procedure in the same position, that is, without lowering your head down.

If the use of an intranasal agent does not bring any results, then it should be discontinued. If cold and flu symptoms change, you should immediately consult a doctor.

Side effects

Sometimes, after using Ingaron, side effects are recorded (they may be absent). The most common manifestations are:

1. feeling of body aches;
2. headache, weakness;
3. temperature increase;
4. itching, burning in the nostrils after the instillation procedure;
5. the formation of an inflammatory process in the area of ​​the body where Ingaron was injected (this is often caused by a needle getting into a nerve or vessel);
6. pain in the joints;
7. skin allergies (there are contour rashes if the patient is intolerant to the medication).

Release form

The drug is produced domestically. It is a white powder that must be diluted with water. The medicine is sold from pharmacies in ampoules of 5 milliliters, which contain 100,000 and 500,000 international units.

There are one, five or ten ampoules in a package. In addition, water and a pipette are included. Keep nasal drops "Ingaron" 100,000 IU at a temperature of +2 to +8 degrees, away from children.

The prepared solution can be stored for ten days in the refrigerator. Freezing the drug is strictly prohibited. Do not use the medicine after the expiration date.

Analogs

If the components of Ingaron are not suitable for a particular patient, then the doctor prescribes an analogue of this drug:

1. "Lipoferon" (treats hepatitis B);
2. "Afonex" (various bacterial, viral infections);
3. "Virogel" (herpes, ARVI, influenza);
4. "Genferon" (flu, acute respiratory infections, ARVI);
5. "Viferon" (a modern antiviral agent);
6. "Alfaron" (strengthens the immune system in case of cancer);
7. "Alpha-inson" (hepatitis C);
8. "Laferobion" (prevention, therapy of viral infections);
9. Pegintron (hepatitis B).

Contraindications

According to the instructions for use, Ingaron nasal drops have certain contraindications:

1. Individual intolerance to components.
2. Lactation.
3. Pregnancy.
4. Autoimmune diseases.
5. Under seven years of age.

Before using the medicine, you should carefully read the instructions. Women of childbearing age should not plan pregnancy during therapy, so it is recommended to use contraceptives. If pregnancy occurs, you should stop using the drug and consult a medical specialist.

Frequently asked questions to doctors regarding ingaron drops

Why is ingaron prohibited for children under 7 years of age?

Some practicing doctors, ignoring official instructions, prescribe medications to children ahead of schedule. There are cases, for example, when immunologists and pediatricians use ingaron as early as five years of age. Is it dangerous?

Theoretically, this is not dangerous, because... Interferon gamma is found in our body and is not foreign. On the contrary, during illness there is not enough of it in the body, which is why ingaron drops were developed to help. Due to the lack of clinical trials in children under 7 years of age, this contraindication was determined.

Therefore, in cases involving dangerous strains of influenza (swine, avian), the drug can be used at an earlier age.

Can ingaron be combined with antibiotics?

Some patients mistakenly believe that ingaron is an antibiotic, but this is not the case.
Ingaron has a combined effect (antiviral, antitumor, immunomodulating and immunostimulating), and antibiotics are only antibacterial. Therefore, if a clinical case requires the “connection” of antibacterial drugs, there are no contraindications to combining them with ingaron.

Is it dangerous to use ingaron (drops) and arbidol together?

There is no danger; on the contrary, the drugs enhance each other’s effects, so it is recommended to take them together for severe influenza and ARVI.

Article on the topic - cheap analogues of arbidol.