Pharmacodynamics and pharmacokinetics
The active component suppresses the production of basal hydrochloric acid in the stomach, as well as that stimulated by acetylcholine , histamine and gastrin HCl. Reduces the activity of pepsin, increases the pH of gastric juice, and reduces the production of HCl.
By increasing the level of glycoproteins , increasing the formation of gastric mucus, stimulating the synthesis of prostaglandins , and the secretion of bicarbonate, the protective and wound-healing effect of the drug is achieved.
The drug helps stop gastric bleeding , promotes healing of damage to the gastric mucosa, and scars stress ulcers .
The drug has a weak effect on the oxidase system of the cytochrome P450 enzyme in the liver system (suppressive effect).
The medicine begins to act within an hour and lasts 12-24 hours. With intravenous administration of solutions with the active ingredient famotidine, the effect is recorded after half an hour. A single dose suppresses secretion for 10-12 hours.
Pharmacological properties of the drug Famotidine
Famotidine is an antisecretory agent, an H2 receptor blocker. Suppresses the production of hydrochloric acid, both basal and stimulated by histamine, gastrin and acetylcholine. Simultaneously with a decrease in the production of hydrochloric acid and an increase in pH, the activity of pepsin decreases. The duration of action after a single dose depends on the dose and ranges from 12 to 24 hours. After oral administration, bioavailability is 40–45%, the effect develops after 1 hour and lasts for 10–12 hours. After intravenous administration, the maximum effect develops within 30 minutes, half-life is 2.3–3.5 hours. With creatinine clearance less than 10 ml/min, the half-life of famotidine from blood plasma increases and can reach 20 hours. After oral administration, 30–35% of famotidine is excreted unchanged in the urine , and after intravenous administration - 65–70%.
Indications for use of Famotidine
What are the pills for?
The medication is prescribed for hyperacidity of gastric juice , ulcerative lesions of the digestive system, stress ulcers, symptomatic ulcers, Zollinger-Ellison syndrome , NSAID gastropathy, erosive variant of reflux esophagitis, heartburn , for the prevention of recurrent bleeding after surgical interventions on the digestive system, polyendocrine adenomatosis, with systemic mastocytosis .
What other indications exist for the use of Famotidine? The medicine is prescribed to prevent aspiration of gastric juice in patients who are given general anesthesia. The drug is effective for dyspeptic disorders. The drug is prescribed for the prevention of aspiration pneumonitis .
Description of the medication
Famotidine, the indications for use of which are listed in detail in the instructions, is produced in the form of tablets. The active component of the medicine is a substance of the same name. Famotidine is contained in tablets at a concentration of 20 or 40 mg. The medicine is in blisters of 10 pieces.
The tablets have a round shape. They are painted brown. The surface of the tablets is smooth, biconvex.
Another form of release of the drug is lyophilisate, intended for the preparation of a solution for intravenous administration.
The medicine, made in the form of a lyophilisate, is colored white or yellowish.
The active component of the drug is famotidine. The medicine also contains auxiliary ingredients such as aspartic acid and mannitol.
Side effects
Digestive tract: epigastric pain, dry mouth, nausea, decreased appetite, vomiting, increased levels of liver enzymes, acute pancreatitis , mixed hepatitis, hepatocellular hepatitis, cholestatic hepatitis.
Sense organs: ringing in the ears, paresis , blurred visual perception.
Genitourinary system: decreased libido, amenorrhea , gynecomastia, hyperprolactinemia .
Agranulocytosis, allergic reactions, tremor, drop in blood pressure, dizziness, asystole, AV block, bradycardia, anaphylactic shock , bronchospasm, myalgia, arthralgia, hallucinations may develop.
Famotidine, instructions for use (Method and dosage)
Instructions for use of Famotidine tablets
Taken orally.
For ulcerative lesions of the digestive system: 0.02 grams twice a day or 0.04 grams before bedtime. In some cases, the amount of the drug is increased to 80-160 mg. Duration of therapy is 4-8 weeks.
In order to prevent relapses of ulcerative lesions, 0.02 grams are prescribed once a day at night.
The initial dose for Zollinger-Ellison syndrome is 20-40 mg 4 times a day, the dose can be increased to 24-48 mg.
Prevention of aspiration of gastric contents: 0.04 grams; before surgery, take 2 hours before surgery. For reflux esophagitis: twice a day, 0.02 grams.
Preparations with Famotidine solution
Intravenously administered slowly over 2 minutes: 20 mg every 12 hours. For the prevention of aspiration pneumonitis: intramuscularly 0.02 grams before surgery, or in the morning on the day of surgery.
Powder for injection is dissolved in sodium chloride 0.9% 5-10 ml.
Conditions of storage and sale
To purchase medication at a pharmacy, you need a doctor's prescription. It is best to store famotidine at a temperature not exceeding 25 degrees, in a place protected from direct sunlight. The shelf life of tablets is 3 years from the date of their release.
The approximate cost of a package of medicine (40 mg) is 100 rubles. How much Famotidine costs depends on the number of tablets in the package, the concentration of the active substance, and the manufacturer. It is worth considering the pricing policy of the pharmacy.
Interaction
Famotidine inhibits the metabolism of Diazepam , aminophenazone, phenazone , lidocaine, caffeine, tricyclic antidepressants , phenytoin, indirect anticoagulants, Aminophylline , metronidazole, Metoprolol, buformin , glipizide, theophylline, metoprolol, clavulanic acid in the liver.
When taking drugs that depress bone marrow, the risk of developing neutropenia increases. Famotidine reduces the absorption of Ketoconazole and Itraconazole .
Sucralfate and antacids slow the rate of absorption. Famotidine is compatible with sodium chloride, dextrose solution. The drug increases the absorption of clavulonic acid, Amoxicillin .
special instructions
Taking Famotidine may mask symptoms indicating carcinoma in the stomach. It is recommended to exclude malignant neoplasms of the digestive tract before prescribing the drug.
The drug must be discontinued gradually to prevent rebound syndrome. With stress and long-term therapy, a bacterial infection in the stomach may develop, and further spread of microbes is possible.
Famotidine must be taken two hours after using Ketoconazole , Itraconazole to prevent their hyperabsorption.
When testing for skin reactions to histamine, it is important to consider that a histamine receptor blocker may suppress the reaction and lead to a false negative result.
Treatment involves eliminating from the diet foods that irritate the gastric mucosa.
Overdose of the drug
If the recommended dosage is systematically exceeded, the patient's well-being may sharply deteriorate. The following symptoms occur:
- decreased blood pressure;
- the occurrence of tremor in the limbs;
- collapse;
- uncontrollable vomiting;
- increased heart rate;
- decreased motor activity.
In case of an overdose of Famotidine, the patient needs hemodialysis. After this procedure, the use of intestinal sorbents and other medications is indicated. Symptomatic treatment is aimed at eliminating complications that arise from an overdose of Famotidine.
Famotidine analogs
Level 4 ATC code matches:
Gastrosidine
Gistak
Ranitidine
Acylok
Cimetidine
Zantac
Kvamatel
Analogues are the following drugs: Gastromax , Gastrotide , Kvamatel , Ulfamid , Famodingexal , Famozol , Famosan .
General recommendations
Famotidine and drug analogues should not be taken in the presence of a low-quality stomach tumor - carcinoma. The drug masks the characteristic symptoms of the disease. As a result, the course of the disease becomes more complicated.
The medicine is withdrawn gradually. This is necessary to prevent a sharp increase in the level of acidity of gastric juice. In addition, during treatment with Famotidine, a strict diet is followed. Foods that irritate the affected gastric mucosa are excluded from the diet.
When using the medicine, it is not recommended to engage in intellectual work. Famotidine reduces concentration. When using anti-ulcer tablets, it is recommended to refrain from driving.
Famotidine price, where to buy
The price of Famotidine in 20 mg tablets ranges from 30 to 50 rubles per pack of 20 pieces.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
ZdravCity
- Famotidine tablets p.p.o.
20 mg 20 pcs. LLC HEMOFARM 44 rub. order
Pharmacy Dialogue
- Famotidine (tablet p/o 20 mg No. 20)Hemofarm
43 RUR order
- Famotidine tablets 40 mg No. 30 Hemofarm
89 rub. order
- Famotidine (tablet p/o 40 mg No. 20) Hemofarm
76 RUR order
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Pharmacy24
- Famotidine-Pharmex 20 mg No. 5 solution TOV "Pharmex Group", Borispil, Ukraine
195 UAH. order - Famotidine-KMP 20 mg N20 tablets PAT "Kievmedpreparat", Ukraine
8 UAH order
- Famotidine-Darnitsa 0.02g N20 tablets PrAT” Pharmaceutical company “Darnitsa”, Ukraine
10 UAH.order
