Genferon nasal spray. Instructions for use for children and pregnancy

Genferon is a drug that has several pharmacological actions, the main of which is immunomodulatory . It also has a number of other properties: regenerating, antiviral, antibacterial, antiproliferative and local anesthetic. Like any other drug, Genferon needs the correct storage conditions prescribed by the manufacturer. Otherwise, the drug will become unusable, and its use will cause much more harm to health than good.

• Best before date
• Temperature
• Storage
• Other Important Factors

Release forms and composition of the drug

This medication is produced in Russia in the form of a nasal spray. The active components are the following substances: recombinant human interferon and taurine.

Additional composition:

• trilon B;
• dextran 40 thousand;
• glycerol;
• sodium chloride;
• potassium chloride;
• 2-substituted sodium phosphate;
• potassium salt of orthophosphoric acid;
• peppermint oil;
• preservative E218 (methyl ester of para-hydroxybenzoic acid);
• injection water.

The medicine is contained in a plastic bottle equipped with a dispenser. Each bottle is packed in a cardboard container.

Nosological classification (ICD-10)

— A49.3 Mycoplasma infection, unspecified — A56 Other sexually transmitted chlamydial diseases — A59 Trichomoniasis — A60 Anogenital herpetic viral infection [herpes simplex] — A63.8 Other specified sexually transmitted diseases — B37.3 Vulvar candidiasis and vagina (N77.1) - B97.7 Papillomaviruses - N34 Urethritis and urethral syndrome - N41 Inflammatory diseases of the prostate gland - N48.1 Balanoposthitis - N48.6 Balanitis - N70 Salpingitis and oophoritis - N72 Inflammatory diseases of the cervix - N74.4 Inflammatory diseases of the female pelvic organs caused by chlamydia (A56.1+) - N75.9 Bartholin's gland disease, unspecified - N76 Other inflammatory diseases of the vagina and vulva - N86 Erosion and ectropion of the cervix

Pharmacodynamics and pharmacokinetics

Genferon is a nasal spray that has an antiviral effect due to an increase in the activity of enzymes that suppress the reproduction and activity of pathogenic microorganisms.

The immunomodulatory properties of the drug are due to an increase in the immune response aimed at the action of most pathogenic microflora and cells exposed to bacterial influence.

The process occurs due to the following reactions:

• increased activity of natural killer cells;
• increased activity of B-lymphocytes and increased antibody production;
• enhanced action of the monocyte-macrophage system;
• activation of cellular processes during which solid particles are digested;
• increasing the immune response at the molecular level, which allows the immune system to recognize affected (infected) cells.

Thus, the drug exhibits a pronounced antibacterial effect.

Under the influence of the main component (interferon), there is an increased production of leukocytes located in the mucous cavity. Moreover, these substances are directly involved in the suppression of pathological processes. Thanks to this effect, the production of immunoglobulin A (IgA) is improved.

The second active substance (taurine), when ingested, leads to the restoration of metabolic reactions and accelerated healing of damaged tissues. This component exhibits high antiviral and immunostimulating properties and is an antioxidant that inhibits the development of various disorders associated with an excess of oxygen in the body.

The combined action of the 2 components leads to a more pronounced therapeutic effect.

The drug has a low degree of absorption and bioavailability. This effect is due to the influence of protein compounds located in the nasal mucosa, which are responsible for the penetration and transportation of various substances.

A small proportion of the drug is able to penetrate the systemic circulation. Thanks to this action, there is an increase in systemic immunity.

Genferon during lactation

Genferon during breastfeeding is allowed to be used to treat infectious diseases, but only after a doctor’s prescription. That is, suppositories and sprays are used under medical supervision. This is explained by the fact that the components of the medication stimulate antibodies and immune cells, which enter the baby’s body during feeding along with suppressed pathogenic microbes.

To protect newborns, they should be switched to infant formula at the time of treatment. After completion of the therapeutic course, lactation is resumed.

Based on all of the above, Genferon during lactation is an effective and relatively safe drug for the treatment of various infections.
In order for the medication to bring only benefit, lactating women must follow the rules of administration. Otherwise, there is a risk of negative reactions in the mother or newborn. Subscribe to our VKontakte group

Instructions for use, dosage

The product is indicated for local use in otolaryngology.

Rules of application:

• Remove the protective cover.
• Make several control presses on the dispenser until a thin stream is formed.
• When using, the bottle with the product must be kept in an upright position.
• Instillation is performed alternately for each nasal cavity.
• After using the medication, the bottle should be closed with a protective cap.

It is not recommended to use the product at once by several family members, as such use can lead to infection of other persons.

For children

Children over 14 years old at the first symptoms of the disease are prescribed 1 irrigation of the mucous membrane 3 times a day. In this case, injection is carried out into each nasal cavity. The duration of therapy is no more than 5 days.

As a preventive measure, as well as in case of hypothermia, 1 injection is prescribed into each nasal cavity 2 times a day. The duration of treatment varies from 5 to 7 days.

For adults

For adult patients, the dosage is calculated based on clinical manifestations. Thus, at the first signs of a cold or ARVI, 1 irrigation of each nasal mucosa 3 times a day is prescribed. In this case, the maximum daily dose of the drug should not exceed 5 thousand IU. The duration of the course is no more than 5 days.

In case of contact with an infected patient (cold or ARVI), as well as in case of hypothermia, 1 injection is prescribed into each nasal cavity 2 times a day. The duration of treatment is 5-7 days. After a break and preliminary consultation with a doctor, it is possible to repeat the course.

During pregnancy and pregnancy

According to clinical studies, the spray can be used during pregnancy, regardless of trimester. No dosage adjustment is required.

The daily dose of the drug is as for an adult patient:

• With the development of ARVI, 1 irrigation is prescribed in each nasal cavity 3 times a day for no more than 5 days.
• As a preventive measure, 1 injection is prescribed 2 times a day for 5 to 7 days.

Preventive treatment can be repeated after a short break and prior agreement with the treating specialist.

Reviews

Genferon suppositories are a drug for the treatment of herpes and human papillomavirus, bacterial and fungal infections. Reviews about the effect of the drug often contain information about the side effects that have occurred (colic, burning).

1. Alina, Moscow: I was diagnosed!!! Herpes, cytomegalovirus, toscoplasmosis! Genferon 1,000,000 was prescribed! Heartburn appeared and my period started ahead of time.
2. Simona, Mariinsk: I was prescribed Genferon for ureplasma. In the morning - 500 IU vaginally, in the evening - 1,000 IU rectally. In addition, vilprofen and metronidazole were prescribed (one tablet in the morning and evening). There are no side effects.
3. Ekaterina, Sacrum: And I got irritation in my crotch from the candles. Maybe the concentration is high (1,000,000 IU)? A course of 10 days was prescribed. Today is the 7th, I’m afraid I won’t be able to stand it, I’ll stop putting candles, it’s very itchy.

Overdose

Cases of drug overdose have not been reported at the moment. If the dosage is observed, the product does not have a negative effect.

However, if the established daily norm is significantly exceeded or the drug is accidentally ingested and negative manifestations develop, it is necessary to contact your doctor for symptomatic therapy. If you accidentally swallow the spray, you must use sorbents and contact your doctor.

Cross-drug interactions

The use of “Genferon” with vitamins E and C, which accelerate the action of interferon, is indicated.

In complex therapy, the drug is prescribed with other antimicrobial drugs or antibiotics. For example, it goes well with Terzhinan vaginal suppositories. They include:

• Antifungal agent nystatin
• Aminoglycoside antibiotic neomycin sulfate
• A substance of the imidazole group, ternidazole, which works against anaerobic microorganisms, including Trichomonas and Gardnerella
• The corticosteroid prednisolone sodium metasulfobenzoate is a topical anti-inflammatory agent.

“Terzhinan” and “Genferon” interact effectively with cystitis, thrush and other infectious diseases of the genitourinary system.

Another antiseptic that works well with Genferon is Hexicon. Its main active ingredient is chlorhexidine. “Hexicon” is produced in the form of vaginal suppositories and solution. Effective against a number of pathogens of various etiologies and locations.

special instructions

This dosage form (spray) can be used during pregnancy or breastfeeding. The drug is well tolerated and does not have a negative effect on the formation and development of the fetus.

The drug is used with great caution in patients at high risk of developing nosebleeds.

The medication does not have a depressing effect on the psyche or visual functions of a person, therefore it is allowed to drive a car or carry out other work that requires high psychomotor reactions.

Side effects

Basically, local allergy symptoms occur: itching and burning in the vagina. They go away on their own a couple of days after stopping the use of the drug. The possibility of its further use should be discussed with your doctor.

When using suppositories with a total dose of 10,000,000 IU per day, reactions are possible that are characteristic of all types of interferon:

• From the hematopoietic system - a decrease in the content of platelets and leukocytes in the blood (thrombocyto- and leukopenia)
• From the central nervous system – headaches, loss of appetite, fatigue
• From the musculoskeletal system - pain in muscles and joints (myalgia and arthralgia)
• Others – hyperthermia (increased body temperature), hyperhidrosis (excessive sweating).

If the temperature rises, you can use paracetamol or ibuprofen (Nurofen).

Analogs

Genferon is a nasal spray, which in rare cases can lead to the development of allergic reactions. If such effects occur, the drug should be replaced with another medication similar in action and indications.

Analogues:

• Thymogen. This medicine is manufactured in the form of a nasal spray by a Russian drug manufacturer. The main substance is alpha-glutamyl-tryptophan. The medication belongs to the category of immunomodulatory agents and is used in the treatment of the following diseases: treatment and prevention of acute respiratory viral infections, influenza and bacterial infections of the upper respiratory tract; postoperative period (to strengthen and restore immunity); infectious pathologies accompanied by decreased immunity; a secondary form of immunodeficiency caused by long-term use of antibiotics, chemotherapy or radiation therapy. Dosage regimen: 1 irrigation in each nasal cavity 2 times a day. The duration of treatment is no more than 1.5 weeks. For prophylaxis, the product is used for 3-5 days. In childhood, 1 injection is prescribed once a day. Repeated use of the medicine is possible after a break of 1 month. Contraindications: children under 1 year of age; intolerance to active components. The medicine can be prescribed during pregnancy and breastfeeding. Terms of sale - without a prescription. The cost of a bottle in pharmacies in Moscow and the Moscow region ranges from 190 to 540 rubles.
• Grippferon. This medication is manufactured in the form of a nasal spray by a domestic pharmaceutical company. The active substance is interferon alpha-2b. The medicine has pronounced anti-inflammatory, antiviral and immunomodulatory properties. The indication for the spray is the prevention and treatment of influenza and acute respiratory viral infections. Dosage regimen (for children): 1-2 drops of the product in each nasal passage 3 to 5 times a day. Adults are prescribed 3 irrigations of each nasal cavity 5-6 times a day. As a preventive measure, the product is used no more than 2 times a day. Preventive treatment can be repeated after a break and in agreement with the treating specialist. List of contraindications: intolerance to the components of the drug; severe course of allergic diseases. The spray can be used during pregnancy and breastfeeding. The method of sale through pharmacies is without a prescription. The cost of the drug in commercial and state pharmacies in Russia ranges from 245 to 370 rubles.
• Aqua Maris. This product is produced in Croatia in the form of a nasal spray. The main component is Adriatic Sea water, which contains various microelements. The medication has a local anti-inflammatory effect, helps cleanse and moisturize the nasal cavity from mucus. List of indications: various diseases of the nasal cavity, nasopharynx or paranasal sinuses; presence of adenoids; rehabilitation after surgical procedures on the nasal cavity; rhinitis (allergic and vasomotor form of pathology); infection of the nasal mucous membranes; excessive dryness of the nasal mucosa. In childhood, the recommended dosage is 2 irrigations 4 to 6 times a day. Adults are prescribed 2-3 injections 4 to 8 times a day. The duration of treatment in both cases varies from 2 weeks to 1 month. Contraindications: children under 1 year of age; intolerance to the components of the drug. The drug can be used during pregnancy or breastfeeding. Method of implementation - without a prescription. The cost of a bottle in regional and regional pharmacies in Russia ranges from 110 to 280 rubles.
• Viferon. This medical product is produced in the form of a gel for external use by a domestic manufacturer. The active substance of the drug is interferon alpha-2b. It exhibits high antiviral, immunomodulatory and antiproliferative properties. List of indications: complex treatment of influenza and ARVI, including pathologies complicated by the development of a bacterial infection; preventive treatment of influenza and ARVI; treatment and prevention of laryngotracheobronchitis (stenotic form of the disease); herpetic lesions of the skin and mucous membranes. The product is applied to the nasal mucosa or tonsils 3 to 5 times a day. The duration of therapy is 5 days. For prophylaxis, the drug should be applied no more than 2 times a day for 2-4 weeks. The medicine can be used during pregnancy and breastfeeding. A contraindication to the use of the gel is intolerance to its composition. Method of sale: over-the-counter. The cost of packaging in regional and regional pharmacies in Russia ranges from 120 to 220 rubles.

Genferon is a nasal spray, which, if hypersensitivity reactions occur, should be replaced with another product only in consultation with the treating specialist. When prescribing analogues, it is necessary to take into account the degree of tolerability of certain components.

It is not recommended to select analogues on your own, since the wrong choice of product can cause the development of allergies or other negative reactions.

Efficiency

In the treatment of inflammation of the prostate gland, suppositories are considered more effective due to the rapid absorption of active substances through the intestines into the prostate tissue. 90% of the components of the suppository reach the site of inflammation.

According to reviews from doctors and patients, the first signs of improvement appear on the second day. The results of therapy are expressed in:

• Activation of local immunity;
• Prevention of tumors;
• Elimination of pain;
• Elimination of degenerative processes;
• Reducing the activity of pathogens;
• Improving metabolism;
• Accelerating cell regeneration.

Price

Prices for the product may vary depending on the region and area of ​​its sale. You can find out the exact cost of the medication at any pharmacy located near your place of residence.

Genferon

Before using Genferon, you should carefully read the instructions for use of the spray and consult a specialist. Additionally, it is recommended to familiarize yourself with patients who have taken the drug as a treatment for nasal diseases.

Terms of sale

Patients who want to independently undergo treatment with the drug Genferon with an interferon concentration of 250,000 IU will be upset that no one will sell them this medicine in a pharmacy without a prescription. Only medicine with a reduced dosage of 125,000 IU of interferon in one suppository is offered for free sale. One pack containing 10 suppositories of 125,000 IU of the active compound will cost 270-340 rubles. To purchase Genferon with a higher dosage of the active component, you will have to pay from 380 to 420 rubles.