Instructions for use of vaginal and rectal suppositories Genferon - composition, side effects and analogues

Genferon is used in the treatment of urogenital and respiratory pathologies. The drug is suitable for eliminating inflammatory and infectious processes. The medicinal effect is the provision of immunomodulatory properties of the active component, which improves the functioning of the body's defense systems. Genferon simultaneously eliminates the pathological process and alleviates the symptoms of the disease.

Immunomodulators belong to the new generation of medicines. These drugs are safer than antibiotics and antiviral drugs. Usually not used as monotherapy.

Genferon suppositories - instructions for use

The medication is an immunomodulatory complex of substances that has an antimicrobial and anti-inflammatory effect. As a rule, Genferon is used to treat diseases of the genitourinary system in men and women. The antiviral effect of the drug extends to a significant group of pathogenic microorganisms - bacteria, viruses, fungi, etc. The immunomodulatory effect of suppositories is manifested due to the activation of immune defense components, ensuring the destruction of long-living bacteria that provoke chronic inflammation.

The components of the drug provide systemic and local action, activating certain elements of the immune system that act in the blood and on the mucous membranes. When administered rectally, a systemic effect is achieved, making it possible to treat bacterial and viral diseases of the respiratory system with Genferon or provide prevention of many other pathologies by activating immune cells and generally strengthening the body's protective properties.

What is treated with geneferon

The instructions for Genferon suppositories provide a list of infections for which the drug has a therapeutic effect:

• Herpes virus - most often used to treat genital viruses, but can also be used for oral and shingles.
• HPV or human papillomavirus.

Bacterial infections:

• Chlamydia.
• Ureplasma.
• Mycoplasma.
• Gardnerellosis.
• Trichomoniasis.

And also fungi (candidiasis). And also - vulvovagenitis and cervicitis in women, prostatitis and urethritis in men.

Compound

The main component of the drug is human interferon alpha 2B; in the drug it can be in a dosage of 250, 500 thousand or 1000 000 IU. Other active substances in the medication are:

• aminosulfonic acid (0.01 g);
• benzocaine or anesthesin (0.055 g).

Since the active components require a special environment for rapid penetration into the circulatory system and fixation on the mucous membrane of the vagina or rectum, the basis of the drug is solid fat. All active substances and other auxiliary components are evenly distributed in it, which include:

• emulsifier T2;
• dextran 60 thousand;
• sodium hydrogen citrate;
• macrogol 1500;
• lemon acid;
• purified water;
• polysorbate 80.

Reviews and prices

Doctors often use this medication in combination with powerful antimicrobial and antifungal drugs to speed recovery and relieve symptoms of the disease. Reviews from patients indicate the effectiveness of suppositories as symptomatic therapy. A single application is sufficient to relieve pain in most cases.

The average price of 10 suppositories (500 thousand IU) is 530 rubles. A similar package with suppositories in a dosage of 250 thousand IU costs approximately 350 rubles. The average price of 10 suppositories with a maximum dose (1 million IU) is 700 rubles.

Pharmacodynamics and pharmacokinetics

The introduction of suppositories into the rectum ensures close contact of the mucous membrane with the drug, due to which the active components of rectal suppositories are absorbed into the bloodstream by 80%. The maximum concentration of interferon and other active substances in the blood is observed 5 hours after using Genferon. Good absorption of the drug provides both local and systemic therapeutic effects.

With vaginal use of suppositories, the maximum local therapeutic effect is achieved, which is due to the accumulation of most of the drug in the foci of infection. The vaginal mucosa cannot provide high absorption, therefore, in this case, the penetration of the active substances of Genferon into the blood is minimal. The drug undergoes breakdown into metabolites, after which it is eliminated in the urine within 12 hours.

Consumer reviews of antiviral suppositories

Women say that this medicine is quite effective. When used in combination, it always shows good results. Patients also talk about the affordable price. One package of Genferon costs approximately 300 rubles. While its analogue “Kipferon”, which can also be used vaginally and rectally, will cost you 700 rubles.

The undoubted advantage of the described medication is that it never stains laundry. The base of the medication does not contain oils or paraffin, unlike its analogue “Viferon”. That is why the use of the medicine does not cause any inconvenience to the fairer sex.

Genferon suppositories - indications for use

The systemic immunomodulatory drug has a wide spectrum of action: it has found application in the complex treatment of various infections of the genitourinary system in women and men. In addition, Genferon is used both as an independent drug and as part of complex treatment with other medications and techniques. Interferon suppositories are indicated for the treatment of HPV and for the following diseases:

• vaginal candidiasis;
• herpes viruses;
• chlamydia;
• mycoplasmosis;
• vulvar candidiasis;
• ureaplasmosis;
• adnexitis;
• viral hepatitis;
• trichomoniasis;
• cervical erosion;
• bartholinitis;
• vaginosis;
• cervicitis;
• gardnerellosis;
• urethritis;
• inflammation of the prostate gland;
• other sexually transmitted infections and urogenital diseases.

The drug "Genferon": reviews

An interferon-based antiviral agent is quite effective. This is exactly what doctors report. Doctors say that, unlike analogues of the drug (Viferon, Kipferon and others), the described medication promotes pain relief and tissue regeneration. This becomes an important factor in the treatment of cervical erosion.

Benzocaine or anesthesin helps relieve pain in damaged membranes. This therapy allows you to avoid the additional use of drugs in this category. Taurine contained in the drug has an antioxidant and anti-inflammatory effect. Due to this, the effect of interferon is enhanced.

Doctors say that the drug is absolutely safe. That is why it can be prescribed to expectant mothers and babies. The medicine almost never causes adverse reactions. However, with excessive use and self-administration, unpleasant symptoms may occur. That is why, before starting treatment, you need to find out what the instructions for use say about the drug “Genferon” (suppositories).

Directions for use and dosage

Suppositories with recombinant interferon are administered vaginally or rectally, depending on the specifics of the disease and the gender of the patient. Genferon completely dissolves in contact with the rectal or vaginal mucosa without causing discomfort. With vaginal administration, a more pronounced local effect is achieved, with rectal administration, a systemic effect is ensured. The latter type of drug can even be prescribed for the treatment of acute respiratory viral infections or other infectious pathologies of various localizations.

Vaginal suppositories Genferon

In gynecology and for inflammatory pathologies, up to the age of 7 years, the drug is prescribed in a dosage of 125,000 IU. For adults and children over seven years of age, vaginal suppositories are prescribed in individual dosages, depending on the severity of the disease and its clinical manifestations. For bacterial infections in the urogenital tract, doctors recommend suppositories at a dosage of 250-500 thousand IU once a day. In this case, the duration of therapy, as a rule, does not exceed 10 days.

If Genferon is used as a local anesthetic and anti-inflammatory agent for the treatment of cervical erosion or other disease, then in gynecology it is prescribed in the following scheme: 1 suppository of 500 thousand IU at night vaginally and 1,000,000 IU rectally. For a chronic disease, three-month therapy is prescribed, which involves inserting suppositories into the vagina 3 times a week.

Rectal administration

With this type of use, suppositories allow the active substance to enter directly into the intestines and then into the blood. Genferon is administered rectally for the most effective treatment of inflammation of various locations and for the treatment of male genital infections. In case of prolonged infectious processes in women, the drug is administered rectally, 1 suppository every second day for 1-3 months. For the treatment of men, suppositories are prescribed rectally in a dosage of 500 thousand or 1 million IU, while the scheme of use remains the same.

Pediatricians prescribe Genferon Light to children, the instructions for which imply the following treatment regimen:

• for viral infections - 2 suppositories rectally with an interval of 12 hours (therapy lasts 5 days, then there is a break for 5 days and the treatment is repeated);
• for chronic viral infections, Genferon is administered rectally to the child every other day at night (the course is 1-3 months).

How to store

To store Genferon, you need to use a refrigerator compartment with a temperature of +2 to +8 °C. Access for children should be limited, so the first aid kit should be locked.

The medication should not be left unattended at room, elevated or sub-zero temperatures: near heaters or in the freezer.

IMPORTANT. The manufacturer reports that due to improper storage - at sub-zero and room temperatures - suppositories can become unmeltable, which makes their use impossible. The same can be observed when trying to use expired candles.

There are no analogues of Genferon based on the complete coincidence of active ingredients. However, within the pharmacological group “Interferons in combinations” you can select a replacement:

• Kipferon;
• Herpferon;
• Giaferon;
• Mycoferon;
• Vagiferon.

Side effects

According to reviews, negative effects rarely develop with the use of the medication. As a rule, they manifest themselves as allergic reactions and are expressed by a feeling of burning or itching in the rectum or vagina. Such side effects go away on their own within a few days after stopping the medication. If you experience such symptoms, doctors advise reducing the dosage. It is extremely rare for patients who have been prescribed suppository treatment to experience the following negative effects:

• chills;
• headache;
• myalgia (muscle pain);
• increased sweat secretion;
• loss of appetite;
• joint pain;
• fatigue;
• decrease in the number of leukocytes.

During pregnancy

The medicine is safe during pregnancy from 13 to 40 weeks, as well as for nursing women (the optimal dosage is 250,000 IU). The decision to treat pregnant women with the drug should be made taking into account the expected benefits and possible risks. If the doctor sees the need to use suppositories during lactation, it is better to temporarily transfer the child to artificial nutrition. Treatment with Genferon for women in the early stages of pregnancy (up to 12 weeks) is extremely undesirable, since there is no objective data on the effect of the medication on the fetus.

Contraindications

The medicine is well tolerated, but not all patients can be prescribed such treatment. Intolerance to any component of suppositories is the main contraindication. It is necessary to take into account the specific allergic history and carefully read the instructions.

The product enhances the production of antibodies

Relative contraindications:

• Childhood.
• Exacerbation of immunological pathologies.
• Autoimmune disorders.

Pregnant patients are allowed to use suppositories (up to 250 thousand IU) only between 13 and 40 weeks.

In childhood

Suppositories are used as an antiviral agent for the treatment of acute respiratory viral infections and inflammation of the genitourinary system. However, the drug for children should be used with caution and only in cases where the expected benefits outweigh the risks. Therapy for pathology of the genital organs and urinary system in children involves a 10-day course of rectal administration of 1 suppository 2 times a day. In this case, the use of Genferon should be combined with taking a vitamin complex that contains vitamins C and A.

Alcohol compatibility

The instructions for the medication do not contain information about the consequences of simultaneous use of Genferon with alcohol. However, since the drug is often prescribed as part of complex therapy, it is worth focusing on the compatibility of other drugs with ethanol. Doctors do not advise combining alcohol with suppositories, since in this case the load on the liver increases (immunomodulators activate metabolism and remove waste products from the body, thereby loading the organ, and alcohol will add extra work to the liver).

Contraindications to the use of vaginal and rectal suppositories

In most cases, the antiviral drug "Genferon" has positive reviews from doctors. The medicine is not prescribed only to people who are hypersensitive to taurine and benzocaine. The medication rarely causes allergic reactions, which disappear on their own without additional treatment.

Interferon is a substance that is normally released by the human body during illness. It allows you to build immunity and protect a person. The composition of the described medicine contains exactly this substance. Therefore, there is usually no negative reaction to interferon.

Drug interactions

The simultaneous use of suppositories with vitamins C and E accelerates the effect of the active components of the medication. As part of complex treatment, the drug is prescribed with other antimicrobial agents or antibiotics. Genferon goes well with Terzhinan vaginal suppositories containing nystatin and the antibacterial substance neomycin sulfate. This set of drugs is used in gynecology for the treatment of cystitis, thrush, and other pathologies of the genitourinary tract. Genferon is also combined with Hexicon to quickly eliminate various infections and to increase immunity.

Interaction of the described product with other compounds

What will happen if you simultaneously use antibacterial drugs and Genferon suppositories (in gynecology)? Reviews from doctors report that this combination is quite acceptable. It’s even worth saying that this is how a variety of treatments are usually carried out. With this interaction, the effectiveness of the antiviral agent “Genferon” is enhanced.

Often during pregnancy, a woman takes vitamin complexes. Such compositions include the main substances - vitamin E and C. They can help enhance the immunomodulatory effect of the drug.

If a woman uses a variety of non-steroidal anti-inflammatory drugs (this is precisely the characteristic of most painkillers and antipyretics), then the effect of benzocaine may be enhanced.

When supplementing the correction with sulfonamines, it is necessary to take a break of 2-4 hours between medications. This is because benzocaine can reduce the effect of the described substances.

Price for Genferon

Suppositories can be purchased at a pharmacy or online without a prescription. At the same time, the cost of the medicine can vary greatly, which is associated with the size of the trade markup, transportation costs and other factors. Since the medication is only produced, there is no difference between cheaper or more expensive suppositories. The table shows how much the antiviral agent costs.

Genferon is not stored in the refrigerator

Please tell me, is it possible to use geneferon and candles if they were not in the refrigerator for about 8 hours, but at room temperature? I bought it at the pharmacy at about 8 pm, came home at 9, fell asleep, forgetting to take it out of my pocket. I woke up at 4 am and remembered and moved it. But now I doubt the effectiveness

1 answer

You can use it, perhaps the therapeutic effect has not decreased.

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Didn't store it in the refrigerator

Irishka, spoiled interferons certainly won’t help.

At most, they survive for about 2-3 days outside the refrigerator. hit the doctor in the face for hopelessly lost money.

Yulch, (sorry, this is off topic) why are you now a forged galvanized slipper?

___________________ Maybe a stupid question. I'm completely stupid. ))))

Still different opinions. Yulch’s opinions are of course more correct for safety reasons, but still distributors and doctors told me this - this is a protein drug. Therefore, store it like all protein products - in the refrigerator at 6-8.

But! They do not deteriorate instantly, so their effectiveness is gradually lost. That is, if Roferonchik lay there for a week, then it is not at all a fact that he turned into water. In principle, you can find information here by searching.

No, I don’t comply, nothing bad will happen. I try to comply and look at the appearance of the products.

BUT! It is clear that the longer the violation takes, the faster it will affect it. Moreover, the reaferon may become unusable faster.

But of course this is unfortunate, however, as Arkady correctly said, it is not fatal if therapy is done at the very beginning. By the way, what were the doses? If every other day 3 IU, then this could definitely have a negative impact.

BUT! It is clear that the longer the violation takes, the faster it will affect it. Moreover, the reaferon may become unusable faster.

Candles Genferon

Pharmacist. Author of articles on the topics of the characteristics of various groups of drugs, a healthy lifestyle and proper nutrition.

Area of ​​professional interests: drugs and non-drug products for the prevention and treatment of respiratory diseases during pregnancy and in children; breastfeeding and child nutrition.

Pharmacist. Author of articles on the topics of the characteristics of various groups of drugs, a healthy lifestyle and proper nutrition.

Genferon suppositories how to store

Genferon is in demand for the treatment of infections of the urogenital tract due to the convenience of the dosage form.

Safety and ease of administration, lack of taste during use have made this medicine in demand among patients with viral diseases of the genitourinary system.

Unfortunately, there are cases where suppositories did not have a therapeutic effect or, when administered, did not melt at human body temperature. Such phenomena are associated with improper storage.

Best before date

The expiration date of Genferon is necessarily printed on packaging: consumer cardboard and on each contour cell.

If, when comparing calendar dates, it is clear that there are only 10 days left until the end of the period, the product can still be used, since expiration dates are set with some reserve. In this case, you can ask the pharmacist where exactly and how Genferon is stored in their pharmacy in order to identify temperature violations.

Genferon should be stored in the refrigerator. If the drug is left at elevated temperatures, the shelf life is sharply reduced, as the candles melt and the active substance decomposes.

As of December 2021, there is no data on rejected batches of the drug. If in doubt, it is recommended to call your local Roszdravnadzor office.

When purchasing a product, you need to check the integrity of the packaging: outer cardboard and inner cell. The manufacturer instructs not to use the product after the expiration date: the suppositories may become insoluble, which means the active substance will not enter the bloodstream.

How to store

To store Genferon, you need to use a refrigerator compartment with a temperature of +2 to +8 °C. Access for children should be limited, so the first aid kit should be locked.

The medication should not be left unattended at room, elevated or sub-zero temperatures: near heaters or in the freezer.

IMPORTANT. The manufacturer reports that due to improper storage - at sub-zero and room temperatures - suppositories can become unmeltable, which makes their use impossible. The same can be observed when trying to use expired candles.

There are no analogues of Genferon based on the complete coincidence of active ingredients. However, within the pharmacological group “Interferons in combinations” you can select a replacement:

Safety of use

The manufacturer does not officially recommend combining Genferon treatment with alcohol intake for the following reasons:

1. Alcohol causes a number of negative phenomena in the body, for example, it inhibits the function of hematopoiesis and puts a strain on the liver and excretory system. The presence of ethanol in the blood can aggravate the course of the disease.
2. Genferon is usually used in complex therapy, that is, other medications are also prescribed. Then you need to take into account not only their compatibility with each other, but also the increased toxic effect of alcohol on the body.
3. Under the influence of alcohol, the antiviral effectiveness of Genferon may decrease.

There have been no cases of overdose with Genferon. If the patient has used more suppositories than required, the manufacturer recommends refraining from administering the next suppository for 24 hours.

There is no data on the incompatibility of the drug with other drugs.

Genferon is sold by prescription, its validity period from the date of discharge is 2 months.

Storage conditions in pharmacies and clinics

In organizations that sell medicines, Genferon is stored in pharmaceutical refrigerators with a temperature range of +2...+8°C.

IMPORTANT. Interferon in suppositories is a human protein that is produced by bacterial cultures with an introduced human gene. It is completely identical to natural, so its storage requires compliance with the temperature regime, as for blood products.

Source: https://mir-espresso.ru/hranenie-produktov/genferon-hranenie-ne-v-holodilnike

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