Pharmacodynamics and pharmacokinetics
This remedy is especially effective against herpes and shingles . In addition, it acts against cytomegalovirus and Epstein-Barr virus . The medicine interacts with enzymes and prevents their reproduction.
After penetration into infected cells, the active substance is converted into acyclovir monophosphate , and then successively into acyclovir diphosphate and acyclovir triphosphate . The latter prevents the synthesis of viral DNA. It has almost no effect on healthy cells.
In the case of herpes, the drug prevents the spread of the rash, accelerates the formation of a crust, reduces the risk of visceral complications and skin dissemination , and reduces the severity of pain during exacerbation of herpes zoster . Gerpevir also has immunostimulating properties.
The tablets are partially absorbed after oral administration (approximately 20%). Their active substance penetrates well into tissues and liquids, as well as into breast milk.
The maximum content of the drug depends on the dosage. On average, it occurs 90-120 minutes after administration. The half-life is approximately 3 hours, and in case of renal failure - 19.5 hours.
The drug is excreted mainly through the kidneys unchanged. With age, elimination time increases.
When applied topically, Gerpevir ointment is almost not absorbed into the systemic circulation. The systemic effect is not significant. When using the drug, a therapeutic concentration is formed on the affected area of the skin, which remains constant for at least 5 hours.
Contraindications for use
Treatment with Gerpevir is canceled if the patient is found to have hypersensitivity or intolerance to the components that make up the drug. In addition, Gerpevir is contraindicated in the following cases:
- If the kidneys fail;
- In case of dehydration;
- For elderly patients.
Side effects
The medicine may cause:
- dizziness , headache , fatigue;
- lack of appetite , vomiting, intestinal colic , nausea, diarrhea ;
- rash, swelling , itching , fever ;
- deterioration of blood counts;
- increased levels of bilirubin , creatinine , urea , and liver transaminases .
In rare cases, baldness .
Instructions for use of Gerpevir (Method and dosage)
For those who use Gerpevir ointment, the instructions for use inform that this should only be done externally. It is advisable to use rubber gloves to prevent the infection from spreading. It is advisable to start therapy at an early stage of the disease.
The ointment should be applied in a thin layer exactly to the areas of the skin and outer mucous membranes where the lesion is present. For adults, a 12.5 mm strip of ointment should be applied to approximately 25 square meters. cm lesions 4-5 times/day. It is rubbed in with light movements for about a minute. For children, the ointment is applied at a dosage of 250 mg per 1 square meter. m of leather.
The instructions for Gerpevir recommend applying the ointment to areas of the skin adjacent to the affected area.
This product should be used regularly. But if you miss one, you shouldn’t double the next dose.
The recommended course of therapy is 10 days, even if the symptoms of the disease have already disappeared.
If there is no effect when using the ointment, experts advise using Gerpevir in tablet form.
In this case, the drug is taken orally. It can also be used at the first signs of the disease. It is advisable to combine taking pills with drinking plenty of liquid.
In case of infection due to Heroes simplex (type 1 or 2), children are given 0.2 g tablets in the following dosage:
- age up to 2 years - prescribe 2.5 tablets per day with an interval of 4 hours;
- age from 2 years - prescribe 5 tablets per day, which are divided into 5 doses with an interval of 4 hours (except for night sleep).
Therapy – from 5 to 7 days.
The recommended dosage for adults is 1 tablet 5 times a day. Therapy is designed for 5 days. Take tablets of 0.2 g.
For people with immunodeficiency , experts recommend taking one tablet (0.4 g) or two tablets (0.2 g). This needs to be done 5 times during the day. Therapy – from 5 to 10 days.
In order to prevent infections caused by Herpes simplex (type 1 or 2), with normal immunity , you need to take a tablet 4 times a day. The time interval between doses should be 6 hours. Tablets of 0.2 g are suitable. It is also permissible to take the medicine in a dosage of 0.4 g. This should be done one tablet 2 times a day with an interval of 12 hours between doses. If necessary, the dosage can be reduced to 0.6 g of the drug, divided into 2 or 3 doses.
In case of significant immunodeficiency , it is advisable to take one tablet (0.4 g) or two tablets (0.2 g) of this drug 4 times a day. In each case, the specialist determines the duration of the preventive treatment individually.
In case of infection due to the Varicella zoster virus, children are given 0.2 g tablets in the following dosages:
- age up to 2 years – one tablet 4 times a day;
- age 2-6 years – you need to take 2 tablets 4 times a day;
- Age from 6 years – you need to take 4 tablets 4 times a day. In addition, you can take 2 tablets (0.4 g) with the same frequency.
Therapy for at least 5 days.
For adults with normal immunity , it is advisable to take 0.4 g tablets. They are taken orally, 2 tablets 5 times a day, leaving an interval of 4 hours (except for night sleep). Therapy for at least a week.
In case of impaired renal function, as well as for elderly people, dosages are selected individually.
Indications for use
The use of Gerpevir is indicated for:
- Infectious diseases of the skin and mucous membranes of the body caused by the herpes virus (types 1 and 2), including primary or recurrent genital herpes;
- Chicken pox;
- Herpes zoster;
- Prevention of recurrence of infections caused by the herpes simplex virus;
- Treatment and prevention of viral herpes in patients with severe immune system disorders.
In addition, injection administration of Gerpevir is prescribed for the treatment of:
- Herpetic encephalitis;
- Infections caused by the herpes simplex virus in newborns.
Overdose
In case of overdose, the ointment in places of application can cause erythema , burning sensation , peeling , and burns . All these symptoms disappear after discontinuation of treatment.
When using Gerpevir tablets in high doses, diarrhea , headache , renal failure , nausea , convulsions , vomiting , shortness of breath , lethargy , coma .
The treatment is to maintain vital functions. Hemodialysis is prescribed .
Interaction with other drugs
No clinically important interactions of acyclovir with other drugs have been identified.
Acyclovir is excreted predominantly unchanged by the kidneys by tubular secretion, therefore any drugs that have a similar mechanism of excretion may increase the concentration of acyclovir in the blood plasma.
Probenecid and cimetidine increase the half-life of acyclovir and the area under the concentration/time curve. When used simultaneously with immunosuppressants in patients after organ transplantation, the plasma level of acyclovir and the inactive metabolite of the immunosuppressive drug also increases, but given the wide therapeutic index
acyclovir, no dose adjustment is necessary.
Analogs
Level 4 ATX code matches:
Aldara
Viru-Merz Serol
Zovirax Duo-Active
Acyclovir
Fenistil Pencivir
Bonafton
Zovirax
Atsik
Alpizarin
Herpferon
Epigen Intim
Lysozyme
Kondilin
Virolex
Gevisosh
Reviews about Gerpevir
This medicine receives very different reviews. Different opinions can be heard especially often about ointments. It helped some quickly and effectively, while others report that the treatment was completely useless. Negative reviews of the ointment are also left by people who are dissatisfied with this form of release of the medicine. They say that the drug spreads, leaves an unpleasant greasy sheen and does not promote healing at all. However, there are also positive reviews about Gerpevir, which report that they managed to get rid of herpes very quickly and painlessly.
Public opinion about this drug in tablet form is much better. Patients note the convenient form of release of this medicine. Reviews of the tablets mainly talk about their effectiveness. People also like the fact that the product can be used for prevention.
special instructions
If the use of Gerpevir in the treatment of genital herpes in women does not have a therapeutic effect within a week, you should consult a doctor.
When opening the package, tablets and powder should have an almost white color; the drug should not be used if its color has changed.
When taking Gerpevir, the patient should drink plenty of liquid.
To monitor the dynamics of renal function, it is necessary to conduct systematic laboratory tests to monitor the level of urea nitrogen in the blood and creatinine in the blood plasma.
Persons taking the drug should refrain from driving.
The use of Gerpevir in the form of an ointment or cream during pregnancy or breastfeeding is allowed only in special cases after consultation with a doctor and if the therapeutic benefit outweighs the expected risk to the fetus and child.
When treating genital herpes, you should avoid sexual intercourse.
You should be careful not to get Gerpevir cream on the mucous surface of the mouth, eyes, or vagina.
Gerpevir price, where to buy
The price of Gerpevir may vary depending on the form of release. This remedy can be found quite often in pharmacies. Patients note that its cost is quite affordable.
The price of Gerpevir tablets of 0.2 g is approximately 325 rubles or 60 hryvnia. The cost of the product in the form of tablets of 0.4 g is similar. The price of Gerpevir ointment is slightly lower. It can cost from 230 rubles or 40 hryvnia in tubes of 15 g.
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
Pharmacy24
- Gerpevir-KMP 200 mg No. 20 tablets PAT "Kievmedpreparat", Ukraine
61 UAH.order - Gerpevir-KMP 2.5% 5 g ointment PAT "Kievmedpreparat", Ukraine
45 UAH order
- Gerpevir-KMP 250 mg N10 powder PAT "Kievmedpreparat", Ukraine
732 UAH. order
- Gerpevir-KMP 2.5% 15 g ointment PAT "Kievmedpreparat", Ukraine
55 UAH order
- Gerpevir-KMP 400 mg No. 10 tablets PAT "Kievmedpreparat", Ukraine
62 UAH.order
PaniPharmacy
- Gerpevir ointment Gerpevir ointment 2.5% tube 5g Ukraine, Kievmedpreparat OJSC
48 UAH order
- Gerpevir bottle Gerpevir pores. d/p in. solution 0.25g No. 10 Ukraine, Kievmedpreparat OJSC
812 UAH order
- Gerpevir tablets Gerpevir tablets. 0.2g No. 20 Ukraine, Kievmedpreparat OJSC
72 UAH order
- Gerpevir tablets Gerpevir tablets. 0.4g No. 10 Ukraine, Kievmedpreparat OJSC
64 UAH order
- Gerpevir ointment Gerpevir ointment 2.5% 15g Ukraine, Kievmedpreparat OJSC
57 UAH order
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Release form and composition
The drug is available in the form of tablets, cream and ointment for external use, and powder for the preparation of solution for injection. The main active ingredient of Gerpevir is acyclovir, its content is:
- 1 tablet – 200 mg, 400 mg;
- 1 g of cream – 50 mg;
- 1 g ointment – 25 mg;
- 1 bottle – 250 mg.
Gerpevir drugs are supplied to the pharmacy chain:
- Tablets – in blister packs of 10 pieces;
- Cream and ointment - in aluminum tubes of 5 g, 10 g, 15 g;
- Powder - in bottles of 250 mg in cardboard packs of 10 pieces.
