Pharmacodynamics and pharmacokinetics
The drug is used to treat infectious and inflammatory diseases in the throat and oral cavity. The components of the drug provide a therapeutic effect: gramicidin C as an antimicrobial agent, lidocaine as a local anesthetic, and menthol with eucalyptus oil are anti-inflammatory emollient components that sweeten and improve taste.
Gramicidin C is an antimicrobial active substance that is active against most gram+ and gram- microorganisms belonging to the group of pathogens in the oral cavity and pharynx. The mechanism of action is based on the ability to increase the permeability of microbial cell membranes, causing disruption of their stability and, as a result, death. During the resorption process, salivation increases, and a natural cleansing of the oropharynx from infection and inflammatory exudate occurs.
Lidocaine hydrochloride is an anesthetic that provides a local anesthetic effect on inflamed mucous membranes in the oropharynx. The therapeutic effect occurs immediately from the moment of resorption and continues for another 30-40 minutes.
The drug is supplemented with menthol and eucalyptus oil to alleviate discomfort, reduce inflammation and make food easier to swallow. In addition, menthol enhances the analgesic effect of lidocaine hydrochloride. Mannitol and aspartame improve the taste of the tablets .
Pharmacokinetic information
Due to low systemic absorption rates, pharmacokinetic data are not available.
How can I replace Grammidin?
The drugs from the Grammidin line have many analogues. One of them is Agisept. This is an antiseptic, produced in the form of lozenges. Indications for use of "Adjisept" are infectious and inflammatory diseases affecting the oral cavity and pharynx. Tablets are contraindicated in case of hypersensitivity to substances from the composition, as well as in people under 5 years of age.
Another analogue of Grammidin with an antibiotic is the drug Anti-Angin Formula. This medication is available in different dosage forms. There are sprays, lozenges, and lozenges. In these preparations, an antiseptic substance is combined with a local anesthetic. Indications for use: prevention and treatment of infectious and inflammatory processes in the oral cavity and pharynx. Contraindications:
- for lozenges - increased sensitivity to substances contained in the drug, age up to 5 years, first trimester of pregnancy;
- for lozenges - hypersensitivity to substances, age under 5 years, first trimester of pregnancy, deficiency of sucrase/isomaltase in the body, glucose-galactose malabsorption, fructose intolerance;
- for the spray - hypersensitivity to substances, age under 10 years, phenylketonuria, inflammation or damage to the mucous membranes in highly vascularized areas.
A fairly effective remedy in the treatment of infectious and inflammatory diseases of the throat and pharynx is Teraflu Lar. Release forms: lozenges and spray. The drug contains antiseptic and local anesthetic substances. Contraindications – hypersensitivity to substances from the composition, breastfeeding period, first trimester of pregnancy, age up to 4 years.
In conclusion, it is worth noting that if there are indications and no contraindications, any drug from the Grammidin line with an antibiotic can be purchased. Many people recommend medications with this name. However, it is worth remembering that the effectiveness of medications largely depends on proper use. In order for the treatment to give the desired result, you must strictly follow the instructions. Under no circumstances should the recommended dosage be exceeded. Ignoring the recommendations specified in the instructions leads to disruption of the gastrointestinal tract - nausea, vomiting, and diarrhea. With such symptoms caused by an overdose, the help of a specialist is necessary.
Indications for use
Tablets should be taken for infectious inflammatory diseases in the mouth and throat with severe pain, for example:
- with acute pharyngitis;
- with tonsillitis;
- for periodontitis;
- with gingivitis;
- for stomatitis.
Spray "Grammidin"
Spray "Grammidin" with antibiotic and mint flavor can only be used by adults (over 18 years of age). The drug is contraindicated for children.
The medicine is used after meals by spraying onto the mucous membrane of the mouth and throat. Single dose – 4 injections. The frequency of use is 3 times a day, and the duration of treatment is 7 days.
Instructions for use of Grammidin with anesthetic (Method and dosage)
The tablets should be taken after meals, gradually dissolving them in the mouth, but without chewing. In addition, after using Grammidin with Anesthetic, it is necessary to maintain an interval of 1 - 2 hours - without consuming food or drinks.
Daily doses depending on age
For adults and children over 12 years of age, the daily dose should not exceed 8 tablets - 2 throughout the day with an interval of at least 20-30 minutes.
Instructions for the use of Grammidin with an anesthetic for children 4-12 years old suggest reducing the daily dose to 4-8 tablets, divided into 4 doses during the day.
The standard course of taking tablets should not exceed 5 - 6 days of therapy.
Buy Grammidin neo with anesthetic lozenges No. 18 in pharmacies
Grammidin with anesthetic neo Buy Grammidin with anesthetic neo in pharmacies DOSAGE FORMS lozenges 3mg+0 2mg+1mg
MANUFACTURERS Valenta Pharmaceuticals (Russia)
GROUP Combined antibiotics
COMPOSITION Gramicidin C, oxybuprocaine, cetylpyridinium chloride.
INTERNATIONAL NON-PROPENTED NAME Gramicidin C + Oxybuprocaine + Cetylpyridinium chloride
PHARMACOLOGICAL ACTION Antibacterial combined drug for local use in the oral cavity and pharynx. The drug contains the antibiotic gramicidin C, the local anesthetic oxybuprocaine and the antiseptic cetylpyridinium chloride. The drug has a pronounced antibacterial effect against pathogens of infectious and inflammatory diseases of the pharynx and oral cavity. Increases the permeability of the microbial cell membrane, which disrupts its barrier functions and leads to its death. The anesthetic oxybuprocaine, causing a reversible block of axonal conduction of nerve impulses, has an analgesic effect on the mucous membrane of the oral cavity and pharynx. Cetylpyridinium chloride, being an antiseptic, inhibits the growth and reproduction of pathogens of infectious diseases of the oral cavity. The drug has antimicrobial, analgesic and anti-inflammatory effects, reduces discomfort in the oral cavity and pharynx, and facilitates the swallowing process. When absorbed, the drug stimulates hypersalivation, which promotes mechanical cleansing of the oral cavity and pharynx from microorganisms. The drug has a local effect.
INDICATIONS FOR USE Infectious and inflammatory diseases of the oral cavity and pharynx: sore throat, pharyngitis, tonsillitis, periodontal disease, gingivitis, stomatitis.
CONTRAINDICATIONS First trimester of pregnancy, children under 4 years of age, hypersensitivity to the components of the drug.
SIDE EFFECTS In some cases: allergic reactions, temporary loss of sensitivity of the tongue.
INTERACTION The drug, when taken together, increases the effectiveness of other antimicrobial agents of local and systemic action.
METHOD OF APPLICATION AND DOSAGE For adults and children over 12 years of age, the drug is prescribed 1 tablet 3-4 times a day; children aged 4 to 12 years - 1 tablet 1-2 times a day. The tablets are used after meals, dissolving in the mouth without chewing. Immediately after using the drug, you should refrain from eating and drinking for 1-2 hours. If there is no therapeutic effect within 7 days of taking the drug, the patient should consult a doctor.
OVERDOSE No data available.
SPECIAL INSTRUCTIONS No data available.
STORAGE CONDITIONS Store out of reach of children, in a dry place, protected from light at a temperature not exceeding 25 degrees. WITH.
Analogs
Matches by level 4 ATC code: Grammidin with anesthetic Neo
Grammidin for children
Grammidin Neo
Grammidin
Bioparox
Gramicidin S
Trachisan
Valenta Pharmaceuticals produces other drugs - lozenges containing gramicidin C : Grammidin with anesthetic Neo , Grammidin Neo , etc.
In addition, there are analogues with similar therapeutic effects, for example Bioparox .
Reviews about "Grammidin"
"Grammidin" is an effective remedy. This short sentence brings together a significant part of the reviews about medicines from the Grammidin line. According to people, the drugs help well. The medications cope with their task, which is to relieve the inflammatory process in the mouth and pharynx and eliminate pain.
Among the huge number of opinions about drugs from the Grammidin line, there are negative reviews. It turns out that not all people are helped by tablets and spray with Gramicidin C. From negative reviews you can also find out whether Grammidin (with an antibiotic), for children (with raspberry flavor) and regular (with mint flavor) is expensive or not. The cost is quite high. Approximate prices:
- package with 18 “Grammidin Neo” tablets – 230 rubles;
- package with 18 tablets “Grammidin with anesthetic Neo” – 260 rubles;
- package with 18 tablets “Grammidin for children” – 250 rubles;
- spray “Grammidin”, designed for 112 doses, – 290 rubles;
- spray “Grammidin for children”, designed for 112 doses, – 305 rubles.
special instructions
Grammidin spray with anesthetic should not be sprayed into the oral cavity if there are open wounds, since cetylpyridinium chloride slows down the healing process.
The spray contains ethanol. Its content in the maximum single dose is up to 0.08 g.
Impact on the ability to drive vehicles and complex mechanisms
Grammidin with anesthetic does not affect the performance of work that requires quick response and special attention (driving vehicles, the work of an operator and dispatcher, controlling complex mechanisms, etc.).
Release form Grammidin
The drug is available in three forms:
- Grammidin is a yellowish-white suckable tablet, each containing 1.5 mg of the antibiotic gramicidin C, as well as a number of excipients (lactose, sugar, methylcellulose, calcium stearate). The tablets are in blisters of 10 pieces, each cardboard package contains two blisters;
- Grammidin Neo are convex-shaped suckable tablets with menthol flavor, with the inscription “GR” on one side. In addition to the antibiotic gramicidin in a dosage of 3 mg, they added another active substance - cetylpyridinium chloride. This component softens the pain in the sore throat that occurs when swallowing. Excipients Grammidin Neo: silicon dioxide, potassium acesulfate, magnesium stearate, menthol, sorbitol and talc. The drug is available in blisters of 6 or 9 pieces, which are packed in cardboard boxes of 4 or 2 blisters, respectively;
- Grammidin with anesthetic - convex-shaped suckable tablets with the taste of lemon, black currant or raspberry. Here, to 1.5 mg of the antibiotic gramicidin, 10 mg of the anesthetic lidocaine is added, which perfectly relieves acute sore throat with sore throat. Excipients: eucalyptus oil, citric acid, hydroxypropylcellulose, menthol, aspartame, mannitol and fruit flavor. The tablets are packaged in the same way as Grammidin Neo.
Conditions of release and storage
The drug can be freely purchased at any pharmacy without a doctor's prescription, but this should not be done. There are known precedents for allergic reactions to both the active and auxiliary components of Grammidin. Your attending physician, based on data from all previous cases of drug allergies in you or your child, will be able to give a competent recommendation on the choice of antiseptic to treat a sore throat.
Grammidin is stored in a dry, cool and dark place for no more than 2 years from the date of manufacture, which is indicated on the cardboard packaging.
Pharmacological action and composition of Grammidin
The name of the Grammidin brand is consonant with the main active component of this drug - the antibiotic gramicidin C. It has a very wide spectrum of bactericidal action, and quickly copes with almost any microbes that infect the human oral cavity, gums and pharynx. This antibiotic is often used not only by therapists and pediatricians, but also by dentists.
Resorption of the tablets promotes abundant salivation, and thanks to this, the antibiotic quickly and evenly spreads throughout the oropharynx. Saliva helps to wash away microbial waste products, which is also important for a speedy recovery. Grammidin weakens the cell membrane of bacteria, and they quickly die. And several medicinal forms of the drug make its use as convenient as possible.
Pharmacological properties
Pharmacodynamics
The composition of Grammidin spray with anesthetic includes three active components: gramicidin C (has antimicrobial properties), cetylpyridinium chloride (antiseptic) and oxybuprocaine (has a local anesthetic effect).
Gramicidin C increases the permeability of the cytoplasmic membrane of microbial cells, which disrupts their stability and leads to death. Active against a wide range of gram-negative and gram-positive bacteria.
The mechanism of action of cetylpyridinium chloride is due to its ability to suppress the reproduction and growth of pathogens of various infectious diseases of the oral cavity and pharynx.
Oxybuprocaine has a local anesthetic effect. It reversibly blocks the conduction and propagation of nerve impulses through the axons of nerve cells located in the mucous membrane of the mouth and throat.
Grammidin tablets with anesthetic contain two active components: gramicidin C (has an antimicrobial effect) and lidocaine (local anesthetic). When the drug is absorbed, salivation increases, which additionally helps cleanse the oral cavity and pharynx from inflammatory exudate and microorganisms. The analgesic effect appears immediately at the moment of resorption of the tablets and persists for another 30–40 minutes after taking the drug. Auxiliary components (eucalyptus oil and menthol) reduce inflammation, soften discomfort and facilitate swallowing food in case of infectious diseases of the oral cavity and pharynx. Menthol promotes additional pain relief and enhances the effect of lidocaine hydrochloride. Aspartame and mannitol improve the taste of the tablets.
Grammidin with an anesthetic can be used in patients who have contraindications or restrictions on taking sugar and sugar-containing medications.
Pharmacokinetics
When sprays and lozenges are applied topically, the active ingredients of the drug are almost not absorbed into the blood through the mucous membrane of the mouth and pharynx.
