Ketosteril (form - tablets) corresponds to the group of drugs for nutrition. Important features of the drug from the instructions for use:
How to dissolve vascular plaques, normalize blood circulation, blood pressure and forget the way to the pharmacy
- Sold only with a doctor's prescription
- During pregnancy: with caution
- When breastfeeding: with caution
- In childhood: possible
- If renal function is impaired: with caution
Compound
Film-coated tablets, 1 tablet contains active ingredients: alpha-keto analogue of isoleucine 67 mg, alpha-keto analogue of leucine 101 mg, alpha-keto analogue of phenylalanine 68 mg, alpha-keto analogue of valine 86 mg, alpha-hydroxy analogue of methionine 59 mg, L- lysine monoacetate 105 mg, L-threonine 53 mg, L-tryptophan 23 mg, L-histidine 38 mg, L-Tyrosine 30 mg.
Excipients: corn starch, polyvinylpyrrolidone, talc, colloidal silicon dioxide, magnesium stearate, polyethylene glycol 6000, soluble polyvinylpyrrolidone.
Shell composition: talc, polyethylene glycol 6000, quinoline yellow, copolymer of methyl methacrylate, dimethylaminoethyl methacrylate and butyl methacrylate, triacetin, titanium dioxide.
Just 1 tablet contains 36 mg of nitrogen and 50 mg of calcium.
Polizhen
What other analogue is there for the drug “Ketosteril”?
The drug "Polizhen" is indicated for use in: the prevention and treatment of hypo- and avitaminosis in children and adults over 12 years of age; decreased physical and mental performance, fatigue, impaired ability to concentrate; accelerating the recovery process after operations, radiotherapy and serious illnesses; anemia; increasing the physical endurance of athletes; prevention of the effects of stress; menopause in women; sexual asthenia and infertility; impotence in men; increased need for vitamins during puberty; following a strict diet; inadequate and unbalanced nutrition; fragility and hair loss; diabetes mellitus, nervousness, inflammatory joint diseases; skin, eye and other diseases; if necessary, increase the overall resistance of the body.
We have reviewed the instructions for use for the drug “Ketosteril”. Reviews and analogues are also described in detail.
Pharmacodynamics and pharmacokinetics
Ketosteril is a drug that contains essential amino acids, without which the body cannot function properly. It is prescribed for renal dysfunction due to damage to the kidney tissue and a gradual increase in the content of toxic metabolic products, mainly protein, in the blood.
A large amount of residual nitrogen and its components are detected in the blood of patients, which have a toxic effect on the body. Residual nitrogen is a collection of non-protein nitrogen (products of protein metabolism in the blood plasma), consisting of isurea, amino acid nitrogen, uric acid, creatine and creatinine.
Violation of protein metabolism leads to the fact that the body does not receive vital amino acids, while toxic products of protein metabolism accumulate in large quantities in the blood. In order to reduce the toxic load on the body, patients are prescribed a protein-restricted diet, which leads to protein starvation.
Ketosteril supplies the body with essential amino acids (the proteins of the human body are built from them), but the amount of nitrogen supplied is limited. This happens due to the fact that ketosteril contains ketone analogues of amino acids, which are quickly absorbed by the body and contribute to the disposal of toxic products of protein metabolism.
This mechanism of action helps to improve protein and mineral metabolism, and therefore the general condition of the patient.
The pharmacokinetics of the drug has not been studied, since all its components are natural components of metabolism, and it is impossible to trace their movement in the body.
Reviews about Ketosteril
Kesteril is a drug that is used as part of a complex treatment for patients with renal impairment. Almost all patients who received it noted a gradual improvement in their general condition, confirmed by laboratory tests.
negative reviews about Ketosteril, but some patients noted that the improvement was too slow, which was most likely due to the severity of the disease.
Instructions for use of Ketosteril
The medicine is taken orally during meals. The tablets must be swallowed whole, with a sufficient amount of liquid - this is how they are best absorbed and included in metabolic processes.
The dosage of the drug is prescribed according to the patient’s weight at the rate of 1 tablet per 5 kg per day. The daily dose is divided into 3-4 doses. The average daily dose for an adult is 12 – 24 tablets.
The instructions for Ketosteril suggest carrying out a course of treatment throughout the entire period of decrease in glomerular filtration below 25 ml/min. At the same time, a diet with a reduced amount of protein is prescribed. When taking Ketosteril for a long time, you should periodically check the calcium level in your blood.
Ketosteril similar drugs
So, as you can understand, the medicine is quite expensive.
Therefore, many are interested in whether Ketosteril has analogues. And if so, what are their costs? And does Ketosteril have a Russian analogue? Unfortunately, neither the Russian nor the international market offers drugs similar to Ketosteril. Why don’t manufacturers see the point in creating an alternative to the product in question? The fact is that the drug itself is unique. Supplying the body with the necessary amino acids that are important for protein synthesis while simultaneously removing toxic products of protein metabolism from the blood is achieved by a well-chosen composition of the Ketosteril product. There is no analogue, since none of the components in the composition can be replaced with another. This means that there is nothing that could reduce the cost of a commercially available drug.
Interaction of Ketosteril with other drugs
Ketosteril cannot be used simultaneously:
- with calcium supplements – this can lead to hypercalcemia;
- with drugs that form poorly soluble compounds with calcium - antibiotics of the tetracycline group, antibacterial drugs of the quinolone group, drugs that contain iron, estramustine and fluorine; There should be a gap of at least two hours between taking the listed drugs and Ketosteril.
If your condition improves while taking Ketosteril, in order to avoid disturbing the acid-base balance, you should gradually reduce the dose of aluminum hydroxide, which was prescribed for acidosis (a shift in the acid-base balance of the body towards increasing acidity).
Selling Ketosteril for cats
Recently, Ketosteril has increasingly been used to treat cats with impaired renal function. Many speak very highly of this drug - it can significantly alleviate the condition of pets. And since cats require significantly fewer tablets than people, owners often try to sell the remaining tablets. But is it worth buying medicines second-hand, since there are so many counterfeits today?
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
ZdravCity
- Ketosteril tablets p.p.o.
100 pcs Labesfal Laboratorios Almiro RUR 3,128 order
Pharmacy Dialogue
- Ketosteril (tab.pl/vol. No. 100) Fresenius
RUB 3,044 order
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Pharmacy24
- Ketosteril N100 tablets Beijing Fresenius Kabi Pharmaceutical Co., China/Labesfal Laboratorios Almiro, S.A., Portugal
1641 UAH order
Drug interactions
To avoid deterioration in health and side effects from taking the medicine, you need to be aware of its interactions with other medications. Reactions that may occur when Ketosteril is used simultaneously with drugs from other groups:
| Medicine | The result of interaction with Ketosteril |
| Preparations containing calcium | The likelihood of hypercalcemia (increased calcium in the blood, during which connective tissue grows in the kidneys and stones form). |
| Quinolones | The risk of a negative reaction with calcium, which is in the tablets. |
| Tetracyclines | May reduce the absorption of the components of the amino acid preparation. |
| Medicines with fluoride, antibiotics | Formation of poorly soluble complexes with calcium. |
| Iron products | Impaired absorption of the active elements of the drug. |
Pharmacology of the drug Ketosteril, pharmacokinetics
The drug "Ketosteril" restores amino acid deficiency in the human body. The drug is responsible for protein synthesis and improves kidney function. In addition, “Ketosteril” restores protein metabolism. The drug is often used in patients with pyelonephritis, nephritis and other diseases of the genitourinary system.
The amino acids that make up the drug are essential. However, a large number of them leads to the accumulation of nitrogen in the human body. That is why Ketosteril is combined with a diet that limits the intake of proteins.
The pharmacokinetics of the drug cannot be studied, since all components of the drug are components of metabolism.
Analogs
There are a number of effective analogues of this drug. The most popular substitutes for this medication are:
- A solution called "Gepasol-Neo", which is a drug with hepatoprotective, metabolic and detoxification properties.
- Another analogue of “Ketosteril” is a drug called “Binocrit”. This solution has a hematopoietic effect and is used for intravenous and subcutaneous injections. Its main active ingredient is epoetin alfa. The medicine is used to treat anemia.
- The drug "Furosemide" is a strong medicine with a diuretic effect. It is produced in the form of pills and solution for injection. Used to eliminate edema caused by kidney and heart failure.
- The Nephrotect solution includes essential and non-essential amino acids. This drug is prescribed to replenish amino acids and treat kidney failure.
Drug interactions
When Ketosteril is used in combination with medications containing calcium, an increase in calcium levels in the blood serum is possible.
In accordance with the decrease in uremic symptoms under the influence of the drug, the dose of concomitantly used aluminum hydroxide should be proportionally reduced.
In order not to interfere with absorption in the intestines, it is not recommended to simultaneously take the drug with drugs that form poorly soluble compounds with calcium (for example, quinolines, tetracyclines, drugs containing fluoride, iron and estramustine). An interval of at least 2 hours should be maintained between taking such drugs and Ketosteril.
Pharmacological effect
A combined amino acid preparation that provides the body with essential amino acids, without burdening the body with nitrogen. The drug contains ketone analogues of amino acids, which naturally undergo transamination to L-amino acids.
The drug has a utilizing effect on nitrogen-containing metabolic products, promotes protein anabolism against the background of a decrease in serum urea concentrations. When taking the drug Ketosteril, a decrease in plasma concentrations of phosphate, potassium and magnesium is observed. Sometimes taking the drug can help delay the date of dialysis, improving the condition of chronic renal failure.
