Infections cannot survive if you use a dropper solution with Metrogyl

Metrogyl is a special drug based on the active synthetic substance Metronidazole. It can be seen on pharmacy shelves in various release forms. For example, it could be a gel for external application, tablets, or a Metrogyl dropper.

The solution is administered either with a syringe or using a dropper. Let's consider the procedure for using the drug intravenously, the procedure itself, its effectiveness and possible contraindications.

When is it recommended to administer the drug intravenously?

Metrogyl for injection is an antiprotozoal agent with effective antibacterial activity, which helps the body overcome:

• single-celled microorganism of the genus Trichomonas;
• bacteria of the monotypic genus Gardnerella, facultative anaerobes;
• flagellated protists from the order Diplomonadidae;
• gram-positive, obligate anaerobic bacteria capable of producing endospores;
• parasitic protozoa amoebozoans;
• gram-negative anaerobic rod-shaped bacteria of the Bacteroidaceae family;
• bacteria of the Fusobacteria phylum and Fusobacteriia class;
• gram-negative anaerobic non-spore-forming coccoid bacteria;
• prevotella;
• gram-positive strictly anaerobic bacteria, etc.

This remedy not only inhibits infections, but also under its influence, tumors and bacteria become maximally sensitive to radiation, and differentiating processes in the body are activated.

The use of the drug intravenously is recommended for severe infection, regardless of location. Doctors also prescribe Metrogyl intravenously if the drug cannot be taken orally. Metrogyl is prescribed intravenously for the following diagnoses:

• intestinal or extraintestinal amoebic dysentery;
• giardiasis;
• invasive disease of the human genitourinary system;
• trichomonas urethritis, as well as vaginitis;
• Borovsky's disease;
• parasitic chronic skin lesion
• giardiasis;
• a disease that causes ulcers to form in the colon due to the action of Balantidium coli;
• infections that affect bone tissue and joints;
• inflammation of the membranes of the brain and spinal cord;
• death of brain tissue;
• bacterial endocarditis;
• inflammation and death of lung cells;
• infectious processes in the intestines and pelvic organs;
• antibiotic-associated diarrhea;
• destruction of body cells due to the harmful effects of alcohol;
• ulcerative colitis and inflammation of the gastric mucosa, which are associated with spiral-shaped gram-negative bacteria that infect the organ (in combination with amoxicillin);
• surgical interventions on the intestinal lining, gynecological and other diseases (to prevent complications caused by infectious processes).

general description

According to the instructions for use, Metrogyl (it is prescribed intravenously quite often) is a very effective broad-spectrum antiprotozoal and antibacterial drug. The main active ingredient is metronidazole; it also contains auxiliary components:

• citric acid (monohydrate);
• sodium chloride;
• anhydrous sodium hydrogen phosphate;
• water for infusion.

Metrogyl droppers are available in 2 types - glass ampoules and polyethylene bottles. 20 ml ampoules are placed in special thermal containers, which are then packaged in cardboard boxes. The number of ampoules in the package is 5 pieces. There are 5 mg of active ingredient per 1 ml, the total volume per ampoule is 100 mg.

"Metrogyl" in a 1 ml polyethylene bottle contains 5 mg of metronidazole, the total volume of the main component per bottle is 500 mg. The bottle is wrapped in cellophane and placed in a cardboard package. The number of bottles in one package is 1 piece. It is a clear liquid, most often colorless, but can sometimes have a yellowish tint. There is a faint characteristic odor.

Dropper with Metrogyl for phlegmonous sore throat

Phlegmonous tonsillitis is an acute inflammatory disease that is localized in the peri-almond tissues. Most often, this disease develops as a complication of sore throat or exacerbation of chronic inflammation of the tonsils, less often as a result of irritation of soft tissues.

This disease occurs in parallel with increased swelling and inflammation, accompanied by unpleasant painful sensations, in which the process of swallowing becomes almost impossible. It becomes impossible to take medications orally, and therefore there is Metrogyl solution for intravenous administration. It is most often prescribed for phlegmonous sore throat.

How to administer the drug intravenously?

The initial dose of the drug should, as a rule, be up to one gram, while the duration of administration of the drug is 30 minutes. Then the drug is administered eight hours later, half a gram at a rate of 5 ml/60 seconds. The course of treatment should last 7 days or more.

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When placing an intravenous drip, the patient must sit in a comfortable position, lying on his back or side. The drug is injected into a vein through a sterile needle. In this case, the rate of infusion should be controlled by the nurse using the IV slider. When the product runs out, the dropper and needle are removed.

When IVs are not recommended

The medicine described in the article is not recommended for use:

• For diseases that negatively affect the functioning of the central nervous system;
• With blood transfusions;
• During the first three months of pregnancy;
• While breastfeeding;
• In case of renal failure.

Contraindications

IV Metrogyl is contraindicated for use in the following conditions and diseases:

• organic lesions of the nervous system ( epilepsy , etc.);
• blood diseases;
• liver failure (large doses cannot be taken);
• blood diseases;
• lactation and pregnancy (first trimester);
• nitroimidazole derivatives .

Intravenous injections are given with caution to people suffering from renal failure.

Metrogyl tablets should not be taken in the following cases:

• with organic lesions of the nervous system, in particular epilepsy ;
• for blood diseases;
• for liver failure (large doses of tablets);
• under the age of 12;
• during pregnancy (first trimester);
• high sensitivity to the active substance, to other nitroimidazole .

Prescribed with caution to people with liver and kidney diseases.

Vaginal gel is not prescribed for the following diseases and conditions:

• impaired coordination of movements;
• leukopenia (also in history);
• lesions of the nervous system of an organic nature, including epilepsy ;
• pregnancy (first trimester);
• liver failure;
• high sensitivity, also sensitivity to nitroimidazole derivatives.

Dosing for children

For patients under 12 years of age, the drug is prescribed in exceptional cases. Schematically, the order of application is similar to the dosage of an adult. The required amount of the drug is determined strictly individually for each small patient. At one time it cannot exceed seven to eight grams.

The regimen of use and prescription of the drug depends on the type of illness. If Metrogyl was prescribed intravenously to treat a purulent disease, then only one course is necessary for recovery. Before surgery, adult and small patients are prescribed one dropper with a dosage of 1 g. drug. On the day of surgery, it is necessary to administer one and a half grams of the drug according to a schedule of five hundred milligrams every 5 hours.

48 hours after surgery, a maintenance drip is prescribed. If desired, the patient can take a tablet or suspension. If the patient has been diagnosed with kidney disease, the dose of the drug administered intravenously is reduced to a milligram twice a day.

In the treatment of cancer, the drug is recommended to be used as a radiosensitizing agent. The dropper is placed several hours before the start of radiation. It is important to maintain a dose of 160 mg per kilogram of weight. Next, the IV must be placed after two weeks, and also before each chemotherapy procedure. During administration, it is not recommended to exceed the maximum dose.

It is not recommended to administer the drug for uterine cancer. It is enough to administer the drug intramuscularly or take a pill before undergoing chemotherapy.

Adverse reactions

When administering the drug intravenously, some side effects should be expected. Conventionally, they can be divided into those that occur frequently and those that do not occur very often.

Of those that occur in 80 percent of cases, there are:

• Drying of the mucous membrane;
• Feeling of nausea;
• Apathy towards products;
• Unpleasant sensations in the stomach;
• Metallic taste in the mouth.

Side effects that occur in 25 percent of cases:

1. From the gastrointestinal tract: insufficient bowel movements, sensation preceding vomiting.
2. From the central nervous system: improper coordination, dizziness, hyperactivity, sleep disturbance, general weakness of the body.
3. Allergic symptoms: skin rashes, nasopharyngeal mucosa begins to swell, increased blood flow.
4. From the genitourinary system: random discharge, acquires a scarlet or brownish tint, inflammation of the ovaries and genitourinary system, thrush, increased protein.
5. Inflammation of the venous walls with the formation of blood clots.

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Reviews

Reviews about Metrogyl (many patients used it intravenously) are very different. Some complain about side effects that are very unpleasant. Others are unhappy with the effect, believing that the result should be much better.

But most people who have experienced the effect of the drug claim that it very effectively eliminates inflammation and is an excellent tool for the prevention of infectious diseases. Other patients note its disinfecting properties: the solution is used to wipe the skin of the face. After several uses, acne and pimples disappear. Moreover, importantly, it is very inexpensive.

Since the cause of most diseases is pathogenic bacteria, Metrogyl is not the last in demand. Timely treatment with the drug will help defeat the disease and restore health.

Be healthy!

Interaction with other drugs

When administering the drug intravenously, it is not recommended to combine it with other pharmacological agents.

The action of the indirect anticoagulant is activated, which leads to the formation of a complex protein, one of the most important indicators of the coagulogram. Disulfiramum causes ethanol intolerance. If the drug is used simultaneously with the described remedy, a variety of neurological symptoms may develop (the interval between prescriptions is at least 14 days).

The H2-histamine receptor blocker inhibits the active substances of Metrogyl, which may cause an increase in their concentration in the blood serum and increase the risk of adverse reactions.

The simultaneous use of drugs that stimulate enzymes of the microsomal redox reaction can adversely affect liver function. As a result, the concentration of Metrogyl in the blood decreases, the drug becomes ineffective and does not bring the desired effect.

If the drug is used simultaneously with other anti-inflammatory drugs, the concentration of the latter may increase. This has a positive effect on the body’s poisoning with toxic substances.

The active substances of the drug should not be combined with drugs that block receptors and membrane channels without opening them, without causing depolarization. Sulfonamides work to enhance the antimicrobial effects of Metrogyl's active substances.

Analogs

Level 4 ATC code matches:
Oflokain

Furasol

Chlorophyllipt

Oflomelid

Rozamet

Currently, numerous analogues of Metrogyl gel, tablets and solution are produced. These are the drugs Deflamon , Batsimex , Klion , Metrovagin , Metrolacare , Metron , Orvagil , Trichobrol , Trichopol , Siptrogil , Rosex , etc. Suppositories with the active substance metronidazole .

Special indications for the use of Metrogyl dropper

While taking the drug and several weeks after completing the treatment cycle, it is not recommended to use drinks containing caffeine and alcohol. Otherwise, a disulfiram-like reaction may develop: local spastic pain, nausea, vomiting, migraine, sudden blood flow to the face.

If the active substances are combined with amoxicillin, the course of treatment is not recommended for patients who have not reached the age of majority. With a long course of treatment, it is necessary to conduct a weekly laboratory blood test to monitor the presence of inflammatory processes.

If the number of leukocytes per unit volume of blood decreases, treatment can be continued only to completely eliminate the possibility of developing infectious diseases. If the patient has a violation of the coordination of movements of various muscles, dizziness or any other deterioration of the neurological system, it is necessary to immediately stop treatment and make its adjustment. This item is mandatory.

Under the influence of active substances, the patient’s urine may occasionally change its natural color, which is considered normal. The shelf life of the drug is 3 years, provided it is stored in a dark place at temperatures not exceeding 30 degrees.

Mechanism of action

Once inside, the drug is perfectly absorbed from the gastrointestinal tract, its maximum level in the blood plasma is reached within two hours. The highest concentrations of the drug are found in the lungs, kidneys, liver, brain and skin. The therapeutic dosage of metronidazole is found in saliva, cerebrospinal fluid, amniotic and seminal fluid, breast milk and vaginal secretions. This is explained by the special ability of metronidazole to penetrate into all tissues and fluids of the human body. The binding rate to plasma proteins of this drug is quite low, the maximum level reaches 18-20%. Most of the medicine is excreted from the body in the urine, only a small amount is excreted in the feces.

Its half-life takes about 6-8 hours; if the patient suffers from impaired liver function, this period may increase. If renal impairment is observed, the drug will not be eliminated with repeated doses, but will accumulate.

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January 17, 2018

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