Neovir: how to use, indications and contraindications

Pharmacological properties

Pharmacodynamics

Neovir is characterized by an antiviral effect against DNA and RNA genomic viruses, as well as a pronounced anti-chlamydial effect.

The use of Neovir leads to a rapid increase in titers of endogenous interferons a, p, y, mainly interferon a. Intramuscular administration of 250 mg of Neovir, based on interferon concentrations determined in serum, is equivalent to the intake of 6–9 million IU of recombinant interferon a into the body. The maximum activity of interferons in the blood is recorded after 1.5–2 hours and persists for 16–20 hours after administration of the drug. As a result, a cascade of immune reactions is activated in the body, associated with the destruction and elimination of pathogens and cells affected by them. Interferon-producing cells become capable of intense interferon production as a response to re-induction caused by a pathological agent. This property remains unchanged for a long period of time after Neovir is discontinued.

The immunomodulatory effect is explained by the drug’s ability to activate hematopoietic stem cells, stimulate the effector parts of the immune system, and normalize the balance of T-lymphocyte subpopulations. Neovir significantly enhances the functional activity of polymorphonuclear leukocytes and macrophages, stimulating their phagocytic activity and migration.

The drug corrects tissue growth: increases the activity of NK cells, enhances any form of cytotoxicity, promotes the regeneration of cell adhesiveness, and inhibits their metastatic and proliferative activity.

Pharmacokinetics

When administered intramuscularly, the bioavailability of the drug exceeds 90%. After administration of 100–500 mg of Neovir, the maximum plasma level is determined after 15–30 minutes and is equal to 8.3 mcg/ml. 5 hours after administration into the body, only minor concentrations of the drug are recorded, and after 6 hours its traces are not detected in the blood plasma.

Neovir is excreted through the kidneys unchanged, without participating in metabolic processes. The half-life is 1 hour.

15-30 minutes after the administration of Neovir, the titers of endogenous interferons, mainly early interferon a, begin to increase in the blood plasma. 2 peaks of interferon a concentration in plasma were detected: 70 IU/ml after 1.5–2 hours and 110 IU/ml after 8–10 hours, after which the level of the substance begins to gradually decrease. After 24 hours, the level of endogenous interferons remains quite high and returns to initial values ​​only 46–48 hours after administration.

fight against bad habits. Is it possible to drink alcohol with Neovir?

Antiviral drugs are used for influenza, ARVI, hepatitis C, depending on their mechanism of action and the origin of the main active substance. With a mild form of the disease, you can do without medications, because The immune system can cope on its own. However, if there are complications, you cannot do without antiviral drugs. In this article we will talk about the action of antiviral drugs, indications, contraindications, and also analyze how compatible antiviral drugs and alcohol are.

Medicines whose main action is aimed at suppressing the symptoms of influenza and ARVI can be divided into several groups:

• Interferon is a protein substance that is produced by cells infected with viruses. The main task is to prevent the formation and reproduction of viruses inside cells. The task of Interferon is to alleviate the symptoms of colds and viral diseases. Most drugs are obtained artificially. The product is available in the form of powder or tablets, the main purpose of which is aimed at eliminating and preventing ARVI; the dosage for prevention and treatment is different. It is worth noting that this remedy is also used to treat viral conjunctivitis;
• Interferon inducer – these substances are aimed at producing the body’s own interferons. Available in the form of tablets or powder that can stimulate cellular immunity and increase the body's resistance to viral infections and bacteria. All drugs in this category can be taken both for prevention and treatment;
• Cyclic amines - this drug is known as Rimantadine, its action is to suppress and neutralize viral bacteria. Release form powder for oral use and tablets. All drugs in this category are aimed at suppressing the virus in the body, and the main effect is to suppress bacteria and block the release of the virus from the infected cell. Thus, ARVI virions are not able to leave the skin cells and die within it. This group of drugs has a strong side effect - the formation of strong hallucinations, the appearance of unreasonable psychosis, mental disorders and disorders of consciousness.;
• Preparations of plant origin contain extracts of alder fruit extracts, which are capable of producing the body’s own interferon naturally and suppressing influenza viruses. Absolutely all products from this category provide strong support to the immune system and help to easily overcome the disease in a short period of time. It is worth noting that the medicinal active substances of these drugs allow their use during lactation and during the first and second trimesters, but only as prescribed by the attending physician.;
• Other antiviral drugs - a medicine in this group is not included in the medicinal substances described above. The most common drugs are Amizon. This antiviral drug helps strengthen the immune system. It belongs to the group of non-narcotic analgesics. Its main action is aimed at reducing fever, fighting inflammation and pain relief.

Viruses are a living organism, with a complete lack of metabolism. In simple terms, viral cells cannot be alive unless they are inside the body. Their active life activity and reproduction is possible only through intracellular parasitism.

Important! Genetically, a viral molecule consists of DNA and RNA molecules placed in a protein shell. During the period of penetration into the cell, all genetic material leaves this shell and penetrates the genome of the body cell. The cytoplasm affected by the virus accumulates viral bacteria, which eventually come out of it and infect healthy cells of the body.

The action of all antiviral drugs is aimed at eliminating the formation of bacteria and viruses:

• complete blocking of the release and penetration of viral bacteria from the cells of the body; Amantadine and Rinantadine cope with this task perfectly;
• absolute blocking of viral replication of DNA and RNA; absolutely all drugs can cope with this task;
• destruction of the process of formation and assembly of viral bacteria inside the cells of the body, blocking their exit from the cytoplasm and further infection.

For information! Most of the antiviral drugs presented do not have high safety and effectiveness, unlike antibiotics, with the help of which medicine has significantly increased the ability to effectively fight viral bacteria.

Antiviral drugs have absolutely no compatibility with alcohol. When combining alcohol with a chemical substance, there is a possibility of a negative and strong effect on the nervous system. It is under the influence of ethanol products that negative consequences can arise, such as:

• depression;
• severe headache and dizziness;
• overexcitation, mental disorders, neuroses, sudden and unreasonable mood swings;
• attacks of nausea and severe vomiting.

Experts do not recommend taking antiviral medications if:

• use of alcohol or drugs;
• terminal process of cirrhosis;
• mental health problems and major depression;
• pregnancy regardless of trimester;
• lactation period;
• rheumatoid arthritis, lupus, psoriasis, diabetes and cardiovascular diseases

All medications have a long-term effect, and as a rule, the activity of the active substance remains in the body for up to 7 days. Is it possible to drink alcoholic beverages during this period? Definitely not, because... it may reduce the effectiveness of treatment, weaken the immune system, and cause irreversible and negative health effects. In medical practice, there are cases where alcohol and medications were combined and the patient did not experience any side effects. However, you should not risk your health. Watch the video to learn how alcohol and drugs behave.

Do not risk your health and life; we advise you to refrain from drinking alcohol and taking medications for ARVI and influenza.

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Latin name

: Neovir

Active substance

: Cridanimod

Manufacturer

: Pharmsintez CJSC (Russia)

Shelf life of the drug neovir

: 3 years

Storage conditions of the drug

: This product should be stored in a dry place, out of reach of children and well protected from light. The temperature should be between 15 and 25 °C.

Conditions for dispensing from pharmacies

: By doctor's prescription

kridanimod as an active ingredient .

The injection solution also contains the following additional components: sodium citrate , water , citric acid .

The tablets have such excipients as dry polyglucin , sodium chloride , polymethacrylate , yellow quinoline , polyvidone or low molecular weight medical PVP , talc , dimethicone .

The medicine is available in the form of a solution for injections and tablets. The solution is contained in dark glass ampoules. One pack contains 5 ampoules. Tablets are sold in bottles or in blister packs.

The drug has an immunomodulatory and antiviral effect.

Indications for use of the drug neovir are:

This drug is used when monotherapy is necessary, and also as a component of complex therapy for diseases with secondary immunodeficiency syndrome, as well as with interferon inhibition. It may be prescribed in the following cases:

• infections caused by the Herpes simplex virus, Herpes simplex genitalis, Herpes simplex genitalis;
• radiation immunodeficiency;
• encephalitis and encephalomyelitis of viral etiology;
• urogenital infections;
• lymphogranuloma venereum;
• multiple sclerosis;
• cytomegalovirus infection with immunodeficiency;
• immune system infections;
• acute chronic hepatitis B and C;
• chlamydial infections;
• oncological diseases;
• candidiasis lesions of the skin and mucous membrane.

Contraindications to the use of the drug neovir are:

The medicine should not be used in case of hypersensitivity to its components, pregnancy, lactation, chronic renal failure (II–III degree), or childhood.

The instructions for Neovir indicate that the solution for internal administration is administered intramuscularly. For this purpose, one ampoule is used. A dosage of approximately 5 mg per 1 kg of weight is also prescribed. If necessary, the single dose can be doubled.

Therapy includes 4 to 10 intramuscular injections with an interval of 1-3 days.

Instructions for use of Neovir tablets recommend a single dosage of 750 mg. If necessary, it can be increased to 1500 mg.

Therapy is designed for 5-7 sessions. Tablets are taken once a day with an interval of 2 days. Thus, the duration of treatment is 10-14 days. For long-term or preventive therapy, a break of 3-7 days is needed between taking pills.

When administering injections, local pain is possible, which quickly passes. If the pain lasts a long time, it is recommended to combine the use of the medicine with a local anesthetic solution, before this you need to make an allergic plug. In addition, allergies may appear, for example in the form of a skin rash.

Analogs of the drug neovir are:

Patients often ask doctors whether this drug is compatible with alcoholic beverages. The answer from experts is clear: alcohol and Neovir cannot be combined, as the toxic effect on the liver increases and the activity of the drug decreases.

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11 Apr 2021 admin 250

Indications for use

According to the instructions, Neovir is used as part of combination therapy for the following diseases:

• Radiation immunodeficiency;
• Cytomegalovirus infection in patients with immunodeficiency;
• Acute and chronic hepatitis B and C;
• Encephalomyelitis and encephalitis of viral etiology;
• Oncological diseases;
• Lymphogranuloma venereum;
• Epididymitis, urethritis, prostatitis, salpingitis and cervicitis of chlamydial etiology;
• HIV infections;
• Multiple sclerosis;
• Infections caused by herpes simplex virus types 1 and 2, as well as the Varicella-Zoster virus (including in patients with impaired immune systems);
• Candidiasis of the skin and mucous membranes;
• Influenza and other acute respiratory diseases, including in persons with immunodeficiency conditions (treatment and prevention).

Neovir and Transfer Factor

The drug Neovir, the price of which is approximately 600 rubles for 5 ampoules, for a full course of therapy you will have to take about 10 ampoules. This does not guarantee that the desired result will be obtained and most likely the course of treatment will need to be repeated several times.

Transfer factor, which performs the same functions, costs about 2,000 rubles per package, which contains 90 capsules. Moreover, the drug is a powerful immunomodulator and immunostimulant, which has no analogues. Unique in its mechanism of action, Transfer Factor is capable of not only supporting the body in the complex treatment of any disease, but also eliminating problems in the DNA structure, which allows us to eliminate the cause of the disease and train the body’s immune system to recognize “enemies” and fight them.

The drug has a natural composition; its components are a concentrate of signal molecules obtained from cow colostrum and chicken egg yolks, and this, in turn, allows the human body to easily perceive and absorb Transfer Factor. The drug is recognized as absolutely harmless and has no contraindications (including age-related) for use. Transfer factor does not cause side effects and is not addictive. The drug has established itself as an excellent remedy that helps restore the immune system both in the complex treatment of the most severe diseases and common colds.

If, nevertheless, the decision to take Neovir has already been made, then the Transfer factor used in combination will eliminate the side effects of Neovir and restore all the necessary immune processes in the body.

Instructions for use of Neovir: method and dosage

The drug is intended for intramuscular administration.

A single dose is 250 mg (1 ampoule) or 4-6 mg/kg body weight. If necessary, it is increased, but not more than 500 mg.

Unless otherwise prescribed by your doctor, the course of treatment consists of 5-7 injections with an interval of 48 hours and lasts 8-12 days. The total course dose depends on the clinical picture of the disease.

For long-term and prophylactic use, the drug is administered once every 3-7 days.

For HIV infections, Neovir is prescribed as part of complex therapy. The course of treatment in this case consists of 10 injections of 250 mg at intervals of 48 hours. The number of courses is unlimited, subject to 2-month breaks between courses.

Neovir price, where to buy

The price of Neovir, the package of which contains 5 ampoules, is about 1200 rubles. The cost of the product, the packaging of which contains 3 ampoules, is approximately 680 rubles. The price of Neovir in Kyiv and other cities of Ukraine is on average 390 hryvnia. The price of Neovir tablets is approximately 600 rubles.

• Online pharmacies in RussiaRussia

ZdravCity

• Neovir solution for in.
  125 mg/ml 2 ml 5 pcs. Russia. cardiol. NPK/Pharmsintez RUB 1,183 order

special instructions

In case of pain at the injection site or poor tolerability of the drug, Neovir is recommended to be administered together with a 0.25-0.5% solution of novocaine (2 ml).

If the storage conditions of the drug are violated, the solution may become cloudy to a milky white color. It cannot be used in this form!

Impact on the ability to drive vehicles and complex mechanisms

The negative impact of Neovir on the ability to drive a car and other vehicles, work with moving machinery, perform the duties of a dispatcher and operator, as well as perform other types of work that require increased focus and concentration, has not been proven.

Side effects

• The immunostimulating drug Neovir can provoke the development of a number of side effects, in particular, general reactions will appear, they will be expressed in the form of elevated temperature, and allergies are also possible, it can be expressed in the form of hives, swelling of the skin, and its redness is possible.
• The drug can lead to the development of local reactions, in particular, after administration of the drug, local soreness may be felt in the muscle, but it goes away quite quickly. If the patient experiences side effects, it is recommended to consult a specialist.
• If the drug Neovir is poorly tolerated, in particular, with severe pain during intramuscular injection, it is necessary to inject it together with a solution of novocaine; this will require 2 milliliters of this drug.
• If there is a visible flaky sediment in the solution, as well as in the absence of the necessary markings on the container, it is recommended to refrain from subsequent use of the immunostimulating agent.

Reviews about Neovir

Numerous reviews of Neovir are mostly favorable. Many patients mention that treatment with the drug has given excellent results in infectious diseases and herpes. It has also proven itself in the treatment of many diseases of the genitourinary system. However, some patients complain that the injections are excessively painful. In some cases, you can’t even do them yourself.

According to doctors, in a number of cases Neovir turned out to be ineffective as an element of combination therapy for chlamydial and urogenital infections. It is not recommended to combine it with antibiotics, since it is primarily a maintenance drug. Sometimes allergic reactions occur when using the drug. It should also be used strictly in accordance with the regimen prescribed by the doctor.

Contraindications

The instructions for use of the drug Neovir (solution) do not allow use in the following cases:

• renal failure;
• autoimmune diseases;
• hypersensitivity to the components of the drug;
• childhood;
• during pregnancy;
• breast-feeding.

The drug Neovir is used with caution in old age.

Treatment of herpes and other diseases should be carried out in a hospital setting under medical supervision. During therapy, the patient should not drink alcohol, since interaction with Neovir can cause unwanted side effects.