Side effects of the drug Omez: features of use, contraindications

Nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the most popular groups of drugs. With regular use of these drugs, damage to the upper gastrointestinal tract often develops - erosive and ulcerative lesions, perforation of the stomach and duodenum, gastric bleeding. Omez, when taking NSAIDs, prevents the development of gastropathy.

In the presence of two or more risk factors, the frequency of complications of NSAID therapy increases. In this case, doctors at the Yusupov Hospital use two preventive tactics simultaneously (using selective COX-2 inhibitors and proton pump inhibitors).

General information

Omez is an antiulcer drug belonging to the group of proton pump inhibitors. The main active ingredient is Omeprazole. This substance prevents the production of hydrochloric acid in the stomach, thereby reducing its negative impact on the mucous membrane.

Taking Omez helps reduce irritation of the gastric and intestinal walls. Systematic use prevents the formation of erosion foci. An auxiliary component of the drug is Domperidone, which reduces the tone of the esophageal sphincter muscles and accelerates peristalsis. Due to the content of this component, Omez has an antiemetic effect and improves the process of defecation.

The effect of the drug occurs, on average, 1 hour after administration. The duration of exposure is 24 hours. Daily intake leads to a decrease in the amount of stomach acid produced.

Omez is available in the form of capsules that are taken orally. One capsule contains 20 mg of active substance. The shell is made of gelatin, which dissolves after entering the stomach.

In addition, Omez is available in the form of a powder intended for the preparation of a liquid suspension. This form of release is recommended for use by patients who, for certain reasons, cannot swallow capsules.

In general, Omez is a combination drug whose action is aimed at reducing the secretory activity of the stomach.

Pregnancy and lactation

The harmful effects of this drug on the mother's fetus have not been proven. For safety reasons, pregnant women and while breastfeeding should not take the drug. A specialist can prescribe Omez only if treatment with other means does not bring positive results.

Contraindicated during pregnancy and lactation.

Omeprazole is not recommended for pregnant women. The use of the drug is contraindicated in the first three months of pregnancy, as its use can disrupt the development of the fetus or lead to serious problems.

In other cases, if this medicine is prescribed, it is done very rarely and very carefully, if the effect from it is much greater than the harm, that is, the risk must be justified.

Main indications

The drug Omez is prescribed for diseases accompanied by increased secretion of gastric juice. Also, the indications include pathologies in which the sensitivity of tissues to the acidic contents of the stomach increases.

Indications for use:

• Ulcerative diseases. Omez is used as part of complex therapy for ulcerative lesions of the stomach or intestines. The hydrochloric acid produced has an irritating effect, causing pain and preventing the ulcer from fully healing. The medicine can be used for both acute and chronic forms of pathology. Omez is also prescribed for therapeutic purposes, but with this use the risk of side effects is minimal.
• Reflux esophagitis. A pathology in which stomach contents regularly enter the esophagus. In this case, stomach acids provoke damage to the mucous membrane of the esophagus. The pathology is accompanied by pain, increased sensitivity to food temperature, burning behind the sternum, swallowing problems, and vomiting with blood.
• Zollinger-Ellison syndrome. A pathology in which the pancreas is activated, which secretes substances that irritate the stomach. Because of this, the production of hydrochloric acid is accelerated, which leads to further damage to the mucous tissues.
• Ulcers due to medication use. Omez is prescribed for the treatment of ulcerative lesions caused by taking certain medications. In particular, we are talking about ulcers with long-term use of anti-inflammatory drugs.
• Infectious lesion. The drug Omez is used in the treatment of gastrointestinal diseases caused by the Helicobacter bacterium. The pathogenic microorganism provokes the formation of ulcerative lesions, which requires a decrease in stomach acidity.

Thus, Omez has a wide range of indications, including diseases accompanied by increased secretion of hydrochloric acid or the presence of ulcerative lesions.

Prevention of gastropathy

To prevent damage to the digestive tract caused by NSAIDs, doctors at the Yusupov Hospital prescribe prophylactic treatment to all patients with previously confirmed peptic ulcers while taking NSAIDs. In the presence of two risk factors (other than a history of peptic ulcer), prophylactic therapy is given to all patients. If patients take non-selective NSAIDs, prophylactic treatment is carried out in the presence of one risk factor.

In patients with low relative risk indicators, before starting NSAID therapy, preference is given to selective COX-2 inhibitors, and testing for the presence of Helicobacter Pylori infection is performed (using a rapid urease test, a breath test, a morphological method, or determination of Helicobacter Pylori antibodies in the blood). If the test results are positive, a proton pump blocker, clarithromycin, amoxicillin is prescribed, or quadruple therapy regimens (proton pump blocker, bismuth preparations, tetracycline, metronidazole) are used.

Patients at high risk of developing NSAID gastropathy are treated with selective COX-2 inhibitors. If the presence of infection is confirmed, therapy is carried out aimed at destroying Helicobacter pylori, followed by taking a proton pump blocker - Omez for the entire duration of NSAID use. If damage to the gastric mucosa develops and it is necessary to continue NSAID therapy, acetylsalicylic acid and other non-selective NSAIDs are discontinued or replaced with selective COX-2 inhibitors. If this is possible, then after transferring the patient to selective COX-2 inhibitors, proton pump blockers (Omez) are prescribed in standard doses for a course of 4 to 8 weeks.

If it is not possible to discontinue aspirin and non-selective NSAIDs, treatment of erosive and ulcerative lesions is carried out against the background of their continued use. In this case, continuous maintenance therapy is prescribed with standard or double doses of proton pump blockers; if an infection is detected, therapy is carried out aimed at destroying Helicobacter pylori.

Contraindications

Before taking Omez, you should pay attention to the list of contraindications. In many cases, the use of a medicine in the presence of certain restrictions causes severe side effects.

Contraindications include the following:

• Age restrictions. The drug can be used by children over 2 years of age, strictly under medical supervision. Intravenous administration of the drug is allowed only from the age of 18 years. Elderly people should take Omez with caution, which is associated with age-related changes in the functioning of the digestive system.
• Individual hypersensitivity. It is an absolute contraindication for use. If the patient’s body does not tolerate any of the components of the drug, its use is unacceptable.
• Intestinal disorders. Taking the drug is not allowed in case of intestinal obstruction. Also a contraindication for use is the presence of damage to the intestinal walls, accompanied by bleeding. It is not recommended to take Omez before surgery.
• Pregnancy and lactation. Self-administration for pregnant or nursing mothers is excluded. The effect of the drug on the fetus has not been fully studied, which is why the use of the drug can lead to negative consequences. Admission is allowed only with the permission of the attending physician, if other medications are not effective.
• Kidney and liver failure. For such pathologies, Omez is used after preliminary consultation with a doctor. Due to organ dysfunction, constant dosage adjustments are required.

In addition, the use of Omez is limited when using other medications simultaneously. The possibility of combination with drugs based on Ketoconazole, Clarithromycin, Warfarin is excluded. It is not recommended to drink Omez and medications containing St. John's wort at the same time.

The drug Omez has contraindications, in which use is completely excluded or allowed in minimal dosages.

Help with overdose

If you have these symptoms, you should call an ambulance. Before the doctors arrive, the patient is given 1-2 glasses of clean water to drink, after which he should induce gastric emptying, take a sorbent, drink warm tea with sugar (do not confuse the sequence). After the examination, the specialist will prescribe the necessary therapy. There are no special antidotes for Omez, so the treatment strategy will be focused primarily on eliminating the symptoms of poisoning and maintaining the microflora of the gastrointestinal tract; Bifiform and other probiotics can be given.

Side effects

Long-term use of the described medication is often accompanied by the development of adverse reactions. As a rule, the nature of the negative effects is poorly expressed, but sometimes, during the use of Omez, serious side effects occur that pose a health hazard.

Possible side effects:

• Stool disorders. Many patients with long-term use of the drug Omez experience defecation disorders. This is due to the effect of the active ingredients on intestinal motility, as well as the quality of food digestion. A common side effect is constipation, in which bowel movements may not occur for several days. Rarely does a reverse reaction occur, resulting in prolonged diarrhea.
• Discomfort in the abdomen. Long-term use is accompanied by unpleasant sensations and sometimes pain in the abdominal area. Typically, an increase in symptoms occurs immediately after taking the next capsule or dose of suspension. Due to a decrease in the secretion of hydrochloric acid, gas formation increases, resulting in symptoms of flatulence.
• Stomatitis. The reason for the development is the antibacterial effect of the drug. Long-term use may result in the development of an imbalance in the oral microflora. Due to the predominance of pathogenic bacteria, ulcers may form on the surface of the mucous membranes.
• Liver disorders. When taking Omez systematically, the activity of liver enzymes decreases. Due to the load to which the organ is exposed, the development of various pathologies, including hepatitis, is possible.
• Nervous disorders. Long-term use may cause disturbances in the functioning of the nervous system. The patient becomes prone to sudden changes in mood, depression, and apathy. In some cases, there is an increase in nervous excitability and irritability.
• Allergic reactions. The nature and intensity of reactions depends on the individual characteristics of the patient. For some, Omez causes skin rashes, hives, and severe itching. In severe cases, anaphylactic reactions may develop, including those accompanied by spasms of the respiratory system.
• Increased sweating. While taking Omez, kidney function is disrupted, which causes fluid retention in the body. Because of this, the work of the sweat glands in patients is activated. A person can sweat profusely even when not under any stress or moving.
• General malaise. In rare cases, the use of the drug causes a deterioration in a person’s condition. Taking it is accompanied by loss of strength, drowsiness, headaches, and lack of appetite. A common side effect is nausea with vomiting, especially in the morning.

In some cases, taking the medicine causes serious complications. When taken against the background of liver disease, the development of hepatic encephalopathy is possible. This is a severe pathology, accompanied by severe intoxication of the nervous system. Also, systematic use of the drug increases the likelihood of developing neoplasms in the organs of the digestive system.

If the patient experiences side effects from Omez, use should be discontinued. In such a situation, it is recommended to consult your doctor to eliminate the risk of complications.

Thus, the use of Omez may be accompanied by numerous side effects, the nature of which depends on the individual characteristics of the patient.

Omez overdose

The main symptoms of overdose are outlined below.

1. Drowsiness. At the same time, it is categorically unacceptable to allow the poisoned person to fall asleep: this is fraught with death.
2. Inability to concentrate and answer simple questions.
3. Increased sweating, nausea and even vomiting - the body tries to independently reject the poison.
4. The oral cavity is dry.
5. Dryness is felt in the mucous membranes.
6. Blurred vision, darkness in the eyes.
7. Strong headache.
8. Heart rhythm disturbance.

Gastritis - stomach disease

Gastritis is an inflammatory process observed in the stomach area, and the mucous membrane of the organ is affected. The pathology must be treated from the first signs, since according to statistics, this disease often leads to cancer diagnoses. The main cause of inflammation is high acidity in the stomach. In turn, a change in the level of acid in the organ is observed for a number of reasons:

1. Autoimmune diseases;
2. Incorrect diet;
3. Side effects from previously taken medications;
4. Consumption of low-quality products;
5. A large number of bacteria Helicobacter pylori (the cause has recently been considered).

Omeprazole prices

The price of the product is quite affordable. You can purchase it both in a regular pharmacy and in an online store.

The price varies depending on the dosage, concentration, number of tablets inside and type of medicine:

• Capsules of 10 milligrams – about 100 rubles (30 pieces);
• Thirty capsules of 20 milligrams cost about 200 rubles;
• Omez D. Thirty capsules - approximately 250 or more rubles;
• Omez Insta. In the amount of five pieces. Can be purchased for 80 rubles;

You can find out the exact price directly in your city at the pharmacy.

The price of Omez depends on the form of release and composition of the drug. On average, 30 capsules cost from 220 to 270 rubles, powder for preparing the Insta suspension - from 80 rubles/5 packets.

The average cost of the drug Omeprazole in Moscow pharmacies is 30-50 rubles. (capsules 20 mg)

How much does Omeprazole cost in pharmacies? The average price is 35 rubles.

special instructions

It is possible to take capsules simultaneously with food, from which the medicine does not lose its effectiveness.

Before you start taking capsules or administering Omez intravenously, you should rule out malignant processes, since therapy can mask symptoms, thereby delaying diagnosis.

Sometimes there are circumstances when it is necessary to avoid swallowing a whole capsule, for which the drug is used in the following way: the capsule is opened and its contents are mixed with soft apple puree (1 tablespoon). You cannot take the contents of the capsule in any other way.

The drug is unlikely to affect the ability to drive vehicles and operate precision equipment.

Reviews

Alexander I have been suffering from stomach ulcers for several years now, periodically undergoing treatment so that the disease does not worsen. I have been taking Omez for a month, 20 mg per day. The capsule form is most convenient for me; I take 1 capsule before dinner. I also follow a diet, so so far the ulcer has not reminded me of itself.

Olga went to the doctor with constant abdominal pain, heartburn, and a feeling of heaviness after eating. It turned out that I had gastroduodenitis. Heartburn was especially bothersome, so the doctor prescribed Omez. The first two weeks I took 80 mg per day, the second - 40 mg. Fortunately, I got rid of heartburn, but I continue to follow the diet as recommended by the doctor.

Instructions

The instructions for using the drug are simple; the dosage and other indications depend on the type of disease that caused heartburn. Therefore, it is not recommended to prescribe treatment with Omez yourself. Capsules and powder for oral use should be consumed half an hour before meals or during meals. The capsules are swallowed whole and do not need to be chewed. The powder dissolves in a small amount of water - a few tablespoons.

The maximum permissible daily dose of the drug is 80 mg. It is divided either into several doses, or taken once in the evening (half an hour before dinner). The average duration of treatment is from 2 to 4 weeks. The dosage and duration of treatment is determined individually.

If Omez is prescribed for prevention, for example, for stomach or duodenal ulcers, the recommended daily dose is 20 mg of the drug. It is taken in the evening, before dinner. The average duration of preventive therapy with the drug is a month.

The dosage for treating children is less than for adults - 20 mg of the drug per day, but it is only allowed for patients weighing more than 20 kg.

Omez in the form of a solution for injection is prepared immediately before its injection into a vein. To do this, use a saline solution in which the powder is dissolved. The drug is administered slowly, the average duration is half an hour.

The drug in intravenous form is usually prescribed for particularly severe conditions, for example, during an exacerbation of an ulcer.

The recommended average dosage of Omez for intravenous administration is 40 mg. In severe conditions, it can increase to 120 mg. If the daily dose is more than 60 mg, it must be divided into several administrations. Sometimes Omez is prescribed in the period before surgery, for example, for Mendelssohn syndrome, then the injection is given the evening before and in the morning, a few hours before surgery.

How to take the medicine

When treating various diseases of the gastrointestinal tract, an integrated approach is possible.

Omez interacts with other drugs in different ways:

1. The simultaneous use of Omez and De-Nol is permitted if prescribed by the attending physician
   with De-Nol. The simultaneous use of these two drugs is permitted if prescribed by the attending physician. Sometimes they are included in the same treatment regimen;
2. With Diclofenac. It is possible to combine medications. Omez is able to protect the stomach from the harmful effects of diclofenac;
3. Omez is compatible with the drug Concor;
4. It is allowed to take Salofalk and Omez at the same time;
5. The simultaneous use of Omez and Trimedat will not bring any complications;

Omez is often prescribed by doctors when using antibiotics. This is necessary to protect the stomach from the negative effects of antibacterial agents on the stomach.

Patients whose stomach ulcers are very difficult to treat are prescribed intravenous injections of Omez. They are done once a day, sixty milligrams. If the results do not reach the desired level, the dosage is selected individually by the attending physician.

In some cases, Omez is administered intravenously through a drip. The powder (forty milligrams) is diluted with a special liquid (ten milliliters) for injection. The resulting solution is 4 mg/ml, which is slowly injected into a vein.

Omeprazole can reduce the absorption of ketoconazole and intraconazole, iron salts and ampicillin.

Increases the concentration and reduces the excretion of indirect anticoagulants, diazepam and phenytoin.

Does not interact with amoxicillin, metronidazole, diclofenac, theophylline, lidocaine, cyclosporine, estradiol, caffeine, propranol, quinidine and concomitantly used antacids.

Omeprazole can enhance the inhibitory effect of drugs that affect the hematopoietic system.

When using the drug, it is necessary to take into account interactions with other medications:

1. There was no interaction with concomitantly taken antacids.
2. May reduce the absorption of ampicillin esters, iron salts, itraconazole and ketoconazole (omeprazole increases gastric pH).
3. Strengthens the inhibitory effect on the hematopoietic system and other drugs.
4. At the same time, long-term use of omeprazole at a dose of 20 mg 1 time per day in combination with caffeine, theophylline, piroxicam, diclofenac, naproxen, metoprolol, propranolol, ethanol, cyclosporine, lidocaine, quinidine and estradiol did not lead to a change in their plasma concentrations.
5. Being inhibitors of cytochrome P450, it can increase the concentration and reduce the excretion of diazepam, indirect anticoagulants, phenytoin (drugs that are metabolized in the liver via cytochrome CYP2C19), which in some cases may require a reduction in the doses of these drugs. May increase plasma concentrations of clarithromycin.

Conditions and periods of storage of the medicine

This medication is approved for sale without presenting a prescription from a doctor to the pharmacist. It should be stored in a very dry, dark place and out of reach of children.

The recommended storage temperature is room temperature, not exceeding twenty-five degrees. The capsules will be stored for three years. Liquid for solutions and injections is stored for no more than two years.

It is not recommended to take the medicine after its expiration date. This can harm the body and lead to complications.

Analogs

An alternative to “Omez” in terms of the structure of the active formula is:

• "Promez";
• "Romesek";
• "Domeprazole";
• "Zerocide";
• "Losek";
• "Omecaps";
• "Omezol";
• "Omeprus";
• "Omefez";
• "Petipak";
• "Omeprazole";
• "Omizak";
• "Orthanol";
• "Gastrozol";
• "Zhelkizol";
• "Ocide";
• "Omipix";
• "Ulzol";
• "Ulkozol";
• "Helicide";
• "Ultop";
• "Omitox";
• "Pepticum";
• "Helol";
• "Cisagast."

Consequences after poisoning

The lethal dose of Omez has not been determined, given the composition, it is impossible to die from it, however, if the above-described signs of an overdose appear, the patient should be kept awake and be sure to call an ambulance, make sure that the victim drinks a sufficient amount of water.

In order to prevent the development of these pathologies, first of all it is necessary to adhere to the course of treatment prescribed by the doctor (including following a diet, regimen and taking all prescribed medications according to the regimen).

If symptoms of the disease remain after the end of the course, this is not a reason to continue taking omeprazole uncontrollably. It is necessary to consult your doctor and undergo additional examination.

Perhaps the pathology was misdiagnosed and needs to be treated with other drugs.

In addition, if a doctor recommends taking Omeprazole for a long time, it is advisable to supplement the course with multivitamins, calcium and iron supplements to replenish the necessary intake of these substances into the body.

To reduce the negative impact of long-term therapy with PPIs, breaks between courses lasting at least 2-3 weeks (so that the body can remove substances accumulated during treatment). If necessary, during these periods you can take antacid medications (Almagel, Maalox) to protect the gastric mucosa from the aggressive effects of acid.

It is very dangerous to take Omeprazole for a long time without a break; this is fraught with the development of serious pathologies. The most reasonable alternative to long-term use of this remedy is a thorough examination of the body and compliance with all recommendations of the attending physician.

If you strictly adhere to the prescribed diet, take all prescribed medications in a timely manner and according to the schedule, and follow preventive measures, you can achieve stable remission or complete cure of gastrointestinal diseases.

In this case, the need to take Omeprazole will no longer be necessary.

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