A drug based on St. John's wort, Negrustin, is a tablet or solution with sedative, antidepressant and anxiolytic effects. The sedative Negrustin is made on a plant basis and is available in pharmacies without a doctor's prescription. In any case, this was the case until recently. But lately, more and more often, users on forums are asking where they can buy this medicine, why it was discontinued, or which analogues are better to choose.
Why is this drug, the main active component of which is St. John's wort extract, so in demand? And at the same time, why is its composition suspicious, since it was discontinued and removed from pharmacies? It is worth understanding in more detail, because modern people are exposed to enormous stress in everyday life, and often, without hesitation, resort to medications when experiencing depression, anxiety, excessive irritability, or, conversely, lethargy and apathy.
Before uncontrollably drinking pills recommended by friends or advertising, you need to consult with a competent specialist.
Compound
One capsule of Negrustin contains 0.425 g of dehydrated extract of the herb St. John's wort .
It also contains additional ingredients: MCC, lactose, aerosil, calcium dihydrogen phosphate, talc, gelatin, magnesium stearate, copper chlorophyll complex, sodium lauryl sulfate, iron oxide, titanium dioxide, water.
The Negrustin solution contains St. John's wort herb extract .
It also contains additional components: 1,2-propanediol, glycerin, sorbitol, flavoring.
Release form
The product is available in the form of hard, opaque gelatin capsules, which have a matte red body and a green cap. The capsules contain green-brown or gray-brown granules with a specific odor. The tablets are packaged in blisters of 10 pieces; cardboard packs may contain 3, 4, 6 or 10 blisters.
The solution for internal use has a brown or red-brown color, it is transparent, and has a pleasant aroma. If the solution is stored for a long time, it may become cloudy or precipitated. The solution is packaged in dark glass bottles of 50 ml or 100 ml. The bottle is packaged in a cardboard box, which also contains a measuring cup.
pharmachologic effect
Negrustin has a sedative effect on the body and has antidepressant and anxiolytic activity. The drug acts on the central and autonomic nervous system.
St. John's wort affects the enzyme monoamine oxidase (type A and B), inhibiting their activity. Therefore, during the treatment process in the human body there is no drop in the level of neurotransmitters, as happens in depressive conditions.
The level of neurotransmitters during treatment with Negrustin rises to optimal levels. The bioflavonoid composition of the product allows you to get a slight calming effect. As a result, when treated with the drug, general mood improves, problems with falling asleep disappear, appetite increases, and performance increases.
How the drug works
Negrustin has a calming effect, improves mood, and improves performance. The drug affects the nervous, digestive and circulatory systems.
It improves the overall tone of the body and really helps to cope with sadness, depression, melancholy, anxiety and panic. This effect is due to the participation of the active components of the drug in the metabolism of melanin and blocking the reuptake of serotonin.
Depressive mood in a person is caused by a sharp decrease in the level of neurotransmitters. Negrustin stabilizes it, which is why the patient feels a surge of strength and energy, cheerfulness and optimism.
Contraindications
Negrustin should not be used if the patient has the following conditions and diseases:
- severe forms of depression;
- endogenous depression;
- photodermatitis;
- pregnancy and feeding ;
- high sensitivity to the components of the product;
- taking MAO inhibitors ;
- therapy with cyclosporine , digoxin ;
- treatment with drugs with which unsafe interactions may occur.
St. John's wort
A predominantly perennial plant known for its antidepressant and sedative properties. Inferior to popular drugs only in cases of severe disorders and abnormalities. Studies prove the effectiveness of St. John's wort on a par with chemical drugs.
Recommended for the following conditions:
- chronic fatigue;
- depression;
- psychological and emotional disorders;
- headaches and rheumatic pains;
- premenstrual tension;
- anxiety, obsessive fear.
It is used as an independent remedy and is part of many herbal antidepressant drugs. Recipe: to prepare a decoction, pour 10 g of herb with a glass of boiling water, leave for 10-15 minutes, and strain. The required dosage is determined by the doctor.
Consumers respond positively to this remedy - in addition to the sedative and calming effect, the plant shows itself positively in diseases of the digestive tract, for the treatment of inflamed gums. But, despite its effectiveness and availability, the use of St. John's wort (and products based on it) should be prescribed and monitored only by a specialist. Self-medication can lead to undesirable consequences.
Side effects
If a patient uses Negrustin tablets or solution, he may experience the following undesirable effects:
- eczematous rashes on the skin;
- urticaria , severe itching of the skin ;
- manifestations of asthenia ;
- anorexia;
- dry mouth;
- headache;
- nausea, epigastric pain;
- increased sensitization to household allergens;
- Iron-deficiency anemia.
Instructions for use of Negrustin (Method and dosage)
The instructions for Negrustin include oral administration of capsules and solution. The patient is prescribed to take one capsule or 1 ml of solution three times a day.
Adolescents aged 12 to 16 years are prescribed 1 or 2 capsules per day. Instructions for use of Negrustin stipulate that a maximum of 6 capsules or 6 ml of Negrustin solution can be taken per day.
It is advisable to take the drug while eating. The capsules should not be chewed; they should be taken with a small amount of water. The course of treatment should last at least 4 weeks, maximum treatment can last for two months. If there is such a need, the patient may be prescribed an additional course of treatment again.
Interaction
There is a weakening of the effect of Negrustin when taken simultaneously with indinavir , protease inhibitors, Digoxin , Cyclosporine , indirect anticoagulants, Amitriptyline , Theophylline , Nortriptyline .
If the patient takes Negrustin with other antidepressant drugs , there may be an increase in side effects, in particular psychomotor agitation, a feeling of fear, nausea and vomiting.
When Negrustin and photosensitizing drugs , increased photosensitivity may be observed.
Simultaneous treatment with Negrustin and the use of oral contraceptives may cause bleeding.
Overdose
There have been no cases of overdose of this drug. After taking high doses, side effects may increase. Also, after taking high doses, it is worth limiting sun exposure to the skin, as photodermatitis may develop. A significant overdose of St. John's wort can lead to panic attacks, dizziness, amnesia and other memory disorders. Also, very strong allergic reactions, including anaphylaxis, are possible, so it is necessary to consult a doctor before use.
special instructions
During treatment with the drug, you should not stay in sunlight for a long time. This warning primarily applies to people with fair skin.
There is no need to allow simultaneous use of other drugs that cause photosensitivity .
sorbitol in Negrustin, of sorbitol enters the body .
If the solution is prescribed to people with diabetes , it must be taken into account that 1 ml of solution corresponds to 0.01 XE.
Prescribed with caution to those diagnosed with fructose intolerance .
There may be an effect of the drug on the ability to drive vehicles and operate precision machinery, especially if Negrustin was taken simultaneously with alcohol.
"Fluoxetine"
A drug based on fluoxetine hydrochloride is often prescribed when other antidepressants are ineffective. Helps improve mood, relieve anxiety, tension, and can lead to weight loss. Effective in the following cases:
- premenstrual disorders;
- kleptomania;
- schizophrenia;
- alcoholism;
- anorexia.
Clinical effectiveness is observed after several weeks (from 1 to 6). It has many contraindications, restrictions, and a wide list of side effects. It is prescribed only by a specialist and is not sold without a doctor's prescription.
Analogs
Level 4 ATC code matches:
Pipofezin
Bethol
Incazan
Melitor
Azafen
Miaser
Velafax
Mirtazonal
Venlaxor
Remeron
Venlafaxine
Lerivon
Mirtazapine
Cymbalta
Velaxin
Coaxil
Pyrazidol
Deprim
Gelarium Hypericum
Trittico
Analogs of the drug Negrustin are products containing a similar active substance. Today, the following analogues can be purchased in pharmacies: Deprim , Gelarium Hypericum , Deprim Forte , Herbion Hypericum , Nervotonic , Novoimanin , Life 600 , St. John 's wort extract , Life 900 , Turinervin , Hypericin , dry extract of St. John's wort . Before replacing Negrustin with another drug, you should consult a specialist.
Reviews for Negrustin
Reviews about Negrustin on forums and websites are often left by people who have undergone a long course of treatment with the drug. There are both positive reviews and negative opinions regarding the lack of effect of therapy with this drug. There are a number of reviews indicating that Negrustin has a positive effect on mood and helps overcome anxiety. When starting to take Negrustin, doctors' reviews should also be taken into account. Experts on the network strongly recommend not to practice such treatment without prior appointment, since there are many cases of uncontrolled use of the drug.
"Cipralex"
This is an antidepressant that has the same effect on the nervous system as Negrustin. The analogue differs in its composition; its active substance is escitalopram. The drug is indicated in the following cases:
- anxiety, fear, mania;
- social phobias (fear of society);
- depression of any severity.
It is considered a stronger remedy compared to herbal medicines. It has many contraindications and side effects, which usually appear 1–2 weeks after starting treatment and disappear with further therapy. "Cipralex" is not used in the treatment of children and adolescents under eighteen years of age, and is not recommended for pregnant and lactating women, or the elderly.
Patients taking the drug for the first time may experience suicidal tendencies, increased anxiety and mania. Persons under twenty-five years of age are especially susceptible to this phenomenon. "Cipralex" affects any activity that requires high attentiveness and concentration. Dispensed only with a doctor's prescription.
