Omez D - instructions for use, indications, composition, analogues and substitutes, side effects and price

Omez D capsules

Before taking the medicine, read the instructions. Omez D are capsules made from Omeprazole and Domperidone. With their help, you can reduce the production of hydrochloric acid and provide an antiemetic effect during the treatment of dyspepsia. The drug belongs to a group of drugs that inhibit the proton pump of the parietal cells of the stomach (the mechanism responsible for the production of hydrochloric acid). As a result of treatment, gastric secretion is normalized.

Omez D tablets are prescribed for various diseases, and they are needed to provide the following effects:

• preventing vomiting;
• rapid gastric emptying;
• improving the tone of the esophageal sphincter;
• improvement of peristalsis of the stomach and duodenum;
• reduction of aggressive effects and reflux of gastric juice into the esophagus.

Composition and release form

The product is available in capsules with a gelatin shell. There is white powder inside. The capsules are engraved with Omez D and DR.REDDY´S. The drug is sold in plates of 10 pieces with instructions for use, in cardboard packaging. The effectiveness of Omez D capsules and a lot of positive reviews are explained by the composition of the drug. Familiarize yourself with the components of the medicine:

What is the difference between Omez and Omez D

An important issue for gastroenterologist patients is the difference between the drugs Omez and Omez D. The second option includes not only Omeprazole, but also a similar concentration of Domperidone. Due to this, the capsules help not only normalize gastric secretion, but also prevent vomiting. In addition, Domperidone increases the tone of the lower sphincter, which separates the stomach and esophagus.

Pharmacodynamics and pharmacokinetics

Omez D is a combination drug based on components that block centrally acting dopamine receptors. Domperidone increases peristalsis of the antrum of the stomach and duodenum. If the patient has a slower process of gastric emptying, the drug speeds it up. Also, due to Domperidone, the tone of the esophageal sphincter is stimulated, nausea and vomiting are prevented.

Another action of the component is aimed at stimulating the production of prolactin by the pituitary gland. Domperidone does not affect the production of hydrochloric acid by the body. The component in the drug is responsible for blocking type 2 dopamine receptors, eliminating the inhibitory effect of the pleasure hormone on the digestive tract. Omeprazole blocks the production of hydrochloric acid at the last stage, thereby reducing stimulated, basal secretion. In combination, the components of the drug reduce the aggressiveness of gastric secretion and its reflux into the patient’s esophagus.

Domperidone is rapidly absorbed after oral administration. 1 hour after consuming the capsules, the maximum concentration of the substance in the blood plasma is observed. The bioavailability of Domperidone is about 15%. The component is distributed throughout all tissues of the patient and binds to blood proteins up to 90%. The substance is metabolized in the walls of the intestines and liver. Excretion occurs through the kidneys and intestines.

Omeprazole begins to act 60 minutes after oral administration. The maximum concentration of the substance in the blood is reached after 2 hours. The component is active throughout the day. Omeprazole is absorbed quickly from the gastrointestinal tract. The bioavailability of the component is 30-40%. The substance binds to blood plasma proteins by 90%. The main part of Omeprazole is metabolized by the liver. 70% of the substance is excreted by the kidneys, 30% with bile.

What does Omez treat?

This drug is prescribed to patients with gastrointestinal problems. Familiarize yourself with the disorders for which Omez D is used:

• stomach ulcer, duodenal ulcer;
• hypersecretory conditions (systemic mastocytosis, gastrointestinal ulcers caused by stress, Zollinger-Ellison syndrome, polyendocrine adenomatosis);
• gastroesophageal reflux;
• NSAID gastropathy;
• destruction of helicobacter pylori microflora in patients with gastric and duodenal ulcers;
• prevention of aspiration of stomach contents into the respiratory tract during general anesthesia.

Effects of omeprazole

This component inhibits the activity of H+-K+-ATPase in the parietal cells of the stomach, as a result of which the final stage of hydrochloric acid production is blocked, and its production is ultimately reduced.

As a result, the level of stimulated and basal secretion decreases - whatever the stimulus. The effect appears after the first hour and lasts for a day. The maximum effect occurs after 2 hours.

Complete restoration of secretory activity occurs 3-5 days after cessation of treatment.

Omez D - instructions for use

In order for the therapy to produce results, it is important to strictly follow the instructions when using capsules. They are drunk without chewing with water. It is allowed to take it 30 minutes before meals or immediately before eating. For elderly patients, the dosage of the drug is not adjusted based on age. The course of therapy depends on the diagnosis:

• For the treatment of gastroesophageal reflux, acute gastric and duodenal ulcers, NSAID gastropathy: 20 mg 2 times a day. The course of therapy is up to 4 weeks, up to 2 months in patients with gastric ulcer.
• For Zollinger-Ellison syndrome, the dosage of the drug is set individually, taking into account the initial level of gastric secretion: 60-120 mg/day.
• Prevention of Mendelssohn's syndrome: 40 mg 60 minutes before surgery.
• To destroy pathogenic microbes helicobacter pylori: 20 mg of the drug, 2 times a day. The course of treatment is 1-2 weeks.
• Prevention of relapse of reflux esophagitis: 20 mg/day. The course of therapy is up to 8 weeks.
• Prevention of recurrence of gastric and duodenal ulcers: 10-20 mg daily 1 time.

Pharmacokinetics of omeprazole

This substance is also quickly absorbed from the gastrointestinal tract. Maximum concentration is achieved after 30-60 minutes.

The bioavailability of omeprozole is 30-40%, and it is 90% protein bound. It is almost completely metabolized in the liver.

The half-life is short - about 30-60 minutes. This substance leaves the body along with bile and through the kidneys. But if a person has chronic renal failure, then the excretion process decreases in proportion to the decrease in the QC indicator.

In the body of elderly patients, omeprazole behaves somewhat differently. Its excretion decreases, but its bioavailability, on the contrary, increases.

During pregnancy

The period of waiting for a child is especially important for a woman. The vast majority of medications are contraindicated for expectant mothers. Omez D can be prescribed to pregnant women in rare cases if the medicine cannot be replaced with a safe analogue. Capsules may be taken if the risk to the fetus is lower than the benefit of treatment. During lactation, Omez is strictly prohibited and is not prescribed by doctors.

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Drug interactions

Before starting treatment, the doctor should tell the patient about other medications the patient is taking. Anticholinergic drugs in combination with Omez D neutralize the effect of Domperidone. Antibiotics, antifungals, Nefazodone, HIV protease inhibitors, on the contrary, enhance the effectiveness of this component and increase its concentration. The combination of taking capsules with sodium bicarbonate, cimetidine, antisecretory, antacid agents reduces the level of bioavailability of Domperidone.

Omeprazole, which is part of the drug, reduces the absorption of iron salts, esters, Itraconazole, Ampicillin, Ketoconazole. This component reduces the excretion of indirect anticoagulants (Diazepam, Phenytoin) from the body. During treatment, it may be necessary to reduce the dosage of capsules. Omeprazole increases the effect of other drugs on the hematopoietic system.

What do the doctor's say?

It is important to answer this question, since we are talking about the instructions attached to the drug. Omez-D receives mostly positive reviews from doctors. However, this is not surprising - in medical practice this is the most common drug belonging to the group of proton pump blockers. It was one of the first to appear on the pharmaceutical market, and immediately established itself well.

Doctors note the ease of use, effectiveness and affordable price, as well as versatility - the tablets are suitable for both course treatment and for use for gastroprotection.

However, some doctors consider Omez-D an outdated remedy. Often you come across fakes in unverified places at a low price. Therefore, specialists often prescribe modern drugs belonging to the same group.

But nevertheless, Omez-D is one of the best medicines among all analogues, which has a huge evidence base and countless studies. And he copes with his tasks 100%.

But there is one small warning. And it is another argument in favor of adequate, competent therapy, rather than self-medication. The fact is that Omez-D can mask signs indicating the presence of a malignant tumor in any location of the gastrointestinal tract. This often causes a delay in making a correct diagnosis. Therefore, before taking any medication, you need to undergo a full examination and pass all the necessary tests.

Side effects

Incorrect use of Omez D capsules or the individual characteristics of the patient’s body can provoke the development of side effects. During therapy with this drug, the following symptoms appear:

• hives;
• extrapyramidal reactions (motor disorders caused by problems of the nervous system);
• transient intestinal spasms;
• increased prolactin levels in women;
• feeling of dry mouth;
• drowsiness;
• stomatitis;
• insomnia;
• hallucinations;
• headache;
• muscle weakness;
• thrombocytopenia;
• increased sweating;
• gastric glandular cysts (in rare cases).

Patient reviews

They also need to be given attention. People who have been treated with Omez-D note its high effectiveness. They say that it not only relieves pain, but also relieves the disease itself.

The drug helps to alleviate unpleasant symptoms, eliminate discomfort, forget about heartburn, and also restore the normal microflora of the stomach. Food is also digested much better, which is very important - since many patients have to eat exclusively broths and crackers.

Patients also note the actual protection of the gastric mucosa from the effects of non-steroidal anti-inflammatory drugs. Against this background, your overall health really improves within a few days. And most importantly, the unbearable pain that occurs literally after every meal disappears.

Side effects, as noted earlier, are extremely rare. The medicine has a gentle effect, much more gentle than many well-known alternatives. Upon completion of treatment, patients have the opportunity not only to eat normally, but even to occasionally indulge in fried food. The main thing is to lead a predominantly healthy lifestyle.

Overdose

If you do not follow the instructions for use and exceed the dose of Domperidone, the patient will develop disorientation, extrapyramidal reactions, and drowsiness. To eliminate symptoms, activated charcoal is prescribed. Extrapyramidal reactions caused by overdose are suppressed by antiparkinsonian, anticholinergic, and antihistamine drugs. Exceeding the dose of Omeprozole provokes blurred vision, blurred consciousness, headaches, nausea, and arrhythmia. Symptomatic treatment is prescribed.

Contraindications

The components of the drug Omez D can negatively affect the condition of a patient who has disturbances in the functioning of internal organs or body systems. Contraindications to the use of the medicine are:

• hypersensitivity to the components of the drug;
• intestinal or stomach bleeding;
• liver diseases;
• renal failure;
• perforation of the stomach or intestines;
• breastfeeding period;
• mechanical gastric obstruction;
• pituitary prolactinoma;
• pregnancy;
• children under 18 years of age.

Pharmacokinetics of domperidone

If you study the instructions for Omez-D, you can understand how the components of this drug behave in the human body. Each substance performs its own action and is absorbed differently.

Domperidone is very quickly absorbed from the gastrointestinal tract. Its bioavailability is low - approximately 15%, but binds to proteins by 91-93%. Due to the reduced acidity of the stomach contents, the absorption of this element may decrease, but if everything is in order, then the maximum concentration is achieved within an hour after using the drug.

Domperidone is distributed in the tissues of the body and only in a small part in the brain. Actively metabolized in the liver and intestinal wall.

It is excreted from the body by the kidneys and intestines, approximately 10% unchanged. The half-life lasts 7-9 hours, but in renal failure it is longer.

Analogs

If there are no capsules prescribed by a doctor in the pharmacy, then the patient can undergo a course of therapy with a medicine similar in action or composition. Analogues of Omez D are presented below:

• Dexilant;
• Omecaps;
• Omep;
• Demeprazole;
• Zerocide;
• Gastrozol;
• Omeprazole;
• Lansoprol;
• Ultop;
• Chrismel;
• Omezol.

Indications and dosage

Now it’s worth looking into the question of why Omez-D is prescribed. The main indications are dyspepsia and gastroesophageal reflux. If these diseases do not respond well to treatment with histamine H2 receptor antagonists or proton pump inhibitors, then Omez-D is prescribed.

The application scheme is very simple. You need to take one capsule twice a day with water. Be sure to take it 20 minutes before meals.

Price Omez D

The cost of this drug depends on the manufacturer, dosage of the drug, region and markup at the point of sale. Check out the prices for Omez D capsules in Moscow pharmacies:

What is it prescribed for?

The drug is prescribed when drugs such as Omez, Omeprazole, Losek are ineffective, as well as in patients with severe impairment of the motor function of the digestive system and frequent vomiting.

Indications for prescribing the medication:

• gastroesophageal reflux - pathological reflux of gastric contents back into the esophagus;
• dyspepsia due to dysfunction of the gastrointestinal tract (nausea, heartburn, pain in the abdomen, belching and bowel dysfunction);
• erosive-ulcerative esophagitis - chronic damage to the inner wall of the esophagus with the appearance of shallow defects on it;
• stool disorders (constipation, functional diarrhea without signs of infection);
• pancreatitis - as an auxiliary therapy, to relieve diarrhea (read about stool disorders with pancreatitis here...);
• chronic gastritis;
• ulcerative lesions of the duodenum and stomach;
• Zollinger-Ellison syndrome is a glandular tumor in the stomach that intensely secretes gastrin, which ultimately leads to hyperacidity.