Osteogenon - indications, contraindications, method of application, side effects

Compound

The core of one Osteogenon tablet contains 830 milligrams of the active ossein-hydroxyapatite compound , which, in turn, consists of collagens (216 mg), non-collagenous proteins and peptides (75 mg), calcium (178 mg), calcium hydrogen phosphate ( hydroxyapatite ) (approximately 444 mg), phosphorus (82 mg), inactive organic fractions (approximately 95 mg).
Among the auxiliary compounds included in the drug are colloidal silicon dioxide, potato starch, microcrystalline cellulose, and magnesium stearate. The drug shell contains hypromellose , titanium dioxide, as well as yellow iron oxide, talc and macrogol.

Pharmacodynamics and pharmacokinetics

Active medicinal compounds contained in Osteogenon function as regulators of phosphorus-calcium metabolism . This drug has found wide use in the treatment and prevention of osteoporosis due to its dual effect on metabolism . On the one hand, the drug stimulates osteoblasts , and on the other, it has an inhibitory effect on osteoclasts .

Due to the content of calcium in the drug in proportion to phosphorus 1:2, the drug promotes the absorption of calcium from the gastrointestinal tract, thereby promoting the production of parathyroid hormone , which, in turn, reduces bone resorption .

The medicine helps slow down the process of calcium release from hydroxyapatite , which blocks the manifestations of hypercalcemia . In addition, phosphorus contained in the chemical composition of the drug is involved in the crystallization of the same hydroxyapatite, which helps slow down the excretion of calcium from the body by the kidneys.

ossein in the drug, bone tissue remodeling occurs. This process inhibits tissue resorption and stimulates bone formation . Osteocalcin contained in the medicinal compound binds calcium, thereby promoting accelerated crystallization of bone tissue, and collagen forms the bone matrix.

pharmachologic effect

Osteogenon is a drug that regulates phosphorus-calcium metabolism. The drug stimulates osteoblasts and inhibits osteoclasts, resulting in the restoration of balance between the processes of bone resorption and bone tissue restoration.

The drug contains calcium in the form of hydroxyapatite, which not only improves the absorption of the drug in the gastrointestinal tract, but also prevents the development of the peak of hypercalcemia due to the gradual release of calcium ions. Calcium inhibits the synthesis of parathyroid hormone and prevents hormonal resorption of bone tissue. Phosphorus complements the strengthening effect of calcium on bone tissue, due to its ability to fix calcium in bone tissue and reduce its excretion by the kidneys.

Ossein contains local regulators of bone tissue remodeling, osteocalcin and type I collagen. Ossein stimulates the process of bone formation and collagen synthesis, increases the number and activity of preosteoblasts, and inhibits the formation of osteoclast precursors. The drug also increases the crystallization of bone tissue, due to the binding of calcium, and regulates the formation of bone matrix.

The active components of the drug after oral administration are absorbed in the duodenum and proximal small intestine.

Indications for use

The drug is recommended for use if:

osteoporosis of any degree of complexity, including those caused by arthritis , hyperthyroidism , kidney and liver diseases, hyperparathyroidism, as well as immobilization , the use of heparin or corticosteroids;
osteopenia and imbalance of calcium and phosphorus in the body, including during pregnancy , as well as during breastfeeding ;
bone fractures , as well as for their speedy healing.

Drug interactions

Osteogenon slows down the absorption of iron supplements, bisphosphonates and tetracycline antibiotics, therefore, when used simultaneously with these drugs, the time interval between their administration should be at least 4 hours.

When using Osteogenon simultaneously with vitamin D or thiazide diuretics, the doctor should assess the risk of developing hypercalcemia due to increased calcium resorption.

special instructions

People with impaired kidney function should avoid using this drug for a long time.

For patients with a predisposition to urolithiasis , it is vitally important to adhere to a special regimen and dosage of the drug.

Since Osteogenon contains a trace amount of sodium chloride in its chemical composition, the drug is approved for use in the treatment of patients who suffer from arterial hypertension .

The drug does not affect the ability to drive vehicles.

Overdose

Patients who take the medication in question must strictly follow the dosage. The main side effect that can aggravate the condition will be hypercalcemia. An overdose with this drug is unlikely.

Clinical manifestations of excess dosage are mainly associated with hypercalcemia and are not considered specific (thirst, increased urine production, nausea, gag reflex, dehydration, increased blood pressure, vasomotor disorders, constipation, loss of appetite, heart rhythm disturbances, malaise, nephrocalcinosis, pain in the bones , psycho-emotional deviations).

In childhood, lack of weight gain and physical retardation precede the above symptoms.

Therapy if the dosage is exceeded: stopping the use of the drug and restoring water balance. Taking into account the severity of hypercalcemia, diuretics or corticosteroids or bisphosphonates should be used. Some patients require peritoneal dialysis or hemodialysis.

Osteogenon analogues

Level 4 ATX code matches:
Prolia

Osteocea

Bivalos

At the moment, no analogues of Osteogenon can be found on the open market. This means that there are no drugs with a similar chemical composition, which, like this drug, will affect the course of mineralization of bone tissue and act as a regulator of phosphorus-calcium metabolism in the body.
However, the attending physician can always select a drug that is similar in action and which will contain other active compounds.

Reviews about Osteogenon

Most reviews of Osteogenon for fractures are positive. We can say that doctors most often prescribe this drug for bone tissue damage of varying severity. People who have taken the drug note that it does not cause side effects and helps in the prevention and treatment of various diseases associated with damage to bone tissue, including osteoporosis .

calcium deficiency , respond well to the drug . Reviews from doctors about Osteogenon can be called more than “cool”. Many doctors are truly skeptical about this drug and its ability to influence the regeneration of bone tissue, and therefore express rather contradictory opinions that diverge from the assurances of the drug’s manufacturers.

However, the number of doctors prescribing Osteogenon as a stimulator of bone tissue mineralization is also large, especially since the effectiveness of the drug in each specific case may vary. Therefore, if you have doubts about the strength of the drug's medicinal effect, it is advisable to study the condition of bone tissue using x-rays , as well as urine and blood tests to determine the calcium content in biological fluids.

Reception and dosage

Osteogenon tablets are swallowed whole, without crushing or chewing, with the required volume of water. Eating food does not affect the effectiveness of the product, so it can be used at any time. Following the instructions for use, Osteogenon is used in the following doses:

For systemic osteoporosis in adults - 3 tablets. twice a day.
For the purpose of accelerated consolidation of bone fractures - 2 tablets. twice a day.
For other indications - 1-2 tablets. throughout the day.

The duration of therapy during osteoporosis is six months to a year. Osteogenon for bone fractures, after joint replacement and other indications is used for 3 months.

The duration of Osteogenon use and dosage is determined by a specialist, taking into account the maturity of the callus. With prolonged use, it is necessary to monitor the amount of calcium in urine and bloodstream.

Increasing the dosage of the drug increases the risk of side effects and their severity. In patients who are prone to urolithiasis, dosage adjustment is required. If there is a malfunction of the kidneys, it is necessary to avoid prolonged use of large doses.

For adults

In adults, if there are no contraindications to the use of the drug, the drug is prescribed in a dosage of up to 6 tablets. during the day. For therapeutic purposes of osteoporosis, the medication is used in a dose of no more than 4 tablets. throughout the day. This volume is divided into 2 doses.

For children

There is no information on the specific dosage of the drug in pediatrics. If important indications are present, the dosage should be adjusted individually, taking into account the child’s age and body weight.

During pregnancy and lactation

Due to the fact that the medicinal compounds contained in the drug in question do not create a negative effect on the health and development of the fetus, Osteogenon can be used even during pregnancy and breastfeeding according to a specialist prescription. The permissible dose should not be more than 2 tablets. per day, this volume is divided into 2 parts. It is necessary to monitor the amount of calcium in urine and bloodstream.