Prestarium A, 5 mg, film-coated tablets, 30 pcs.

pharmachologic effect

This drug converts angiotensin I to angiotensin II, which occurs thanks to the ACE inhibitor exopeptidase. A decrease in the concentration of angiotensin II in blood plasma occurs due to ACE inhibition.

Prestarium tablets

As a result, renin activity increases and aldosterone secretion decreases. The drug also promotes the breakdown of the vasodilator bradykinin into an inactive heptapeptide.

Composition and release form

The drug has three release forms:

• 2 mg: the main substance is perindopril tertbutylamine salt. One tablet contains 2 mg of this component (corresponding to 1.668 mg of perindopril);
• 4 mg: the main ingredient is perindopril tert-butylamine salt in an amount of 4 mg (corresponds to the amount of this substance - 3.387 mg of perindopril);
• 8 mg: consists of a substance such as perindopril tert-butylamine salt in a volume of 8 mg (corresponding to 6.675 mg of perindopril).

As for the additional components, they include lactose monohydrate, colloidal hydrophobic silicon dioxide and magnesium stearate.

As for the description of the dosage form, then:

1. 2 mg is a round, convex tablet of snow-white color;
2. 4 mg – oblong capsules, rounded at both ends, pale green in color, scored on both sides;
3. 8 mg – perfectly smooth, rounded, salad-colored tablets.

It is important to note that one plate of tablets contains 14 or 30 pieces. This applies to dosages of 2 and 4 mg. The packaging of the drug with a dosage of 8 mg contains one blister containing 30 tablets.

Prestarium A

The medicine is divided into three types according to the dosage of the active substance:

1. Prestarium dispersible tablets in the oral cavity at a dose of 2.5 mg. The main substance is perindopril arginine (2.5 mg). Auxiliary components: acesulfame potassium - 0.1 mg, aspartame - 0.1 mg, magnesium stearate - 0.2 mg, anhydrous colloidal silicon dioxide - 0.2 mg, a mixture of lactose and corn starch - 36.9 mg.
2. tablets, dispersible in the mouth (5 mg). The composition is completely identical to the first type, only the dose of all substances is doubled.
3. tablets for oral administration (10 mg). The dosage of all components is twice as high as in the previous form.

These tablets are round in shape and white in color.

Prestarium Bi

Bi-Prestarium 5 mg/5 mg tablets have:

• 5 mg perindopril arginine;
• 5 mg amlodipine;
• lactose monohydrate.

Tablets Prestarium
Bi-Prestarium 5 mg/10 mg consists of similar components of the same dosage as the first type, only it contains 10 mg of amlodipine.

1. 10 mg/5 mg. The composition is the same as in the first dosage, only it contains 10 mg of perindopril arginine;
2. 10 mg/10 mg . The composition is the same as in the first point, only the dose of ingredients is twice as large.

Prestarium Combi

One tablet of the drug contains:

• active substance called perindopril tertbutylamine salt at a dose of 4 mg;
• indapamide at a dose of 1.25 mg;
• additional ingredients in the form of colloidal hydrophobic silicon dioxide, lactose monohydrate, magnesium stearate and microcrystalline cellulose.

Prestarium Arginine Combi

The composition of this product includes: perindopril arginine - 5 mg, indapamide - 1.25 mg, maltodextrin, lactose monohydrate, magnesium stearate, sodium starch glycolate (type A), colloidal anhydrous silicon dioxide, macrogol 6000, glycerin, hypromellose, titanium dioxide (E171 ).

Indications for use

The drug Prestarium is used in the following cases:

• to prevent the risk of recurrent stroke in patients suffering from cerebrovascular diseases;
• stable ischemic heart disease;
• chronic heart failure;
• arterial hypertension;
• to prevent the risk of cardiovascular complications in patients with coronary heart disease.

Combination with other medications

Prestarium in combination with some other drugs can lead to an increase in potassium levels in the blood.

This condition can be dangerous not only for the general condition, but also for the life of the patient.

For example, Prestarium and Cardiomagnyl have negative compatibility. But Prestarium and Amlodipine are sometimes prescribed together.

Therefore, it is recommended to inform your doctor about combinations of Prestarium with any other medications. The doctor will not only select a safe dosage, but also, if necessary, select analogues of the previously used medication.

Contraindications

Prestarium, like all medicines, has a number of contraindications. It is not prescribed for:

• pregnancy and lactation. But if the child stops breastfeeding, the drug can be used;
• if hypersensitivity to the drug or other ACE inhibitors is detected, because this can cause complications in different body systems;
• with a history of angioedema;
• hypokalemia.

The drug should be taken with caution when:

• reduced circulating blood volume (CBV). If you take the drug, various side effects are possible, which may manifest themselves in the form of: cerebrovascular diseases, vomiting, diarrhea, hemodialysis, decreased blood pressure;
• renovascular hypertension;
• therapy with hypoglycemic agents for diabetes mellitus. In this case, there is a possible risk of hypoglycemia;
• surgical interventions, as well as after general anesthesia. In this case, use may cause the development of arterial hypotension;
• age category up to 18 years;
• systemic connective tissue diseases. In this case, agranulocytosis and neutropenia may develop;
• stenosis of the artery of the only functioning kidney. There is a possible risk of developing severe arterial hypotension;
• elderly age category. In this case, patients are prescribed a minimum dose of the drug to further determine treatment;
• carrying out hemodialysis;
• renal artery stenosis. Possible risk of developing renal failure;
• carrying out desensitizing therapy. In this case, allergic reactions may develop;
• aortic valve stenosis;
• lactase deficiency;
• chronic renal failure, as well as heart failure, there is a risk of hypokalemia.

Duration of taking the medication

How long can Prestarium be taken?
Unfortunately, the answer to this question cannot be found in the instructions for use. The reason is that treatment with this drug is prescribed by the doctor on an individual basis, so there is no general period for all patients. The dosage, duration and intensity of the treatment period are determined based on the health status and age of the patient.

It is permissible to take the medicine regularly for several months. However, during a long period of treatment, it is recommended to take short breaks, and then resume taking it again.

The presence of pauses and strict adherence to the rules of administration and dosage ensures the absence of side effects in the form of dysfunction of the gastrointestinal tract.

Instructions for use

The drug Prestarium is prescribed exclusively for oral use.
The dosage of this drug is selected individually and depends on the patient’s condition and his blood pressure readings.

Prestarium is often combined with antihypertensive drugs of other classes. Its starting dose in such cases is usually 5 milligrams. After a month of treatment with this drug, the dosage can be increased to 10 milligrams.

During the use of Prestarium, arterial hypotension may occur - this manifestation is possible if the patient simultaneously uses diuretics. For this category of people, care must be taken during treatment, because they may have a risk of water or salt deficiency in the body.

If possible, you should stop taking diuretics, but this should be done at least three days before starting treatment with Prestarium.

For hypertensive patients who cannot stop taking diuretics, treatment may be prescribed, but the initial dosage will be 2.5 milligrams per day.

A further increase in the amount of the drug is possible, however, it is necessary to constantly pay attention to blood pressure. If necessary, combined therapy with a diuretic can be resumed.

The tablets must be taken once a day in the morning.

For elderly patients, treatment with this medication is prescribed with an initial dosage of 2.5 milligrams per day. But with good indicators, it can be increased to 5 milligrams after a thirty-day period from the start of treatment, and then to 10 milligrams, but the functioning of the kidneys will be taken into account.

For patients with heart failure, the use of the drug is permitted with extreme caution and under close medical supervision.

The starting dosage of the drug is 2.5 milligrams per day in the morning. In the future, after consultation with a doctor and with good tolerance, the dose of the drug can be increased to 5 milligrams 1 time per day.

The amount of medication in this case is determined individually and depends on the clinical effectiveness for each patient. To prevent recurrent stroke in patients with cerebrovascular diseases, the initial dose of this drug is 2.5 milligrams.

Apply once a day in the morning. After 14 days, it can be increased to 5 milligrams with the same dosage schedule.

Prestarium price

The prescription of tablets is carried out exclusively by a cardiologist, who selects individual therapy for the patient, providing for a certain dosage and duration of use of the drug. Average cost of medication in Moscow pharmacies:

Side effects

The following side effects are possible when using Prestarium:

• nervous system : sometimes there is increased drowsiness, confusion, vertigo, frequent headaches, paresthenia, dizziness may occur;
• from the metabolic side : hypoglycemia, hyponatremia, hyperkalemia;
• from the hearing organs : severe ringing in the ears may occur, which occurs quite often;
• from the organs of vision : problems with visual impairment may often occur;
• heart : palpitations, palpitation, myocardial infarction (occurs in the event of a strong decrease in blood pressure in patients at high risk), angina pectoris, tachycardia;
• vascular system : hypotension, stroke (this symptom is rare and may occur due to a sharp and excessive drop in blood pressure in patients who are at high risk);
• respiratory system : frequent cough, eosinophilic pneumonia, shortness of breath, bronchospasm, rhinitis;
• digestive system : nausea, abdominal pain, vomiting, dry mouth, taste disturbance, diarrhea, pancreatitis, dyspepsia;
• from the connective tissue and musculoskeletal system : muscle cramps are often observed and myalgia and arthralgia are more rare;
• from the reproductive system : erectile dysfunction may rarely be observed;
• from the kidneys : symptoms are observed quite rarely, and may include renal failure and acute renal failure;
• general disorders : asthenia, chest pain, malaise, hyperthermia, peripheral edema, depression.

Overdose

Not enough information has been collected about cases of overdose with Prestarium, however, the following symptoms that may be associated with this are observed:

• circulatory shock;
• bradycardia;
• hyperventilation;
• arterial hypotension;
• sense of anxiety;
• cough;
• electrolyte imbalance;
• dizziness;
• renal failure;
• tachycardia.

Video on the topic

Instructions for using the drug Prestarium in the video:

Prestarium is an antihypertensive drug that is used for arterial hypertension, cardiovascular failure and for the prevention of coronary artery disease. The drug has a small number of contraindications and has an impressive list of side effects. Cases of overdose occur extremely rarely.

The information on the MyMedNews.ru website is for reference and general information, collected from publicly available sources and cannot serve as a basis for making a decision on the use of medications in the course of treatment.

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About the drug

Prestarium is a drug intended to lower blood pressure. The medication has a wide range of actions.

The substances contained in the medicine help:

• reduce blood pressure;
• restore the elasticity of large arteries;
• narrow large (arterial) vessels;
• restore cardiac metabolic processes;
• reduce heart rate;
• increase the body's resistance to physical activity;
• improve blood circulation;
• reduce the size of the left ventricle increased due to disease.

The substances contained in the drug reach their peak effect after approximately 4-6 hours, and the pressure is maintained at a normal level for the patient for 24 hours after administration. The pressure stabilizes, and unpleasant symptoms weaken or completely disappear after stable use of Prestarium for 1 month.

To achieve the desired effect, it is necessary to select the correct dosage of Prestarium.t