Compound
Aktiferrin drops (100 ml) contain 4.72 grams of ferrous sulfate heptahydrate ; 3.56 grams of serine + additional ingredients ( potassium sorbate, ethanol, raspberry and cream flavors, water, ascorbic acid, invert sugar syrup ).
In one capsule: 113.85 mg of ferrous sulfate monohydrate + 129 mg of serine + excipients ( lecithin, soybean oil, gelatin, beeswax, glycerol, rapeseed oil, sorbitol, black and red iron oxide ).
Per 100 ml of syrup there are 3.42 g of ferrous sulfate heptahydrate ; 2.58 g serine + sugar syrup, vitamin C , raspberry flavor, water, ethanol, cream flavor .
Aktiferrin Compositum capsules contain 113.85 mg of ferrous sulfate monohydrate ; 129 mg serine ; 0.5 mg folic acid + excipients ( beeswax, soy lecithin, rapeseed oil, soybean oil, sorbitol, gelatin, black iron oxide, glycerol, titanium dioxide, yellow iron oxide, titanium dioxide, brown iron oxide, shellac, red iron oxide, butanol, methanol, ethyl acetate ).
Release form
drops are produced in the form of a transparent yellow-green solution with a raspberry smell and taste, in 30 ml bottles.
The drug is also produced in the form of dark brown capsules in a gelatin shell, inside the capsule there is a light beige oily liquid. The product is available in packs of 20 and 50 pieces.
syrup is transparent yellow-green, has a raspberry smell, with a capacity of 100 ml.
Aktiferrin Compositum - capsules are light brown on one side, dark brown on the other, on the tablet there is a white inscription “Aktiferrin F”, inside there is a grayish-yellow paste. There are 30 pieces in a package.
Description
Actiferrin syrup is a popular remedy for the treatment of iron deficiency anemia. This is a vitamin in syrup. It contains bivalent iron, which is well absorbed.
This drug is prescribed only by the attending physician and if indicated. Taking Actiferrin on your own is not recommended. Before this, you need to take a blood test (general).
Pharmacodynamics and pharmacokinetics
Iron is a very important element for the normal functioning of the body. The substance is part of hemoglobin , cytochromes and myoglobin , participates in the process of oxygen transfer to all organs and tissues, stimulator of erythropoiesis . About 60% of the substance is part of red blood cells (hemoglobin) , 1 gram is the reticuloendothelial system of the liver and spleen . Iron is found in the bone marrow ; about 25 mg of the substance is found there every day.
The alpha amino acid serine improves iron absorption without requiring much less iron. It spreads faster throughout the body and is absorbed.
Folic acid is involved in the synthesis of amino acids , nucleic acids and nucleotides , and also takes part in erythropoiesis . The acid is very useful for pregnant women, protects against various teratogenic factors.
Absorption of the active components occurs in the duodenum and upper small intestine . About 15% of iron is absorbed here. However, if the patient has very low hemoglobin and increased erythropoiesis , then this figure can reach 50%. After 3 hours the drug reaches its maximum concentration in plasma.
Already in the bloodstream, iron binds to the enzyme transferrin and is transported to the necessary tissues and organs. The maximum amount of iron that reacted with the enzyme is 12 mg.
The deposition process takes place in the liver , bone marrow and spleen . Iron can cross the placenta and enter breast milk.
Every day the body loses up to 1 mg of iron, this occurs especially intensely in women during menstruation. After hemoglobin breaks down, the iron released in the process can be reused to synthesize a new oxygen carrier.
Features of good stagnation
To avoid possible overdose, it is necessary to take special care when stagnating grub or other additives that remove salinity.
If there is a history of inflammation or swelling of the mucous membrane of the scuteal-intestinal tract, it is important to consider the risk of inflamed scute-intestinal illness and irritation during treatment.
When taking Aktiferin capsules on a course, systematic monitoring of serum levels and hemoglobin levels is necessary.
Monitoring the progress of the treatment: if necessary, approximately through the skin 4 days, such parameters are assessed to determine the level of the deficiency of treatment, the response to treatment and the need to continue replenishing the body with treatment: hemoglobin, red blood cell count, mean red blood cell volume (MCV), mean values instead of hemoglobin in erythrocytes (MCH), reticulocyte quantity, blood serum level, transferrin level. A significant level of feritin in serum allows one to evaluate the accumulation of fluid; A serum feritin level of <15 µg/l indicates a lack of fertilin reserves in the body.
Looking at the rhizik, swellings of the mucous membrane of the oral cavity appear and the filling of the teeth of the capsule cannot be soaked, chewed or trimmed in the oral cavity. Roll the capsules whole with water.
Against the backdrop of treatment with Actiferin, you can be careful about the evaporation and emptying of the black color, due to the sight of the liquid that has not gotten wet. This has no clinical significance.
A benzidine test or similar tests for detecting blood in postpartum women may show a positive reaction. Three days before such an examination, it is necessary to take Aktiferin capsules.
To avoid reduced absorption, it is not recommended to drink Aktiferin with black tea or milk. The mixture may also include bread, grains, dairy products and eggs; components of vegetarian hedgehogs (agents that stabilize salivary complexes, such as phosphates, phytates and oxalates).
Aktiferin capsules contain sorbitol. Patients with rare episodes of fructose intolerance should not take medication.
This medicinal benefit cannot be limited to patients with hypersensitivity to soy or peanuts.
Treatments with care will prevent patients with the following illnesses: leukemia, chronic illness of the liver and liver, inflammation of the scylculo-intestinal tract, virulent disease of the scutum and duodenum, illness of the intestines (enteritis, Virus colitis, Crohn's disease).
Suspension during pregnancy or breastfeeding.
And information about impaired fetal development and subsequent pregnancy intoxication. During the period of pregnancy, Aktiferin can be taken only at a drop, if the crust exceeds the rhizic.
Medicinal methods to prevent infection, there is insufficient research into embryotoxicity in animals.
During the period of breastfeeding, Actiferin can be used to stool the breasts at the end, if the bark overextends the rhizic.
This is due to the fluidity of the reaction during treatment with vehicles or other mechanisms.
Didn't follow up.
Contraindications
The medicine is not prescribed:
- if you are allergic to the components of the drug;
- for hemochromatosis and hemosiderosis ;
- for anemia (including lead, sideroachrestic, thalassemia, hemolytic and caused by a lack of vitamin B12 );
- if you take other products containing iron;
- for serious gastrointestinal ( stenosis , intestinal obstruction );
- with fructose or galactose intolerance;
- if regular blood transfusions .
Contraindicated
- Hypersensitivity to active components or other components of a medicinal product.
- Hemosiderosis, hemochromatosis.
- Anemia with impaired salivary metabolism (phlegm-refractory anemia, lead anemia, thalassemia, sideroachrestic anemia).
- All other types of anemia, which do not resemble insufficiency (hemolytic anemia, megaloblastic anemia and anemia caused by vitamin B12 deficiency).
- Immediately stagnation of parenteral forms of injection.
- Stenosis of the grass tract and/or other obstructive diseases of the grass tract.
- Intestinal diverticula, intestinal obstruction.
- Regular blood transfusions.
Side effects
Possible occurrence:
- constipation , flatulence , diarrhea , abdominal pain, nausea, bitter taste in the mouth, loss of appetite;
- weakness, headaches , dizziness , rarely – encephalopathy ;
- pain or pressure in the chest, sore throat or toothache;
- allergies , skin rashes, anaphylactic shock .
If there are disturbances in the gastrointestinal tract , you should try to reduce the daily dose, the symptoms should disappear.
Instructions for Aktiferrin (Method and dosage)
The treatment regimen with the drug should be determined by the attending physician based on the results of tests and monthly monitoring. It makes no sense to take the drug for less than two months; indicators should be monitored every 4 weeks.
Aktiferrin drops, instructions for use
The dosage is calculated according to the formula: 5 drops of medication per kg of patient weight, the drug is taken 3 times a day:
- for infants, the daily dose is 30-45 drops per day;
- for preschoolers – 75-100 drops;
- for schoolchildren – 150 drops.
To open the bottle of medicine, lightly press on it and turn in the direction of the arrow, and after use, close it tightly.
Instructions for capsules
Do not chew or crack the capsules , wash them down with water or preferably orange juice, half an hour before meals. The daily dosage for adults is 1 tablet - 2 times a day, for children - the same amount once a day.
Instructions for syrup
To calculate the daily dose for persons over two years of age, you need to calculate 5 ml of the drug for every 12 kg of body weight.
As a rule, schoolchildren take 5 ml 3 times a day, preschool children - 5 ml 2 times a day.
Aktiferrin Compositum capsules
Also taken whole, before meals, washed down with juice; it is desirable that the juice contains a lot of vitamin C.
Adults and persons weighing more than 50 kg drink 2 capsules per day. For children, the dosage is one capsule per day.
Who is allowed to use
The instructions for "Actiferrin" emphasize that the drug being studied is safe. It suits almost all categories of citizens.
More precisely, you can use an iron-containing product:
- newborns;
- small children;
- teenagers;
- adults;
- old people;
- pregnant women;
- women during lactation.
The main thing is to choose the right dosage and follow the recommendations of doctors. Self-medication is prohibited. Even such a safe remedy as Actiferrin can, under certain circumstances, harm a person.
Overdose
The greatest risk of overdose is in children. Already taking one gram can pose a threat to the child’s life, so the drug must be well hidden.
Symptoms of overdose are: nausea, diarrhea , vomiting, drowsiness , shock and vascular collapse 5 hours after the onset of the first symptoms, an improvement may be observed, but within 12-48 hours the clinical picture may worsen significantly (shock, toxic liver failure , coagulopathy , Cheyne-Stokes respiration ).
Due to toxic hepatitis jaundice may appear , and disorders of the nervous system may occur, including coma. If therapy was carried out on time, the likelihood of death is significantly reduced.
First, you should rinse your stomach with bicarbonate or phosphate solutions , then take milk and a raw egg.
Deferoxamine may be prescribed intravenously. And another injection the next day.
Clinically proven ineffectiveness of hemodialysis peritoneal dialysis may be used .
In very severe conditions, sodium dimercaptopropanesulfonate .
Overdose
Symptoms
In young children, the risk of acute intoxication from mucus is particularly high; It is not safe for life. Intoxication is possible when taking 1 g of saliva sulfate. After the unbearable use of a large quantity of Aktiferin, fatigue, severe pain in the mouth, diarrhea and vomiting of blood through the development of hemorrhagic gastroenteritis occur. In severe episodes, cyanosis may develop, loss of fluid pressure and hyperventilation followed by the development of acidosis and loss of peripheral blood flow. After approximately 4–6 years, remission begins. After 12-48 years, severe shock may develop, which will be accompanied by Cheyne-Stokes syndrome, oliguria, diarrhea associated with toxic hepatitis, toxic liver failure and coagulopathy.
In some episodes, disorders of the central nervous system such as paralysis, stroke and coma may dominate; In some cases, coagulation is impaired. This phase of remote shock is likely to be lethal.
In the convalescent phase, bowel-intestinal strictures and symptoms similar to intestinal obstruction are rarely observed.
Likuvannya
Absorption of a large amount of saliva follows before the yakmog before. Before carrying out specific therapy, add milk and raw eggs.
Symptomatic arrivals:
call for vomiting, rinse the bottle with water or grub soda, or phosphate-buffer solution. If necessary, treat shock and acidosis.
Special therapy:
For patients with symptoms of acute overdose, in whom the serum level exceeds 300-350 mcg/dL, deferoxamine (Desferal) should be administered in the form of a trival intravenous infusion (according to The total infusion rate may become 15 mg/kg/year).
The first step for effective treatment is to overdosage and to ensure that the complex of the body enters the body, so patients with oliguria/anuria should be prescribed peritoneal dialysis or hemodialysis.
Whenever necessary, when treating shock, prevent artificial ventilation of the lungs, symptomatic support for blood flow, conduct x-ray control of the elimination of toxins from the body, monitor the level of serum flow and other indications. no blood serum.
In cases of severe intoxication: supplement with calcium diethylenetriamine pentaacetate parenterally.
Interaction
Tetracycline , ciprofloxacin , norfloxacin , ofloxacin , levofloxacin , penicillamine , carbidopa , levodopa and methyldopa under the influence of the drug may be poorly absorbed by the body; dose adjustment is required.
When combined with thyroxine and zinc, iron salts will be less absorbed in the stomach.
Citric and ascorbic acids enhance the absorption of iron.
Calcium, magnesium, chloramphenicol , cholestyramine, antacids containing aluminum, magnesium, calcium or bismuth reduce iron resorption.
When combined with glucocorticosteroids, of erythropoiesis may be enhanced .
Vitamin E reduces the activity of iron in the body, especially in children.
Side effects
On the side of the immune system:
allergic reactions, including anaphylaxis, scalp rashes, exanthema, urticaria, itching, episodes of ulceration of dental enamel in children.
On the side of the grass tract:
when administered in high doses, lungs may be affected by bowel-intestinal problems, such as heaviness of the bowel, flatulence, constipation or diarrhea, abdominal pain, boredom, pain in the epigastric tract, dyspepsia I, vomiting, virazkovic stomatitis (div. section “Peculiarities of stasis” )*. Taking this medicine may change the frequency of these side effects (section “Method of administration and dosage”).
*Be careful in case of improper infusion, such as chewing capsules, soaking them or rinsing them in your mouth. In patients of summer age and patients with sleep disorders, there is also a risk of strangulation and the development of bronchial necrosis due to improper congestion.
special instructions
bronchial asthma , rheumatoid arthritis , hepatitis , alcoholism , liver and kidney diseases, and diabetes should be careful .
Do not take tablets or capsules with black tea, milk, or coffee. Also, you should not simultaneously take (two hours apart) raw cereals, solid foods, bread, eggs and various dairy products.
The stool may turn black. In order to avoid staining your teeth black, you should brush your teeth after taking medications and do not drink undiluted syrup or drops.
Analogs
Level 4 ATC code matches:
Ferroplex
Fenyuls
The closest analogues: Sorbifer Durules, Ferroplekt, Maltofer, Totema, Gemoferon, Ranferon-12, Feron Forte, Gemsineral - TD .
Which is better Maltofer or Aktiferrin?
Maltofer , unlike the original drug, contains a polymaltose complex of ferric hydroxide and has some advantages over ferrous iron . For example, the likelihood of poisoning in case of an overdose is greatly reduced, the drug is less toxic, better tolerated, does not interact with food and other drugs, and tooth enamel does not turn black. However, the cost of Aktiferrin is slightly lower than that of its analogue. Judging by reviews on the Internet, both products are quite effective. The incidence of adverse reactions from both drugs is the same.
Indications for use
According to the instructions, Actiferrin is prescribed for iron deficiency anemia and iron deficiency caused by:
- Major blood loss;
- Lactation and pregnancy;
- Chronic gastritis;
- Gastrointestinal ulcer;
- Tumor diseases;
- Gastric resection;
- Past infections.
The use of Aktiferrin for children is effective during active growth, during periods of reduced body resistance, as well as in infectious and tumor diseases.
Reviews about Aktiferrin
The drug has generally good reviews. It is well tolerated, side effects are infrequent. Many people like the relatively low cost and variety of dosage forms. Actiferrin Compositum was more suitable for many, as it was better absorbed.
Reviews of Aktiferrin for infants
The product raises hemoglobin levels well, the child becomes more active, and skin color improves. However, side effects still occur and it is difficult to wash off clothes.
Additional Information
While taking this medication, tooth enamel may darken and stool may turn dark. Drinking strong alcoholic beverages while taking Actiferrin increases its absorption and provokes the appearance or intensification of side effects. The drug should be used with caution by people with kidney disease, liver disease, stomach ulcers, or duodenal ulcers.
The average cost of Aktiferrin drops in Russia is 270 rubles. The price depends on the region of residence and pharmacy chain.
Aktiferrin price, where to buy
The price of Aktiferrin drops is about 247 rubles per 30 ml.
The cost of 50 capsules of Actiferrin is 275 rubles.
The price of syrup is 198 rubles per 100 ml.
30 capsules of Actiferrin Compositum cost 241 rubles.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Aktiferrin drops for internal use.
approx. 30mlLudwig Merckle RUR 315 order - Aktiferrin syrup 100mlLudwig Merckle
RUB 243 order
Pharmacy Dialogue
- Aktiferrin (bottle 30ml)Merckle GmbH
RUB 375 order
- Aktiferrin (syrup 100ml)Merckle GmbH
RUB 157 order
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PaniPharmacy
- Aktiferrin capsule Aktiferrin caps.
No. 20 Germany, Merckle 294 UAH. order - Aktiferrin liquid Aktiferrin drops 30ml Germany, Merckle
309 UAH. order
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Cost of the medicine
We have studied the instructions for Actiferrin drops for children and adults. What do patients think about this drug? Numerous consumer reviews help judge the reliability of a drug.
Many people are dissatisfied with the price of an iron supplement. It is noted that a bottle of drops costs 350-500 rubles. Taking into account the duration of the course of treatment, we can come to the conclusion that eliminating anemia and replenishing iron in the blood will have to cost a lot.
Important: Actiferrin tablets are cheaper than drops and syrup, but this is not a suitable form of medication for everyone.
