To treat viral diseases such as human papillomavirus, colds, flu and herpes, the drug Allokin alpha is often used. In addition, it is used to treat hepatitis B and C. Such diseases will occur more quickly if a person’s immune system is so weakened that it cannot resist pathogenic bacteria and viruses. Allokin acts in such a way that interferons are produced as a result. They are known to have a positive effect on the body's immunity. In other words, interferons seem to inhibit all the mechanisms responsible for immune defense. Such drugs include not only Allokin alpha , but also Amiksin, Lavomax.
Pharmacological group
Alloferon, which is the active element of the drug Allokin-alpha, is an oligopeptide that exhibits pharmacological properties similar to interferon alpha. The antiviral effect of the drug is to induce the formation of endogenous interferon proteins and stimulate the activity of the natural killer cell system. Alloferon promotes the recognition and dissolution of defective cells by lymphocytes of the cytotoxic form.
A wide range of clinical studies prove the high degree of effectiveness of Allokin-alpha against infectious pathologies caused by strains of herpes viruses types 1 and 2, influenza A and B, human papilloma and hepatitis C and B.
The main pharmacological effects of Allokin-alpha are:
- elimination of symptoms of current infectious pathology of a viral nature;
- suppression of disease development;
- reducing the duration of exacerbation;
- reducing the likelihood of complications;
- eliminating the risk of relapse of pathology.
The active substance of the product does not have embryotoxic effects, does not cause allergic reactions, does not affect the reproductive system, and also does not have carcinogenic, mutagenic or general toxic properties.
Pharmacological action of Allokin-alpha
Allokin-alpha contains alloferon. Alloferon induces the synthesis of endogenous interferons and activates natural killer systems. This substance promotes rapid recognition and lysis of infected cells by cytotoxic lymphocytes.
When using Allokin-alpha, all parts of the patient’s immune system are strengthened: cellular and humoral.
During the treatment, the activity of T-lymphocytes, which constitute cellular immunity, increases. T-lymphocytes are designed to suppress and destroy the virus at the moment when interaction with the drug Allokin-alpha occurs.
Reviews of Allokin-alpha indicate that the drug is capable of producing endogenous interferon. It is this that allows the body to actively fight viruses.
After taking the drug, the transmission of neuromuscular impulses is stimulated, the conduction of excitation through cells and nerves is regulated. In addition, there is an increased effect of histamine, acetylcholine, serotonin, and oxytocin on smooth muscles.
The use of Allokin-alpha does not have a toxic effect on the patient’s body, and also does not cause activation of the immune system after the disease has been cured.
The main results of the pharmacological action of Allokin-alpha include:
- Reducing the duration of exacerbation of the disease;
- Complete removal of symptoms of viral infection;
- Qualitative reduction in the risk of possible complications;
- Excluding the occurrence of relapses in the future.
Indications for use
The use of Allokin-alpha is justified in case of a sharp decrease in the patient’s immune defense and, as a result, an outbreak of a viral infection. The drug is used to suppress the development of pathology and strengthen the immune system to effectively combat the cause of the disease.
for adults
Allokin-alpha is highly effective in combating the following pathologies:
- labial herpes;
- genital herpes;
- human papillomavirus;
- ARVI;
- cervical dysplasia;
- chronic form of viral hepatitis C and B;
- flu;
- mixed forms of urogenital infectious diseases;
- pathologies of herpetic nature;
- condylomas and warts.
for children
Children under the age of 18 are strongly not recommended to take Allokin-alpha.
for pregnant women and during lactation
Despite the absence of embryotoxic effects, the drug is strictly contraindicated for use by pregnant and lactating women. During lactation, Allokin-alpha can be used exclusively in conditions of complete refusal to feed the child breast milk.
Storage in pharmacies and clinics, transportation and disposal
Order No. 706n dated August 23, 2010 “On approval of the Rules for the storage of medicines.”
The drug "Allokin-Alfa" must be stored in clinics and pharmacies in accordance with the instructions on the primary packaging, at a temperature of 2 - 8 ° C. It is mandatory to use pharmaceutical refrigerators that allow the storage of thermolabile drugs in strict compliance with the required temperature and provide monitoring of storage conditions. Compliance with the rules for storing medicines is checked by a nurse or pharmacist. Readings must be recorded daily in a log book.
Medicines that have not been sold on time are prohibited from being stored together with other medicines. An employee of a clinic or pharmacy must move such drugs to the quarantine zone in a timely manner. Next, the drugs are transferred to the disposal service.
When transporting medicines, the instructions on the primary packaging from the manufacturer are taken into account. Vehicles must be equipped with refrigeration chambers and protection from mechanical shock and contamination.
Contraindications
Absolute contraindications to the use of the drug Allokin-alpha are:
- children under 18 years of age;
- the patient has autoimmune pathologies (for example, Libman-Sachs disease, diffuse toxic goiter, scleroderma);
- breastfeeding period;
- individual intolerance or excessive sensitivity to the composition of the drug;
- pregnancy.
Also, throughout the entire period of use of the drug, you must avoid drinking alcoholic beverages and alcohol-containing medications.
Mechanisms of interferon operation
When a virus enters the body, the immune system begins complex interactions between cells. Any cellular action is caused by cytokines - molecules made of protein. About two hundred such signaling molecules have been studied to date, and their peculiarity is that they have no effect on foreign antigens. They are useful only in that they transmit signals from one cell to another. Therefore, without the participation of cytokines, the immune system will not work. Interferon is just such a cytokine.
Interferon is produced in humans by white blood cells, but can also be stimulated by special drugs, for example, Allokin. In a healthy body, cytokines begin to be produced as soon as harmful microorganisms enter. They also activate natural killer cells - cells that digest viruses and bad bacteria . Thus, drugs with interferons are weapons against bacteria and cancer cells.
Applications and dosages
Allokin-alpha is used exclusively in the form of an injection solution for injection under the skin. In order to prepare the solution, it is necessary to dissolve the contents of the ampoule in 1 ml of physiological solution (0.9%). Do not dissolve the product with other drugs or foreign solvents. It is also contraindicated to mix several medications in one syringe. The Allokin-alpha solution should be used immediately after its preparation. For the most effective therapy, the dosage regimen and dosage of the drug are selected by the attending physician on an individual basis.
for adults
The drug should be administered exclusively subcutaneously.
In case of relapse of herpetic disease, 1 mg (1 ampoule) of the drug is prescribed every other day. The total amount of medication in a therapeutic course is 3 ampoules.
For the treatment of moderate exacerbation of hepatitis B, the drug should be administered immediately after final confirmation of the diagnosis in the amount of 1 mg (1 ampoule) 3 times a week. The duration of treatment is 3 weeks (9 ampoules).
The dosages of the medication required for the treatment of other pathologies from the list of indications are selected purely individually.
for children
Children and adolescents under 18 years of age are an absolute contraindication to the use of the drug Allokin-alpha.
for pregnant women and during lactation
During pregnancy and breastfeeding, the use of the product is strictly prohibited. If the patient refuses to breastfeed, the drug can only be used under the supervision of a specialist.
instructions for use. Price, reviews, analogues of Allokin-Alfa.
I also treated herpes with Allokin. I was prescribed exactly 3 injections. Maybe you have some kind of severe form, of course.
The dermatologist also prescribed me 6 injections of Alokin alpha for type 1 herpes. After 3 days the visible manifestations disappeared. Now I don’t know, should I inject the rest or are these enough?
I was pierced for HPV (several types), without any symptoms. It helped, HPV was not detected for 3 months. It’s nice, especially since it’s unexpected, I didn’t think it would go away the first time.
The drug is of course expensive. But it cures HPV. Most of the world's population contains a carrier. For example, I had cervical erosion. At first I tried drug treatment. The doctor warned, let’s try it, maybe it will help you. After treatment, the erosion decreased slightly, but did not go away. I was sent to get tested for human papillomavirus. And my result was positive. They prescribed me Allokin alpha and Viferon. And so I was cured!
My answer is late, Valentina, a month has passed. But maybe it will be useful to someone. My Allokin lay in the medicine cabinet for a day and a half (well, there’s no need to put it in the refrigerator). I got the piercing, but according to the tests, there is no HPV. It's not 30 degrees there. I have a cabinet by the window; they hadn’t heated it in the fall yet; the temperature was 16 degrees.
I had Allokin lying in my bag at work for half a day (I bought it at lunch and forgot to put it in the refrigerator), has it gone bad? Who knows?
Completed a course of treatment for gene. herpes Allokin and Valtrex six months ago. So far there have been no blisters. The drug seems to be working.
Valeria, HPV can go away on its own. You just need to be observed, take smears for HPV, and cytology. If the virus increases, then antiviral treatment is needed. My virus went away within a year. And one more thing - you can infect your partner, and he can infect you, too - so until the virus goes away, use a condom.
The papilloma virus can be completely cured, but the herpes virus cannot. I’ve had herpes since I was 17, it didn’t show up for a long time, but now it’s come out again. So, HPV seems to have gone away for now, tests show its absence, but herpes had to be treated again with Allokin-alpha injections. I liked this drug for the treatment of HPV, look what happens with herpes
Girls, hello! They also found HPV in me (((. The doctor said that since there is no erosion and condylomas, then there is no need to treat. Should I wait until something happens? And not be treated?
Hello. I was also prescribed Allokin for HPV. First, the condylomas came out (it was terrible), then HPV was discovered in the tests. The following treatment helped me: allokin-removal-viferon.
I read reviews - Allokin was prescribed for herpes. And I was prescribed Allokin for HPV. They took cytology - mild dysplasia. And so they assure me that it’s not scary, it happens, etc. I have doctors in my family, so I consulted. I took an HPV test and found types 16 and 18. I went to another gynecologist (based on reviews). Allokin, geneferon, spray were prescribed. Dysplasia has not been touched yet. After treatment, tests showed no HPV (I tested it after 3 months). Let's watch the neck.
I was treated for genital herpes with allokin and famciclovir, and also a spray. This was in the fall. So far there haven't been any during the winter and spring. The doctor said that the virus will not go away, but the rashes will be less frequent. Well, at least that’s how it was, otherwise there were almost every month.
With genital herpes, not everything is so simple, only those who are sick will understand. I was also prescribed isoprinosine along with allokin. It also popped up every month, after treatment it’s no longer 4 months (for me this is an achievement). A normal doctor will choose a treatment, of course it won’t go away at all, but at least not so often.
I no longer know what or how can help me. Every month after my period I get genital herpes. I treated him with everything, including Allokin-alpha, to no avail. First of all, it is very expensive and after several injections I did not see any effect, my immunity did not increase, and besides, other sores persisted.
Side effects
In most cases observed in medical practice, patients demonstrate a high level of tolerability of the medication. The main factors contributing to the development of side effects during the use of Allokin-alpha are:
- failure to comply with personal hygiene rules;
- incorrectly performed subcutaneous injection;
- ignoring doctor’s instructions and information in the instructions for the drug;
- simultaneous use of incompatible medications;
- using too large dosages of the drug;
- non-compliance with the dosage regimen.
The above factors can cause side effects such as:
- muscle weakness;
- feeling dizzy;
- worsening of herpetic disease.
Pharmacodynamics and pharmacokinetics
Allokin-Alpha is used for subcutaneous administration, after which it quickly penetrates the systemic circulation and interacts with immunocompetent cells . During clinical studies, it was revealed that the metabolites of the active component of the pharmaceutical drug are similar in structural structure to blood plasma proteins, therefore the time to reach the maximum concentration and its level is difficult to determine.
Within two hours after using the drug, an increase in the level of endogenous interferon compared to the usual background by 2-2.5 times. This amount of protein, which has immune properties, remains for the next 6-8 hours. An increased number of natural killer cells is observed for 7 days after a single use of the pharmaceutical drug.
Interaction with other drugs
During the treatment of a chronic form of recurrent genital herpetic disease, Allokin-alpha can be used in conjunction with acyclovir, as well as its derivatives. Both drugs complement their medicinal effects in the fight against viral infectious pathologies, despite the differing mechanisms of pharmacological action.
When treating the acute form of hepatitis B, the medication is used simultaneously with drugs included in the basic therapy complex.
There is no information on other drug interactions of Allokin-alpha.
Interaction
You should approach with caution the combination of Allokin-Alpha and immunomodulators in complex therapy. It is recommended to carry out regular diagnostic blood tests if the simultaneous use of these drugs is unavoidable.
The combination of Allokin-Alpha with Acyclovir in complex therapy of chronic recurrent forms of genital herpes is allowed, since due to the different mechanism of action of the active components of pharmaceutical drugs, their antiviral effects potentiate each other (the overall therapeutic effectiveness increases significantly).
special instructions
The use of the drug should begin immediately after the first manifestations of symptoms of pathologies. If a patient is suspected of having hepatitis B, treatment should begin almost immediately after symptoms of jaundice are identified.
Due to the fact that the medication can cause a feeling of dizziness, during the period of use of Allokin-alpha it is recommended to refrain from driving any vehicles, as well as from engaging in extreme activities and working with high-precision or dangerous mechanisms.
Allokin alpha and alcohol: is it possible or not?
This issue is very common , and therefore doctors warn the patient not to consume any alcoholic beverages during treatment. This ban is due to the fact that the medicine can interact unpredictably with ethanol. Drinking alcohol causes changes in the chemical composition of the blood. And the interferon produced is very sensitive to the slightest change in blood composition.
In the worst case, the ethanol concentration may increase and human intoxication may occur. Or there may be unpleasant side effects. In addition, ethanol can reduce the effectiveness of the drug, and then taking it will be useless.
Those who mixed the drug with alcoholic cocktails experienced weakness in the limbs, impaired visual concentration, dizziness and depression. Large doses of alcohol led to central nervous system disorders: disorientation in space, acute psychosis, manic states and even personality disorders.
It is precisely because of such terrible consequences that you need to follow the doctor’s instructions, giving up idle pastime for the entire period of therapy. But you should not drink alcohol immediately after finishing treatment, but only after two weeks. Why is this happening? The production of interferon after Allokin injections remains at an elevated level for a long time, protecting the body from negative environmental influences. And drinking alcohol can reduce the body's immune defense. Therefore, it is better to think before drinking, because it can lead to various consequences.
Analogs
The most common analogues of Allokin-alpha are the following drugs:
- Ergoferon. The dosage form is represented by lozenges. Active ingredient: complex of antibodies to histamine, human interferon gamma and CD glycoprotein
- Tiloram. The active substance is tilorone. Available in tablet form. Prescribed for the treatment of leukoencephalitis, tuberculosis and chlamydia. Can be combined with a number of antibiotic medications.
- Panavir. It differs from Allokin-alpha in the content of the active component of plant origin. Available in the form of a solution for intravenous injection, gel, as well as rectal and vaginal suppositories.
- Alpizarin. The active ingredient is tetrahydroxyglucopyranosylxanthene. The active element is of plant origin. Available in tablet form. It is most often used to treat herpes, shingles and chickenpox.
Allokin-alpha for HPV: application features
If warts and papillomas appear on the body with enviable regularity, then it is necessary to urgently contact a dermatologist for examination to determine the type of papillomavirus. Genital condylomas, which inhabit the mucous membrane of the genital organs, are considered especially dangerous for women. Such neoplasms can appear as a result of infection with strains such as 16, 31, 45, 18, 52, 39, 33, 51. It is completely impossible to cure the virus; there is no medicine yet that could completely defeat it, but it can be suppressed. If more than one method does not help, then we recommend Allokin-alpha for HPV. This is one of the most powerful and effective means.
Composition, release form and analogues
The active ingredient of Allokin-Alpha is alloferon (cytokine-like peptide), which is obtained by chemical synthesis methods. It is patented in many countries, including Russia, the USA, Japan and some European countries.
Currently, the drug is available in the form of a lyophilized white powder for the preparation of a solution. One ampoule of Allokin-Alpha contains 1 mg of alloferon. Ampoules are packaged in cardboard packs of 1, 2, 3, 5 or 10 pieces in special cell forms made of polymer materials.
There are no exact analogues of the drug (with the same active component), but there are drugs with a similar pharmacological action or effect (antiviral immunomodulatory). However, the active substance of such drugs is different, which means that the purposes and side effects are also different. For example, Lavomax, Amiksin, Giporamin and some other drugs are often mistakenly classified as analogues of Allokin-Alpha.
