The discovery of gamma-aminobutyric acid in 1950 created a tremendous sensation in the pharmaceutical market. Thanks to its ability to improve cerebral metabolic processes, provide a sedative effect, and promote the restoration of brain function after cerebrovascular accidents and injuries, aminalon has become widely used in mental retardation and in gerontological practice.
The pharmacological effects of nootropics consist of metabolic and neurotrophic effects. This, in turn, causes processes to improve redox reactions, reduce the aggressive effect of lipid peroxidation (LPO) products, and have a positive effect on neurotransmission. In addition, these drugs have a vasoactive and mild antiplatelet effect. Nootropics, including Aminalon, have found wide use in pediatric practice as effective and safe means for improving mental and motor functions in children.
Yusupov Hospital provides timely diagnosis and treatment of various neurological and mental diseases, both in adults and children. When treating mental disorders, clinic specialists use complex techniques. It is the combination of different types of procedures and the prescription of certain medications that allows us to provide effective assistance that will help a person return to a normal, fulfilling life. The medical center's hospital is equipped with high-tech equipment and powerful clinical and laboratory facilities. Each patient receives high-quality and effective medical care, which is provided by doctors of the highest category.
Aminalon: mechanism of action
GABA (gamma-aminobutyric acid) is the main mediator involved in the processes of central inhibition as a result of interaction with specific GABAergic receptors. Under the influence of the drug, brain metabolic processes are restored:
- energy processes are activated;
- glucose utilization improves;
- respiratory activity of tissues increases;
- blood supply improves.
GABA helps remove toxic metabolic products and normalizes the dynamics of nervous processes. Increases thinking productivity, improves memory, has a mild psychostimulating effect, and has a beneficial effect on the restoration of movements and speech after cerebrovascular accident. Has anticonvulsant activity. In patients with diabetes mellitus, it reduces the level of glycemia; in healthy people with normal blood sugar levels, the opposite effect occurs due to glycogenolysis.
Expert opinion
Author:
Elena Mikhailovna Bunina
Psychiatrist, doctor of the highest category
Aminalon is a nootropic, psychostimulant drug aimed at activating metabolic processes in the brain. The active ingredient of the drug helps neutralize toxins, has a beneficial effect on the restoration of memory and speech, thinking and motor functions after disruption of circulatory processes in the brain.
Main indications for use of Aminalon:
- atherosclerotic deposits on the walls of blood vessels;
- high blood pressure;
- consequences of traumatic brain injuries;
- pathologies of cerebral vessels;
- impairment of memory, speech, attention as a result of chronic cerebrovascular insufficiency;
- alcoholic polyneuritis;
- seasickness.
The drug is prescribed to children after traumatic brain injuries, with reduced psychophysical activity, and cerebral palsy.
The main contraindications for use include hypersensitivity to the components included in the product, acute renal and liver failure.
Aminalon is initially prescribed in an amount of 0.5 grams, after which it is increased to 1-2 grams per day, divided into two doses. The course of treatment can be extended from 2 weeks to several months and repeated if necessary. Specialists at the Yusupov Hospital practice comprehensive diagnosis and treatment of the listed diseases using Aminalon.
Pharmacodynamics and pharmacokinetics
Pharmacodynamics
Gamma-aminobutyric acid restores metabolic processes in the brain, helps the brain utilize glucose molecules and evacuate toxins from it, and regulates the dynamics of processes in the brain. Increases the productivity of thinking, has a psychostimulating effect, stimulates memory, activates the processes of restoration of motor skills and speech after cerebrovascular accidents. Stabilizes and lowers high blood pressure, weakens the subjective symptoms of arterial hypertension.
Has anticonvulsant and antihypoxic effects. In people with diabetes mellitus , it reduces blood glucose levels; with normal glucose concentrations, it has the opposite effect.
Pharmacokinetics
Absorption from the intestine is rapid and complete. The highest concentration in the blood is reached after 50-60 minutes, after which it quickly decreases. After a day, the drug is no longer detectable in the blood.
Some important tips
When using this medication, you must monitor your blood pressure. It should not be taken in the evening to avoid unwanted consequences such as sleep disturbance. During treatment with Aminalon, as mentioned above, it is prohibited to drink alcohol-containing drinks.
It is necessary to behave carefully and monitor your well-being after the first use of these tablets and when taking them for a long time. After all, psychomotor reactions may decrease and concentration may be impaired.
This drug is available without a prescription, but its use must be discussed with your doctor.
Indications for use of Aminalon
Indications for use of Aminalon:
- conditions after cerebrovascular accidents and traumatic brain injuries;
- polyneuritis and encephalopathy of alcoholic origin;
- atherosclerosis of cerebral vessels in combination with softening of brain tissue;
- cerebral palsy;
- worsening sleep due to arterial hypertension , dizziness , headache ;
- kinetoses;
- delayed intellectual development in children;
- consequences of birth and traumatic brain injury in children.
Signs of overdose
Signs of overdose appear when the permissible dose is exceeded many times. For adult patients, the dose causing an overdose is 10-20 g per day.
Exceeding the dose manifests itself:
- drowsiness;
- headache;
- vomiting;
- decreased heart rate;
- pain in the area of the stomach projection;
- increase in body temperature.
In case of overdose, treatment with the drug is stopped, and the patient is called a doctor and given first aid. If the victim is conscious, he is given gastric lavage and an ambulance is called, then Polysorb, Enterosgel or Activated Carbon are given.
Side effects
The drug is low-toxic, but in some cases the following reactions cannot be ruled out:
- on the circulatory side: increase or decrease in blood pressure;
- from the digestive system: nausea , dyspepsia , vomiting ;
- from the skin: rash , itching ;
- from nervous activity: feeling of heat, increased body temperature, insomnia , sleep disturbances.
When the dosage is reduced, these phenomena usually disappear quickly. If any adverse reactions develop, you must stop taking the drug and immediately consult your doctor.
Treatment of cerebrovascular pathologies at the Yusupov Hospital
Specialists at the Yusupov Hospital use modern treatment and patient management protocols in their practice. All drugs prescribed to the patient have undergone strict testing at the research stage and are approved by the international company FDA. In the Yusupov Hospital, in addition to effective diagnosis and excellent treatment, each patient and his relatives will receive psychological support from doctors and nursing staff. Cozy rooms and restaurant service will make the patient’s stay in a hospital bed comfortable. For more information, please make an appointment with a clinic specialist by phone. Also, anyone can do it online on the official website of the hospital.
Instructions for use of Aminalon (Method and dosage)
Aminalon tablets, instructions for use
The tablets are taken before meals. The total daily dose for adults is 3-3.75 grams. It is divided into 3 doses. The treatment cycle can last from 2 to 16 weeks.
For the prevention and treatment of kinetosis, are prescribed to take 500 mg of the drug three times a day for 4 days.
How to take Aminalon KB?
Capsules are taken orally before meals. Adults are recommended to take 2-5 capsules at a time, depending on the severity of the condition. The total daily dose recommended by the manufacturer is 6-12 capsules, divided into 3 doses.
For pediatric patients, the drug is prescribed starting from 5 years of age, 2-12 capsules per day, depending on the course of the disease. The daily dose is divided into 3 doses, the treatment cycle can last from 2 to 25 weeks. If necessary, additional courses of therapy are allowed after consultation with the attending physician.
For the treatment of motion sickness, adults are recommended to take 2 capsules of the drug (children over 5 years old, 1 capsule) three times a day for 4 days. In order to prevent motion sickness, adults are prescribed to take 2 capsules of the drug three times a day for 3 days preceding the intended trip.
Patient reviews
Elena, 46 years old:
After an injury, I was diagnosed with encephalopathy of complex origin. The attending physician recommended taking two drugs at the same time: Vinpocetine and Aminalon. According to the annotation, it is undesirable to combine these means, but in my case such a solution is considered appropriate. 2 weeks after the start of therapy, the alarming symptoms almost completely disappeared, but the course continued for another couple of months.
The main advantage of the medicine is its composition, which is safe for health.
Vladimir, 34 years old:
Since adolescence, I suffered from periodic headaches. After the examination, disturbances in cerebral circulation due to narrowed blood vessels were revealed. One of the medications recommended by the doctor was Aminalon. I had to take it for about 3 months.
The result was noted after the first month of taking the pills. Headaches became less frequent and intrusive.
During the therapy period, no side effects were observed, and there was no addiction to the drug. There are no complaints about Aminalon.
Interaction
When used simultaneously with benzodiazepine tranquilizers and anticonvulsants , as well as with barbiturates , a mutual enhancement of their effects is revealed.
Vitamin B6 can enhance the effects of gamma-aminobutyric acid .
When used in combination with benzodiazepine drugs, each drug should be prescribed in the lowest effective dose.
Reviews from neurologists
Aleksandrova N.M., work experience 17 years:
An excellent nootropic without an overstimulating effect. It is not recommended to use without prescription, guided by the safe composition and minimal risk of side effects. Only a specialist, after collecting a history of the disease, will be able to assess the symptoms of the disease and its progression.
Often, hardware testing is required to make an accurate diagnosis. Based on the data obtained, a suitable remedy is selected.
Efremov I. O., work experience 22 years:
An effective remedy that has been proven over the years. I mainly prescribe Aminalon tablets to older patients and children with mental retardation. The nature of the action is similar to drugs that stimulate brain activity. The result of treatment is not immediately noticeable, so the recommended course is mainly long-term, consisting of 2-3 months.
Despite the appearance on the modern pharmaceutical market of many new drugs with a pronounced effect, Aminalon has not lost its relevance.
Analogs
Level 4 ATC code matches:
Valparine
Gammalon
Convulex
Depakine Enterik 300
Depakin Chrono
Depakin Chronosphere
Depakin
The most available analogues of Aminalon are listed below: Gammalon , Biotropil , Lucetam , Nootropil , Piracetam , Phenibut , Phezam , Amylonosar , Noofen , Cavinton , Vinpocetine .
Aminalon price, where to buy
The price of Aminalon in tablets No. 50 in Russia averages 150 rubles. The price of such a package of medicine can reach 25 hryvnia.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Aminalon tablet p/o 250 mg No. 50 Borisov plant
132 rub. order - Aminalon tablets p.p.o. 250 mg 100 pcs. JSC Organika
RUB 163 order
- Aminalon tablets p.p.o. 0.25g 100 pcs. Borisov Medical Preparations Plant OJSC
186 RUR order
- Aminalon tablets p.p.o. 250 mg 50 pcs. JSC Organika
107 RUR order
Pharmacy Dialogue
- Aminalon (tablet p/o 250 mg No. 50) BZMP
87 RUR order
- Aminalon (tablet p/o 250 mg No. 100)Organika (Novokuznetsk Autonomous Okrug)
186 RUR order
- Aminalon (tablet p/o 250 mg No. 100) BZMP
RUB 176 order
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Pharmacy24
- Aminalon 0.25 No. 50 tablets PAT "Vitamin" Ukraine
26 UAH order - Aminalon-KV 0.25 No. 10 capsules PAT "Kiev Vitamin Plant", Kiev, Ukraine
5 UAH order
- Aminalon-KV 0.25 N50 capsules PAT "Kiev Vitamin Plant", Kiev, Ukraine
27 UAH order
PaniPharmacy
- Aminalon capsule Aminalon caps. 0.25g No. 50 Ukraine, Kiev Vitamin Plant PJSC
33 UAH order
- Aminalon tablets Aminalon tablets. p/o 0.25g No. 50 Ukraine, Vitamins PJSC
32 UAH order
- Aminalon capsule Aminalon caps. 0.25g No. 10 Ukraine, Kiev Vitamin Plant PJSC
6 UAH order
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