Cerebrolysin: instructions for use (ampoules, injections)

Cerebrolysin is a complex of peptides that are obtained from pig brain. Doctors at the Yusupov Hospital use the drug as part of complex therapy for diseases of the central nervous system. Cerebrolysin consists of 25% low molecular weight peptides and 75% free amino acids. The preparation contains high concentrations of microelements (magnesium, phosphorus, potassium, selenium) and vitamins. Cerebrolysin tablets are not available in the pharmacy chain.

Cerebrolysin is released in the form of a clear amber solution. The drug is administered intramuscularly, intravenously by stream and drip. According to indications, after a course of therapy in the form of injections, neurologists prescribe tablets of Cerebrolysin analogues. Their price is low. Medicines contain different active ingredients, but have the same effect as Cerebrolysin. Neurologists decide which drug to prescribe after studying the results of studies obtained using the latest devices in Europe and the USA.

pharmachologic effect

The drug is a stimulator of neurometabolic processes (has a nootropic effect).

Deproteinized hydrolyzate of pig brain substance stimulates cell differentiation processes, improves the functional state of nervous system cells and activates protection and renewal mechanisms.

Animal experiments have shown that the biologically active amino acids and peptides have a direct effect on neuronal and synaptic plasticity, which in turn helps improve higher brain functions .

Cerebrolysin or Actovegin - which is better for blood vessels in adults

Actovegin is an analogue of Cerebrolysin injections, also available in tablets for maintenance therapy. It is based on a hemoderivative of calf blood. Among the therapeutic effects are activation of metabolism in tissues, improvement of trophic processes and stimulation of regeneration.

To figure out which is better – Actovegin or Cerebrolysin, and whether these drugs can be taken at the same time, you need to compare them:

• both drugs have a nootropic effect;
• for ischemic stroke, dementia, neurological pathologies, any medication can be used;
• Cerebrolysin is better for improving cognitive functions - memory, attention, learning;
• Actovegin is often prescribed for peripheral circulatory disorders and diabetic polyneuropathy;
• Sharing is possible, and two medications cannot be taken into one syringe.

What is best in a particular case is determined by the doctor.

Pharmacodynamics and pharmacokinetics

As a result of studies using models of cerebral ischemia, it was possible to establish that the use of the drug allows:

• reduce heart attack ;
• prevent the development of edema ;
• stabilize microcirculation;
• normalize cognitive and neurological disorders ;
• double survival rates.

Based on studies using models of Alzheimer's disease , the following conclusion was made: in addition to the fact that the drug has a direct effect on neurons , it also helps to increase the number of molecules that transport glucose across the BBB (blood-brain barrier), and as a result, compensates for critical energy deficiency in the body.

A quantitative analysis of the encephalograms of healthy people and patients diagnosed with vascular dementia showed that with the use of the drug Cerebrolysin:

• neuronal activity increases significantly (activity indicators are dose-dependent);
• higher brain functions are objectively improved ;
• the ability to self-care and perform everyday tasks increases (as a result, the patient needs less outside care);

The drug has neurotrophic activity , which can significantly slow down, and in some cases stop, the progression of neurodegenerative processes .

During the experiments, it was revealed that Cerebrolysin does not provoke the formation of antibodies or the development of anaphylactic reactions, does not affect the immune system , does not stimulate histamine receptors and does not affect the hemagglutination of red blood cells .

Since the proteolytic peptide fraction obtained from porcine brain includes short biologically active peptides similar or identical to those produced in the body, it is not possible to conduct an accurate pharmacokinetic analysis of the drug.

Based on data on the pharmacodynamics of the drug, it was concluded that after a single administration of the drug, the neurotrophic activity of the hydrolyzate in the blood plasma is determined within 24 hours.

Cerebrolysin components have the ability to penetrate the BBB . Preclinical studies in vivo made it possible to establish identical pharmacodynamic effects of the drug on the central nervous system when administered into the ventricles of the brain and when administered peripherally. These studies provide indirect confirmation of Cerebrolysin's ability to cross cell membranes of the BBB .

Mechanism of action of Cerebrolysin

Cerebrolysin is a peptide drug produced by standardized enzymatic digestion of defatted porcine brain proteins. The peptides contained in Cerebrolysin are fragments of a number of brain-derived neurotrophic factors, neurotrophic factor, insulin growth factor-1 and insulin growth factor-2. Cerebrolysin neurotrophic factors exhibit neuroprotective and neuroregenerative effects in nervous tissue, enhance neuroplasticity and stimulate the formation of neurons. The clinical effectiveness of Cerebrolysin has been confirmed for the treatment of ischemic stroke, dementia (Alzheimer's disease, vascular dementia) and traumatic brain injury.

Cerebrolysin has a multimodal and pleiotropic effect. The term “multimodal action” indicates that Cerebrolysin exhibits all of the above effects: neuroprotection and neuroregeneration (neuroplasticity, neurogenesis). The term “pleiotropic effect” indicates that Cerebrolysin exhibits all components of the neuroprotective effect.

The antioxidant effect of Cerebrolysin is to reduce the enzymatic activity of the main enzymes that are activated under oxidative stress. It does this by reducing the formation of superoxide anion and hydrogen peroxide, which are substrates for these enzymes. Cerebrolysin has the ability to reduce the formation of hydroxyl radicals.

Cerebrolysin also has the following effects:

• Anti-inflammatory (in nervous tissue);
• Anti-apoptotic (reduces the severity of programmed neuronal death);
• Anti-amyloid (reduces the formation of Aβ deposits and intracellular TAU tangles in Alzheimer's disease).

Cerebrolysin increases the neuroplasticity of the brain - enhances the formation of nerve processes and their involvement in synaptic contacts. The drug enhances the formation of neurons both in a healthy brain and in cases of pathological damage.

Indications for use of Cerebrolysin

Indications for the use of Cerebrolysin are:

• organic lesions, metabolic disorders and degenerative diseases of the NS (especially Alzheimer's disease );
• complications that developed as a result of a stroke ;
• brain injuries and their consequences (conditions after neurosurgery, concussions and closed head injuries);
• delayed mental development in children;
• mental disorders that are accompanied by memory impairment, absent-mindedness , etc.

Indications

Cerebrolysin is indicated for many neurological diseases. Among them:

• Alzheimer's disease.
• Dementia of various origins.
• Encephalopathy.
• Ischemic stroke.
• TBI (concussion, brain contusion).
• Spinal injury.
• Mental retardation in pediatric practice.
• Endogenous depression, especially with resistance to antidepressants.

Side effects

In rare cases, Cerebrolysin injections can provoke:

• loss of appetite;
• depressive states;
• apathy;
• general weakness;
• arterial hypo- or hypertension;
• pulmonary hyperventilation syndrome;
• the appearance of shortness of breath;
• chest pain;
• increased fatigue;
• the appearance of flu-like symptoms.

Sometimes the therapeutic effect can be accompanied by agitation - strong emotional arousal with manifestations of aggression, confusion, and insomnia.

Too rapid administration of the drug can cause disorders of the nervous system, skin and subcutaneous tissues: dizziness , tremor , drowsiness , headache , sensation of heat , increased sweating, itching and redness of the skin, skin rashes (including the appearance of maculopapular rash ), urticaria .

In isolated cases the following were noted:

• hypersensitivity reactions or allergic reactions, angioedema , anaphylactic shock , chills and fever ;
• generalized epileptic seizures ;
• increased seizure activity;
• sensation of your own heartbeat, tachycardia , heart pain, arrhythmia (similar symptoms occurred when the drug was administered too quickly);
• dyspepsia;
• nausea and vomiting ;
• constipation or diarrhea ;
• reactions at the injection site (erythema, burning, local inflammatory reactions);
• painful sensations in the neck, back (in its lower part), and limbs.

Since the drug is often used to treat elderly people, some of the side effects that occurred during clinical trials may not have a cause-and-effect relationship with taking Cerebrolysin (most of them occur in this category of patients not only during the use of the drug).

Some of the identified side effects occurred with equal frequency in both patients treated with the drug and in patients taking placebo (changes in blood pressure, tremor, nausea, lethargy, dizziness, shortness of breath, tremor, diarrhea).

Answers on questions

1. Cerebrolysin - prescription or not?
   

   Yes, the drug is a prescription and is used as prescribed by a doctor. The dosage and course of treatment are also determined by a specialist.

2. How is Cerebrolysin administered - intravenously or intramuscularly?
   

   The method of administration is determined by the doctor based on the patient’s condition, severity of the disease, and age. Medicine up to 5 ml is administered intramuscularly, up to 10 ml intravenously, over 10 ml is prescribed in the form of droppers with other approved solutions.

3. Does Cerebrolysin increase or decrease blood pressure?
   

   Among the side effects when using the medicine and exceeding the dosage are arrhythmia, increased heart rate, increased or decreased blood pressure.

Cerebrolysin injections, instructions for use (Method and dosage)

The drug is intended for intravenous and intramuscular administration.

IV Cerebrolysin is administered in its pure form in a dose of 5 to 10 ml. If the patient is indicated for a dose of 10 to 50 ml (the maximum allowable dose), it is recommended to administer the solution exclusively by slow intravenous infusion after preliminary dilution to 100 ml with one of the standard solutions: Ringer's solution, isotonic NaCl solution, 5% glucose solution.

According to the instructions for use of Cerebrolysin, when diluted at room temperature and in a place unprotected from sunlight, the drug remains physically and chemically stable throughout the day, however, from a microbiological point of view, the solution for infusion should be administered immediately after preparation.

The duration of the course of treatment, as a rule, is from 10 to 20 days (daily administration of the drug is assumed).

A one-time administration of the maximum dose of the drug (50 ml) is allowed, but course use of Cerebrolysin is considered more effective.

Of fundamental importance for achieving the clinical effect of therapy is the use of dosages of the drug that are adequate to the diagnosis, as well as the correct choice of the method of its administration.

Recommended daily doses:

• from 5 to 30 ml - for degradation of cognitive function, organic pathologies and metabolic disorders of the brain;
• from 10 to 50 ml - to eliminate the consequences of a stroke;
• from 10 to 50 ml - for the treatment of brain injuries and their consequences.

For neurological diseases in children, injections with the administration of 1 to 2 ml of solution to the patient are indicated.

The recommended dose for children under six months of age is 0.1 ml per kilogram of body weight. The maximum daily dose for patients of this age category should not exceed 2 ml.

The effectiveness of treatment increases with each repeated course. Treatment is usually continued until there is a significant improvement in the patient's condition.

When conducting an initial course, the number of administrations can be reduced to 2 or 3 times a week. An interval should be maintained between repeated courses, the duration of which should be no less than the duration of the previous course of treatment.

The manufacturer does not produce the drug in tablet form, so it is pointless to look for instructions for Cerebrolysin tablets.

Cerebrolysin solution for intramuscular administration 5 ml 5 amp

Cerebrolysin

- a peptidergic nootropic with neurotrophic effects. It is used for various forms of neurological and psychiatric pathology: dyscirculatory encephalopathy, ischemic stroke, traumatic brain injury, concussion, dementia syndromes, mental retardation in children.

Latin name

Cerebrolysin / Cerebrolysin

Composition and release form
Cerebrolysin
solution for injection in ampoules of 1, 5 and 10 ml.
5 or 10 pcs. packaged. Cerebrolysin
aqueous solution contains 215.2 mg of Cerebrolysin concentrate (a complex of peptides obtained from pig brain).
The active fraction of Cerebrolysin
is represented by peptides whose molecular weight does not exceed 10,000 daltons.

Properties / Action

Cerebrolysin is a peptidergic nootropic with neurotrophic effects. Cerebrolysin contains low molecular weight biologically active neuropeptides that cross the blood-brain barrier and directly enter nerve cells. Cerebrolysin has a unique organ-specific multimodal effect on the brain, which is manifested in the ability of Cerebrolysin for metabolic regulation, neuroprotection, functional neuromodulation and neurotrophic activity.

• Metabolic regulation: Cerebrolysin increases the efficiency of aerobic energy metabolism of the brain, improves intracellular protein synthesis in the developing and aging brain.
• neuroprotection: cerebrolysin protects neurons from the damaging effects of lactic acidosis, prevents the formation of free radicals and reduces the concentration of lipid peroxidation products in the ischemia-reperfusion model, increases survival and prevents the death of neurons under conditions of hypoxia and ischemia, reduces the damaging neurotoxic effect of excitatory amino acids (glutamate).
• neurotrophic activity: Cerebrolysin is the only nootropic peptidergic drug with proven in vitro and in vivo neuron-specific neurotrophic activity, similar to the action of natural neuronal growth factors, but manifested in contrast to them, under conditions of peripheral administration. Cerebrolysin stimulates the differentiation of neurons and the sprouting of neurites in the process of postnatal brain development, supports the vital activity and survival of neurons, protecting them from damaging influences, slows down and stops the process of neurodegeneration in an experimental model that reproduces the pathological changes that occur in Alzheimer's disease.
• functional neuromodulation: cerebrolysin exhibits a positive effect in cases of cognitive impairment, improves concentration, processes of memorization and reproduction of information associated with short-term memory, increases the ability to acquire and retain skills, activates the process of mental activity, improves mood, promotes the formation of positive emotions, thus providing thus, a modeling influence on behavior. The multimodal, neuron-specific action of Cerebrolysin has been established in numerous experimental studies, and the clinical effectiveness of Cerebrolysin has been confirmed in prospective, randomized, double-blind, placebo-controlled clinical trials conducted taking into account GCP requirements in a number of international centers over the past 10 years.
• Pharmacokinetics

  The complex composition of Cerebrolysin, the active fraction of which consists of a balanced and stable mixture of biologically active oligopeptides with a total polyfunctional effect, does not allow for conventional pharmacokinetic analysis of individual components. Under these conditions, some insight into the pharmacokinetics of Cerebrolysin can only be obtained indirectly. Thus, it was found that after a single administration, the specific neurotrophic activity of plasma can persist for 8 hours.

• Indications

  Cerebrolysin is used for various forms of neurological and psychiatric, including neuropediatric and psychogerontological pathology, accompanied by progressive impairment of cognitive and intellectual-mnestic functions:

• chronic cerebrovascular pathology (dyscirculatory encephalopathy);
• ischemic stroke (acute phase and rehabilitation stage);
• traumatic brain injuries (traumatic brain injury, concussion, conditions after brain surgery);
• mental retardation in children;
• attention deficit disorders in children;
• dementia syndromes of various origins (presenile dementia, Alzheimer's disease, senile dementia of the Alzheimer's type, vascular dementia, mixed forms of dementia);
• endogenous depression resistant to antidepressants.
• Instructions for use and dosage

  Cerebrolysin is used only parenterally: in the form of intramuscular injections (1-5 ml) or intravenous drip infusions (10-60 ml). Doses and duration of treatment with Cerebrolysin depend on the nature and severity of the disease, as well as the age of the patient. The standard duration of treatment for Cerebrolysin injections is 4 weeks (minimum 5 injections per week, if possible - daily). In acute conditions (ischemic stroke, traumatic brain injury, complications of neurosurgical operations), Cerebrolysin is recommended to be administered as intravenous drip infusion in a daily dose of 10-60 ml in 100-250 ml of saline solution for 60-90 minutes. Course duration is 10-25 days. In the residual period of stroke and traumatic brain injury, Cerebrolysin is prescribed intravenously, 5-10 ml, for 20-30 days. For psychoorganic syndrome (dementia, depression), Cerebrolysin is prescribed as infusions of 5-10 ml for 20-25 and 10-15 days, respectively. In neuropediatric practice, Cerebrolysin is prescribed 1-2 ml (up to 1 ml per 10 kg of body weight) intramuscularly, daily, for a month, with the course repeated 2-3 times a year.

• Overdose

  Currently, no cases of overdose of Cerebrolysin have been reported.

• Contraindications
• acute renal failure;
• status epilepticus;
• individual intolerance to Cerebrolysin.
• Use during pregnancy and lactation

  Cerebrolysin should be used with caution in the first trimester of pregnancy.

• Side effect

  Cerebrolysin is one of the safest drugs. The low molecular weight of its constituent neuropeptides eliminates the possibility of anaphylactic reactions. Cerebrolysin is not mutagenic, teratogenic, or pyrogenic. In case of increased individual sensitivity, a very rapid intravenous infusion of Cerebrolysin may cause a slight increase in temperature. Adverse reactions to Cerebrolysin, which are observed extremely rarely, are short-lived and do not pose a danger to the patient.

• Special instructions, precautions, interactions

  Cerebrolysin is prescribed with caution for allergic diathesis, grand mal seizures; in the first three months of pregnancy.

• Drug interactions

  The simultaneous use of antidepressants in combination with Cerebrolysin may increase their effect.

  Read also:  Kameton shelf life after opening
• Storage conditions

  Store in a place protected from light at a temperature not exceeding 25°C. Shelf life: 5 years. Conditions for dispensing from a pharmacy - available with a prescription.

Interaction

The drug is incompatible:

• with drugs that can change its pH (5.0-8.0);
• lipid-containing drugs.

Cerebrolysin can be used with balanced solutions of amino acids , with vitamins , and drugs for the treatment of diseases of the heart and vascular system ; however, it is contraindicated to mix these drugs in one infusion bottle.

It is recommended to pay special attention to the potential pharmacological effects when used concomitantly with monoamine oxidase inhibitors (MAOIs) or antidepressants .

Cerebrolysin or Ceraxon

Ceraxon is a nootropic drug based on citicoline, prescribed for ischemic and hemorrhagic stroke, head injury and cognitive impairment. Often used for older people.

One of the differences between the analogue of the drug Cerebrolysin is the additional form in the form of an oral solution. It is packaged in a bottle with a dispenser syringe or disposable sachets.

Ceraxon ampoules are administered intramuscularly or intravenously, depending on the indications and severity of the patient’s condition. Then it is possible to enhance the effect with an oral solution.

The analogue restores damaged brain cells, improves cognitive functions, prevents the death of ischemic tissue, and reduces the severity of neurological manifestations of diseases.

Ceraxon differs from Cerebrolysin in its lower price and the presence of an additional release form - an oral solution. Both medications are used for recovery from TBI and stroke, and in cases of impaired cognitive function. However, Cerebrolysin is also used in children with developmental delay, hyperactivity and attention deficit disorder, and Alzheimer's disease. The mechanisms of action of drugs are different due to the incoming substances - Cerebrolysin consists of polypeptides, the cheap analogue Ceraxon contains citicoline.

Citicoline is also contained in the drugs Proneuro, Recognan, Neypilept, etc. Which is better is determined by the doctor specifically for each patient.

special instructions

The drug is prescribed with caution to patients with allergic (exudative-catarrhal) diathesis .

evidence that the drug may increase the load on the kidneys ; however, it should not be administered to patients with severe forms of renal failure .

Clinical studies did not reveal any effect of the drug on the ability to engage in activities requiring attentiveness and speed of psychomotor reactions, as well as on the ability to drive a vehicle.

However, in some cases, the possibility of developing undesirable side reactions from the mental sphere and the nervous system cannot be excluded, which in turn may temporarily impair the ability to drive a car and operate machinery.

The drug should be taken from an ampoule or vial immediately before injection or infusion. In this case, only a one-time set of solution from an ampoule or bottle is allowed.

If sediment or foreign impurities appear in the solution, as well as if the color of the solution changes, it is prohibited to use it. Under normal conditions, the color of the liquid is amber.

Analogs of Cerebrolysin

Level 4 ATX code matches:
Bravinton

Acefen

Carnicetine

Pyracesin

Nooclerin

Semax

Piracetam

Olatropil

Fezam

Vinpocetine

Cerebrocurin

Cavinton Forte

Calcium Hopanthenate

Glutamic acid

Cephabol

Olanzapine

Cerebrolysate

Pramistar

Sidnocarb

Vinpotropil

Analogues of Cerebrolysin in ampoules are the drugs Amylonosar , Bravinton , Vinpocetine , Cavinton , Cortexin , Piracetam , Lucetam , Nootropil , Piracetam Bufus , Piracetam-Vial , Picamilon , Ceraxon , Cerebrolysate , Escotropil , Vinpotropil , Cellex , Thiocetam .

The drug also has analogues in tablets: Amylonosar , Acefen , Vero-Vinpocetine , Vinpotropil , Vinpocetine , Vincetine , Ginkgo Biloba , Glycine , Idebenone , Gopantam , Cavinton , Calcium hopanthenate , Ginkoum , Carnicetine , Combitropil , Lucetam , Memotropil , Neuromet , Noben , NooKam , Noopept , Nootropil , Pantogam , Picamilon , Pikogam , Piracezin , Omaron , Piracetam , Pyriditol , Telektol , Pantocalcin , Phezam , Phenotropil , Encephabol , Korsavin , Celestab , Carniteps .

Cheaper analogs of Cerebrolysin are Cerebrolysate , Glycine , Nootropil , Cinnazarin , Instenon .

Cerebrolysin or Cortexin - which is better for adults and children

Cortexin is a cheaper analogue of Cerebrolysin in ampoules, also obtained from pig brain. Available in powder, dissolved in sodium chloride, water or novocaine before use. The drug is administered intramuscularly once a day, for severe lesions - twice a day. Is a painful injection.

Cerebrolysin substitute has similar effects. The medicine improves cognitive function, improves metabolism in damaged brain tissue and protects cells from destruction and adverse factors, accelerates the synthesis of peptides and metabolic processes. Restrictions on use include pregnancy and individual intolerance to the components.

Cerebrolysin is a similar drug in the form of ampoules ready for administration. It has the same therapeutic effects as Cortexin. Has positive reviews from doctors.

What is the difference between the two analogues:

• The cost of Cortexin is lower.
• Cerebrolysin is not used for status epilepticus and acute renal failure; in this case, Cortexin is the drug of choice.
• For children and adults with mild brain damage, Cortexin is recommended; for severe conditions, Cerebrolysin is more often prescribed.

Which is better, Cortexin or Cerebrolysin, depends on the severity of the patient’s condition, indications, history of contraindications, and financial capabilities.

During pregnancy (and lactation)

Studies conducted on animals did not reveal the toxic effect of the drug on the reproductive system. However, there is currently no data on how Cerebrolysin can affect human reproductive function.

In this regard, it is prescribed to pregnant women only in cases where there is no alternative to therapy using Cerebrolysin. If it is necessary to undergo a course of treatment with the drug during lactation, it is necessary to decide on stopping breastfeeding.

Reviews of Cerebrolysin

As with any other drug, reviews from doctors and patients about Cerebrolysin can be found very different. Moreover, many foreign experts consider it an expensive dummy with unproven effectiveness. At the same time, our doctors prescribe the drug quite often, and patients - if you believe the reviews left - are often satisfied with the achieved treatment results.

For children, injections are effective when necessary to eliminate the consequences of birth trauma , in case of perinatal pathology of the central nervous system , to reduce tension in the nervous system . In addition, the drug stimulates brain and speech development in children who have been diagnosed with delayed speech development .

At the same time, many mothers note that the effectiveness of the drug directly depends on the correct selection of the dose and duration of treatment. Some believe that Cerebrolysin works well in high dosages and in combination with a complex of physiotherapeutic measures.

According to parents whose children were treated with the drug, especially pronounced progress in children is observed if therapy was started before one year.

A number of negative reviews about Cerebrolysin for children are due to the fact that the injections are quite painful, expensive and have contraindications.

Reviews from adults about the drug are quite contradictory. On forums where people discuss certain medications, many positive reviews have been left about Cerebrolysin as an effective and time-tested remedy.

Some patients say they did not notice the expected effect. However, the instructions for Cerebrolysin warn that the greatest clinical effectiveness is observed after not one, but several courses of treatment.

Drugs available in both forms

Many pharmaceutical companies produce Cerebrolysin substitutes in two dosage forms - for oral and parenteral use.

Cavinton

It is produced in the form of parenteral solution and tablets. The drug is effective in the treatment of cerebrovascular disorders, neurological and systemic pathologies. The drug prevents the development of ischemia in brain cells and restores cognitive function after a stroke. The active ingredient in the medicine is vinpocetine.

Cavinton is used for:

• hypoxia and ischemia;
• decreased concentration and attention;
• decreased intelligence and memory;
• encephalopathy of discirculatory type;
• Meniere's syndrome.

Cavinton is not prescribed for:

• cardiac pathologies with disturbances in the rhythm of myocardial function and hypertension;
• kidney failure;
• pregnancy and breastfeeding.

The tablets are taken orally three times a day, 1-2 tablets after meals. The solution for parenteral use is administered by injection or drip. The solution should be used once a day. After a course of injection therapy, the patient is transferred to taking tablets.

Side effects:

• blood pressure fluctuations and arrhythmia;
• dizziness and headache;
• insomnia or drowsiness;
• dyspepsia;
• skin rash, hyperemia, itching, as well as allergic rhinitis and bronchospasms.

Mexidol

This is a membrane-protective drug based on ethylmethylhydroxypyridine succinate. The medicine is prepared in tablets and solution for injections.

Mexidol has the following properties:

• antihypoxic and antisiolytic;
• nootropic and anticonvulsant;

Mexidol is used for:

• impaired cerebral blood flow;
• encephalopathy;
• withdrawal syndrome;
• vegetative-vascular dystonia;
• atherosclerosis of cerebral arteries;
• infectious stomatitis and caries.

Mexidol is not prescribed for:

• severe pathologies of the liver and kidneys;
• allergies to the composition;
• breastfeeding and childbearing.

Also not prescribed to children under 12 years of age, pregnant women and mothers whose children are breastfed. Prescribed with restrictions for sharp fluctuations in blood pressure - hypertension and hypotension.

Mexidol is used intravenously by injection or dropper, as well as intramuscularly. Acute attack of stroke - therapy is carried out from the first hours of the attack 200-300 mg 2-3 times a day. After the patient’s condition has stabilized, they switch to oral medication.

The maximum dosage per day of Mexidol for cerebrovascular pathologies is 800 mg. Treatment of dementia is carried out with tablets - 3 doses per day, 1-2 pieces each

Side symptoms:

• dyspepsia;
• insomnia;
• headache;
• urticaria and bronchospasms.

Vinpocetine

Vinpocetine corrects blood flow when blood flow in the brain is impaired. The active ingredient is vinpocetine. The medicine is produced in the form of a solution and tablets.

Vinpocetine is used for:

• encephalopathies and migraines;
• cerebral infarction;
• atherosclerosis of the cerebral arteries;
• head injuries;
• Meniere's syndrome;
• dementia;
• withdrawal symptoms – medication and alcohol.

Not prescribed for:

• cardiac diseases and arrhythmias;
• intolerance to components;
• hemorrhagic stroke.

Vinpocetine is not used in pediatric practice, in the treatment of women with breastfeeding and childbearing. Tablets should be taken 1-2 tablets three times a day, course from 2 weeks to 2 months.

The solution is injected into a vein only by drip. Dosages are prescribed by the doctor individually to each patient.

Negative symptoms:

• skin allergies;
• dyspepsia;
• sleep disturbance and headache.

See also:

TOP 10 analogues of Cavinton - a substitute in tablets and other forms

Cerebrolysin price, where to buy

Price of Cerebrolysin in Russia

Prices for Cerebrolysin injections on the Russian pharmaceutical market are as follows:

• ampoules 1 ml No. 10 - 660 rubles;
• ampoules 2 ml No. 10 - 910 rubles;
• ampoules 5 ml No. 5 - 970 rubles;
• ampoules 10 ml No. 10 - 1350 rubles.

There is no point in looking for the price of Cerebrolysin in tablets, since the drug is available exclusively in solution form.

Price of Cerebrolysin ampoules in Ukraine

The cost of ampoules of 1 ml No. 10 is 200 UAH, you can buy ampoules of 5 ml No. 5 for about 330 UAH. Ampoules of 10 ml No. 5 in Ukrainian pharmacies cost an average of 540 UAH.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

LuxPharma* special offer

• Cerebrolysin amp.
  1 ml No. 10 2680 rub. order

ZdravCity

• Cerebrolysin solution for in. 20ml 5 pcs EVER Neuro Pharma GmbH

  RUB 2906 order

• Cerebrolysin solution for in. 10ml 5 pcs EVER Neuro Pharma GmbH

  RUB 1,373 order

• Cerebrolysin solution for in. 5ml 5 pcs EVER Pharma Jena GmbH/Hameln Pharmaceuticals GmbH

  RUR 886 order

Pharmacy Dialogue

• Cerebrolysin (amp. 20ml No. 5)EVER Neuro Pharma

  RUB 3,066 order

• Cerebrolysin ampoules 10ml No. 5EVER Neuro Pharma

  1410 rub. order

• Cerebrolysin (amp. 5 ml No. 5)EVER Neuro Pharma

  RUB 1,077 order

• Cerebrolysin (amp. 2ml No. 10)EVER Neuro Pharma

  1110 rub. order

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Pharmacy24

• Cerebrolysin 5 ml N5 solution for injection
  715 UAH. order
• Cerebrolysin 10 ml N5 injection solution

  1147 UAH. order

• Cerebrolysin 430.4 mg 2 ml No. 10 injection solution Ever Neuro Pharma GmbH., Austria

  678 UAH. order

• Cerebrolysin 20 ml N5 injection solution Ever Neuro Pharma GmbH., Austria

  2025 UAH. order

PaniPharmacy

• Cerebrolysin ampoule Cerebrolysin solution for injection 20ml No. 5 Austria, EVER Neuro Pharma

  1979 UAH order

• Cerebrolysin ampoule Cerebrolysin solution for injection 2ml No. 10 Austria, EVER Neuro Pharma

  684 UAH. order

• Cerebrolysin ampoule Cerebrolysin solution for injection 10ml No. 5 Austria, EVER Neuro Pharma

  1175 UAH. order

• Cerebrolysin ampoule Cerebrolysin solution for injection 5ml No. 5 Austria, EVER Neuro Pharma

  745 UAH. order

• Cerebrolysin ampoule Cerebrolysin solution for injection 1ml No. 10 Austria, EVER Neuro Pharma

  673 UAH. order

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Price

Cerebrolysin is dispensed from pharmacies with a doctor's prescription; prices may vary depending on the markups of the pharmacy chain. Average prices are:

• Packaging of 1 ml ampoule No. 10, 580-650 rubles.
• Packaging of 2 ml ampoule No. 10, 951-1146 rubles.
• Packaging of 5 ml ampoule No. 5, 918-1143 rubles.
• Packaging of 10 ml ampoule No. 5, 1289-1667 rubles.
• Packaging 20 ml ampoule No. 5 2500-2700 rubles.

You should not treat yourself; there are contraindications. Before using Cerebrolysin, consult your doctor!