"Eufillin": reviews. "Eufillin": indications for use

In what cases is a drip with aminophylline prescribed?

Parenteral administration of aminophylline is indicated in the following cases:

• Relief of status asthmaticus, reversible bronchospasms of various etiologies, pulmonary emphysema;
• Pulmonary hypertension, as a component of complex therapy for “emphysematous heart”;
• Combinations of cardiac asthma and bronchospasm, respiratory disorders of central origin;
• Relief of cerebral vegetative-vascular crises against the background of atherosclerosis of cerebral vessels;
• In the treatment of cerebral blood flow insufficiency, cerebral edema, osteochondrosis of the cervical spine;
• Intensive therapy of ischemic stroke.

  

Contraindications to the use of aminophylline:

• Acute cardiovascular failure;
• Angina pectoris, acute coronary syndrome;
• Severe disturbances of rhythm and intracardiac conduction;
• Hemorrhagic stroke, intracerebral hemorrhage;
• Pulmonary edema;
• Peptic ulcer of the stomach and duodenum in the acute stage;
• Epilepsy, convulsive syndrome;
• Hormonal pathology of the thyroid gland;
• Multiple organ failure;
• Pregnancy and breastfeeding.

Contraindications for use

The drug "Eufillin" (indications for the use of this drug include many exceptions) has a large number of contraindications.

So, the presented medication is highly not recommended for use for treatment if you experience at least one of the following phenomena:

• hypersensitivity to one of the constituent substances, including derivatives of an element such as xanthine (pentoxifylline, caffeine, theobromine);
• arterial hypertension;
• arrhythmia;
• myocardial infarction;
• myocardial pathology;
• heart failure;
• ulcer of the duodenum or stomach;
• chronic or acute (especially in the acute phase) gastritis;
• diarrhea;
• prostate adenoma;
• pulmonary heart;
• fibrocystic mastopathy;
• hypoxemia;
• alcoholism;
• hyperthyroidism;
• fever;
• diseases of the rectum;
• respiratory tract infections;
• liver dysfunction;
• acute or chronic kidney failure;
• edema syndrome;
• breast-feeding;
• hypernatremia;
• pregnancy.

Technique, solution components and frequency of procedure

Eufillin is administered exclusively intravenously under the supervision of medical personnel!

Instructions for using aminophylline for droppers require the following certain rules:

• The solution temperature should be 370C;
• If possible, administer in the first half of the day (the drug has a stimulating effect on the central nervous system);
• Aminophylline should be diluted only in 0.9% sodium chloride solution;
• It is prohibited to mix the drug in one syringe for bolus administration.

Prepare the solution immediately before administration. Storage of residues and reuse is unacceptable.

When injecting aminophylline, the patient should be in a supine position. It is necessary to monitor blood pressure, heart rate, breathing parameters and the general subjective state of the patient. In case of rapid administration, increased heart rate, nausea, and vertigo may occur.

Asthmatic status. In case of a serious condition of the patient, it is permissible to administer aminophylline intravenously as a bolus for 5 minutes under blood pressure control with a transition to intravenous drip administration. Dilute 15 ml of aminophylline solution 2.4% in 200 ml. saline solution, add 90-120 mg of prednisolone and administer at a rate of 30-50 drops per minute. When the patient’s condition normalizes, they are transferred to alternative forms of the drug.

Pulmonary hypertension. Dilute 10-15 ml of 2.4% aminophylline in 150 ml of saline solution. Inject at a rate of 30-40 drops per minute. The saturation dose is 3 mg/kg/day. When systemic pressure decreases, they switch to tablet forms of methylxanthines.

Cerebral vascular crisis. The administration of aminophylline is combined with papaverine 2-4 ml, beta blockers (anaprilin 0.25% diluted in 500 ml. 5% glucose).

Ischemic stroke and cerebral edema. 10 ml of a 2.4% solution of aminophylline in 150 ml of saline in combination with dexamethasone, 2.0-4.0 ml of Lasix, 10 ml are administered intravenously. 25% magnesia. Additionally, L-lysine aescinate is administered 5-10 ml per 100 ml of saline solution slowly by drip. This treatment is carried out until clinical improvement.

Osteochondrosis. During periods of exacerbation, it is advisable to prescribe combined droppers with aminophylline, painkillers (analgin, baralgin), dexamethasone, Lasix, papaverine. The course of treatment lasts no longer than 7-10 days.

If possible, you need to monitor the level of potassium and theophylline in the blood serum, and do not exceed a daily dose of 10 mg/kg.

During treatment with aminophylline, you should refrain from drinking alcohol and products containing methylxanthine (coffee, cocoa, chocolate, tea).

Forms of release and composition of the drug

Currently, the drug can be purchased in two different forms, namely:

• In tablets that contain 150 mg of the active ingredient aminophylline. This drug is sold in cardboard packages of 50, 10, 30 or 20 pieces.
• The drug "Eufillin" in ampoules. 2.4% solution for injection (1 ml) contains 24 mg of aminophylline.

Only your attending physician should recommend which form of medication to use to treat a particular disease.

What effect is expected from taking a dropper?

Effects of parenteral aminophylline:

• Relieves obstruction in patients with bronchial asthma, emphysema;

  

• Optimizes the functions of the respiratory and intercostal muscles;
• Improves respiratory function parameters, blood oxygen saturation, stimulates the respiratory center;
• Balances blood rheological parameters, inhibits platelet aggregation;
• Stimulates the activity of the central nervous system, cardiac contractility, increases coronary blood flow;
• Relieves the tone of the walls of blood vessels;
• Reduces perifocal cerebral edema, intracranial pressure;
• Reduces the general resistance of the arteries of the pulmonary circulation;
• Increases renal perfusion, moderately stimulates diuresis;
• Improves microcirculation in cartilage tissue, relieves inflammatory swelling.

It is worth remembering the likelihood of side effects:

• Vertigo, migraine, psychomotor agitation, sleep disorder, tremor, convulsive syndrome, insomnia, hallucinations;
• Epigastric discomfort, nausea, gastroesophageal reflux, heartburn, exacerbation of stomach ulcers, diarrhea, anorexia;
• Metabolic imbalance, disturbance of the acid-base state of the blood;
• Rhythm disturbances, tachycardia, vascular collapse, exacerbation of angina pectoris, extrasystoles, progression of heart failure;
• Hyperthermia, facial redness, sweating, shortness of breath.

The principle of action of the medication

The mechanism of action of the presented drug is that it inhibits the enzyme phosphodiesterase, due to which cyclic adenosine monophosphate accumulates in the tissues, and also reduces the flow of calcium ions into the cells that are responsible for muscle contraction, which relaxes the smooth muscles of the bronchi.

It should also be noted that the drug "Eufillin" (ampoules, tablets) is capable of stimulating cardiac activity by increasing the frequency and force of myocardial contraction. It lowers the tone of blood vessels in organs such as the kidneys, brain and skin.

By having a relaxing effect on the walls of the veins in the pulmonary circulation, this medication helps to lower the pressure in it. The use of the drug "Eufillin" significantly improves blood supply to the kidneys. Thanks to this, the formation and, accordingly, the excretion of urine significantly increases. The drug helps slow down platelet aggregation. It should also be said that “Eufillin” makes red blood cells resistant to damage. In other words, it significantly improves the rheological properties of blood.

It is also known about the tocolytic effect of this drug on the uterus. It can also increase the acidity of gastric juice.

Drug interactions

• When used simultaneously with this medication, the bronchodilating effect of Salbutamol and Terbutaline is noticeably enhanced.
• Simultaneous use of the drug "Eufillin", the price of which does not exceed 40 Russian rubles, with beta blockers can quite easily cause bronchospasms.
• When using this remedy, it should be borne in mind that its effect is noticeably enhanced if simultaneously treated with drugs such as Erythromycin and Cimetidine, as well as taking an influenza vaccine and using oral contraceptives.
• The level of concentration of this drug in the blood decreases when used simultaneously with the drugs Carbamazepine, Rifampicin and Phenytoin.

Pharmacology

The instructions accompanying the Eufillin ampoules indicate that the drug belongs to the PDE category. The main active agent is theophyllion ethylenediamine salt. Such a chemical molecule quickly dissolves and is effectively absorbed upon penetration into organic tissues. The active compound promotes the expansion of bronchial lumens. It is assumed that this effect is explained by the fact that the active substance relaxes the smooth muscle fibers of the respiratory system, thereby correcting the activity of the blood vessels of the pulmonary system and the respiratory muscles. The scientists who conducted the study of aminophylline believe that this effect is associated with selective inhibition of the activity of a number of PDEs. As a consequence, the intracellular concentration of cyclic AMP increases.

Intended for intravenous infusion, "Eufillin", as stated in the accompanying official documentation from the manufacturer, contains an ingredient that can affect the body due to the third and fourth types of isoenzymes, which become less active. Potential side effects caused by the drug are associated with these same processes and features. For example, it is noted that theophylline can cause a decrease in blood pressure and the appearance of a gag reflex. The active ingredient of the drug inhibits purine receptors. Scientists believe that this fact is one of the aspects of the complex effect on the bronchial system.

general information

Aminophylline is the international nonproprietary trade name of the drug. It is produced in the form of tablets (one hundred and fifty milligrams) and in ampoules for injection.

Chemical composition. The main active ingredient is aminophylline. Magnesium, potato starch and povidone act as excipients. One ampoule (five milliliters) contains one hundred and twenty milligrams of aminophylline, as well as an additional substance - water for injections. May be transparent or acquire a yellowish tint.

Dispensed with a doctor's prescription. The medicine should be stored in a dry place. The temperature should not exceed twenty-five degrees. The medication has several analogues (for example, “Theotard”, “Teopek” or “Combipack”).

Eufillin - side effects and overdose during treatment with the drug

Eufillin can provoke in a sick body the presence of side effects in the form of vomiting, heartburn, pain in the chest, increased sweating, migraines, chills, skin reactions at the injection site.

Cases of overdose have also been recorded in medical practice. Thus, with a systemic overestimation of the daily dose of Eufillin, the patient develops gastrointestinal bleeding and arrhythmia in the ventricle, and symptoms such as fear of light, nausea, convulsions, and vomiting predominate. You should respond to such alarming signals immediately: first of all, completely stop taking Eufillin, perform gastric lavage and take sorbents.

Are there any analogues

Pharmaceutical products contain aminophylline, like Eufilin:

• "Aminophylline".
• "Aminomal."
• "Diaphilin".

The preparations Teopek and Teotard are similar in belonging to the same group, but differ in ingredients. They also belong to the class of bronchodilators that inhibit phosphodiesterase. From this class, quite popular pharmaceutical products are “Apo-Oxtrifillin”, “Afonium”, “Ventax”.

If necessary, replacing the prescribed drug with an alternative is important and it is necessary to coordinate the choice of an analogue with the doctor. Unsuccessful selection of a replacement will cause the ineffectiveness of the therapeutic course, and is also associated with the danger of undesirable effects

Application for cellulite

According to numerous reviews, the drug is actively used in the fight against “orange peel”, which occurs due to various circumstances (improper lifestyle, hormonal imbalance). To prepare a special product, mix a little Vaseline, baby cream, and an Eufillina ampoule (one piece per seventy kilograms of body weight). Instead of a solution, tablets are also suitable, but they must be crushed to the consistency of a powder.

Apply the finished product to problem areas affected by cellulite and wrap them in cling film. Before use, you need to use a scrub and take a hot shower to steam the skin. The duration of such procedures does not exceed half an hour. They are performed every other day for two months.

special instructions

In what cases should you take Eufillin with extreme caution? Reviews from experts indicate that this drug should be used only as prescribed by a doctor and strictly under his supervision, especially if the patient has a fever of unknown origin. Elderly persons should take the drug with extreme caution.

It should be noted that the drug "Eufillin" can increase the level of uric acid in the urine. While using this medication, use extreme caution if you consume large amounts of caffeine-containing foods and drinks at the same time.

Before parenteral administration, it is recommended to warm the medicinal solution to body temperature.

Pharmacological ability

The action of "Eufillin" is aimed at reducing the tone of smooth muscles. Under the influence of the drug, muscle spasms are reduced. This property of the medicine is used by official medicine to treat congestive conditions; the injection improves vascular circulation and helps cleanse the bronchi. Eufillin injections have the following therapeutic effects:

• relieve spasm in the bronchi;
• activate the respiratory center;
• increase myocardial heart rate;
• improve coronary circulation;
• reduce vascular tone;
• prevent the development of allergies.

The range of pathologies for which the Eufillin solution is used is quite wide, but the main indication for the use of the drug is the relief of bronchospasm.

Side effects

The medicine "Eufillin", the instructions and reviews indicate this, can cause negative reactions in the body. Side effects include:

• increased sweating;
• excitation;
• nausea;
• headache;
• diarrhea; heartache.
• vomiting;
• insomnia;
• arrhythmias;
• heartburn;
• dizziness;
• decreased blood pressure;
• increased heart rate;
• allergies;
• stomach ache;
• tremor.