pharmachologic effect
Many people wonder: Is Nolitsin an antibiotic or not? The active substance has an antimicrobial effect against staphylococci, Klebsiella, Enterobacteriaceae, Neisseria, Escherichia coli, Chlamydia, Legionella, Salmonella, Shigella and other pathogens of infectious diseases. The mechanism of action of the drug is based on the interaction of norfloxacin with DNA gyrase (an enzyme of a microorganism), which leads to destabilization of the DNA chain and subsequent death of the microorganism. From this we can conclude that Nolitsin is an antibiotic, as it has a detrimental effect on bacteria.
The antimicrobial effect can last up to 12 hours. The antibiotic Nolitsin can be prescribed for diseases caused by mycobacteria and enterococci. Wikipedia contains a complete list of microorganisms that are sensitive to the action of the antibiotic.
Composition of the drug
The active ingredient of Nolicin tablets for cystitis is norfloxacin (NF), each containing 400 mg of the active ingredient. Acquired resistance to NF in clinical strains of bacteria develops relatively slowly, which is important when choosing this drug for the treatment of urinary tract diseases of an infectious nature.
The bactericidal and bacteriostatic activity of NF against a large number of microorganisms has been studied on tens of thousands of strains. The antibiotic quickly penetrates the microbial cell and is well tolerated when administered orally. It also remains highly effective against multiresistant strains of bacteria.
Composition of one Nolitsin tablet
Pharmacodynamics and pharmacokinetics
The active substance is absorbed quite quickly from the digestive system , peak concentrations in the blood are recorded within 1-2 hours after taking the medication. The biological availability of the drug reaches 30-40%. About 15% of the active substance binds to plasma proteins.
unchanged
through the renal system In patients with severe pathology of the renal system, pharmacokinetic parameters are changed.
Admission rules
Before taking Nolitsin, you must study the instructions in detail. In addition, taking the drug must be agreed with your doctor.
The medicine must be taken 50-60 minutes before meals or two hours after. In this case, you need to take the medicine with one or two glasses of clean water at room temperature. Doctors do not recommend consuming various dairy products (milk, yogurt, kefir, etc.) while taking Nolicin, as they greatly slow down the absorption of the drug. Because of this, the positive effect may occur later.
When using the medicine, the following rules must be observed:
- It is very important to drink the required amount of fluid (at least 2 liters per day) and try to monitor the amount of urine excreted.
- It is recommended not to overload the body with physical exercise. If, with minimal load, the patient feels severe pain in the tendons, Nolitsin should be completely abandoned.
- Remove all types of alcoholic drinks (even the weakest) from your daily diet.
- Doctors advise refraining from long walks on a hot day while taking the drug. In addition, direct sunlight should be avoided.
- It is prohibited to drive a car or any other vehicle. In addition, you should refrain from operating equipment that requires increased concentration and attention. Otherwise, there is a high probability of an emergency or accident.
Indications for use of Nolicin
Nolicin tablets, what are they for? The drug is prescribed for the treatment of infectious and inflammatory diseases of the genitourinary system:
- chronic prostatitis of bacterial origin;
- endometritis;
- cervicitis;
- cystitis;
- pyelonephritis;
- urethritis;
- uncomplicated form of gonorrhea.
What else can Nolitsin be prescribed for: bacterial gastroenteritis, shigellosis , salmonellosis . Additional indications for the use of tablets: prevention of traveler's diarrhea and prevention of septic complications in patients with neutropenia .
Nolitsin for cystitis
Cystitis is a disease accompanied by an inflammatory process in the mucous membrane of the bladder. Characterized by the manifestation of an acute or chronic form of the disease.
The causative agents of the disease are microorganisms related to streptococci, staphylococci, and Escherichia coli.
Predisposing factors:
- Hypothermia
- Phenomena of hypovitaminosis
- Reduced immunity
- Failure to comply with hygiene rules, including intimate hygiene
Nolicin is used as an effective drug for the treatment of cystitis, which is used as a first-line drug.
Depending on the course of the disease, the presence of characteristic symptoms, the patient’s condition, acute or chronic form, as well as complications that occur, the doctor selects the dosage of the drug and determines the duration of the course:
In the case of an acute, uncomplicated form, a Nolitsin tablet is taken twice a day, usually for a week. In the chronic form, the same dosage is used, but treatment takes 2-4 weeks.
Even a short course of treatment may be sufficient to eliminate the infection.
Contraindications
The summary of the drug contains the following absolute contraindications:
- intolerance to fluoroquinolones;
- carrying a pregnancy;
- congenital deficiency of the enzyme glucose-6-phosphate dehydrogenase.
The drug is not used in pediatrics.
Relative contraindications:
- allergic responses to acetylsalicylic acid;
- epileptic syndrome;
- disorders of cerebral blood supply;
- atherosclerotic changes in cerebral vessels;
Side effects of Nolicin
From the genitourinary system:
- hypercreatininemia;
- glomerulonephritis;
- polyuria;
- urethral bleeding;
- crystalluria;
- dysuria;
- albuminuria.
From the digestive tract:
- pseudomembranous enterocolitis;
- epigastric pain;
- appetite disorders;
- diarrhea syndrome;
- vomit;
- nausea;
- bitterness in the mouth;
- increase in ALT, AST.
The development of hallucinations, headaches, arrhythmia, tachycardia , vasculitis, itching, fainting, insomnia, swelling, urticaria, exudative erythema with a malignant course is possible. Candidiasis, decreased hematocrit, changes in blood counts, arthralgia , chemosis, and fear of light are rarely recorded.
Instructions for use of Nolicin (Method and dosage)
How to use Nolitsin correctly? Instructions for use instruct you to take the medication orally.
For infectious lesions of the genitourinary system: 400 mg twice a day, course 7-10 days.
Treatment of uncomplicated cystitis is carried out within 3-7 days.
Chronically recurrent infectious diseases of the urinary tract are treated within 12 weeks.
How to take Nolicin for acute gastroenteritis of bacterial origin : 400 mg twice a day for 5 days. For cervicitis, proctitis , urethritis and pharyngitis, 400 mg of norfloxacin is prescribed once.
Overdose
To exclude cases of drug poisoning, you should consult a doctor so that he can tell you the dose required to take. They may vary depending on the state of health, women's cycles, and oral contraceptives taken.
The main symptoms of overdose are:
- feeling of nausea;
- vomit;
- diarrhea;
- rarely, but drowsiness, puffiness on the face, and cold sweat may occur.
In case of drug intoxication, patients undergo gastric lavage. In case of acute poisoning, detoxification using forced diuresis (administration of isotonic solutions) and other treatment methods are prescribed.
Interaction
The medication reduces the effectiveness of nitrofurans , increases the concentration of cyclosporine (mutual action) and indirect anticoagulants . Norfloxacin reduces the total clearance of theophylline by 1/4.
When treated simultaneously with medications that lower the epileptic threshold, epileptiform seizures . Antacids reduce the absorption of Nolicin. When taking antihypertensive drugs, a sharp drop in blood pressure is recorded. The use of medications for general anesthesia requires mandatory monitoring of heart rate, blood pressure, and heart function (ECG).
special instructions
Before prescribing an antibiotic, it is necessary to determine the sensitivity of the flora to norfloxacin. Why is this being done? Infectious agents may be sensitive to this drug, and the expected therapeutic effect will not be achieved in the required time frame.
For pyelonephritis, Nolitsin is recommended to be prescribed in combination with herbal medications (for example, Canephron ). When treating with norfloxacin, reviews for pyelonephritis are mostly positive. Monural is also used to treat diseases of the genitourinary system. Only the attending physician can decide what is best to prescribe.
Reviews
There are both positive and negative reviews about the use of Nolicin for cystitis, which is natural.
- Among the positive reviews from patients are mentioned: improvement in general condition after the first day of treatment, rapid elimination of pain and the urge to urinate, reasonable cost of the drug even with prolonged treatment.
- Among the negative reviews, there are complaints about difficult to tolerate side effects, exacerbations of stomach diseases, but it remains unknown whether the rules for taking the drug were followed and whether the doctor prescribed it to this patient. There are references to the absolute ineffectiveness of Nolitsin, but again, it is unknown whether bacterial studies have been carried out to determine the type of pathogen.
- Among the reviews from doctors, positive reviews predominate, especially when treating uncomplicated cystitis.
Analogues of Nolitsin in Russia
Level 4 ATX code matches:
Siflox
Hyleflox
Leflobakt
Lefoccin
Gatifloxacin
Ofloxacin
Faktiv
Tigeron
Lebel
Zanotsin
Lomefloxacin
Eleflox
Lomflox
Pefloxacin
Tsiprobay
Sparflo
Tariwid
Zoflox
Abaktal
Moxifloxacin
Loxon-400, Sophasin, Norfatsin, Norilet, Norbactin , Renor.
Nolitsin price, where to buy
The price of tablets depends on the packaging. You can buy Nolitsin in Russia at a price of 10 pieces - 200 rubles, 20 pieces - 430 rubles. You can find out how much the medicine costs in your region by calling the pharmacy chain.
- Online pharmacies in RussiaRussia
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Nolicin tablets p.p.o.
400 mg 10 pcs. Krka-Rus LLC 209 rub. order - Nolicin tablets p.p.o. 400 mg 20 pcs. Krka-Rus LLC
RUB 390 order
Pharmacy Dialogue
- Nolicin tablets 400 mg No. 10KPKA
RUB 235 order
- Nolicin tablets 400 mg No. 20KPKA
RUR 464 order
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