- April 6, 2020
- Cardiology
- Natalia Koroleva
Trimectal tablets are an antihypoxic agent. It was created to fight coronary heart disease and angina pectoris. We will talk about its medicinal properties in our article.
Compound
1 tablet contains 35 mg of trimetazidine dihydrochloride , the active ingredient.
Additional Ingredients:
- 137.5 mg - Kollidon SR (0.2% - silicon dioxide, 19% - povidone, 80% - polyvinyl acetate, 0.8% - sodium lauryl sulfate);
- 2.5 mg – magnesium stearate;
- 1.2 mg – colloidal silicon dioxide;
- 73.8 mg – calcium hydrogen phosphate dihydrate.
Film casing:
- 4.8 mg – hypromellose;
- 1.6 mg – talc;
- 0.88 mg – titanium dioxide;
- 0.72 mg – macrogol 4000.
Release form
The drug "Trimectal" is available in the form of white or milky film-coated tablets. They have a round shape, convex on both sides.
The tablets have a certain property - modified release. This means that they dissolve according to a pre-planned pattern. This enhances their effectiveness.
The pills are packaged in blisters made of aluminum foil and PVC film. They are also packaged in plastic jars.
There are several options for packaging the drug on sale:
- 3 or 6 blisters of 10 tablets (30 or 60 pieces per package);
- 2, 3, 5 or 6 blisters of 20 tablets (packaging - 40, 60, 100 and 120 pieces);
- 1, 2 or 4 blisters of 30 tablets (packaging - 30, 60 or 120 pieces);
- one plastic jar (pack of 60 pieces).
In each case, the drug is placed in a cardboard pack. It contains the name of the medicine and other useful information.
Pharmacodynamics and pharmacokinetics
In the brain, trimetazidine has a direct effect on neurons and cardiomyocytes , optimizing their function and metabolism.
The cytoprotective effect of the drug is due to an increase in energy resources, activation of oxidative decarboxylation and improvement of oxygen consumption , due to the acceleration of aerobic glycolysis and blocking the oxidation of fatty acids.
The drug supports myocardial function and prevents a decrease in the amount of intracellular phosphocreatine and ATP . During acidosis, it maintains the normal functioning of membrane ion channels , inhibits the accumulation of sodium and calcium in cardiomyocytes , and normalizes the concentration of potassium ions inside the cell.
Reduces the increased amount of phosphates and intracellular acidosis , which are caused by reperfusion and myocardial ischemia . Prevents the damaging effects of free radicals and activation of neutrophils in the area of ischemia , helps maintain the integrity of cell membranes, increases the duration of the electrical potential , reduces the release of creatine phosphokinase and the severity of ischemic disorders in the myocardium.
Trimectal MV reduces the number of possible attacks of angina pectoris and reduces the patient's need for nitrates . Already after 14 days of use, an increase in tolerance to physical activity and a decrease in sharp fluctuations in blood pressure .
The drug also reduces possible tinnitus and accompanying dizziness . In diseases of the organs of vision of vascular origin, it has a beneficial effect on the functionality of the retina .
After oral (internal) administration, trimetazidine is absorbed quite quickly and almost 100% from the gastrointestinal tract. Bioavailability is 90%. Plasma Tmax is 3 hours. Connection with plasma proteins 16%.
Achieving a stable state is observed within 60 hours. Vd at 4.8 l/kg, which implies good tissue penetration.
T1/2 is about 7 hours, in patients over 65 years of age it increases to 12 hours. It is excreted mainly in the urine (approximately 60% of the drug unchanged).
With age, the hepatic clearance of trimetazidine decreases, and the renal clearance directly correlates with CC. The drug easily bypasses histohematic barriers .
Manufacturer
acts as a pharmaceutical company. It specializes in the production of medicines, cosmetics and dietary supplements. All products are of high quality.
The company was twice awarded the “Best Innovative Product” award from the St. Petersburg government in 2021 and 2021. She became a laureate of the Russian Government Award in the field of quality in 2021. The quality management system of Vertex LLC complies with the ISO 9001 standard. This means that the company adheres to certain norms and rules in the organization of technological and business processes that guarantee the established quality of products or services. This is a good signal for the consumer: the activities of the pharmaceutical company meet high European standards.
Indications for use
Indications for use of Trimectal MV in cardiology (as part of complex treatment):
- angina pectoris , as a prophylaxis for attacks;
- IHD ( coronary heart disease );
- cochleovestibular disorders of ischemic etiology, including tinnitus , dizziness , auditory disorders.
Indications for use of Trimectal MV in ophthalmology:
- chorioretinal disorders of vascular etiology with ischemic disorders.
special instructions
Instructions for use of Trimectal MV, reviews of cardiologists about this drug warn patients against inattentive driving during the course of treatment. The fact is that the medicine slows down the reaction rate and negatively affects concentration. Therefore, during therapy when driving, you need to be extremely careful and spend as little time behind the wheel as possible.
Trimectal tablets and alcohol are incompatible. Ethyl alcohol does not combine well with trimetazidine. Patients may experience weakness, headache, nausea, tremor in the fingers, and heart failure. Sometimes negative consequences are characterized by a lack of blood supply to the heart muscle and a drop in pressure in the aorta. At a minimum, alcohol almost completely neutralizes the effect of trimetazidine. Therefore, you should not drink alcohol during it.
Side effects
CNS:
- symptoms of parkinsonism (including tremor , increased tone , akinesia );
- dizziness;
- unsteadiness of gait and instability in the Romberg position;
- insomnia;
- headache;
- restless legs syndrome;
- other movement disorders (usually resolving after discontinuation of therapy);
- drowsiness.
Digestive system:
- stomach ache;
- dyspepsia;
- diarrhea;
- nausea , with possible progression to vomiting;
- constipation.
The cardiovascular system:
- heartbeat;
- pronounced decrease in blood pressure;
- tachycardia;
- extrasystole;
- orthostatic hypotension , accompanied by weakness, loss of balance, dizziness, especially when taking antihypertensive drugs in parallel;
- tides.
Skin:
- rash on the skin;
- hives;
- itchy skin;
- acute exanthematous generalized pustulosis;
- angioedema.
Circulatory system:
- agranulocytosis;
- thrombocytopenic purpura;
- thrombocytopenia.
Are common:
- asthenia;
- hepatitis.
Interesting fact
It is interesting that trimetazidine was not immediately recognized in Russia. Moreover, in 2007, the Russian Academy of Medical Sciences included it in the list of substances with unproven effectiveness. However, in Europe, experts had a different opinion. In 2013, the European Society of Cardiology (ESC) officially recognized the antianginal and anti-ischemic effectiveness of trimetazidine. And in 2015, the World Anti-Doping Society completely recognized it as doping and banned its use by professional athletes. This is due to the fact that the drug significantly increases the user's endurance.
Currently, no one doubts the effectiveness of trimetazidine. Therefore, Trimectal, as a medicine made on the basis of this substance, is also recommended for use.
Analogs
Level 4 ATX code matches:
Vazonat
Phosphaden
Hawthorn fruit
Preductal
Meldonium
Angiosil Retard
Ranexa
Lily of the valley tincture
Neocardil
Rimecore
Triductane
ATF-Long
Hawthorn tincture
Triductan MV
Trimectal
Neoton
Predisin
Trimetazidine
Tivortin Aspartate
Metamax
- Vasomag;
- Dibikor;
- Cardionate;
- Coraxan;
- Kudesan;
- Meldonium;
- Mildronate;
- Orocamage;
- Riboxin;
- Ubinon , etc.
Contraindications
Trimectal is not prescribed to patients in the following cases:
- severe renal failure;
- childhood and adolescence (up to 18 years);
- hypersensitivity to the components of the drug;
- Parkinson's disease;
- movement disorders (tremor, restless legs syndrome, etc.);
- pregnancy;
- lactation.
Patients with severe liver failure and moderate renal failure should take the medicine with caution.
Reviews of Trimectal MV
As a rule, this drug is prescribed in combination with other drugs, and therefore it is quite difficult to determine the degree of its positive effect on the patient’s body.
Despite this, positive reviews about Trimectal MB are quite common, which, combined with a minimal number of negative assessments of its effectiveness, makes it possible to assume the advisability of using this drug, provided there are no contraindications and the need for its prescription.
Directions for use, doses and overdose
Instructions for use of Trimectal inform patients that it is taken orally with meals. A single dose is one tablet. Time and frequency of administration: twice a day, in the morning and evening.
The duration of therapy depends on the attending physician. Only he can determine how long the course of treatment will last. The fact is that the drug is addictive. Over time, the body stops responding to it properly, and the therapy becomes useless. To avoid such developments, you need to limit the duration of use to 1-2 months.
Certain groups of patients require special treatment. These are elderly people and patients with moderate renal failure. They are prescribed the drug once a day: in the morning, during the first meal.
Overdose is extremely rare. If necessary, experts recommend symptomatic treatment.
Price, where to buy
On average, the price of Trimectal MV No. 60 is 350-400 rubles, No. 120 – 550-600 rubles.
- Online pharmacies in RussiaRussia
ZdravCity
- Trimectal MV tablets p.p.o.
35 mg 120 pcs. Vertex AO RUB 751 order - Trimectal MV tablets p.p.o. 35 mg 60 pcs. Vertex JSC
RUR 461 order
