"Furadonin Avexima" is a medicinal product of synthetic origin with a wide range of effects. The drug is able to stop and slow down the growth and development of pathogenic bacteria, thanks to its bactericidal and bacteriostatic effects. The instructions for use of Furadonin Avexim 50 mg say that this occurs due to the influence on the processes of protein synthesis, after which they die.
Composition and release form
The medicine is produced in tablet form. These tablets are round in shape and yellow in color.
The main substance of the drug is nitrofurantoin. 1 tablet of the medicine contains 50 mg or 100 mg. One package of Furadonin contains from 1 to 5 cell packs. Each of them contains 10 tablets.
In addition, the preparation also contains the following auxiliary components:
- stearic acid;
- starch;
- polysorbate 80.
- colloidal silicon dioxide.
Interaction with other tools
Treatment of diseases of an infectious and bacterial nature is complex, therefore other drugs are also prescribed while taking Furadonin Avexim. This means that it is necessary to take into account the compatibility of the tools:
- Magnesium stearate and nalidixic acid reduce the effect on bacteria.
- Drugs that increase the pH level in urine reduce the ability to influence bacteria in the genitourinary system.
- “Sulfinpyrazone” and “Probenecid” slow down the removal of the components of the drug from the body.
It is also not recommended to use Furadonin Avexima with drugs containing fluoroquinolones.
For effective treatment, all medications must be prescribed by a doctor, and before taking it, you must read the instructions for use of Furadonin Avexim 50 mg or other forms.
Pharmacological action and pharmacokinetics
Absorption of Furadonnin occurs in the stomach, and its breakdown occurs in the liver. The bioavailability of the drug is 50%. Moreover, eating food increases this indicator significantly.
The drug is excreted in the urine (about 50% in unchanged form). It is thanks to this property that the drug is one of the most effective in treating diseases of the urinary system. The binding of the drug to plasma proteins is 60%.
The drug can penetrate the placenta and can be excreted in breast milk.
How to take furadonin avexima correctly for cystitis
Furadonin Avexima: instructions for use and reviews
Latin name: Furadonin Avexima
ATX code: J01XE01
Active ingredient: nitrofurantoin (nitrofurantoin)
Manufacturer: Irbit Chemical and Pharmaceutical Plant, JSC (Russia)
Update of description and photo: 11/22/2018
Prices in pharmacies: from 47 rubles.
Furadonin Avexima is an antimicrobial agent used in the treatment of urinary tract infections.
Release form and composition
The dosage form of Furadonin Avexim is tablets: flat-cylindrical, yellow or yellow with a greenish tint (in a cardboard pack there are 1–5 blister/cellless packages of 10 tablets; 1 blister pack or 1 jar of 20 tablets).
Composition of 1 tablet:
- active substance: furadonin (nitrofurantoin) – 50 or 100 mg;
- auxiliary components (50/100 mg): aerosil – 2/4 mg; potato starch – 46.15/92.3 mg; stearic acid – 1/2 mg; polysorbate 80 – 0.85/1.7 mg.
Pharmacological properties
Furadonin Avexima is one of the antimicrobial agents from the nitrofuran group; used primarily to treat urinary tract infections. Nitrofurantoin disrupts protein synthesis in bacteria and cell membrane permeability.
In small doses the substance has a bacteriostatic effect, in large doses it has a bactericidal effect.
Effective against gram-positive/gram-negative bacteria, including Proteus spp., Escherichia coli, Streptococcus spp., Staphylococcus spp., Shigella flexneri, Shigella dysenteriae, Shigella sonnei, Shigella boydii.
Acinetobacter spp., Pseudomonas cepacia, Pseudomonas aeruginosa, Providencia spp. are resistant to nitrofurantoin.
The drug is not used in the treatment of urinary tract infections caused by mycoplasmas, chlamydia, and gonococci.
Nitrofurantoin is well absorbed from the gastrointestinal tract. Bioavailability is 50%; food intake increases bioavailability. The rate of absorption depends on the size of the crystals - the microcrystalline form is characterized by rapid solubility and absorption rate, a short time to reach Cmax (maximum concentration of the substance) in the urine.
The connection with blood plasma proteins is 60%. Penetrates the blood-brain barrier, the placenta, and is excreted in breast milk. Effective therapeutic concentrations are achieved in the urinary tract rather than in tissues and blood.
Metabolism occurs in muscle tissue and liver.
T1/2 (half-life) is in the range of 20–25 minutes. Completely excreted by the kidneys (unchanged - from 30 to 50%).
With impaired renal function, T1/2 and plasma concentrations of nitrofurantoin in the blood increase. When creatinine clearance is less than 60 ml/min, the therapeutic concentration of the substance in the urine is not achieved, accumulation of nitrofurantoin and an increased likelihood of toxicity are possible.
Nitrofurantoin exhibits greater activity in acidic urine. When urine pH is above 8, Furadonin Avexima loses its bactericidal activity.
Indications for use
According to the instructions, Furadonin Avexima is prescribed for bacterial urinary tract infections caused by microorganisms sensitive to the action of nitrofurantoin:
- severe complicated recurrent infections;
- acute uncomplicated infections;
- urinary tract infections, including for uncomplicated chronic diseases and urological operations/examinations - cystoscopy, catheterization of the urinary tract, etc. (for preventive purposes).
Contraindications
- chronic renal failure;
- heart failure stage II–III;
- deficiency of glucose-6-phosphate dehydrogenase;
- chronic hepatitis;
- cirrhosis of the liver;
- acute porphyria;
- oliguria, anuria;
- polyneuropathy/neuritis;
- pulmonary fibrosis;
- pregnancy and lactation;
- age up to 3 or 12 years (for tablets 50 or 100 mg, respectively);
- individual intolerance to the components of the drug.
Relative (Furadonin Avexima is prescribed under medical supervision):
- diabetes;
- electrolyte imbalance;
- anemia;
- liver function failure;
- deficiency of B vitamins;
- tendency to the appearance of peripheral neuropathies (itching of legs, hands, numbness);
- lung diseases.
Instructions for use of Furadonin Avexim: method and dosage
Furadonin Avexima is taken orally with plenty of water.
Recommended application:
- adults: 100–150 mg 3–4 times a day; maximum single dose – 300 mg, daily dose – 600 mg;
- children: 5–8 mg/kg per day in 4 divided doses. Children 3–12 years old are prescribed Furadonin Avexima 50 mg tablets.
The duration of treatment for acute urinary tract infections is from 7 to 10 days.
It is necessary to take into account that the symptoms of the disease may disappear before the infection is cured, and if therapy with Furadonin Avexima is stopped, the disease may worsen again.
If nausea occurs, reduce the dose or stop taking the drug.
Preventive, anti-relapse therapy with Furadonin Avexim is carried out from 3 to 12 months (depending on the nature of the disease). In such cases, the daily dose is 1–2 mg/kg.
Furadonin Avexima: prices in online pharmacies
Furadonin Avexima 50 mg tablets 10 pcs.
Furadonin Avexima tablets 50 mg 10 pcs.
Furadonin Avexima 50 mg tablets 20 pcs.
Furadonin Avexima tablets 50 mg 20 pcs.
Furadonin Avexima tablets 100 mg 20 pcs.
Furadonin Avexima 100 mg tablets 20 pcs.
Education: First Moscow State Medical University named after I.M. Sechenov, specialty “General Medicine”.
Information about the drug is generalized, provided for informational purposes and does not replace official instructions. Self-medication is dangerous to health!
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Source: https://ginekologiya-urologiya.ru/venericheskie-zabolevaniya/kak-pravilno-prinimat-furadonin-aveksima-pri-tsistite
Instructions for use
In most cases, the medicine is prescribed to patients to treat the following diseases:
- cystitis of bacterial origin;
- inflammatory lesions of the urinary tract;
- inflammation of the kidneys (including in normal form);
- infectious processes in the urogenital part.
In addition, the medicine can be recommended to patients during the postoperative period, as well as when using a urinary catheter or cytoscope. This is necessary to prevent infectious complications.
Reviews
Basically, the drug is given good recommendations. This is due to its effectiveness in treating many diseases. The description of the drug can be read in the instructions for use. Many patients claim that when using a remedy to treat cystitis, the unpleasant symptoms disappeared after just a few days of therapy. Everyone also notes its low cost and availability in pharmacies.
Some people report side effects that caused them some discomfort during treatment (they are described in the instructions for use). Reviews about “Furadonin” are mostly positive, but there are also neutral ones.
Mode of application
The tablets should be swallowed whole without chewing. It should be taken after meals. You should take the medicine with a sufficient amount of liquid (and it is advisable that it is not carbonated).
For infectious and inflammatory diseases of the urinary system, you need to take 0.4 g 3-4 times a day (depending on the severity of the disease). The course of therapy in this case should be 6-10 days. If during this period there is no improvement in your well-being, then you need to change the medicine.
For prevention purposes, the medicine should be taken at a dose of 1-2 mg per 1 kg of weight. The number of such appointments per day is determined by the attending physician.
The medicine is not recommended for use in children under 3 years of age.
Children over 3 years old can be given 5-8 mg of furadonin per 1 kg of weight. This is a daily dose, which should be divided into 4 doses.
Taking the pills is contraindicated for pregnant women.
Cost and storage conditions
The drug has a low price. It can be purchased in pharmacies for 42-110 rubles. The cost depends on the amount of the drug and the content of the active substance in it.
Available without a prescription.
The storage conditions for Furadonin Avexim state that the drug should be kept indoors at a temperature not exceeding 25 degrees Celsius, in a dry and dark place. Access to the drug for children should be limited to avoid accidents.
The shelf life is 48 months; after its expiration, the product cannot be used.
Side effects
In some cases, patients may experience side effects when treated with medications. These include:
- allergies, which can manifest themselves in different ways (this includes angioedema, skin rash, etc.);
- breathing problems;
- changes in stool and nausea, which may result in vomiting;
- drowsiness;
- violation of orientation in space;
- migraine;
- disruption of the hematopoietic process;
- fever;
- pain in joints and muscles.
If any adverse reactions occur, the patient should immediately inform the doctor.
Analogs
Furagin
A drug whose main active ingredient is furazidin. It is a substitute for Furadonin Avexim tablets, as it has similar therapeutic effects. The medicine is presented in the form of a tablet for oral administration. It is used for infectious pathologies of the structures of the urinary system, mainly in adults.
Urofuragin
A drug substitute that is available in tablet form for oral administration and contains furazidine. The medication has antibacterial activity; it is mainly prescribed for infectious and inflammatory pathologies of various structures of the urogenital tract. The medicine is contraindicated for children, pregnant and breastfeeding women.
special instructions
The instructions for the drug do not indicate anything about its compatibility with alcohol. However, in the presence of infectious and inflammatory processes in the organs of the urinary system, drinking alcohol is not recommended. This can significantly increase the stress on the kidneys.
Furadonin is strictly contraindicated in severe renal and liver dysfunction.
Using the drug simultaneously with nalidixic acid, antacids, and drugs with magnesium trisilicate reduces the effectiveness of the former.
It is strictly forbidden to combine the drug with fluoroquinolones.
The effect of the drug is significantly reduced if the patient takes drugs that block tubular secretion. Also in this case, the risk of intoxication of the body increases.
In order to increase the effectiveness of the drug, patients must adhere to a special protein diet at the time of treatment. Ideally, it should be compiled by the attending physician.
Contraindications
The drug is not recommended for use in the following cases:
- high sensitivity to the components of the product;
- chronic renal failure;
- chronic failure of the cardiovascular system of the second and third degree;
- liver damage (cirrhosis);
- porphyria in acute form;
- hepatitis in chronic form.
Doctors also note that the drug should not be taken during pregnancy or while breastfeeding. For children, it can only be used from the 32nd day of life.
Opinions of patients and doctors about the drug
In most cases, reviews about the drug are positive.
Furadonin is the drug of first choice for patients with inflammatory and infectious processes in the urinary tract. According to my observations, their unpleasant symptoms of the disease disappear after 1-2 days of treatment with this drug. However, I do not recommend self-medication. Before taking the drug, you need to consult a specialist.
Zhukov V.M. doctor
Furadonin is a very effective drug for the treatment of diseases of the urinary system. Full recovery usually occurs within a week after the start of therapy. However, this drug can cause dizziness and drowsiness, so I do not recommend it for patients whose work requires increased attention and reaction.
Oberemok L.D., doctor
For a long time I suffered from chronic cystitis. Exacerbations usually occurred after hypothermia or with decreased immunity. In this case, the urologist recommended Furadonin to me. This drug helped get rid of the unpleasant symptoms of the disease in the shortest possible time. No relapses were observed after this.
Larisa, 28
I had to take the drug for kidney inflammation. In this regard, it turned out to be quite effective. Unfortunately, throughout the course of therapy I was bothered by nausea. Despite this, I recommend the medicine.
Mikhail, 38
This morning I woke up and felt a nagging pain in my lower back. The doctor diagnosed kidney inflammation and prescribed Furadonin. I found it at the first pharmacy, I was pleasantly surprised by the price. The product turned out to be very effective and helped already on the 3rd day of treatment. I recommend to everyone.
Tatiana, 51
Just 2 days after treatment with Furadonin, my symptoms of cystitis completely disappeared, and I stopped taking the medication. However, the disease soon returned again. In this case, I started treatment with the drug again, but had already completed the full course. After this there were no relapses. For this reason, I do not recommend ending treatment early.
Natalia, 44
Throughout the entire period of treatment with Furadonin, I felt nauseated. However, I have noticed that the unpleasant side effect is much less severe if I eat well. I recommend that patients eat small meals every 2-3 hours. It is better to give preference to white meat and fish. Also in this case, drinking plenty of fluids, tea with mint and ginger will help. It is better to drink the drug with milk, and take it immediately after a heavy meal.
Valery, 64
Advantages and disadvantages
Furadonin Avexima, like any other drug, has its advantages and disadvantages.
The advantages of the drug include:
- efficiency;
- wide spectrum of action;
- low price;
- small tablet size (easy to swallow);
- Possibility to purchase at any pharmacy.
Among the disadvantages of Furadonin are the following:
- nausea is a common side effect;
- should not be used by pregnant women and children.
Pharmacological properties
The instructions for use of Furadonin Avexima state that the drug is not an antibiotic.
The drug is classified as a nitrofuran. Bactericidal and bacteriostatic properties disrupt the process of protein synthesis in bacteria and cell membranes. The drug is active against bacteria of gram-positive and gram-negative species. It is particularly effective in the treatment of infectious diseases of the urinary system.
