Inspiron - instructions, indications, composition, method of application

Compound

• One Inspiron tablet contains 80 mg of fenspiride hydrochloride . Additional substances: calcium hydrogen phosphate, dihydrate, hypromelose, povidone, colloidal silicon dioxide, magnesium stearate, Opadry mixture.

• 5 ml of Inspiron syrup contains 10 mg of fenspiride hydrochloride. Additional substances: propyl parahydroxybenzoate, methyl parahydroxybenzoate, sugar, potassium sorbate, licorice root extract, honey linden aroma, glycerin, vanillin, sodium saccharin, water.

Contraindications

According to the instructions, Inspiron is contraindicated in case of hypersensitivity to one or more components that are part of the tablets or syrup.

Additional contraindications for the use of the product in syrup form are conditions that are accompanied by impaired absorption of sugars. Among them are the following pathologies:

• Glucose malabsorption;
• Galactose intolerance;
• Fructose intolerance;
• Sucrose intolerance.

Inspiron tablets are contraindicated in children under 14 years of age.

It is not recommended to use the drug during pregnancy and breastfeeding.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Inspiron has antibronchoconstrictor and anti-inflammatory effects due to the following mechanisms:

• inhibits histamine H1 receptors , has a relaxing effect on bronchial smooth muscles;
• has an anti-inflammatory effect, leading to a decrease in the synthesis of a number of anti-inflammatory factors ( TNF-a, cytokines , free radicals, arachidonic acid metabolites, leukotrienes, thromboxane, prostaglandins ), producing a bronchoconstrictor effect;
• suppresses a1-adrenergic receptors , which stimulate the production of viscous mucus in the bronchi.

Pharmacokinetics

Maximum blood levels are achieved 6 hours after consumption. The half-life is 12 hours. It is excreted from the body mainly in urine.

Inspiron manufacturer's instructions

Compound

active ingredient:
fenspiride;

5 ml of syrup contains fenspiride hydrochloride in terms of dry matter - 10.00 mg;

Excipients:

methyl parahydroxybenzoate (E 218), propyl parahydroxybenzoate (E 216), potassium sorbate, honey linden aroma, licorice root extract, vanillin, glycerin, sodium saccharin, sugar, purified water.

Dosage form

Syrup.

Basic physical and chemical properties:

colorless or yellowish liquid with a specific odor. Light opalescence is acceptable.

Pharmacotherapeutic group

Other agents for systemic use in obstructive diseases of the respiratory system. Fenspiride.

ATX code R03D X03.

pharmachologic effect

Inspiron has antibronchoconstrictor and anti-inflammatory properties due to the interaction of several related mechanisms:

– blocking of H1-histamine receptors and antispasmodic effect on bronchial smooth muscles;

– anti-inflammatory effect, which leads to a decrease in the production of various pro-inflammatory factors (cytokines, TNFα, arachidonic acid derivatives, prostaglandins, leukotrienes, thromboxane, free radicals), some of which also have a bronchoconstrictor effect;

– inhibits α1-adrenergic receptors, which stimulate the secretion of viscous mucus.

Pharmacokinetics

The maximum concentration in blood plasma is achieved on average 2.3 ± 2.5 hours (fluctuation range from 0.5 to 8 hours) after oral administration. The half-life is 12 hours. Fenspiride is excreted from the body primarily through urine.

Indications

Treatment of acute and chronic inflammatory processes of the ENT organs and respiratory tract (otitis, sinusitis, rhinitis, nasopharyngitis, tracheitis, rhinotracheobronchitis, bronchitis), as part of complex therapy of bronchial asthma.

Seasonal and year-round allergic rhinitis and other manifestations of allergies from the respiratory system and ENT organs.

Respiratory manifestations of measles, influenza.

Symptomatic treatment of whooping cough.

Contraindications

– Hypersensitivity (allergy) to the active substance or to any of the components of the drug.

– Children under 2 years of age.

Interaction with other drugs and other types of interactions

No relevant studies have been conducted.

The simultaneous use of fenspiride and sedatives or alcohol consumption is not recommended. Sedatives and alcohol can increase the sedative effect of drugs that have H1-histamine receptor blocker properties (including fenspiride).

Features of application

Treatment with the drug does not replace antibiotic therapy.

The drug contains sucrose, so patients with rare hereditary forms of fructose intolerance, glucose and galactose malabsorption syndrome, sucrase-isomaltase deficiency are not recommended to prescribe this drug.

Patients with diabetes mellitus when using the drug Inspiron, syrup, must take into account the following information: 1 teaspoon of the drug (5 ml) contains 3 g of sucrose, respectively, 1 tablespoon (15 ml of syrup) contains 9 g of sucrose.

Due to the presence of parabens (methyl parahydroxybenzoate and propyl parahydroxybenzoate) in the drug, this medicine may cause allergic reactions (possibly delayed).

Shake before use.

The ability to influence reaction speed when driving a vehicle or operating machinery

Studies regarding the effect of Inspiron on the ability to drive vehicles or operate other machinery have not been conducted.

Because the drug may cause drowsiness, it has little effect on the ability to drive or operate machinery, especially at the beginning of treatment or if alcohol is used at the same time.

Use during pregnancy or breastfeeding

Pregnancy.

Data on the use of fenspiride during pregnancy are limited. Therefore, it is not recommended to use the drug during pregnancy, however, diagnosing pregnancy during treatment with fenspiride is not a reason to terminate the pregnancy.

In animal studies of fenspiride, there have been cases of cleft palate in rats and rabbits.

Lactation.

It is unknown whether fenspiride passes into breast milk, so Inspiron should not be used during breastfeeding.

Fertility.

Preclinical studies of the effect of fenspiride on reproductive function have demonstrated the absence of an effect of fenspiride on the fertility of female and male rats.

Directions for use and doses

For oral use.

Prescribed to children from 2 years of age and adults. The use of the drug is contraindicated in children under 2 years of age.

The daily dose should be divided into 2-3 doses and taken before meals.

The recommended daily dose should be based on the child's weight and age, but should not exceed the recommended daily dose (see information below).

Children from 2 years old.

The recommended daily dose is 4 mg/kg body weight (2 ml/kg).

• If body weight is less than 10 kg:

the daily dose is from 2 to 4 teaspoons of syrup (10-20 ml), respectively 20-40 mg of fenspiride hydrochloride per day.

• If body weight is more than 10 kg:

the daily dose is from 2 to 4 tablespoons of syrup (30-60 ml), respectively 60-120 mg of fenspiride hydrochloride per day.

For use in adults and children over 12 years of age.

The daily dose of syrup is from 3 to 6 tablespoons (45-90 ml), respectively 90-180 mg of fenspiride hydrochloride per day.

For adults, the drug is prescribed in tablets.

1 teaspoon of syrup (5 ml) contains 10 mg of fenspiride hydrochloride.

1 tablespoon of syrup (15 ml) contains 30 mg of fenspiride hydrochloride.

A course of treatment.

The duration of treatment depends on the course of the disease and is determined by the doctor individually.

Children

The drug can be used in pediatric practice for children from 2 years of age.

Overdose

When taking a large amount of the drug, drowsiness or agitation, nausea, vomiting, and sinus tachycardia may occur.

Treatment. It is necessary to rinse the stomach and monitor the ECG. Treatment is symptomatic.

Adverse reactions

The most common adverse reactions when using fenspiride are gastrointestinal disorders.

During clinical trials and/or use of fenspiride in the post-registration period, adverse reactions were reported with the following frequency of manifestations: very often (≥ 1/10), often (≥ 1/100, < 1/10); uncommon (≥ 1/1000, < 1/100), rare (≥ 1/10000, < 1/1000), very rare (≥ 1/100000, < 1/10000), frequency unknown (cannot be estimated from available data).

*According to post-registration observation data.

Best before date

2 years

Storage conditions

Store in original packaging at a temperature not exceeding 25 ºС. Keep out of the reach of children. Do not freeze. After opening, store for no more than 30 days.

Package

150 ml per bottle, 1 bottle per pack.

Vacation category

On prescription.

.

Manufacturer's location and address of place of business

Ukraine, 79024, Lviv, st. Opryshkovskaya, 6/8.

© Translation into Russian by the editorial team of apteka24.ua.

Source: “State register of medicinal facilities of Ukraine”, 2020.

Indications for use

• treatment of acute and chronic inflammatory processes of the respiratory tract and ENT organs ( sinusitis, otitis, rhinitis, rhinotracheobronchitis, tracheitis, rhinopharyngitis, bronchitis ), obstructive pulmonary diseases of a chronic nature, as part of multicomponent therapy in the treatment of bronchial asthma ;
• allergic rhinitis of all types and other manifestations of hypersensitivity from the ENT organs and the respiratory system;
• symptomatic treatment of whooping cough ;
• respiratory symptoms of measles and flu .

Shelf life, storage and sales conditions

Now you know what the drug “Inspiron” (syrup) is. Instructions, reviews and indications for the use of this medicine are presented in the materials of this article.

You can purchase this drug at a pharmacy without a doctor's prescription. It is advisable to store the oral suspension at a temperature of less than 25 degrees and out of the reach of children.

It is advisable to use the syrup within two years. After the expiration date, it is prohibited to take the drug.

Side effects

• phenomena from the digestive system: nausea, indigestion, diarrhea , stomach pain, vomiting;
• phenomena from the circulatory system: sinus tachycardia , which disappears after dose adjustment;
• skin phenomena: erythema , rash, angioedema, erythema pigmentosa, urticaria , itching ;
• phenomena from the nervous system: drowsiness ;
• general reactions: weakness, fatigue .

Patient reviews of medicinal syrup

Most patients using the drug in question leave positive feedback about it. They report that this medication copes with its task quite effectively, but only if the recommended dosages are followed.

Also among the advantages of this drug, patients note its low cost.

As for negative reviews, they are extremely rare. In them, patients complain of allergic reactions that appear while taking the syrup. By the way, many people are bothered by the smell of the drug and its unpleasant taste.

Instructions for use (Method and dosage)

The instructions for Inspiron recommend taking the drug orally after meals, regardless of the form of release.

Inspiron tablets, instructions for use

The recommended daily therapeutic dose used for the treatment of chronic processes is one tablet twice a day. To enhance the effect or in the case of treating acute diseases, it is recommended to take 3 tablets three times a day. The duration of treatment depends on the clinical picture of the disease and is decided by the attending physician individually.

Instructions for Inspiron syrup

Children over 2 years of age are recommended to take the drug at a dose of 2 ml/kg body weight divided into two or three doses. If you weigh less than 10 kg, take 20-40 mg of syrup per day (divided into two or three doses). If you weigh more than 10 kg, take 60-120 mg of syrup per day (divided into two or three doses).

The daily dose for children over 12 years of age and adults is 90-180 mg of syrup per day (divided into two or three doses). The duration of treatment depends on the clinical picture of the disease and is determined by the doctor individually.

One teaspoon contains 5 ml of syrup. One tablespoon contains 15 ml of syrup.

special instructions

The use of Inspiron can be combined with the use of antipyretic drugs and various antibiotics. Concomitant use of the drug with sedatives is not recommended.

In cases where doses recommended in the drug instructions are exceeded, side effects such as nausea and vomiting, agitation or drowsiness, sinus tachycardia and dyspepsia may occur. In such situations, the use of the drug must be stopped, gastric lavage and symptomatic therapy must be carried out.

Inspiron does not affect the ability to drive vehicles or the speed of psychomotor reactions when engaging in potentially hazardous activities.

1 teaspoon of syrup contains 3 g of sugar, which must be taken into account in patients with diabetes and on a low-calorie diet.

The drug is dispensed from pharmacies with a doctor's prescription.

Inspiron price, where to buy

The price of Inspiron tablets in Ukraine is on average 72 hryvnia, and syrup costs 48 hryvnia.

• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

Pharmacy24

• Inspiron 80 mg N30 tablets PAT "Kievmedpreparat", Ukraine
  80 UAH. order
• Inspiron 4 mg/ml 150 ml syrup + measuring spoon

  72 UAH order

• Inspiron 2 mg/ml 150 ml syrup

  48 UAH order

PaniPharmacy

• Inspiron liquid Inspiron syrup 4 mg/ml 150 ml Ukraine, Galichfarm JSC

  84 UAH order

• Inspiron liquid Inspiron syrup 2 mg/ml 150 ml Ukraine, Galichfarm JSC

  52 UAH order

• Inspiron tablets Inspiron film-coated tablets 80 mg No. 30 Ukraine, Kievmedpreparat OJSC

  87 UAH order

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Composition, description and packaging of medicinal syrup

Inspiron syrup, reviews of which are presented below, contains such an active element as fenspiride hydrochloride. As for the excipients, they are used: propyl parahydroxybenzoate, sugar, methyl parahydroxybenzoate, potassium sorbate, linden honey flavor, water, licorice root extract, vanillin, glycerin and sodium saccharin.

This drug is a colorless or light yellow liquid with a specific odor (weak opalescence is acceptable).

The oral suspension is sold in vials and cardboard boxes, respectively.

Kinetics

What kinetic properties are inherent in the drug "Inspiron"? Instructions for use indicate that the maximum content of the active component of this medicine in the blood is observed six hours after taking it.

The half-life of the drug is 12 hours. It is removed from the body along with urine.

Consumer Reviews

Consumer reviews of Inspiron syrup and tablets are positive. Patients claim that this remedy quite effectively treats diseases of the respiratory tract. Although it should be noted that the medication in question often contributes to the occurrence of allergic reactions.

There are also reviews from patients who say that the taste and aroma of this drug are not very pleasant.