Instructions for use of Khairabezol
The official medical classification classifies the drug Khairabezol as an antiulcer drug from the group of proton pump inhibitors (certain enzymes). The active component of the composition is rabeprazole sodium, which reduces the secretion of gastric juice and eliminates the uncomfortable manifestations of the disease already on the second day of treatment or prevents its development.
Composition and release form
The drug is available in the format of tablets coated with an enteric film coating. Their description and composition:
| Description | Round pink (10 mg) or yellow (20 mg) tablets |
| Concentration of active substance, mg per piece. | 10 or 20 |
| Auxiliary components of the composition | Red or yellow iron oxide (color), magnesium oxide, titanium dioxide, corn starch, cellacephate, mannitol, sodium stearyl fumarate, low-substituted hyprolose, povidone |
| Package | Blisters or strips of 10, 14 or 15 pcs. |
Pharmacodynamics and pharmacokinetics
A drug with an antiulcer effect belongs to the proton pump inhibitors, whose metabolism is carried out in the cells of the stomach to sulfonamide derivatives that inactivate the sulfhydryl groups of enzymes. The action of the medication is to block the last stage of hydrochloric acid production with a decrease in secretion.
The tablets are highly lipophilic, penetrate into the cells of the stomach, and have a cytoprotective effect. The antisecretory effect of the drug occurs an hour after administration and reaches its maximum level after three hours. The duration of the medication is two days. After finishing taking the tablets, acid production returns to normal within 2-3 days. In the first two weeks of therapy with Hayrabezol tablets, the concentration of gastrin in the blood increases, but it returns to its original level 10 days after discontinuation of treatment.
Absorption of the active substance occurs in the small intestine in 3.5 hours, it has 52% bioavailability, and is bound to plasma proteins by 97%. Metabolism of rabeprazole occurs in the liver with the participation of cytochrome isoenzymes; the component is excreted in three hours by the kidneys and intestines in the form of metabolites (a conjugate of mercapturic and carboxylic acids).
Indications for use
The drug can be used in combination or independently. In the first case, it is used for eradication (elimination) of helicobacter pylori in patients with stomach ulcers, duodenal ulcers or gastritis and for the treatment and prevention of relapse of this disease. The main indications for drug monotherapy are:
- exacerbation of peptic ulcer of the stomach and duodenum;
- gastroesophageal reflux disease (GERD);
- Zollinger-Ellison syndrome and other hypersecretory conditions, reflux;
- ulcers of the gastrointestinal tract that arise due to stress.
Reviews about Khairabesol
According to studies in which the drug was prescribed for the treatment of erosive and ulcerative defects of the stomach, on the 2nd day of therapy in 75% of patients the pain syndrome decreased, and after a week of use no one had any complaints. In 91% of patients, by the end of the 2nd week of treatment, according to the results of FGDS, healing of erosive and ulcerative defects . The drug has a persistent antisecretory effect; when taken, the number of refluxes . All this is confirmed by patient reviews.
- “...The medicine Khairabezol was prescribed for an exacerbation of an ulcer. Feeling better within a day. I was treated for a month and the discomfort and pain in the stomach went away.”
- “... The pills worked for me, I’m happy with the result of the treatment. They're inexpensive."
- “...I liked the drug!!! The pain and heartburn disappeared. I used to take Pariet, but it is very expensive. I didn’t see any difference in the effectiveness of those and other tablets.”
- “... I take it for exacerbations of ulcers. It helps me personally. Conveniently, you only need to take it once a day and the package lasts for 15 days. Satisfied with the price and efficiency. I didn’t feel any side effects.”
- “...Only Pariet helps me. I only take this drug.”
Side effects included minor headache and constipation .
Directions for use and dosage
The drug is taken 20 mg once a day. The tablets are swallowed whole, without chewing or crushing, in the morning before meals. Recommended dosages:
| Disease | Dosage, mg once/day | Course of treatment, weeks |
| Gastric and duodenal ulcers in the acute stage | 20 | 4-6 |
| GERD | 20 | 4-8 |
| Maintenance therapy for GERD | 10- or 20 | |
| GERD without esophagitis | 10 | 4 |
special instructions
Before starting therapy with rabeprazole and after its completion, endoscopic monitoring should be carried out to eliminate the risk of developing malignant neoplasms, the signs of which may be masked by the substance. Patients with serious pathologies of liver function must be careful when treated with the drug. No dose adjustment is required for renal impairment.
- Thirty-ninth week of pregnancy
- Blood transfusion - rules. Compatibility of blood groups during transfusion and preparing the patient for blood transfusion
- Cough syrups for children
Drug interactions
Rabeprazole in the medication may slow down the elimination of Diazepam, indirect anticoagulants, Phenytoin and other drugs whose metabolism occurs in the liver by microsomal oxidation. Other drug interactions:
- Reduces the concentration of Ketoconazole and Digoxin.
- Does not interact with liquid antacids.
- Can be combined with Warfarin, Theophylline.
- For peptic ulcers or gastritis associated with bacterial infection by Helicobacter pylori, seven-day therapy with Khairabezol is combined with Clarithromycin, Amoxicillin or Clarithromycin and Metronidazole.
Compatibility of Khairabezol and alcohol
The entire period of drug therapy must be accompanied by a ban on alcohol intake. This limitation is due to the fact that ethanol further increases the risk of developing ulcers and discomfort, and increases the load on the liver, because both rabeprazole and alcohol are metabolized by its cells. Drinking alcohol-containing drinks during treatment will lead to intoxication and negative reactions.
Side effects of Hairabezol
During drug treatment, side effects may occur. Popular ones include:
- gastritis, diarrhea, stomatitis, nausea, anorexia, vomiting, taste disturbance, abdominal pain, dyspepsia, flatulence, dry mouth, constipation, belching;
- blurred vision, headache, depression, dizziness, drowsiness or insomnia, nervousness, asthenia;
- convulsions, myalgia, arthralgia;
- bronchitis, inflammation of the respiratory tract, sinusitis, cough;
- leukocytosis, leukopenia, thrombocytopenia;
- allergic reactions, rash, itchy skin;
- pain in the back, chest, arms, legs, swelling, chills;
- bladder infections;
- fever, flu-like symptoms.
Side effects
| Often (1-10%) | Uncommon (0.1–1%) | Rarely(0.01–0.1%) | Very rare (up to 0.01%) |
| diarrhea, nausea; headache | constipation, bloating, abdominal pain, vomiting | belching, dry mouth, digestive disorders; dizziness, asthenia, sleep disturbances; muscle pain; infectious and inflammatory diseases of the respiratory system, cough; low level of platelets, leukocytes; skin allergic reactions; back pain, chest pain, swelling, urinary tract infections, flu-like condition | taste disturbance, stomatitis, gastritis, anorexia; depression, drowsiness, visual impairment; joint pain, cramps in the calves; bronchitis, sinusitis; leukocytosis; weight gain, sweating. |
Rarely, during long-term treatment with drugs of the PPI group (three months or more), which include Khairabezol, cases of hypomagnesemia (a decrease in the blood concentration of magnesium) have been observed, which leads to arrhythmias and convulsions.
Contraindications
Khairabezol is not prescribed for individual sensitivity to components and for patients under 18 years of age, since such experience is lacking. Use the drug with caution in the treatment of patients with severe impairment of hepatic or renal function.
Pregnancy and breastfeeding
Khairabezol is not intended for the treatment of pregnant women and is contraindicated during breastfeeding.
Drug poisoning
Symptoms of drug poisoning are not described. But if there is a suspicion of an overdose, therapy is carried out aimed at eliminating the symptoms. Dialysis in this situation has no effect.
Other Features
If drowsiness occurs during the course of treatment, the patient is advised to stop driving and using equipment that requires concentration and quick reaction.
Before and after the course , endoscopic examinations are performed to exclude malignant processes. This need arises due to the fact that the drug can mask characteristic symptoms, and then the patient does not receive timely medical care.
When treating persons with impaired renal or liver function, the dose is not adjusted. However, their blood concentration is higher than that of patients without such pathology.
In old age, the maximum concentration of rabeprazole in the blood is 60% higher than in young people.
Khairabezol's analogs
Other drugs with the same active ingredient in the composition can replace the drug. Analogues of the drug include:
- Pariet - tablets based on rabeprazole, with antiulcer effect;
- Zulbex is an antisecretory drug with the same active ingredient;
- Zolispan - reduces the secretion of gastric glands;
- Rabeloc – helps with helicobacter pylori infection;
- Razo - anti-ulcer tablets based on rabeprazole;
- Noflux is a Hungarian drug with the same principle of action.
Reviews
The drug has a good reputation. The benefits of the drug for patients include:
effect after the first tablet;- rare side effects;
- economical packaging;
- small tablet size.
- Disadvantages include a long therapeutic course and relatively high cost.
Read patient reviews at the end of the article.
Price
The cost of the medicine depends on the concentration of the active substance, the number of tablets in the package and the level of the network’s markup. You can buy or order the drug on the Internet or in Moscow pharmacies at prices:
| Variety of tablets | Internet price in rubles | Pharmacy price tag in rubles |
| 20 mg 30 pcs. | 800 | 820 |
| 20 mg 15 pcs. | 557 | 580 |
| 20 mg 15 pcs. | 598 | 621 |
| 10 mg 15 pcs. | 398 | 420 |
| 10 mg 30 pcs. | 598 | 620 |
Hayrabezol price, where to buy
You can buy Khairabezol in all pharmacies. Tablets of 20 mg are offered at a price of 590-711 rubles, the cost of tablets of 10 mg is 415-484 rubles.
- Online pharmacies in RussiaRussia
ZdravCity
- Khairabezol tablets p.p.o.
enteric solution 10 mg 15 pcs. Highglans Laboratories Pvt. Ltd IN RUR 349 order - Khairabezol tablets p.p.o. enteric solution 20 mg 30 pcs. Highglans Laboratories Pvt. Ltd IN
RUR 731 order
- Khairabezol tablets p.p.o. enteric solution 20 mg 15 pcs. Highglans Laboratories Pvt. Ltd IN
RUR 556 order
- Khairabezol tablets p.p.o. enteric solution 10 mg 30 pcs. Highglans Laboratories Pvt. Ltd IN
500 rub. order
