Klimonorm for women with menopause. Reviews, instructions for use, analogues, how it affects weight, composition, price

Klimonorm is a proto-menopausal remedy for pre- and postmenopausal periods.

The drug contains levonorgestrel and estradiol valerate, which reduce menopause syndromes, improving the condition.

Levonorgestrel prevents the occurrence of endometrial cancer and the development of hyperplasia. Estradiol valerate, in turn, compensates for the lack of estrogen in the female body, relieving women of such symptoms of menopause as increased sweating, irritability, frequent mood swings, tearfulness, vaginal dryness, rapid heartbeat, sleep disturbance, headache, decreased libido, etc. .d.

In addition, Klimonorm is indicated for women after surgical removal of the ovaries, with atrophy of the mucous membranes and skin in postmenopause, for the prevention of osteoporosis.

Klimonorm is available in yellow and brown dragees. Women should take yellow pills for the first 9 days, and brown pills for the next 12 days. The tablets are taken at the same time once a day. If you miss a pill, you must take it within the next 24 hours, otherwise bleeding may occur. After taking a package of 21 tablets, you need to take a break for 7 days. At this time, vaginal bleeding should occur, similar to menstruation.

Klimonorm has a number of contraindications, under which it is prohibited to take the drug. This is the period of pregnancy and lactation, myocardial infarction, severe liver diseases and tumors, acute cerebral circulatory disorders, diabetes mellitus, endometriosis, hormone-dependent tumors, congenital disorders of lipid metabolism.

Side effects when taking the drug may include: nausea, dizziness, migraines, stomach pain, changes in libido, itching, chloasma, chest pain.

Compound

The package contains two types of dragees: brown (12 pcs.) and yellow (9 pcs.).
1 yellow dragee contains 2 mg estradiol valerate . 1 brown tablet contains 150 mcg of levonorgestrel and 2 mg of estradiol valerate. Auxiliary components: carnauba wax, magnesium stearate, potato starch, lactose monohydrate, polyvidone, titanium dioxide, calcium carbonate, magnesium carbonate, purified water, macrogol, glucose, gelatin.

pharmachologic effect

An antimenopausal agent containing gestagen and estrogen . In a woman’s body, estrogen, presented in the drug in the form of estradiol valerate, is metabolized to natural 17 beta-estradiol. Thanks to the addition of levonorgestrel (gestagen) for 12 days of each cycle, it is possible to prevent the development of endometrial malignancy and hyperplasia . In patients suffering from irregular menstruation, while taking the medication, the menstrual cycle (relevant for women with a non-removed uterus).

Estradiol is able to compensate for the lack of estrogen in a woman’s body upon the onset of menopause and allows to relieve negative psycho-emotional manifestations and vegetative symptoms:

dizziness;
excitability;
rushes of blood flow to the face;
irritability;
decreased libido;
increased sweating;
cardialgia;
migraine headache;
joint pain;
sleep disorders;
nervous excitability;
muscle pain;
vaginal dryness;
pain during sexual intercourse.

With a lack of estrogen, bone loss occurs. Estradiol helps prevent bone destruction. The principle of action is based on a shift in bone remodeling (towards the formation of bone tissue) and suppression of osteoclast activity. It has been proven that long-term hormone replacement therapy can significantly reduce the risk of fractures in women entering menopause. Properly selected hormonal therapy slows down the aging process, the formation of facial wrinkles, increases the level of collagen in the skin, and has a beneficial effect on its density.

Additionally, the drug lowers cholesterol and stabilizes the ratio of lipid profile indicators. It has been observed that hormonal therapy in postmenopausal women reduces the risk of developing colon cancer .

Overdose

Klimonorm for women during menopause (reviews about the product are negative, which most often indicates intolerance to the drug) is considered a relatively safe drug, and therefore rarely provokes an overdose.

Klimonorm during menopause can cause dizziness

In this case, the patient notes severe headache and dizziness, irritability. The patient's sleep deteriorates, and severe dyspeptic disorders occur in the form of nausea and vomiting. After emptying the stomach, the patient's condition does not improve. In addition, increased pain in the stomach and intestines is possible.

The most pronounced symptoms appear on the skin. The patient notes the appearance of a rash, unbearable itching and peeling of the skin. Sometimes acute urticaria develops, the itching intensifies, and allergic rhinitis and conjunctivitis occur.

The most severe symptom of an overdose is considered to be Quincke's edema, in which swelling of the mucous membranes of the throat occurs, accompanied by difficulty breathing, even suffocation. If signs of overdose appear, you should stop taking the pills and seek medical help. Usually a specialist prescribes symptomatic treatment to improve the condition.

Indications for use

urogenital dystrophy (reverse form of development of female genital organs);
menstrual irregularities due to menopause ;
atrophic changes in the mucous membranes and skin (thinning, dryness);
prevention of osteoporosis ;
emotional instability due to menopausal syndrome;
hormonal therapy after surgical removal of the ovaries;
irritation of the urethra and bladder, urinary incontinence due to stress during postmenopause.

Changes in a woman's body

It all starts in parts of the brain - in the pituitary gland and hypothalamus. With their help, the amount of necessary hormones entering the blood is regulated. Menopause combines the period several years before menopause and the postmenopausal period, which lasts until the end of life . Every woman begins menopause at a certain age: for some it is after 40 years, and for others after 55.

IMPORTANT!

Statistics say that women who smoke, as well as those who frequently drink alcohol, experience menopause one and a half to two years earlier.

As soon as estrogen begins to decrease in quantity, the woman notices sudden hot flashes. And even on cool nights the bed is wet with sweat. There is weakness in the body and the endless desire to sleep is annoying all the time. Arrhythmia, problems with the heart and blood vessels appear, and weight increases sharply. The gastrointestinal tract also makes itself felt. And these unpleasant sensations of itching, burning and a feeling of dryness in the vagina - what a discomfort it is.

Contraindications

hereditary pathology of lipid metabolism;
neoplasms of liver tissue, severe liver disease;
individual hypersensitivity;
myocardial infarction;
thromboembolism;
pathological genital bleeding, endometriosis ;
diagnosis or suspicion of the presence of hormone-dependent tumors of the mammary glands, ovaries, uterus;
acute stage of cerebrovascular accident ;
carrying a pregnancy ;
diabetic angiopathy , severe diabetes ;
breast-feeding;
progressive otosclerosis, herpes infection , skin itching , idiopathic form of jaundice .

Instructions for Klimonorm (Method and dosage)

Instructions for using Klimonorm while maintaining the menstrual cycle: start treatment on the 5th day of the cycle (the first day is counted from the moment menstrual bleeding appears). In case of rare menstruation, amenorrhea , or during menopause, the drug can be started on any day, excluding pregnancy. The package is designed for 21 days. Treatment begins with taking yellow tablets: 1 pc. every day for 9 days. Then take 1 brown tablet daily for 12 days. After this, a 7-day break is taken, during which bleeding occurs, similar to menstruation. Then they begin treatment again, taking the pills according to the same regimen. Dragees are not designed to be chewed; they must be swallowed whole with water. It is recommended to take the drug every day at a specific time. , vaginal bleeding may occur .

How it works?

First use yellow pellets. Eat one piece per day. When the yellow tablets run out, they switch to brown ones, maintaining the same dosage (one piece per day). After completing the tablets in the blister, you must take a week's break. Normally, this interval is accompanied by bleeding reminiscent of menstrual bleeding. Then the cycle is repeated. Each pill is swallowed completely, without chewing, washed down with water. It would be optimal to choose a specific time and use the drug constantly at that hour. If more than one dose is missed, there is a high chance of vaginal bleeding.

Does Klimonorm affect weight? Reviews about the results of treatment with the drug are varied. Mostly women agree that there was no weight gain, despite a long course of taking the medication. In rare cases, patients taking the drug complained of weight gain, but it is not always clear whether it was caused by the influence of the drug or by a complex of reasons (diet, physical activity, lifestyle, environment). Doctors recommend maintaining an active life, regularly giving yourself exercise and watching your diet. This approach will allow you to avoid problems with extra pounds, including during hormone replacement therapy.

Interaction

Before treatment, all hormonal contraceptives are discontinued. To prevent unwanted pregnancy, it is recommended to use non-hormonal contraception . Clinical effectiveness and clearance of sex hormones are reduced while taking liver enzyme inducers ( antibiotics , anticonvulsants). A similar effect is observed when treating with Rifampicin , Carbamazepine , barbiturates, Griseofulvin . The maximum rate of enzyme induction is recorded after 2-3 weeks of therapy and can persist for 4 weeks after discontinuation of the medication. A drop in estradiol levels is observed when taking Tetracycline and Penicillin.

Due to competitive inhibition of conjugation during absorption, the bioavailability of estradiol increases during simultaneous therapy with drugs that are largely subject to conjugation (including Paracetamol ).

In patients with diabetes mellitus, glucose tolerance may change, which requires adjustment of the dose of insulin and hypoglycemic drugs. Drinking alcoholic beverages can increase the level of extradiol in a woman’s body.

Hormone replacement therapy

Since when menopause appears in the female body there is a deficiency of the necessary hormones, then in order to normalize the general condition they simply need to be replenished and restored. To achieve this, women resort to hormone replacement therapy (HRT). This therapy is aimed at raising the necessary hormones in a woman’s body. When taking such drugs, hot flashes decrease and problems with the cardiovascular system fade into the background.

It is necessary to take HRT medications for about two years to reduce unpleasant symptoms during the initial stages of menopause.

Such drugs contain only natural estrogen, which improves the functioning of the cardiovascular system and improves the psycho-emotional state. When using progesterone, the possibility of uterine cancer decreases.

To use hormone replacement therapy drugs, you simply need to select the required dose and determine the duration of its use. HRT drugs contain much lower doses of hormones than birth control pills

It is also important to note that hormone replacement therapy does not have contraceptive properties.

special instructions

Under no circumstances should the medication be used as a contraceptive . Before treatment, it is necessary to examine the condition of the mammary glands, liver system, cholesterol levels, and blood pressure . For porphyria, multiple sclerosis , otosclerosis, varicose veins , arterial hypertension , sickle cell anemia, additional consultation with specialists is carried out before starting hormonal therapy. of migraine headaches increases , if auditory or visual perception is impaired, bile stasis, or thromboembolic disorders, treatment is stopped.

Precautionary measures

Cannot be used as a contraceptive. Before starting use, it is necessary to carry out gynecological control and PAP smear, examination of the mammary glands and liver function, monitoring of blood pressure, blood cholesterol levels, and urine analysis. It should be used with caution in persons with diabetes mellitus, accompanied by vascular changes, with arterial hypertension, varicose veins, phlebitis, otosclerosis, multiple sclerosis, porphyria, sickle cell anemia. Effectiveness decreases with excessive alcohol consumption. You should stop taking the drug if there is an increase in migraine-like headaches, acute visual impairment, hearing and other symptoms of sensory dysfunction, acute thrombosis, thromboembolic disorders, bile stagnation, jaundice, a constant feeling of itching, if liver tumors are detected, a significant increase in blood pressure, increased frequency of epileptic seizures, prolonged bed rest, 6 weeks before surgery. In patients with diabetes mellitus, it is possible to change the dosage regimen of hypoglycemic agents.

Analogs

Level 4 ATX code matches:
Femoston

Structural analogues:

Femoston;
Cliogest;
Climodien.

Medicines with similar pharmacological effects:

Estrovel;
Onagris;
Menopace;
Inoclim;
Feminal.

What is better Femoston or Klimonorm?

When choosing a combined hormonal drug, the doctor always takes into account the patient’s age, the presence of contraindications, weight, and concomitant pathology. Therefore, it is better to rely on the opinion of your attending physician, who will take into account all the features and select exactly the medication that is most suitable for your body: Femoston or another combined hormonal medication.

Best for yourself

It is not always clear from reviews which is better: Klimonorm or Femoston. Both hormonal drugs affect the female body in a similar way, although the chemical characteristics are somewhat different. Klimonorm also has other competitors. It is better to choose a specific option after consulting your doctor. There may be cases of individual intolerance, and the effect on the body is specific in each individual case. In order not to encounter unpleasant results and side effects, it is better to give preference to the drug recommended by the treating doctor.

If the remedy was chosen successfully, under its influence the blood is cleared of cholesterol, thereby improving the quality of the lipid profile. Also, clinical trials have clearly demonstrated that the likelihood of malignant neoplasms in the large intestine, which is one of the highest cancer risks for the period after menopause, is reduced.

Reviews of Klimonorm

Feedback from women about Klimonorm indicates the absence of pronounced negative reactions during treatment. Patients indicate that the drug really helps to cope with unwanted psycho-emotional reactions, reduces irritability and excitability. Forums on relevant topics contain reviews from doctors, who also confirm the high effectiveness of the drug in the treatment of negative symptoms of the postmenopausal period. In general, reviews of Klimonorm are positive.

Summing up

Reviews from both doctors and women who have used Klimonorm are generally positive. The medication has a rather gentle effect on the female body, rarely provokes side effects, does not cause weight gain, and has a positive effect on both well-being and appearance. At the same time, some patients noted intolerance to the drug or its lack of effectiveness. Presumably, this is explained by the individual characteristics of the body and is adjusted by choosing another medication together with the attending physician.