Trental, 100 mg, enteric film-coated tablets, 60 pcs.

• October 11, 2020
• Other drugs
• Ulyana Romanova

Intended for administration through a dropper, Trental is a vasodilating drug. It helps reduce blood viscosity and significantly improve its rheological properties (that is, fluidity). In what cases is it prescribed? What conditions does it help cope with? Are there any contraindications? You will learn the answers to these and many other questions from this article.

Release form, composition and price

Before we talk about in what cases Trental is administered to a patient through an IV, we need to discuss the features of this drug.

It is produced in the form of a concentrate intended for preparing a solution. It is transparent and colorless, and 1 ml contains 20 mg of the active substance, which is pentoxifylline. There are auxiliary components - water for injection and sodium chloride.

The average price of a package with 5 ampoules is 150-160 rubles. It is also worth knowing that Trental is also available in tablet form.

Impact on the body

What effect does this drug have? Trental, administered through a dropper, lowers blood viscosity and improves the rheological properties of blood, because it significantly improves the condition of deformed red blood cells, and also reduces their aggregation (as well as platelets, however). In addition, as a result, the concentration of fibrinogen, the activity of leukocytes and their adhesion to the vascular endothelium decrease.

Pentoxifylline itself is a xanthine derivative. Its mechanism of action is associated with the accumulation of cAMP in blood cells and smooth muscle cells, as well as with the inhibition of phosphodiesterase.

Due to the vasodilating myotropic effect inherent in the drug, peripheral vascular resistance decreases somewhat and the coronary vessels dilate.

Also, the medication has a slight positive effect on the heart, improves the condition of the brain, microcirculation, and in case of occlusive pathologies of peripheral arteries it leads to other positive results - walking distance increases, night cramps disappear, and pain that often bothers patients at rest disappears.

Operating principle

In order to calmly give droppers and/or injections of the drug, you need to understand exactly how it helps provide treatment to a person. This is how Trental works.

When the solution enters the bloodstream, it begins to interact with damaged capillaries. Thanks to the active substance of the drug, the elasticity of the walls of red blood cells is successfully restored, the increased clotting of platelets is inhibited, and the blood begins to flow better due to the fact that its overall viscosity is noticeably reduced. The walls of blood vessels also expand somewhat due to the fact that spasms in them decrease.

In addition, metabolism is normalized in the tissues and structures of the spine and gas exchange is restored. Blood flow is restored through the vessels of the spinal cord after a stroke. Nerve conduction is also restored due to proper nutrition and correct blood supply to the nerve endings in the affected area.

Pharmacokinetics

If you administer Trental through a dropper, you will be able to achieve high bioavailability, thanks to which the active substance will quickly be distributed throughout the body.

Pentoxifylline does not bind to plasma proteins, like its metabolites. By the way, the latter are actively formed in the liver and red blood cells. The concentration of the main metabolite, which is 1-(5-hydroxyhexyl)-3,7-dimethylxanthine, is twice the volume of pentoxifylline itself initially entering the body.

The half-life lasts 1.6 hours. About 90% is excreted by the kidneys in the form of water-soluble unconjugated metabolites.

In patients suffering from kidney problems, this process is slowed down. People with kidney problems have a different problem - in their body, pentoxifylline exhibits increased, absolute bioavailability, and the half-life is extended.

Indications

They are described in detail in the instructions for use of Trental. A dropper with this drug can be prescribed to treat the following conditions:

• Trophic disorders. For example, gangrene or trophic ulcers of the legs.
• Otosclerosis, as well as degenerative changes that have arisen due to pathologies of the vessels of the inner ear and hearing loss in general.
• Occlusive disease affecting peripheral arteries. It can have one of two genesis - either diabetic or atherosclerotic. But most often, of course, patients suffer from diabetic angiopathy or intermittent claudication.
• Post-stroke and ischemic conditions.
• Problems with cerebral circulation. They usually occur as a result of cerebral atherosclerosis and are accompanied by memory impairment, dizziness, and impaired concentration.
• Problems with blood circulation in the choroid and retina of the eye.

By the way, the tablets have similar indications. A dropper with Trental, however, has a faster effect - but in what form a person will take this remedy will be determined by his attending physician.

Similar drugs

It is definitely worth mentioning analogues of this product. After all, it is often necessary to select a replacement. And it must match the active components and principles of action. So, today in the list of analogues to Trental they call:

• Agapurin;
• Vazonite;
• Pentilin;
• Pentoxifylline;
• Trenpental;
• Flexital.

All of them are offered in pharmacies and are freely available. But this does not mean that you should prescribe them yourself and select the dosage according to the instructions. After all, there is a risk of not meeting the specified parameters and significantly harming your health.

All replacements must be agreed with your doctor. After all, the dosages may not be the same. And this is fraught with problems with undertreatment and overdose.

Contraindications

So, why droppers with Trental are prescribed is clear. But you need to understand that such a serious drug has contraindications. Namely:

• Massive bleeding. The use of medication can strengthen it.
• Brain hemorrhage.
• Pregnancy.
• Extensive hemorrhage in the eye.
• Acute myocardial infarction.
• Lactation period.
• Young age (under 18 years old).
• Individual intolerance to galactose.
• Glucose-galactose malabsorption syndrome.
• Lactase deficiency.
• Hypersensitivity experienced in relation to pentoxifylline or any other substance included in the drug.

There are also a number of conditions in which the medicine should be taken with caution - only if the benefit outweighs the possible risk. They can be identified in the following list:

• Severe heart rhythm disturbances.
• Arterial hypotension.
• Chronic heart failure.
• Ulcer of the duodenum and stomach.
• Kidney problems (creatinine clearance less than 30 ml/min).
• Severe liver dysfunction.
• Increased risk of bleeding.
• The need to treat with anticoagulants, hypoglycemic agents, theophylline, ciprofloxacin or platelet aggregation inhibitors.

In general, there are many contraindications, and if you want to avoid the consequences that may arise, you need to take the medication only in accordance with medical instructions.

What do Trental tablets help with? Instructions for use

Category: t 11/04/2016 · : 2 · Reading time: 4 min · Views:
Trental tablets, what do they help with? The medicine has vasodilating properties and reduces blood viscosity. The instructions for use recommend taking the drug "Trental" for stroke and encephalopathy.

Pharmacological properties

The active substance that is part of the drug “Trental”, which helps with circulatory abnormalities, reduces platelet aggregation, blood viscosity, and improves the elasticity of red blood cells. When taking the medication regularly, adenosine monophosphate accumulates in the blood and vascular tissues. The drug produces a myotropic and vasodilating effect, improves blood properties.

The drug is well absorbed from the gastrointestinal tract. Its highest concentration in plasma is observed 60 minutes after administration. The active substance is completely metabolized by the liver and excreted through the kidneys.

Composition and release form

Produced in the form of tablets and solution for infusion. The active element of Trental tablets, which helps the medicine for heart problems, is pentoxifylline. Its content in capsules reaches 100 mg.

Better absorption of the drug is facilitated by: starch, silicon dioxide, magnesium stearate, etc. The concentrate for solution for infusion contains 20 mg of pentoxifylline per 1 ml.

Long-acting tablets "Trental" 400 contain 400 mg of the active substance.

Injections, tablets "Trental": what does the drug help with?

Indications for use are as follows:

• ischemic stroke;
• Raynaud's disease;
• encephalopathy;
• angioneuropathy;
• trophic ulcers;
• insufficient blood circulation in the retina and inner ear;
• respiratory diseases;
• frostbite;
• sexual dysfunction due to circulatory problems.

Trental tablets: why and how to take them

The volume of the prescribed drug and the duration of therapy are determined by a specialist for each patient. As a rule, 6-8 tablets are taken per day. This form of the drug is used as part of complex therapy or to prolong treatment after injections. The maximum daily volume of medication should not be more than 1.2 g.

Instructions for use "Trental 400"

Extended-release tablets are prescribed to be taken 3 times a day, 1 capsule. The maximum daily dosage is 1.2 g.

Price, where to buy

In Moscow, St. Petersburg and other Russian cities, you can buy Trental tablets for 525 rubles. The cost of the drug in Kyiv reaches 31-111 hryvnia. In Minsk, the medicine is sold for 8-16 bel. rubles, in Kazakhstan – 1,970 tenge (Trental 400 mg (pentoxifylline) No. 20 tablets (pack) AVENTIS PHARMA, Ltd. (India)).

Opinions of patients and doctors

People who have taken the drug "Trenatal" give different reviews about its action. They indicate the effectiveness of the drug when prescribed according to indications. But the overall positive impression is spoiled by reviews of side effects. Often after taking the medicine, nausea, headache, increased blood pressure, and disturbed sleep occur.

Reviews from doctors confirm the effectiveness of the product. Their observations prove that after taking the product, microcirculation improves. It is often used for diabetes. The drug is prescribed both in tablets and solution of 100 and 400 mg. Reviews from doctors warn that blood fluidity increases after using the drug Trental, which can cause hemorrhage in the retina.

Many patients ask: “Which is better – Trental or Pentoxifylline?” Doctors answer that “Pentoxifylline” is included in the drug “Trental” as an active element. In this case, it is presented as a separate drug, has similar properties and a lower price.

Source: https://www.otchegopomogaet.ru/trental.html

Treatment during pregnancy

As mentioned above, this position in which the patient may find itself is a contraindication. During pregnancy, it is dangerous to use droppers with Trental, since there is very little data regarding how pentoxifylline affects the fetus. Therefore, it is better not to take risks.

However, it is known for sure that this substance passes into breast milk. And if a woman has been prescribed treatment with this medication, she will have to stop breastfeeding and transfer her to artificial formula.

Pharmacological properties

The drug Trental belongs to the group of angioprotectors that correct blood microcirculation. It is effective for vascular diseases due to its properties:

• improvement of blood circulation in diseased tissues;
• saturation of tissues with oxygen;
• positive effect on the bioelectrical activity of the brain;
• dilates the walls of blood vessels;
• has a positive effect on the state of respiratory function;
• blood viscosity decreases;
• heart function improves;
• acts as a prophylactic against platelet aggregation;
• the elasticity of red blood cells increases;
• the functioning of the central nervous system is normalized.

The tablet is very quickly absorbed by the intestinal walls. 90% of the substance is excreted by the kidneys.

Dosage

It is always determined on an individual basis, taking into account the severity of circulatory disorders and the presence (or absence) of personal intolerance to the medication. In general, the doctor takes into account all the characteristics of the patient.

However, general recommendations can still be found in the instructions for use of Trental.

The dropper is indicated in more severe cases of the disease, unlike tablets. The dosage can vary from 100 to 600 mg. Dilute the concentrate in 250 or 500 ml of 0.9% sodium chloride solution. The procedure is done 1-2 times a day. Here are other features of the drug that need to be taken into account:

• Compatibility with other infusion solutions must be tested separately. Only transparent ones are allowed for use.
• The minimum duration of infusion containing 100 mg of the drug is 1 hour.
• It is necessary to reduce the administered volumes if a person has concomitant diseases - for example, chronic heart failure. Then doctors resort to using a special infuser to control the procedure.
• If the doctor deems it necessary, he will also prescribe the patient Trental tablets, which will enhance the effect. However, the total daily dose should not exceed 1200 mg.
• Trental can be administered dropwise (intravenously) for 24 hours. This is called a continuous infusion, and during this entire time, 1200 mg of the drug enters the patient's body. Sometimes the dose is divided into two doses of 600 mg, but then each of them lasts at least 6 hours.
• Often the individual dose is calculated using the following formula: 0.6 mg per 1 kg of patient body weight per hour. For a person weighing 70 kg, for example, the daily dosage in this case will be 1000 mg.
• If the patient suffers from renal failure, then the amount of drug administered should be reduced by approximately 30-50%. Adjustment is also necessary for people with liver problems.
• Over time, the patient can be switched to tablets - but only after the desired result can be achieved through droppers. The instructions for Trental state that the initial dose is: 100 mg three times a day. Then it is slowly increased to 200 mg.
• In patients with low blood pressure, treatment always begins with small doses. The same applies to people at risk due to a possible decrease in blood pressure. These are patients with coronary artery disease, hemodynamically significant stenoses and other pathologies.

In general, as one might understand, when determining the dosage, everything is taken into account - from age to indications for use. Droppers with Trental are effective, but it is important to use them correctly so as not to harm the body.

Recommendations for analogues and patient reviews

The main analogues of the drug include drugs with the active substance pentoxifylline. These are Pentin, Vazonit, Pentamon, Aguparin, Pentohexal, Arbiflex, Pentoxifylline. Some analogues of Trental tablets are much cheaper, but before replacing the drug with them, you should consult with your doctor.

Structural analogues also include a number of other drugs: Agapurin, Radomin, Pentilin forte, Flexital, Arbiflex, etc.

Reviews on social networking sites dedicated to Trental, submitted by patients as well as doctors, indicate positive aspects. Patients note an improvement in their condition, a quick and noticeable effect.

• Alekseev V.B., therapist, 10 years of experience: I often prescribe Trental to my patients for a number of diseases. I like the result of therapy that I see at the end of the course. Side effects are extremely rare. I make sure that the concentration of the medication taken in the blood increases gradually. I tell patients in detail about the effect of the substance on the body. My recommendations to Trenthal!
• Olga A., 40 years old: After suffering from the flu, some time later, she discovered that she had hearing problems. I did nothing for several years until a young ENT doctor at Prof. took charge of me. inspection. He prescribed Trental for me and explained that my hearing loss was due to problems with the intra-ear vessels. Personally, the drug helped me. After the course, I began to hear better, and my overall health improved. Now I will take the medicine twice a year to support my body.
• Ivan A., 28 years old: Despite my young age, during a medical examination I was diagnosed with high blood pressure and increased eye pressure. I was prescribed a course of the drug Trental. Am I pleased with the result?

Overdose

It may arise. Therefore, it is important to know the symptoms that indicate this condition. Among them:

• Nausea and vomiting like “coffee grounds.”
• Redness of the skin.
• Dizziness.
• Blood pressure problems.
• Arrhythmia.
• Tachycardia.
• Loss of consciousness.
• Areflexia.
• Chills.
• Convulsions of a tonic-clonic nature.

In case of overdose, symptomatic therapy should be started as soon as possible. The appearance of the first alarming signs is a signal to urgently stop taking the drug.

It is very important to take all measures that can prevent absorption of the active substance. The main efforts are directed towards maintaining respiratory function and normal blood pressure. If convulsive seizures occur, administer diazepam. Unfortunately, there is no specific antidote for this substance.

Side effects

It is important to discuss them too. They are described in detail in the instructions for use of Trental. This medication is administered intravenously (by dropper) in special cases, and therefore adverse reactions in a weakened body may be different:

• Gastrointestinal tract: anorexia, xerostomia, vomiting, nausea, feeling of fullness in the abdomen, constipation, diarrhea, increased salivation.
• Hematopoietic system: hypofibrinogenemia, neutropenia, leukopenia, pancytopenia, thrombocytopenia.
• Skin and subcutaneous tissues: rash, itching, redness (erythema), increased brittleness of nails, urticaria, swelling.
• Cardiovascular system: arrhythmia, tachycardia, angina pectoris, problems with blood pressure, hot flashes, bleeding (from mucous membranes, skin vessels, in the intestines, stomach, etc.).
• Liver and biliary tract: intrahepatic cholestasis, increased activity of alkaline phosphatase and transaminases in the liver.
• CNS: convulsions, headache, dizziness, aseptic meningitis.
• Psychiatry: anxiety, sleep disturbances, agitation.
• Visual organs: scotoma, problems with clarity of perception of reality.
• Immune system: anaphylactoid or anaphylactic type reactions, shock, edema, bronchospasms.

Of course, most of these reactions are extremely rare, but every patient should be warned about them, since they are listed in the instructions. Droppers with Trental are usually well tolerated by people, but you need to be aware of the likely consequences.

special instructions

There are a number of features that you need to be familiar with before starting treatment. The doctor will definitely familiarize the patient with them, but for the sake of general development, it won’t hurt to study them:

• During therapy, be sure to keep blood pressure under control.
• Prescribing Trental simultaneously with anticoagulants requires regular blood checks for patients.
• If the medication is prescribed to a patient with diabetes mellitus who is being treated with hypoglycemic drugs, then you need to know that this combination can cause hypoglycemia in him. Therefore, the doses of all medications must be adjusted.
• Patients with unstable and low blood pressure are prescribed smaller doses of Trental. The same goes for older patients.
• In people who have recently undergone surgery, hematocrit and hemoglobin levels should be checked.
• You need to know that smoking reduces the therapeutic effectiveness of droppers with Trental. Reviews confirm this - even the patients themselves recommend giving up the habit in the name of health and achieving the desired result.
• The drug is not prescribed to children, since the effectiveness and safety of this medication in their case have not been sufficiently studied.

Also, taking into account possible side effects, it is recommended to refrain from performing potentially dangerous work and activities that require increased concentration during treatment.

Drug interactions

During therapy, it should be taken into account that Trental, when used simultaneously, enhances the effect of:

• Medicines that lower blood pressure (nitrates, ACE inhibitors);
• Antibiotics, including cephalosporins;
• Medicines that affect the blood coagulation system (thrombolytics, indirect and direct anticoagulants).

Cimetidine can increase the concentration of the active component of Trental (pentoxifylline) in plasma, which increases the risk of side effects.

Excessive nervous excitement can result from the combined use of Trental with other xanthines.

During simultaneous administration of Trental with anticoagulants, blood coagulation parameters should be carefully monitored.

What do the experts say?

This question should also be answered, since the Trental instructions are being discussed. In reviews of IVs, doctors talk in detail, claiming that this remedy is a real “classic” for the treatment of polyneuroangiopathies and peripheral circulatory disorders. And here are some of their comments that are most common:

• The medicine has the best effect on the functioning of the heart - Trental is completely irreplaceable in the treatment of compression-ischemic syndrome.
• Unlike its analogues, the product has proven itself well - which is why it enjoys great confidence among doctors. Side effects from Trental are rare, and the result always lives up to expectations.
• For chronic ischemia of the lower extremities, the medication helps reliably. There has never been a case where, as a result of its use, the distance of pain-free walking did not increase.
• The drug helps to normalize the condition of patients suffering from acute and chronic vascular insufficiency. The main thing is to drip slowly, otherwise nausea, weakness and dizziness will appear.
• In the field of neurosurgery, this drug is popular and is often used in the treatment of traumatic brain injuries, compressive radiculopathy and peripheral nerve injuries.
• The therapeutic effect is produced quickly and clearly, pain relief and normalization of all patient functions occurs quickly.
• Intravenous administration helps to achieve a faster and more stable result, however, due to infusions, patients' blood pressure often drops, and therefore, if the condition is not too serious, the person can be prescribed medication in tablets.
• Doctors also admit that the drug in the form of pills quite adequately replaces infusion therapy. In addition, it is much more convenient to use it in an outpatient setting. Microcirculatory disorders, arterial pathologies, chronic venous ulcers and CHF can be treated with tablets.

In general, at a relatively low price, Trental is a reliable, time-tested drug that has earned credibility among doctors of various profiles - phlebologists, rheumatologists, neurologists, orthopedists-traumatologists and many others.

The main thing is that patients follow the instructions for use. Droppers with Trental, reviews of which are extremely positive, really help - but any medicine can turn out to be poison, and it is important to prevent this under no circumstances.

What reviews are there about the drug?

Today Trental is quite common. Therefore, many have used it and have already formed their opinion about this product.

User llkasimov notes that this is a good drug for microcirculation in kidney diseases, and he does not find any shortcomings in it. He says that he was treated in the hospital for quite serious kidney problems in which there was a deterioration in their blood supply. At first, to solve the problem, he was prescribed Curantil, but it gave a side effect in the form of a headache. Then they changed it to Trental. Now he uses it regularly for preventive purposes. This remedy is well tolerated and does not produce side effects.

User Khranya is sure that such a drug perfectly improves blood flow. Convenient reception is one of its advantages. It is important to understand that it should be taken very carefully and exclusively under the supervision of a doctor. Her husband has too high a hemoglobin, which in the future is fraught with too viscous blood. Therefore, he has already started taking Trental for the purpose of prevention. Course once a year for 2-3 weeks. And against this background, the indicators are noticeably changing for the better.

User Gauhariya notes that it was Trental who helped his brother save his legs from amputation. But at the same time he says that such a remedy as a permanent therapy will be expensive. The author's brother began to have problems with his legs - pain, limbs were frozen even in summer. It turned out that the vessels were clogged and blood did not move well through them. The question of amputation even arose. However, after a course of therapy with Trental, the situation changed dramatically for the better, and my legs were saved.