Composition of Kalcemin Advance
The drug contains, per 1 tablet: calcium (in the form of carbonate and citrate ) - 500 mg, vitamin D3 - 200 IU, boron - 250 mcg, magnesium 40 mg, manganese 1.8 mg, zinc 7.5 mg, copper oxide - 1 mg.
Additionally, the composition includes: magnesium stearate, microcrystalline cellulose, crocscarmellose, stearic acid, maltodextrin.
The shell consists of: magnesium silicate, hypromellose, titanium dioxide, silicon dioxide, mineral oil.
Pharmacological properties
Pharmacodynamics
Calcemin Advance contains 2 macroelements (calcium and magnesium), 4 microelements (boron, zinc, copper and manganese) and vitamin D3 (colecalciferol). These nutrients are necessary for the normal functioning of the body and perform the following functions:
- calcium: takes part in the formation of bone tissue, increases its density and reduces resorption; strengthens joints and bone tissue; prevents the development of diseases of the musculoskeletal system;
- magnesium: participates in protein synthesis and the formation of bone and muscle tissue;
- boron: improves calcium absorption; prevents the development of osteoporosis; reduces excess activity of PTH (parathyroid hormone); reduces the risk of developing vitamin D3 deficiency;
- zinc: necessary for the synthesis of female and male sex hormones, which has a beneficial effect on bone tissue and prevents its destruction and loss of density;
- copper: takes part in the synthesis of elastin and collagen, which are part of connective and bone tissue, which, in turn, affects the formation of bone mass;
- manganese: necessary for the synthesis of proteoglycans, which improve the quality of bone tissue and participate in the formation of the collagen matrix of bone tissue;
- vitamin D3: the main element regulating the metabolism of phosphorus and calcium; enhances intestinal absorption of calcium and renal reabsorption of phosphorus; necessary for maintaining bone structure and skeletal formation.
Thanks to the special form of calcium in the preparation (calcium citrate), the best absorption of this macronutrient is ensured, regardless of the state of the gastrointestinal tract. That is why Calcemin Advance can be used in patients with reduced secretory function of the digestive tract, as well as simultaneously with other drugs that reduce secretion. In addition, calcium citrate does not increase the calcium and oxalate levels in the urine, and therefore does not lead to the formation of kidney stones. This form of calcium does not interfere with the absorption of iron, thereby reducing the risk of iron deficiency anemia.
Pharmacokinetics
Information on the pharmacokinetic parameters of Calcemin Advance is not provided.
Reviews about Kalcemin Advance
Numerous reviews indicate the widespread use of the drug for beauty. Girls and women believe that thanks to the product, nails, teeth and hair are well strengthened. There is extensive experience in use for osteoporosis and fractures.
The disadvantage is the large size of the tablet, which makes swallowing difficult, and the presence of various dyes and excipients.
There are reviews from dentists who widely prescribe the medicine to strengthen teeth, and traumatologists also use it to accelerate the healing of bones in fractures .
Overdose
Taking high doses of Calcemin Advance and/or long-term treatment can lead to overdose, manifested by hypervitaminosis of vitamin D3, hypercalciuria and hypercalcemia. The main symptoms of overdose: thirst, decreased appetite, dizziness, nausea, headache, vomiting, fainting, muscle weakness, abdominal pain, constipation, urolithiasis, bone pain, nephrocalcinosis, polyuria, mental disorders, fatigue, coma; in severe cases - arrhythmias. Long-term intake of calcium in a daily dose of more than 2500 mg can lead to soft tissue calcification and kidney damage.
At the first signs of an overdose, you should reduce the dose of the drug or stop it completely, and then consult a doctor. It is possible to carry out symptomatic therapy and standard measures to prevent intoxication (gastric lavage, inducing vomiting).
Patients with hypercalciuria (more than 300 mg per day) are prescribed loop diuretics, calcitonin, glucocorticosteroids, bisphosphonates, rehydration, and in severe cases, hemodialysis.
Price Calcemin Advance, where to buy
The cost of the drug ranges from 293 rubles. for 30 tablets up to 731 rub. per pack of 120 tablets.
In Moscow, the price of Calcemin Advance is on average 441 rubles. for 60 tablets and 589 rubles. for 120 pieces.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Calcemin Advance tablets p.p.o.
60 pcs. Sagmel Inc/Contract Pharmacal Corporation 564 RUR order - Calcemin Advance tablets p.p.o. 30 pcs. Sagmel Inc/Contract Pharmacal Corporation
460 rub. order
- Calcemin Advance tablets p.p.o. 120 pcs. Contract Pharmacle Corporation
RUB 859 order
Pharmacy Dialogue
- Calcemin Advance tablets b. #60Sagmel Inc.
RUB 894 order
- Calcemin Advance tablets No. 30Contract
RUR 499 order
- Calcemin Advance (tablet no. 60)Contract
RUR 712 order
- Calcemin Advance tablets No. 120Sagmel Inc.
915 rub. order
- Calcemin Advance (table p/o No. 120)Contract
RUB 1,027 order
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Pharmacy24
- Calcemin Advance N60 tablets Contract Pharmacal Corporation, USA
150 UAH. order
PaniPharmacy
- Calcemin Advance film-coated tablets No. 60, Contract Pharmacal Corporation
157 UAH order
- Calcemin Advance film-coated tablets No. 30, Contract Pharmacal Corporation
95 UAH order
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Contraindications
Absolute:
- active tuberculosis;
- severe renal failure;
- urolithiasis disease;
- increased calcium levels in urine;
- Besnier–Beck–Schaumann disease (sarcoidosis);
- vitamin D hypervitaminosis;
- high concentration of calcium in blood plasma;
- allergy to soy and peanut butter (since the tablets contain soy polysaccharide);
- children under 12 years of age;
- hypersensitivity to the ingredients of the drug.
Relative (Kalcemin Advance tablets are used with caution):
- mild to moderate renal failure;
- pregnancy period;
- breast-feeding.
Side effects
According to patient reviews and post-registration experience, Calcemin Advance can provoke unwanted reactions.
Identified side effects are indicated in the instructions, these include:
- abdominal discomfort, increased gas formation, diarrhea or constipation, vomiting;
- skin rashes, itching, nettle fever;
- systemic allergic reaction, including lung obstruction syndrome, manifestations of damage to the upper respiratory tract, heart or vascular system in the form of sneezing, swelling of the larynx or tongue, copious nasal discharge, bronchospasm, hypotension, tachycardia;
- anaphylaxis.
The simultaneous intake of vitamin A helps reduce the toxicity of cholecalciferol, and cardiac glycosides, on the contrary, increase their toxic effect when taken together. The absorption and effectiveness of the vitamin-mineral complex is also affected by glucocorticosteroids, hormonal contraceptives, barbituric acid derivatives, tetracyclines, bisphosphonates, and sodium fluoride.
Combining Calcemin Advance with the following medications has a negative effect:
- Furosemide;
- thiazide diuretics;
- loop diuretics;
- calcium antagonists;
- aluminum-containing antacid preparations.
You should refrain from simultaneous or sequential use of Calcemin Advance tablets with this group of drugs or consult a doctor for adjustment of administered doses, monitoring the body’s reaction and monitoring the clinical condition.
Drug interactions
When using Calcemin Advance together with other drugs, the following drug interactions are possible:
- vitamin A: the toxicity of vitamin D3 is reduced;
- cardiac glycosides: the toxicity of cardiac glycosides increases (it is necessary to monitor the electrocardiogram and the clinical condition of the patient);
- laxatives: decreased absorption of vitamin D3;
- diuretics from the thiazide group: increases the risk of hypercalcemia;
- loop diuretics (for example, furosemide): increases calcium excretion by the kidneys;
- barbiturates, glucocorticosteroids and phenytoin: the effectiveness of vitamin D3 is reduced;
- levothyroxine, hormonal contraceptives for oral administration, glucocorticosteroids: absorption of calcium ions decreases;
- antacids containing aluminum: the effectiveness of Calcemin Advance is reduced.
Calcemin Advance is not recommended to be taken simultaneously with tetracycline antibiotics (the interval between doses of these drugs must be at least 3 hours), sodium fluoride and bisphosphonates (the interval must be at least 2 hours).
Calcemin Advance should not be combined with calcium channel blockers.
Analogs
If you are individually intolerant to Calcemin Advance, your doctor may suggest an analogue of the drug.
- Vitrum Osteomag. Prevents vitamin D and calcium deficiency in adolescents, during menopause and postmenopause in women, and in old age in men.
- Kaltsinova for children. Provides the need for calcium and vitamin D in case of allergies to milk and dairy products. Serves
prevention of caries and other dental diseases. Strengthens bones. - Tetravit Pregna is the best vitamin complex for pregnant women. Eliminates toxicosis, protects against the threat of miscarriages and premature births, congenital defects in newborns.
- Pantoshka calcium . Recommended for those prone to fractures and the formation of calluses. The best vitamin complex for teenagers and athletes.
- Undetab is a vitamin complex for older people that restores metabolic processes and helps strengthen immune defense.
- Calcemin Citra . Approved for use not only by adults, but also by children over five years of age. Strengthens periodontal, cartilage and bone tissue.
- Calcium D3 Nycomed.
- Multi-tabs Baby Calcium+ . Vitamins for preschool children. (from 2 years old).
Video: “Review of calcium preparations”
special instructions
Calcemin Advance should be taken in doses prescribed by your doctor or indicated in the instructions. Excessive intake of calcium into the body can lead to impaired absorption of zinc, iron and other vital minerals.
Impact on the ability to drive vehicles and complex mechanisms
There is no data on the effect of Calcemin Advance on reaction speed and concentration when driving a car or other vehicles and machinery.
Adverse reactions
The drug, if the dose is observed, is well tolerated by most patients. Rarely may occur:
- nausea, vomiting;
- unstable stool;
- abdominal pain, bloating;
- rashes, redness on the skin, itching.
In case of overdose the following appears:
- weakness,
- headache,
- loss of appetite,
- dizziness,
- short-term loss of consciousness,
- bone pain,
- heart rhythm disturbances,
- tendency to constipation.
If you take high doses for a long time and uncontrollably, calcium is deposited in organs and artery walls, and blood circulation worsens. An extremely high level of calcium salts leads to a comatose state with a fatal outcome.
Vitrum Osteomag
When choosing Kalcemin analogues based on composition, you can pay attention to the Osteomag mineral complex, which regulates the content of microelements in the body. Vitrum Osteomag, produced in tablets, contains a complex of microelements:
Vitrum Osteomag, produced in tablets, contains a complex of microelements:
- vitamin D3;
- magnesium oxide;
- manganese sulfate;
- sodium borate;
- copper oxide.
Indications for use for preventive and therapeutic purposes:
- lack of minerals during menopause;
- osteomalacia;
- active bone growth during adolescence;
- osteoporosis.
Calcemin substitute is contraindicated:
- with the development of urolithiasis;
- with severe symptoms of renal failure;
- with an excess of components of the composition in the body;
- with sensitivity to the constituent components.
Side effect: allergic reaction and possible dyspeptic disorders.
If the original product and the analogue have similar characteristics, what is the difference between Kalcemin Advants and Vitrum Osteomag? There are practically no differences between the drugs, with the exception of the manufacturer company and the price of the mineral complex. Vitrum Osteomag costs a little less – from 350 rubles.
The complex of vitamins and minerals Osteocare is a complete analogue of Calcemin in composition and pharmacological action.
The drug contains minerals, including calcium, magnesium hydroxide and others. Osteokea is available not only in the form of tablets, but also in the form of a solution.
The substitute is prescribed for pathologies:
- calcium metabolism disorder;
- different forms of osteoporosis;
- excess growth in children and adolescents;
- bone fractures.
Contraindications:
- excess levels of vitamin D3 in the body;
- decalcifying neoplasms;
- nephrourolithiasis;
- immobilization osteoporosis;
- renal osteodystrophy;
- the likelihood of an allergy to components from the composition;
- phenylketonuria.
In exceptional cases, when taking Osteocare, an adverse reaction occurs in the form of gastrointestinal disorders and various types of allergic reactions.
The cost of a cheap analogue of Osteokea is from 350 rubles.
Calcemin Advants and analogues are drugs whose action is aimed at strengthening joint and bone tissues. It is not recommended to take Calcemin and other drugs without a doctor's prescription. You should remember about contraindications and adverse reactions.
Complivit calcium D3
An analogue of Calcemin Advants - Complivit calcium D3, just like the original product, regulates mineral metabolism in the body. The cheap drug is used to prevent and treat diseases of the joints and bones.
A cheap analogue is available in chewable tablets with different flavoring additives. Complivit calcium D3 for babies is an analogue that is intended for pediatric patients. Vitamins for children can only be prescribed by a specialist.
The active ingredient is calcium in combination with cholecalciferol.
A cheap analogue of Calcemin is taken for prophylaxis in case of calcium deficiency, accompanied by symptoms:
- chronic weakness, sleep disturbance;
- aggressiveness, emotional stress, depression;
- fragility of bones, long healing of wounds.
The cheap drug is also prescribed to patients who have joint pain and problems with the skeletal system:
- fractures;
- osteoporosis;
- accelerated development of children in adolescence (physical);
- deficiency of bone tissue mineralization (40 years old);
- vitamin D3 deficiency.
For the purpose of prevention in case of a lack of minerals, a cheap analogue can be recommended for pregnant and lactating women.
Contraindications:
- hypercalciuria, hypercalcemia or hypervitaminosis D;
- calcium nephrourolithiasis;
- osteoporosis resulting from prolonged immobilization;
- renal failure;
- decalcifying tumors;
- phenylketonuria;
- pulmonary tuberculosis;
- sensitivity to the composition.
By-effect:
- gastrointestinal dispersion;
- allergy;
- excess calcium.
Considering Russian analogues of Kalcemin, it should be noted that Complivit calcium D3 is the cheapest substitute. Its cost is from 150 rubles.
Use during pregnancy and lactation
Calcemin Advance can be used during pregnancy and breastfeeding, but only after consulting a doctor.
Pregnant women should not receive more than 600 IU of vitamin D3 and 1500 mg of calcium per day, since hypercalcemia can cause defects in the physical and mental development of the fetus.
Colecalciferol, as well as its metabolites, are secreted into breast milk, which must be taken into account when additionally administering vitamin D3 and calcium to a breastfed child.
