Drug development Clenbuterol was carried out solely for the purpose of obtaining medicine against asthma. This medication was successfully tested, began to be used for its intended purpose, but soon enough demonstrated properties and qualities, thanks to which it became much more widely used. Along with asthma therapy, Clenbuterol is often taken by bodybuilders.
Compound
1 tablet of the pharmaceutical drug Clenbuterol Sopharma contains the following components:
- Clenbuterol hydrochloride (main biologically active substance) – 0.2 mg;
- lactose monohydrate – 70 mg;
- microcrystalline cellulose (MCC) – 48.5 mg;
- wheat starch – 31.48 mg;
- povidone K 25 – 6 mg;
- colloidal silicon dioxide – 2 mg;
- Magnesium stearate – 2 mg.
1 ml of syrup contains the following components:
- clenbuterol hydrochloride – 1 mcg;
- sorbitol;
- glycerol;
- propylene glycol;
- sodium citrate dihydrate;
- citric acid monohydrate;
- methyl parahydroxybenzoate, propyl parahydroxybenzoate and butyl parahydroxybenzoate;
- sodium benzoate;
- Raspberry essence in liquid form;
- purified water.
Clenbuterol composition and properties of the drug
Clenbuterol is a unique medicine for getting rid of all types of cough. The main properties of the syrup are a powerful expectorant effect, moisturizing the respiratory tract, softening irritated mucous membranes, and eliminating pain.
The drug helps remove signs of inflammation, activate the cells' production of new healthy mucus, and prevent the proliferation of pathogenic microorganisms.
Clenbuterol is available in the form of syrup, which is very convenient, and also has a delicate sweetish taste, as a result of which it is successfully used among pediatric patients. The drug is accompanied by official instructions (annotation) and a measuring spoon.
Clenbuterol contains original and highly effective components that provide relief to the patient in the shortest possible time:
Clenbuterol hydrochloride is the most basic and important active ingredient with a bronchodilator effect. Citric acid, which creates a strongly acidic environment at the site of inflammation, harmful to many bacteria
Sorbitol - gives the medicine that same sweet taste, acts as a sugar substitute, which is especially important for patients who have contraindications to its use. Glycerin, sodium citrate, sodium benzoate, raspberry extract and other substances - as additional auxiliary components.
The components of the syrup, as a rule, do not cause hypersensitivity reactions - which, undoubtedly, is also a big advantage when choosing this medicine.
Release form
In pharmacies the medicine can be found in the form of:
- Clenbuterol tablets 0.2 mg each. Packaged in blisters (blister packs made of aluminum foil or PVC) of 10 pieces. A cardboard pack usually holds 5 records.
- Transparent and slightly viscous Clenbuterol syrup is colorless to light yellow in color with a characteristic raspberry odor. This form of the drug is packaged in 100 ml dark glass (or dark polyethylene terephthalate) bottles with a measuring cup and spoon included. The cardboard package contains 1 bottle of pharmaceutical preparation and the above mentioned elements.
How safe is clenbuterol?
Most of the research has been done on animals, so we don't know enough about how seriously it can affect us humans.
However, we know that it is not safe, which is why clenbuterol is not approved for human consumption in most countries. Here is a list of potential side effects:
- Nausea.
- Nervousness.
- Dizziness.
- Drowsiness.
- Dry mouth.
- Redness and feeling of heat in the facial area.
- Headache.
- Heartburn.
- Increased sweating.
- Insomnia.
- Impaired sense of balance.
- Muscle spasms.
- Vomit.
- Chest pain.
Everyone's sensitivity to the drug is different, but most people will likely experience some of these problems while using it.
pharmachologic effect
The main component of the drug Clenbuterol Sopharma is a selective beta2-adrenergic agonist , that is, the mechanism of action of the biologically active component includes a stimulating effect on this type of receptors, which are mainly located in the bronchial tree . In response, the following cycle of secondary messengers in the following sequence: Adenylate cyclase - cAMP - Protin kinase A. Further, the effects of Clenbuterol extend to myosin , a component of smooth muscle fibers, which, interacting with actin, leads to relaxation of the bronchi . Thus, the problem of narrowing the lumen of the respiratory tract during attacks of bronchial asthma is eliminated and respiratory processes are significantly facilitated.
Clenbuterol also has a secretolytic effect . In particular, the main component of the pharmaceutical drug slows down the release of inflammatory mediators and other active biological substances from mast cells, which increase bronchospasm. Thanks to these therapeutic properties edema is reduced , congestion in the lumen of the bronchial tree is eliminated, and mucociliary clearance is improved .
Separately, it should be noted the properties of Clenbuterol, which are used in sports pharmacology . The active component of the drug has anabolic properties like steroids, but exhibits its effects with less strength. The pharmaceutical drug is an active fat burner . The mechanism of this action is a slight increase in the internal temperature of the body, thereby increasing calorie consumption. Among athletes and bodybuilders, there is an opinion that an increase in temperature of 1 degree Celsius speeds up fat metabolism by 5 percent.
Thanks to such therapeutic effects, the rigidity of the muscle frame and strength significantly exceeds the initial indications before undergoing a conservative course. The body is given relief , vascularity and the desired appearance.
Externally, such effects are comparable to a long-term low-calorie diet.
Clenbuterol for weight loss. Mechanism of action
Clenbuterol binds to type 2 beta receptors in human muscle and fat tissue. After this, a series of biochemical reactions are triggered that increase the synthesis of cyclic adenosine monophosphate (cAMP).
Cyclic adenosine monophosphate (cAMP) activates enzymes that mobilize fatty acids from fat cells (adipocytes).
Additionally, clenbuterol, by acting on beta-2 adrenergic receptors, promotes the production of adrenaline (the fear hormone) and norepinephrine (the rage hormone), which provide a fat-burning effect.
The secretion of thyroid hormones, which are the body’s natural fat burners, also increases.
Clenbuterol affects lipoprotein lipase, suppressing its activity, thereby making the process of fat deposition in adipose tissue impossible.
As a result of all the above reactions, the level of basal metabolism increases by 20-30%.
Is the mechanism of action clear in terms of weight loss? Let me explain briefly again.
- Clenbuterol binds to type 2 beta receptors in fat and muscle tissue in the human body.
- A series of biochemical reactions are triggered that increase the synthesis of cyclic adenosine monophosphate (cAMP).
- cAMP activates enzymes that mobilize fatty acids from adipose tissue cells (adipocytes).
- The secretion of adrenaline, norepinephrine and thyroid hormones (natural fat burners) increases.
- The activity of lipoprotein lipase is suppressed, and fat deposition becomes impossible.
- Basic metabolism increases by 20-30%.
Many recent studies, for example, Li P. 2015 on formoterol (beta-2 selective agonist), talk about the anti-catabolic effect of clenbuterol, i.e. about its ability to preserve muscle tissue while losing weight.
Experiments on humans in 2015 confirm the ability of clenbuterol to keep muscles dry and accelerate protein synthesis, which makes the drug relevant for bodybuilding.
I am sure that my experience in using clenbuterol will be useful to you. I will describe it in great detail towards the end of the article, but for now let’s look at some of the effects of using this drug.
Pharmacodynamics and pharmacokinetics
The drug is used orally , after which it is quite completely and well absorbed from the gastrointestinal tract. Clenbuterol begins to act within 10-15 minutes after ingestion, and maximum therapeutic properties appear after 2-3 hours. are metabolized in the liver, after which 78 percent of the metabolic products are excreted in the urine. A small amount of metabolites is eliminated with bile into the lumen of the digestive tube.
How does clenbuterol work?
This drug is notable for its ability to activate the sympathetic nervous system, which activates the process of fat breakdown, which is important in losing weight. Beta-adrenergic agonists, to which clenbuterol belongs, begin to contact beta-2 receptors, triggering a list of chemical reactions and thereby stimulating the work of all muscle tissues.
The use of clenbuterol in combination with regular training and a properly selected diet allows you to notice a number of changes in a short time, namely:
- reducing the proportion of fat;
- drying the body without significant loss of muscle mass;
- decreased appetite;
- increased body temperature;
- change in emotional state;
- anabolic effect (slightly expressed);
- anti-catabolic effect.
Contraindications
- increased individual sensitivity to the constituent components of the drug;
- acquired or hereditary intolerance to biologically active substances of Clenbuterol Sopharma;
- tachycardia and tachyarrhythmia;
- thyrotoxicosis;
- idiopathic hypertrophic subaortic stenosis ;
- severe forms of coronary heart disease ;
- acute period of myocardial infarction .
Conservative treatment with Clenbutrol against the background of the following pathologies should be carried out with caution , which implies therapy in special hospitals under the constant supervision of qualified medical personnel and regular diagnostic tests:
- hyperthyroidism;
- diabetes;
- diseases of the cardiovascular system (in particular, severe arterial hypertension, cardiomyopathy, heart defects, coronary disease or a tendency to arrhythmias ).
When can you use Clenbuterol?
Clenbuterol is a drug that is used to treat adults and children. It is prescribed if the patient suffers from a constant or paroxysmal cough that has developed against the background of bronchitis or bronchospasm
It is important to keep in mind that syrup can be prescribed to children of any age, even the youngest. With tablets the situation is different! They are prescribed only to those patients who are at least 6 years old
It is interesting that for newborn children, the dose of medicine is always selected individually, at the discretion of the doctor. Clenbuterol should not be prescribed to infants based solely on the dosage indicated in the instructions.
The indications for which the medication is prescribed include:
- bronchial asthma;
- bronchitis of chronic obstructive type;
- damage to the lungs by emphysematous phenomena;
- recurrent tracheitis (the severity of the disease is not important, the frequency of relapses is important);
- other diseases accompanied by obsessive cough and bronchial obstruction syndrome.
Clenbuterol can be prescribed to patients who have impaired air flow through the bronchial structures, which causes respiratory failure and other symptoms that reduce the patient’s quality of life. The drug affects the respiratory system in such a way as to facilitate the passage of air and eliminate at least some of the negative symptoms that cause inconvenience to the patient.
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Side effects
- From the nervous system - headache and dizziness , anxiety, disturbance of sleep and wakefulness in the form of insomnia , intention tremor of the fingers.
- From the cardiovascular system - tachycardia, increased blood pressure, extrasystole , cardialgia.
- Gastrointestinal tract – dry mouth, gastralgia , nausea leading to vomiting.
- Local and generalized allergic reactions - urticaria , skin rash, bronchospasm, angioedema .
- From other organ systems and tissues - muscle cramps, intense facial flushing , increased sweating, hypokalemia and, as a result, muscle pain.
- There is a possibility of developing rebound syndrome and resistance when discontinuing a pharmaceutical drug.
Separately, it should be noted the development of muscle cramps when Clenbutrol tablets are used by athletes and bodybuilders. This side effect is caused by depletion of endogenous taurine reserves, deficiency of sodium and potassium electrolytes, and general insufficiency of water-salt metabolism. To relieve muscle cramps, the following dietary changes are recommended
- eating plenty of fruit (especially bananas, as they contain a lot of potassium);
- drinking plenty of water;
- additional inclusion of taurine in the amount of 3-5 grams per day;
- tableted potassium supplements daily before bed on an empty stomach (at least 200-400 mg).
special instructions
Clenbuterol may enhance the therapeutic effect of other drugs. Clenbuterol is not compatible with all medications:
- when used simultaneously with beta-blockers, bronchospasm may develop;
- Clenbuterol enhances the therapeutic effect and side effects of theophylline and beta-agonists;
- negatively affects the therapeutic effect of hypoglycemic drugs;
- simultaneous use with triglyceride antidepressants may lead to cardiac arrhythmias.
To relieve an acute cough attack, a three-day treatment course is usually sufficient. In severe cases, when the disease is prolonged, taking the drug can last a week.
In some cases, Clenbuterol can be prescribed to small children, but provided that the weight has reached four kilograms. In order to reduce the risk of side effects, the drug is simultaneously prescribed with antihistamines.
Before using Clenbuterol, you should gargle so that any remaining food and phlegm do not interfere with the action of the active ingredients. In the next half hour after taking the drug, you should refrain from eating.
Considering all of the above, we can highlight a number of unconditional advantages of Clenbuterol:
- convenience of dosage forms;
- the ability to purchase without a prescription;
- effectiveness for dry and wet cough;
- providing a bacteriostatic effect, that is, slowing down the growth and reproduction of pathogenic microflora;
- soothing throat;
- the active components have a complex effect.
Clenbuterol tablets, instructions for use (Method and dosage)
The syrup is prescribed for oral administration. For adults, the optimal dosage is 15 ml 2-3 times a day at the beginning of a course of conservative treatment. After relief of a serious condition, the amount of the prescribed drug should be reduced to a maintenance dose of 10 ml 2 times a day.
The instructions for use of the pharmaceutical drug allow its use in pediatric practice , however, with strict adherence to the following dosages:
- children under 8 months weighing 4-8 kg - 2.5 ml 2 times a day;
- from 8 months to 2 years (weighing about 8-12 kg) – 5 ml 2 times a day;
- age category from 2 to 4 years (12-16 kg) – 7.5 ml 2 times a day;
- children from 4 to 6 years old and weighing between 16-22 kg - 10 ml 2 times a day;
- from 6 to 12 years (22-35 kg) – 15 ml 2 times a day;
- children over 12 years old and weighing more than 35 kg - 15 ml 2-3 times a day.
Tablets , like syrup, are administered orally. The dosage of a pharmaceutical drug depends on body weight and the body's response in the form of side effects or adverse effects of the drug. The average amount of the drug used for men is about 100-140 mcg, and for women - 80-100 mcg per day. Reception should not begin with the optimal dosage , but accumulate it gradually to provide the maximum therapeutic effect. That is, a conservative course starts with 1 tablet per day, and then increases by 1 tablet every day.
average duration However, a special dosage regimen , since Clenbuterol does not exert its anabolic effects after 18 days of continuous use.
Therefore, the course consists of 2 weeks of continuous use and 2 weeks of rest alternately, until the pharmaceutical drug runs out or the attending physician stops its further use.
Questions about taking clenbuterol
Let's look at the main questions that arise when taking clenbuterol.
Should I take clenbuterol if I just started working out?
No. At the beginning of training, progress is already taking place by leaps and bounds; there is no need to take clenbuterol. Instead, focus on creating a sound training and nutrition plan and stick to it. This will give much greater and more stable progress than a course of clenbuterol.
After the course ends, will I gain the same kilograms back?
No. I didn't notice such an effect. As a rule, after a course of clenbuterol, fat burning slows down slightly, i.e. you begin to lose weight at the same rate at which you lost weight before the course. But it all depends on your diet and genetic makeup.
Why take asparkam?
Taking clenbuterol creates a potassium deficiency in the body. Aspartic acid preparations (asparkam and panangin) increase the content of potassium and magnesium ions in the body, replenish aspartic acid deficiency, improve skeletal muscle tone, and have an antioxidant effect. In short, the cramps disappear.
It’s one thing if your leg or arm cramps. What if your heart breaks? After all, it is the same muscle. It is better, as they say, to be safe than sorry.
Drink asparkam and more water (from 3 liters per day, on average).
If I stick to a diet, do strength training and cardio training, will the effect be better?
Diet, proper strength training and low-intensity cardio training will only improve the results of taking clenbuterol.
What also plays an important role is how clenbuterol itself will affect you. The sensitivity of beta-2 adrenergic receptors is initially different for everyone.
Cardio training can make a HUGE difference in your fat loss if done in the right way. Be sure to read my article on how a cardio workout should be designed to burn fat. The link contains a lot of cool practical information!
How much can I lose on the Clenbuterol Solo course?
It all depends on your individual sensitivity to clenbuterol, gender, age, the severity of your diet and training. Also, there are different manufacturers of clenbuterol. Each of them works differently. I used clenbuterol from Balkan.
Is it true that clenbuterol makes your periods disappear?
Clenbuterol does not cause loss of periods. The cause may be sudden weight loss. Some girls lose weight relatively quickly (up to 3-4 kg per week). The body perceives this as stress and protects itself by stopping the cycle. It's not even about the lost kilograms, but about the speed of their loss. And in general, the problem with a broken cycle in girls is a fairly common phenomenon, even without clenbuterol.
Overdose
Taking dosages that exceed the prescribed ones is accompanied by:
- arrhythmia;
- tachycardia;
- hypolkalemia;
- arterial hypertension;
- tremor of the limbs;
- pain in the heart.
detoxification and symptomatic therapy is used as treatment , that is, gastric lavage, administration of oral sorbents (for example, activated carbon ), the use of water-salt solutions to restore the corresponding metabolic disorders, monitoring the level of potassium in the blood serum and correction it properly.
Indications for use
If we ignore the benefits for the figure, there are several indications for the use of the drug in liquid or tablet form:
- Bronchial asthma.
- Asthmatic bronchitis.
- Emphysema.
- Chronic pulmonary diseases.
You can buy Clenbuterol in a pharmacy only with a doctor's prescription. If there is none, and the product itself is necessary to solve a problem with excess weight or prepare for professional competitions, then it is possible to order via the Internet.
Interaction
When prescribing Clenbuterol Sopharma, the following clinical interactions of the pharmaceutical drug should be taken into account:
- beta-blockers that have opposite effects ;
- impaired intracardiac conduction when combined with MAO inhibitors (monoamine oxidase) and Theophylline ;
- decreased effectiveness of the use of hypoglycemic drugs (requires recalculation of dosages for diabetes mellitus);
- increased toxicity of cardiac glycosides (the risk of developing a pathological condition such as arrhythmia increases significantly);
- increase in own toxicity in combination with sympathetic mimetics .
Reviews after use
Responses to the drug are positive. During treatment with Clenbuterol, a person stops coughing much faster. In addition, patients note relief in nasal breathing. Doctors also speak positively about the medicine, emphasizing its high clinical effectiveness despite the short treatment course.
Good recommendations for the drug are given by people involved in bodybuilding and who have decided to get rid of excess weight. The possibility of implementing combined courses reduces the risk of side effects.
Clenbuterol is initially a prescription drug, which indicates the inadmissibility of self-use. Taking the drug without prior medical consultation results in the development of severe complications.
During pregnancy and lactation
Clenbuterol tablets to a certain extent have tocolytic properties , therefore should not be prescribed during pregnancy, during the prenatal and childbirth periods. The drug is absolutely contraindicated in the 1st trimester of pregnancy.
Clinical studies have not reliably confirmed or refuted the fact that the active ingredient can pass into breast milk. Due to the lack of relevant data, it is possible to prescribe a pharmaceutical drug only if the expected beneficial therapeutic effect from the tablets significantly outweighs the potential risk to the child.
Positive effects of clenbuterol
Based on research, the use of clenbuterol provides the following positive effects:
- Burning fat, drying muscles.
- Increased strength and endurance.
- Decreased appetite.
- Preventing muscle catabolism.
- Slight anabolic effect (weak muscle growth).
- Quite a low incidence of side effects (virtually no irreversible effects).
At the bottom of the article I will write in detail about my experience and feelings from using clenbuterol; I am sure that my experience will be useful to many.
One of the famous authors, Yuri Bombela, claims that in large doses (more than 250-300 mcg/day) clenbuterol can destroy muscles, promoting subsequent hypertrophy of muscle tissue, but this statement is not true, because there is no research, much less no empirical justification was provided. These are just the author's guesses. And taking this drug in such dosages is simply stupid. Later you will understand why.
In 2010, a study was conducted that shows the synergistic effect of using clenbuterol on a cycle of anabolic steroids (if you are using them, of course).
Reviews of Clenbuterol Sopharma
First of all, it should be noted that there are many more reviews about the pharmaceutical drug as a means of effectively stopping spasm of the bronchial tree during attacks of bronchial asthma . This therapeutic effect is widely used in medicine and is confirmed by clinical studies by qualified specialists. Of course, the drug has certain side effects, but its effect develops within 10-15 minutes after ingestion, which makes it possible to eliminate a life-threatening pathological condition in the shortest possible time.
However, on thematic forums and Internet resources there are reviews about another area of application of Clenbuterol. Athletes and bodybuilders prefer to use this pharmaceutical drug as diet pills or so-called “cutting pills.” The drug copes with this task, as well as with the elimination of bronchospasm, with a bang, since this action is based on completely justified mechanisms. However, the course is accompanied by severe side effects in the form of muscle cramps, because, as a rule, such patients strive to lose excess weight as quickly as possible.
We can definitely say that during a conservative course of taking the drug Clenbuterol Sopharma, you should strictly adhere to the dosages indicated in the instructions. Thanks to such simple actions, you can save yourself from unnecessary suffering, trips to the doctor and other adverse consequences.
Clenbuterol in bodybuilding
First, I propose to understand what clenbuterol is.
Clenbuterol (from the English “Clenbuterol”, or among bodybuilders “maple”) is an adrenergic agonist, i.e. a drug that is used in medicine to treat bronchial asthma.
Clenbuterol does not belong to the class of anabolic steroids; I repeat, it is an adrenergic agonist (a medicine for bronchial asthma).
For us, this is not primarily what interests him.
Clenbuterol is used in bodybuilding for its ability to burn fat by stimulating beta-2 adrenergic receptors.
Don’t be alarmed if you come across words you don’t understand; the mechanism of action is quite simple.
Doping status:
Clenbuterol has been banned by WADA for use in sports since 1992. Standard anti-doping tests usually respond to a urine concentration of 5-10 ng/L, which is observed 4-5 days after the last dose. More sensitive tests increase the detection time for clenbuterol to 2-3 weeks or higher (1-2 ng/L). The drug accumulates in adipose tissue and can be more actively released during exercise or competition.
One of the possible ways that clenbuterol enters an athlete’s body may be through meat, since in some countries (China, Mexico) it is used to increase the weight of fattened animals.
Several scientific articles report the frequent inappropriate inclusion of clenbuterol in fat-burning supplements.
Clenbuterol course without ketotifen:
- Day 1: 20 mcg (0.02 mg);
- Day 2: 40 mcg (0.04 mg);
- Day 3: 60 mcg (0.06 mg);
- Day 4: 80 mcg (0.08 mg);
- Day 5: 100 mcg (0.10 mg);
- Days 6-12: 120 mcg (0.12 mg);
- Day 13: 80 mcg (0.08 mg);
- Day 14: 40 mcg (0.04 mg);
- Break.
The dose of clenbuterol should be increased progressively during the first week. The optimal time to take clenbuterol is in the morning (so as not to provoke insomnia, and in the morning the effectiveness of the drug is higher). When increasing the dosage, start taking it in 2 doses: morning and afternoon.
Clenbuterol + ketotifen course:
Ketotifen
- an antiallergic agent with the unique ability to restore the sensitivity of beta-2 adrenergic receptors to clenbuterol. This property has been repeatedly proven in studies involving not only asthma patients, but also isolated lymphocytes. The mechanism of this effect is obviously associated not with histamine receptors, but with inhibition of phosphodiesterase, which regulates cAMP-dependent metabolism of all cells, which allows us to extrapolate the results obtained in work with lymphocytes to adipose tissue. Similar receptor resensitization effects have been observed with ketotifen and other beta-agonists, which has been confirmed by a large number of studies.
With the help of ketotifen, you can speed up the process of losing weight or drying by 10-20 percent and extend the course up to 8 weeks. In addition, ketotifen will help eliminate mental agitation, tremors of the limbs, insomnia and rapid heartbeat.
- Day 1: 20 mcg clenbuterol;
- Day 2: 40 mcg clenbuterol;
- Day 3: 60 mcg clenbuterol;
- Day 4: 80 mcg clenbuterol;
- Day 5: 100 mcg clenbuterol + 1 mg ketotifen;
- Day 6-27: 120 mcg clenbuterol + 2 mg ketotifen;
- Day 28: 80 mcg clenbuterol + 2 mg ketotifen;
- Day 29: 50 mcg clenbuterol + 1-2 mg ketotifen;
- Day 30: 33-35 mcg clenbuterol + 1 mg ketotifen;
- At least two weeks break.
Ketotifen is taken at night, clenbuterol - in the morning.
Combination:
To maximize the effectiveness of the course, clenbuterol is combined with thyroxine. However, in this case the risk of side effects increases.
