Brustan - description of the drug, instructions for use, reviews

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Manufacturers: Ranbaxy Laboratories Ltd

Active ingredients

• Ibuprofen
• Paracetamol

Disease class

• Migraine
• Acute upper respiratory tract infection of multiple and unspecified localization
• Flu, virus not identified
• Rheumatoid arthritis, unspecified
• Joint pain
• Osteocondritis of the spine
• Spondylosis, unspecified
• Lumbago with sciatica
• Myositis
• Synovitis and tenosynovitis, unspecified
• Enthesopathy, unspecified
• Myalgia
• Neuralgia and neuritis, unspecified
• Fever with chills
• Headache
• Unspecified pain
• Superficial trauma to an unspecified area of ​​the body
• Fracture of an unspecified area of ​​the body, closed
• Dislocation, sprain and overstrain of the capsular-ligamentous apparatus of a joint of an unspecified area of ​​the body
• Unspecified injury
• Pathological reaction to a drug or drugs, unspecified
• Unspecified complication of surgical and therapeutic intervention
• Dysmenorrhea, unspecified

Clinical and pharmacological group

• Not indicated. See instructions

Pharmacological action

• Anti-inflammatory
• Antipyretic
• Analgesic (non-narcotic)

Pharmacological group

• NSAIDs - Propionic acid derivatives in combinations
• Anilides in combinations

Indications for use

• For adults: pain of moderate intensity; traumatic inflammation of soft tissues and the musculoskeletal system (including bruises, sprains, dislocations, fractures); postoperative period; algodismenorrhea; toothache; neuralgia; myalgia; lumbago; fibrositis; tenosynovitis; headache; febrile syndrome; articular syndrome (rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gouty arthritis); sinusitis; tonsillitis.
• For children (as an auxiliary drug): tonsillitis; acute infectious and inflammatory diseases of the upper respiratory tract (pharyngitis, tracheitis, laryngitis).

Brustan, instructions for use (Method and dosage)

Take Brustan tablets after meals, 1 tablet 3-4 times a day. The duration of administration is determined by the effectiveness of the drug. If there is no effect, stop taking it and consult a doctor.

Shake the suspension thoroughly before use. To measure the dose, use the measuring spoon included with the drug.

The dose depends on the age and body weight of the child. Duration of treatment: as an antipyretic - no more than 3 days; as a pain reliever - no more than 5 days.

Contraindications

Peptic ulcer of the stomach and duodenum in the acute phase; gastrointestinal bleeding; severe renal failure (creatinine clearance less than 30 ml/min); complete or incomplete combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses and intolerance to acetylsalicylic acid or other NSAIDs (including a history); damage to the optic nerve; genetic absence of glucose-6-phosphate dehydrogenase; diseases of the blood system; period after coronary artery bypass surgery; progressive kidney disease, severe liver failure, or active liver disease; confirmed hyperkalemia; active gastrointestinal bleeding; inflammatory bowel diseases; children under 12 years of age; III trimester of pregnancy; hypersensitivity to ibuprofen, paracetamol, and other NSAIDs.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

A drug with a combined effect. Ibuprofen - the mechanism of anti-inflammatory action is based on the process of inhibiting the activity of COX ( cyclogenases ) and suppressing the synthesis of prostaglandins .

Paracetamol blocks COX in the central nervous system , affecting the centers of thermoregulation and pain, has an antipyretic and analgesic effect.

Pharmacokinetics

Ibuprofen is quickly absorbed from the stomach; food intake slightly reduces absorption. Tmax is one hour. High binding to plasma proteins. The substance is slowly distributed and eliminated from the synovial fluid .

Biotransformed by carboxylation and hydroxylation in the liver, where it is converted to the active S-form . Elimination is carried out in two stages. It is excreted unchanged in the urine; the period of complete elimination from the body is one day.

Paracetamol is completely absorbed from the stomach. Communication with blood proteins is about 15%. Time to reach Cmax is one hour. Distributed evenly in tissues and body fluids. Penetrates through the BBB . Biotransforms in the liver to form inactive metabolites. Excreted in urine in the form of conjugates.

special instructions

With caution: coronary heart disease, chronic heart failure, cerebrovascular diseases, dyslipidemia/hyperlipidemia, diabetes mellitus, peripheral arterial disease, smoking, creatinine clearance less than 60 ml/min, history of ulcerative lesions of the gastrointestinal tract, presence of Helicobacter pylori infection, old age, long-term use of NSAIDs, alcoholism, severe somatic diseases, simultaneous use of oral corticosteroids (including prednisolone), anticoagulants (including warfarin), antiplatelet agents (including acetylsalicylic acid, clopidogrel), selective serotonin reuptake inhibitors (including including citalopram, fluoxetine, paroxetine, sertraline), viral hepatitis, mild or moderate hepatic and/or renal failure, benign hyperbilirubinemia (Gilbert syndrome, Dubin-Johnson syndrome, Rotor syndrome), liver cirrhosis with portal hypertension, nephrotic syndrome .The simultaneous use of the drug with other drugs containing paracetamol and/or NSAIDs should be avoided. When using the drug for more than 5-7 days as prescribed by a doctor, peripheral blood parameters and the functional state of the liver should be monitored. When using indirect anticoagulants simultaneously, it is necessary to monitor blood coagulation parameters. Co-administration of this combination with other NSAIDs should be avoided. To avoid possible damaging effects on liver, you should not drink alcohol while taking the drug. The drug may distort the results of laboratory tests when quantitatively determining glucose, uric acid in blood serum, and 17-ketosteroids (the drug must be discontinued 48 hours before the test).

Impact on the ability to drive vehicles and operate machinery. During the treatment period, the patient should refrain from engaging in potentially hazardous activities that require increased attention and speed of psychomotor reactions

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** The Drug Directory is intended for informational purposes only. For more complete information, please refer to the manufacturer's instructions. Do not self-medicate; Before starting to use Brustan, you should consult a doctor. EUROLAB is not responsible for the consequences caused by the use of information posted on the portal. Any information on the site does not replace medical advice and cannot serve as a guarantee of the positive effect of the drug.

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** Attention! The information presented in this medication guide is intended for medical professionals and should not be used as a basis for self-medication. The description of the drug Brustan is provided for informational purposes and is not intended for prescribing treatment without the participation of a doctor. Patients need to consult a specialist!

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Interaction

The combined use of Brustan with anticoagulants increases the risk of hemorrhagic complications. Taking Brustan simultaneously with antihypertensive drugs and diuretics reduces their effectiveness. Brustan increases the concentration of methotrexate , digoxin , lithium and phenytoin in the blood plasma.

Inducers of microsomal oxidation ( ethanol , phenytoin , rifampicin , tricyclic antidepressants, barbiturates , phenylbutazone ) increase the production of hydroxylated metabolites, thereby increasing the risk of developing severe hepatotoxic reactions . Brustan increases the side effects of glucocorticosteroids and mineralocorticosteroids .

It is strictly forbidden to take the drug together with drinks containing ethyl alcohol. Myelotoxic drugs increase the risk of Brustan hematotoxicity.

Cefamandole , valproic acid , cefoperazone , plicamycin , cefotetan increase the risk of developing hypoprothrombinemia .

Analogues of Brustan

Level 4 ATC code matches:
Artrum

Ketonal Duo

Nurofen Plus

Nurofen Express

Nurofen Forte

Nurofen Express Lady

Nurofen for children

Nurofen

Ibuprom

Ibuprofen

Advil

Mig 400

Has

Ketoprofen

Vimovo

Naproxen

Flexen

Nalgesin

Flamax

Novigan

Ibuklin , Next , Bolaren , Nurofen , Gripomed , Lugakold , Novalgin , Payremol , Parafex , Tilofen and others.

Release form and composition

Brustan is produced in the following dosage forms:

• film-coated tablets: orange, biconvex, oval, on one side with the inscription RANBAXY printed in black edible ink (10 pieces in a blister, 1 blister in a cardboard pack);
• suspension for oral administration: yellow liquid with a characteristic odor (60 or 100 ml in dark glass bottles, 1 bottle with a measuring spoon/cup in a cardboard box).

Composition of 1 tablet:

• active ingredients: paracetamol – 325 mg; ibuprofen – 400 mg;
• additional components: isopropanol, purified talc, calcium hydrogen phosphate, povidone, corn starch;
• film shell: purified water, opadry orange dye 06G53189 (titanium dioxide, hypromellose 15 cP, propylene glycol, hypromellose 5 cP, sodium lauryl sulfate, macrogol, sunset yellow dye).

Composition of the suspension (per 5 ml):

• active ingredients: paracetamol – 125 mg; ibuprofen – 100 mg;
• additional components: sodium citrate, disodium edetate, polysorbate 80, methyl parahydroxybenzoate, xanthan gum, propyl parahydroxybenzoate, carmellose sodium, citric acid monohydrate, sodium hydrosulfite, colloidal silicon dioxide, sucrose, glycerol, purified water, orange flavor (521-00014-11), quinoline yellow dye, peach flavor (ST 5977/01).

Overdose

Symptoms of overdose may be: abdominal pain, vomiting/nausea, headache, tinnitus, acute renal failure, metabolic acidosis, decreased blood pressure, tachycardia, bradycardia, coma. There is also the possibility of a hepatotoxic effect associated with paracetamol, with further development of hepatonecrosis.

To treat this condition, gastric lavage is performed within an hour after administration (but not later), activated charcoal and forced diuresis are prescribed. The patient is provided with abundant alkaline drinks, donors of SH groups and precursors of glutathione synthesis are administered - N-acetylcysteine ​​and methionine. The need for additional measures is determined depending on the level of paracetamol in the blood and the time elapsed after its administration. The use of symptomatic remedies is also recommended.

An overdose of Brustan occurs very rarely; if you suspect its occurrence, you should immediately consult a doctor.

Brustan price, where to buy

The price of Brustan No. 10 tablets varies between 127-221 rubles per pack. You can purchase the drug without difficulty in most pharmacies in Moscow and other cities.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine

ZdravCity

• Brustan tablets p.p.o.
  725 mg 10 pcs. SUN Pharmaceutikal Industries Ltd. 184 RUR order

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Pharmacy24

• Brustan N10 tablets Sun Pharmaceutical Industries Ltd., India
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