Why is Crinon Gel prescribed for IVF and how to use it

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Even before the day of the artificial insemination procedure, a lot of global changes and preparations occur in the life of the couple, but the most active support for the body is carried out after. Why do you need Krynon Gel for eco? The drug is prescribed by the attending physician in order to create the best possible conditions for the implantation of the egg and the preservation of pregnancy, which should occur after implantation.

• 1 Crinon for IVF: composition and effect of the drug
• 2 Detailed information about the need to use Crinon gel during IVF
• 3 How to use the gel for IVF
• 4 Contraindications and possible side effects after using the drug 4.1 Vaginal discharge

Dosage

"Krinon" (gel) is prescribed to girls and women in the following quantities as prescribed:

• As a substitute for hormone therapy in postmenopause - 1 dose (90 mg) 2 times a week.
• To maintain the luteal phase - 1 applicator daily, starting from day A, when the long-awaited pregnancy occurs, you need to continue to administer the medicine intravaginally for up to 12 weeks.
• For uterine bleeding resulting from progesterone deficiency, with secondary amenorrhea, 1 dose is prescribed every other day, from the 15th to the 25th day of the menstrual cycle. If necessary, the gynecologist can either reduce or increase the dose of this drug.

Rules for using the drug

The use of Krinon, a medicine that solves serious problems, is not difficult. For ease of use and compliance with hygiene rules, this drug is packaged in disposable containers, which must be used as follows:

1. Take the plastic device with the medicine and shake it.
2. Holding the applicator by the upper end of the container, remove the cap by turning it sharply.
3. The product can be administered in two positions: sitting or lying down with bent legs.
4. The applicator should be inserted slowly.
5. In order for the medicine to completely enter the vagina, it is necessary to squeeze the container.

Properties of Krinon gel

Crinone is sometimes called progesterone gel. This is a bioadhesive gel that contains micronized hormone. Crinone is produced in the form of a homogeneous white gel with a specific odor. Among the auxiliary components are glycerol, liquid paraffin, palm oil, sorbic acid, sodium hydroxide, polycarbophil.

Natural progesterone is produced by the corpus luteum in preparation of a woman's body for pregnancy. The hormone provokes the transition of the uterine mucosa from proliferation to the secretory phase. Progesterone serves to eliminate excessive excitability and contract the muscles of the uterus and fallopian tubes. It slows down the secretion of release factors of follicle-stimulating and luteinizing hormones, as well as pituitary gonadotropic hormones.

Analogs

Progesterone

Dalkhimfarm, Russia

Price from 271 to 729 rubles.

The drug contains a steroid hormone that supports the second phase of the cycle. The use of the drug is indicated in the treatment of a number of gynecological ailments, during IVF and maintaining pregnancy (1st trimester). The drug is produced in the form of a 1% and 2% solution.

Pros:

• Low price
• Reduces swelling caused by hormonal imbalances
• Regulates the menstrual cycle.

Minuses:

• Contraindicated in case of hormone-dependent oncological pathologies occurring in the internal genital organs and mammary glands
• May provoke the development of dysphoria
• Dispensed by prescription.

Prajeesan

Sun Pharmaceutical Industries, India

Price from 223 to 434 rubles.

Prajisan is a progestogenic drug that promotes the transition of the uterine mucosa into the proliferative phase. Used for PMS, fibrocystic changes in the mammary gland, MC disorders, and infertility. It is produced in two dosage forms: capsules and gel.

Pros:

• Can be used for early menopause
• Treats endometriosis
• Promotes successful implantation of a fertilized egg.

Minuses:

• Allergic reactions are possible during use
• Contraindicated in persons with porphyria
• Not recommended for use with enterosorbents (capsules).

Indications and contraindications

When using a dose containing 90 mg of progesterone, the maximum concentration of the substance in the blood is reached in 6 hours. The half-life is 34-38 hours. Progesterone is excreted primarily by the liver.

Indications for use of Crinon:

• the need to increase the luteal phase when using assisted reproduction methods;
• secondary amenorrhea and uterine bleeding due to progesterone deficiency;
• replacement therapy during postmenopause.

Contraindications to Crinon:

• hypersensitivity;
• acute porphyria (pigment metabolism disorder);
• malignant formations in the pelvis or mammary glands;
• acute thrombosis, thrombophlebitis;
• cerebrovascular accident;
• incomplete abortion;
• vaginal bleeding;
• breast-feeding.

Take with caution in the following conditions:

• diabetes;
• bronchial asthma;
• renal or cardiovascular failure;
• epilepsy;
• arterial hypertension;
• depression;
• hyperlipoproteinemia.

When treating progesterone deficiency with Crinon, side effects are possible. Often these are headaches, breast tenderness, drowsiness and signs of allergies. There is no information on the interaction of the gel with other drugs. Simultaneous use with other intravaginal agents is not recommended; the effect may be weakened or enhanced.

General rules of treatment

Before starting the course, the gynecologist is obliged to point out to the patient the important nuances of therapy:

• during the period of use of progestogens and estrogens, an increase in blood sugar levels is possible,
• A consultation with a gynecologist and examination with cytological examination are required before starting therapy. It is important to know that there is no acute inflammatory or tumor process in the mammary glands, uterus and appendages,
• if there is a threat of miscarriage, in parallel with the use of vaginal gel, it is important to periodically evaluate the hCG level, do a gynecological ultrasound,
• One of the properties of drugs in the progestogen group is the effect on fluid excretion. To prevent swelling, patients with chronic renal failure and acute renal failure, cardiovascular diseases, asthma, migraine, epilepsy should be treated with Crinon under the supervision of specialists in a gynecological department,
• if thrombotic diseases are detected, it is necessary to urgently discontinue the use of progesterone-based vaginal gel,
• It is forbidden to combine the drug Crinon with alcohol,
• Some patients complain of drowsiness after applications. If the negative effect is severe, you should refrain from driving vehicles and doing things that require a high concentration of attention.

Pharmacological properties

When pregnancy occurs naturally, the body begins to produce hormones that provide:

• preparing the endometrium to receive a fertilized egg;
• fixation of the egg in the uterine cavity;
• full-fledged implantation and provision of the embryo until the moment when the woman’s own body “comes to its senses” and rearranges its work to carry the pregnancy.

Important! If during a physiological pregnancy the processes necessary for a further successful outcome occur under the influence of natural factors immediately after fertilization, then an artificial pregnancy must be provided with conditions for the acceptance of the embryo and its development.

Thanks to him:

• the uterine mucosa (endometrium) passes from the proliferative to the secretory phase;
• the excitability and tone of the uterus and fallopian tubes decreases;
• ovulation is suppressed;
• the production of gonadotropic and some other hormones slows down;
• The body's hormonal system is adjusted to bear an artificially implanted embryo.

Did you know? It is a mistake to consider progesterone a sex hormone

In fact, it is the matrix of all sex and steroid hormones, and it is this “progenitor” function that determines its importance and exclusivity for the body.

The importance of progesterone in a woman's body

If there is a lack of the hormone progesterone, fertilization may be impossible, because the fertilized egg is simply not able to implant in the uterus. In some cases, due to underdevelopment of the epithelium, which occurs against the background of progesterone deficiency, miscarriages occur, since the embryo does not receive enough nutrients for full development.

With hormone deficiency, various disorders can be observed: from disruptions in the menstrual cycle to infertility. Crinone contains a natural hormone identical to the one synthesized by the woman’s body. Normal progesterone levels ensure healthy menstruation and a successful pregnancy.

Release form, composition and packaging

Vaginal gel is homogeneous, white or almost white in color, soft consistency, with a specific odor.

Excipients: glycerol, light liquid paraffin, hydrogenated palm oil glyceride, carbomer 974P, sorbic acid, polycarbophil, sodium hydroxide, purified water.

1 dose (1.125 g) - disposable vaginal polyethylene applicators (1) - bags (6) - cardboard packs. 1 dose (1.125 g) - disposable vaginal polyethylene applicators (1) - bags (15) - cardboard packs.

How to enter

For in vitro fertilization, Crinon is prescribed intravaginally once a day, preferably at night. The dosage is 90 mg of progesterone, which means 1.125 g of gel, which is contained in a single-use applicator.

USEFUL INFORMATION: Luteinizing hormone in men

Therapy begins from the day the embryo is transferred into the woman’s body and continues after confirmation of pregnancy throughout the first trimester. The manufacturer has done everything to ensure hygienic, safe and most comfortable insertion of the gel into the vagina:

• strictly adjusted dosage;
• disposable applicator;
• Convenient self-administration.

Before use, grasp the applicator between your thumb and forefinger and shake vigorously, like a medical thermometer. This is necessary in order to move all the gel to the lower end of the device.

Important! It is very important to carefully follow the recommendations and not skip taking a pregnancy-supporting medication, since the consequences of such neglect can be very sad.

Take it by the top (flat) end of the container filled with air and break it off by twisting the cap on the opposite end without pressing on the air container yet.

1. Take a position convenient for administering the medicine: sitting or lying down with your knees apart and insert the lower end of the device into the vagina.
2. Squeeze the air container with force with your fingers while inserting the gel from the applicator into the vagina.
3. There is no need to try to introduce absolutely all of the drug, some part of it will inevitably remain in the device, however, the dose is considered to be applied in full.
4. After use, the applicator with any remaining drug should be thrown away.

Distinctive features of Crinon gel

The gel covers the vaginal walls and gradually penetrates the endometrium, without entering the systemic bloodstream and excluding primary breakdown in the liver. Thanks to this, a maximum concentration is created in the uterus, and progesterone enters other tissues in minute quantities.

Unlike drugs in this group, Crinon is intended for vaginal use. Since the product is in the form of a suspension, it penetrates into tissues from the aqueous phase. This ensures a continuous, dosed release of progesterone from the gel.

There is no need to lie down before administering the gel. Due to the bioadhesive properties of the suspension, the gel attaches to the vaginal mucosa in almost any position of the body.

It is the composition and form that make it possible to compensate for the lack of progesterone with a dose that is several times less than when using other hormonal drugs. Capsules, tablets and suppositories cannot provide continuous release of active substances. The effectiveness of one dose of Crinon is equivalent to two or three doses of most other drugs in this group.

Another advantage of Crinon is the need to use the gel only once a day. With one application per day, patients are less likely to forget about the procedure.

Due to the convenience and simplicity of the gel, most women choose it to treat progesterone deficiency. Crinone is a somewhat unique drug that delivers progesterone directly to the uterus.

Crinon begins to act instantly. Just one injection of the gel per day allows you to keep progesterone levels under control and combat the problem of infertility. The convenience and effectiveness of the product have been noted by many experts, which is why Crinon is most often prescribed for a deficiency of female hormones.

Women's doubts about using Crinon

When starting treatment with the drug , women often wonder: how should they behave after the drug is administered - is it necessary to go to bed after the procedure? Experts give a negative answer to this. Crinon is a unique drug: the substances included in its composition quickly attach to the walls of the vagina , which eliminates the need for patients to lie down after the procedure for introducing the gel.

Also, women who are prescribed IVF have another, no less important question: is it possible to continue to be sexually active while taking Crinon? Experts do not give any prohibitions in this regard. They note that sexual relations will not interfere with the delivery of progesterone contained in Crinone to the uterus. Therefore, women who have been prescribed Crinon can continue to lead a normal life.

special instructions

Crinon contains sorbic acid, which can cause a local skin reaction (contact dermatitis).

During long-term therapy, it is necessary to conduct regular gynecological examinations in order to exclude the possibility of developing endometrial hyperplasia.

When using Crinon, the level of human chorionic gonadotropin should be determined or an ultrasound should be performed to prevent the occurrence of a threatened abortion.

Prescribe the drug with caution in case of liver dysfunction. In case of sudden bleeding, as in the case of irregular vaginal bleeding, a non-functional cause should be excluded.

If vaginal bleeding of unknown etiology occurs, appropriate examination should be performed.

In case of sudden bleeding, as in the case of irregular vaginal bleeding, a non-functional cause should be excluded. If vaginal bleeding of unknown etiology occurs, appropriate examination should be performed.

The drug is prescribed with caution and under constant monitoring to patients with epilepsy, migraine, asthma, chronic heart failure, and impaired renal function (due to possible fluid retention in the body). Patients with a history of depression should be closely monitored and the drug should be discontinued if depression worsens.

Patients with a history of depression should be closely monitored and the drug should be discontinued if depression worsens.

During the use of estrogens and progestogens, some patients may experience a decrease in glucose tolerance (the mechanism of this disorder is unknown). While using the drug, patients with diabetes mellitus should be closely monitored.

The effect of the drug on the ability to drive a car and control other mechanisms

Patients using Crinon should be careful when engaging in activities that require increased attention (as a feeling of fatigue may occur)

USEFUL INFORMATION: Male infertility: azoospermia

Drinking alcohol may increase this effect.

Drug interactions

During progestogen therapy, it is not advisable to use other formulations for intravaginal use. If it is necessary to introduce a combination of drugs, the optimal interval between procedures should be 6 hours or more.

Learn about the symptoms of acute pancreatitis in adults, as well as the rules for treating the pathology.
The causes of high blood sugar in a child and ways to correct the indicators are written in this article.

On the page https://fr-dc.ru/zabolevaniya/diabet/tolerantnost-k-glyukoze.html read about the need for a glucose tolerance test during pregnancy.

Women's opinions

The medication "Krinon" receives only favorable reviews from girls who have used it. So, users of this medicine note that it is easy to use, there is nothing supernatural or complicated. This is a mobile device that can be used in any situation, wherever the girl is: at work, visiting, on a train or on a plane. Women also note that the procedure for introducing this gel is absolutely painless, unlike those previously prescribed to people. And of course, the effect of this medication is amazing: those women who decided to undergo IVF note that an important factor in the onset of their pregnancy is the use of Crinon gel. Also, for many girls who previously had problems with menstruation, their periods became regular. Such positive reviews about this medication indicate only one thing: the medicine really brings an effect, because it is no coincidence that many gynecologists prescribe it.

Use during pregnancy

In cases where the function of the corpus luteum is insufficient, including with assisted reproductive methods, which include IVF, progesterone preparations are prescribed, for example, the same Crinon gel. The product cannot be used during breastfeeding.

Did you know? Progesterone in a woman’s body is produced by the ovaries and placenta during pregnancy. The first is called luteal, the second - placental. Despite the identity of their structure, the functions of each of them are different.

Until when should I take it?

It makes no sense to use this drug later than the first trimester; it is also not recommended for later periods.

How to cancel

Self-indulgence in taking a pregnancy-supporting drug is not encouraged and can result in tragedy. It is unacceptable to stop taking progesterone on your own; this is done only under the supervision of a doctor.

It is believed that this should occur upon reaching the 12th week of a developing pregnancy, when the placenta is already sufficiently developed for independent production of progesterone. In some cases, therapy can be continued up to 16 weeks.

However, modern observations of pregnancies developing as a result of artificial insemination make it possible to draw conclusions about earlier cessation of progesterone intake.

Currently, when it comes to the standard protocol, some clinics recommend that their patients stop taking the drug at 6-7 weeks, and even at earlier times when a positive hCG result is obtained.

Important! It is believed that for a healthy fetus to fully develop, the support provided is enough, and a pregnancy with pathological processes in the fetus is still doomed to be terminated, only at a later date with artificial support, which is very undesirable for the woman’s health.

The above does not apply to cryoprotocols, protocols with a donor egg and a surrogate mother: they have their own characteristics.

Why is it prescribed for IVF?

During the use of in vitro fertilization, a drug with progesterone artificially maintains the luteal phase, which allows for the successful attachment of the embryo and its further development until the woman’s body has the opportunity to use its own resources.

It is prescribed from the day of transfer of the fertilized egg and continues to be used as prescribed by the doctor.

Important! It has been established that it makes no sense to use the product before the day of puncture. The maximum result of taking progesterone is obtained if you start using it from the first to the third day after the introduction of the embryo.

Dosage and methods of application

For patients with luteal phase deficiency during artificial insemination, this drug is prescribed from the first day of embryo transfer. The duration of treatment is 30 days. The gel is used in an amount of 90 g (one applicator), inserting it into the vagina. If suppositories are used, they are also administered intravaginally, one at a time, before bedtime.

In case of uterine bleeding, as well as the absence of menstruation not associated with pregnancy and breastfeeding, the gel is administered in an amount of 90 mg, starting from the 15th to 25th day of the menstrual cycle.

As hormone replacement therapy, Crinon is used at a dose of 90-180 mg (1-2 applicators) twice a day.

If there is a threat of miscarriage caused by low progesterone levels, the gel is inserted into the vagina during the first trimester of pregnancy.

Special Notes

During treatment with Crinon, the following side effects may occur:

1. From the digestive system - pain in the stomach.
2. From the reproductive system - soreness of the mammary glands.
3. Genital organs. Rarely, spotting is observed between periods. It is also possible that the vaginal mucosa may become irritated in the area where the gel layer was applied.
4. From the central nervous system - headaches, drowsiness, depression.

Fortunately, to date there is no evidence of overdose with Crinon.

Features of the use of the drug during pregnancy and lactation

You can use the hormonal drug in question during pregnancy only in the early stages with complex therapy with other drugs. Nursing mothers are prohibited from using it.

Answers to user questions

Future parents who are interested in the topic, but have not yet chosen a clinic and a doctor, as well as those who are already in the protocol, but a fertility specialist is currently unavailable, most often search the Internet for answers to the following questions.

How long does it take for it to be absorbed?

"Krinon" is a product in the form of a gel that is injected directly into the vagina. Thanks to the polymer delivery system, which is included in the formula of the drug, it binds to the vaginal mucosa and is gradually released, being constantly and evenly absorbed for the most part during the first 6 hours.

Did you know? The production of progesterone occurs not only in the ovaries, because men do not have them. A small amount sufficient for the male body is produced by the adrenal glands.

That is why it is recommended to use it at night. Almost the entire product is absorbed into the vaginal mucosa within 12 hours after administration. Doctors often advise immediately after the appointment to remain calm and, if possible, in a lying position for at least the next half hour, if for some reason this is no longer possible.

Does it delay your period?

If an attempt at in vitro fertilization fails, your period comes around the sixth day. If this happens, additional studies are carried out to make sure that pregnancy has not occurred. In this case, "Krinon" is not able to delay menstruation if implantation of the fertilized egg has not occurred.

Important! There is no need to observe bed rest, however, due to the formed functional cysts, it is advisable to avoid not only vigorous sex, but also additional stress in the form of sports training.

Is it possible to have sex while using the drug?

"Crinon" is not a contraindication to intimate life; doctors' observations indicate that the effectiveness of IVF does not increase or decrease, however, some restrictions should be observed, which, however, do not particularly affect personal life:

1. You should know that condoms contain spermicides - substances that kill all living things, so do not use them while in the IVF program.
2. During a puncture, a woman develops ovarian cysts, and too active sex can cause injury to them, which can lead to pain and bleeding, so it is advisable to exercise some caution.

Why does it come out with brown streaks and what to do in this case?

It happens that “Krinon” comes out with brown lumps and/or streaks. This most often occurs a few days before the hCG test. This occurs due to a decrease in the production of progesterone and estradiol by one’s own corpus luteum, the resource of which has been exhausted.

If the egg has successfully implanted and the embryo has begun producing its own hCG, it will stimulate the corpus luteum. If this does not happen, then there are problems with implantation.

Did you know? In addition to preparing the uterus for pregnancy and acceptance of the embryo, progesterone has other “responsibilities”: calm the nervous system, relieve spasm of smooth muscles and stimulate the growth of the uterus, help the mammary glands prepare for lactation and... stimulate sebum production.

With scanty discharge, there is a chance to maintain the pregnancy, since, most likely, the lower layers of the uterine mucosa, the endometrium, located near the cervix, have begun to peel off, while the embryo is transferred to the bottom of the uterus.

Brown streaks may also indicate a local vaginal reaction to the drug. You should know that a dark color (brown, brown, black, grayish) indicates that this is blood, but it is old, and at the moment the woman does not have an acute condition. There is red blood in the blood vessels, and if you see it, consult a doctor immediately, especially if the bleeding does not appear to be a normal period.

Important! Bleeding occurs due to the fact that the embryo is of poor quality, and never vice versa, so there is no indication to continue such a pregnancy, it will still be terminated, only later. In any case, if the color of the drug coming out of the vagina changes, you should consult a doctor. He will most likely prescribe a clarifying ultrasound, which will show the processes occurring inside and the condition of the embryo.

If full menstruation has begun, this time there is no chance of maintaining the pregnancy; in this case, hCG is not required to be clarified, and progesterone support is canceled. Technically the bleeding can be stopped, but there is no chance that the embryo will be okay.

Side effects

Any drug in some cases can cause unwanted side reactions, and Crinon is no exception in this sense. Many of the reactions can be mistaken for normal weakness during pregnancy.

USEFUL INFORMATION: Increased sperm viscosity. What to do

Read more about why IVF does not work, and also find out what to do if you have pain after IVF.

It can be:

• local reactions;
• pain in the head, perineum or joints;
• general weakness;
• memory impairment;
• drowsiness;
• depression;
• nervous state;
• aggressiveness;
• fainting;
• cramps and bloating;
• diarrhea or constipation;
• nausea and/or vomiting;
• increased sensitivity of the mammary glands;
• decreased libido;
• thrush;
• vaginal discharge or, on the contrary, dryness, etc.

Patient reviews

Alice, 24 years old : “My opinion is absolute support for the drug Crinon and its effectiveness. This vaginal gel helped me a lot during IVF. I am infinitely grateful to my doctor for such a prescription, although it is not cheap. But my little joy in my arms is simply priceless compared to medicine or anything else.”

Marina, 32 years old : “I used Crinon vaginal Gel. The only thing I didn’t like was that from time to time the vagina needs to be cleaned of its residue. The only side effects were a slight increase in temperature, but it was well tolerated.”

Features of the use of Crinon in the treatment of infertility

The gel is used intravaginally. For convenience and to ensure sterility, it is packaged in disposable applicators with a cap and container. Many patients note the ease of administration of the gel.

Crinone is well tolerated by most patients. In some cases, breast tenderness, nausea, constipation, drowsiness and headaches are possible. If symptoms are severe, you should immediately consult your doctor.

How to apply Crinon gel:

Hold the applicator between your thumb and index finger and shake. The gel should move to the bottom end of the container. Hold the applicator by the flat tip and twist the cap off. Do not squeeze the container. The applicator can be inserted while sitting or lying down, with your knees slightly bent

You need to act carefully so as not to damage the vaginal mucosa. Squeeze the container so that the gel enters the vagina. There may be some left in the container, but there is always a little more in the gel applicator.

Crinone can be prescribed in the first trimester of pregnancy, when there is insufficient functionality of the corpus luteum. In later periods of pregnancy, the drug is not recommended. Crinon should not be used while breastfeeding. The therapy does not limit the patient’s sex life, since sexual activity does not interfere with the absorption of progesterone.

Crinon gel dosage:

1. To maintain the luteal phase. From the day of fertilization, 1.125 g daily. If pregnancy occurs, therapy is continued until the 12th week, or at 10-12 weeks.
2. For amenorrhea and uterine bleeding. 1.125 g every other day on days 15-25 of the cycle. The dosage may be reduced or increased by your doctor.
3. For replacement therapy. A similar dose twice a week.

When treating with Crinon, you must strictly follow your doctor’s recommendations, since the drug contains hormonal components. It is possible to use the gel in the morning: physical activity does not affect the effectiveness.

The gel may accumulate in the vagina, but this is harmless. The hormone carrier attaches to the vaginal tissues until progesterone enters the uterus completely. If the accumulation of gel causes discomfort, you can clean the vagina with a sterile swab before administering a new dose.

When treated with Crinon, you may notice vaginal discharge. This happens when the gel is used daily and it accumulates. Sometimes, after progesterone is released, its carrier, polycarbophil, may leak from the vagina. Crinon gel does not cause vaginal dryness, unlike many other drugs.

How does the artificial insemination procedure take place?

Discussion: 2 comments

1. Olesya:
   06/09/2018 at 03:50

   Good day. I have 3 dpp. Questions have arisen. For two evenings in a row the temperature rises to 37.2-37.4, and after three to four hours it returns to normal. This is fine ? Second question about kraynon. Do I need to remove any residual krainon before inserting the next applicator?

   Answer

   Yana:

   06/09/2018 at 14:41

   Hello, Olesya! 1 question: your temperature most likely rises due to the attachment of the embryo or embryos to the wall of the uterus - this is normal. It is worth noting that a temperature above 38 degrees may be a sign of other diseases, in which case you should immediately consult a doctor. Question 2: it is better to definitely remove the remnants of Krainon in order to protect yourself from accidental reactions with other vaginal products.

   Answer

Composition, release form

The active ingredient in Crinona is progesterone.

The composition of the drug includes excipients:

• 145.1 mg glycerol;
• 47.25 mg liquid paraffin;
• 11.25 mg of specially prepared palm oil;
• 11.25 mg carbomer;
• 0.9 mg sorbic acid;
• 22.5 mg polycarbophil;
• sodium hydroxide and water.

Did you know? Progesterone, testosterone and estrogens are present in different physiological proportions in both female and male bodies.

This medicine comes only in the form of a gel, which, however, some patients may mistakenly call a cream or ointment. The gel itself has a white color and a specific smell of fat.

Video: all about Crinon gel

A single dose of the drug - 1.125 g - is placed in a white polypropylene applicator, the cap of which breaks off. Each applicator is packaged in laminated foil. The package may contain 6 or 15 packets of applicators containing one portion of the medicine.

Find out what IVF is and how it is done, how to prepare for an IVF pregnancy, and why IVF is harmful for a woman.

What to do if the gel leaks

If a woman uses this remedy every day, then, of course, the medicine accumulates in the vagina. Some girls may experience clear or white discharge even after 5-6 days after use. This is not scary, because it indicates that a special progesterone carrier is coming out of the vagina. And it is transported because the hormone itself has already moved from the medication to the uterus. This is how the medicine “Krinon” works. Discharge may bother a woman, but in reality there is no need to worry. Although, to be more sure, it is still better to consult your doctor.