Mebendazole – description of the drug, instructions for use, reviews

Write a review

Reviews: 0

Manufacturers: Grindeks

Active ingredients

• Mebendazole

Disease class

• Echinococcosis
• Liver echinococcosis, unspecified
• Taeniasis
• Trichinosis
• Hookworm disease
• Ascariasis
• Strongyloidiasis
• Trichuriasis
• Enterobiasis
• Intestinal cappilariasis
• Intestinal helminthiasis of mixed etiology
• Gnathostomiasis

Clinical and pharmacological group

• Not indicated. See instructions

Pharmacological action

• Antihelmintic (anthelminthic)

Pharmacological group

• Antihelminthics

Pharmacokinetics

Mebendazole is practically not absorbed from the intestine. Its half-life is 2.5–5.5 hours. The active substance of the drug binds to plasma proteins by 90% and is unevenly distributed throughout the organs, which causes the accumulation of Mebendazole in helminth larvae, liver, and adipose tissue. In the liver, the drug is metabolized to form the 2-amino derivative mebendazole. More than 90% of the dose taken is excreted unchanged in the feces. The absorbed portion (approximately 5-10%) is excreted through the kidneys. In case of liver failure, the half-life increases to 35 hours.

Compound

According to the instructions for use, the drug contains the active ingredient mebendazole 100 mg/tab. Other substances included in Mebendazole:

• magnesium stearate;
• sodium starch glycolate;
• lactose monohydrate;
• dibasic calcium phosphate;
• povidone;
• corn starch.

Instructions for use Mebendazole: method and dosage

Mebendazole tablets are taken orally.

Recommended dosage:

• Enterobiasis (it is necessary to use tablets by all family members at the same time): patients 10 years and older - 100 mg, children from 2 to 10 years - 25-50 mg once. To avoid re-infestation, it is recommended to repeat the dose at the same dose after 2-4 weeks;
• Mixed helminthiases, ascariasis, hookworm disease, trichuriasis, strongyloidiasis, taeniasis: 100 mg 2 times a day (morning and evening), course of treatment – ​​3 days;
• Trichinosis: 200-400 mg 3 times a day for the first 3 days, then 400-500 mg 3 times a day for the next 7 days;
• Echinococcosis: 500 mg with a dosage frequency of 2 times in the first 3 days of therapy and 3 times a day in the next 3 days. Next, treatment is continued at a daily dose corresponding to 25-30 mg per 1 kg of patient weight, divided into 3-4 doses.

Indications for use

Mebendazole, according to the instructions for use, is an extended-spectrum anthelmintic and is highly effective, but to completely get rid of parasites, the whole family must undergo treatment. The drug shows the greatest effectiveness during the treatment of trichuriasis and enterobiasis, but the drug is also used in other cases of damage to the body by parasites. The instructions for use additionally indicate what Mebendazole tablets can help with:

• multiple nematodes;
• taeniasis;
• trichinosis;
• gnathostomiasis;
• ascariasis;
• mixed helminthiasis;
• echinococcosis;
• strongyloidiasis;
• hookworm disease.

Side effects

• Nervous system: with high doses during long-term therapy – headache; rarely - dizziness;
• Digestive system: rarely – abdominal pain, nausea; at high doses during long-term therapy - diarrhea, vomiting, transient increase in the activity of liver enzymes in the blood serum;
• Urinary system: at high doses during long-term therapy – hematuria, cylindruria;
• Hematopoietic system: at high doses during long-term therapy, anemia, leukopenia, and eosinophilia may develop;
• Other: at high doses during long-term therapy – hair loss, development of allergic reactions.

Mebendazole for prevention

It is recommended to take prophylactic use of the drug Mebendazole against worms once a year, at the end of the summer period. For preventive purposes, a dose of 100 mg of the component is sufficient. Preliminary consultation with a specialist is required to avoid negative reactions from organs and their systems. Prophylactic use of the drug for children under 12 years of age is prohibited.

• How to get through a divorce from your husband easier. Advice from a psychologist on how to behave after a divorce, video
• How to lose weight
• Can MRI replace colonoscopy?

special instructions

Long-term use of Mebendazole must be accompanied by careful monitoring of kidney, liver and peripheral blood function indicators.

Drinking alcohol is contraindicated within 24 hours of taking the tablets.

Laxatives should not be used in combination with mebendazole.

After stopping the use of the drug, periodic laboratory tests of stool and smears of the anal area are required. The effectiveness of therapy is determined by the absence of helminths and their eggs in the patient within 1 week after completion of therapy.

What is Mebendazole

A synthetic drug used in the treatment of diseases caused by helminths. International name: Mebendazole. The medication comes in tablet form, with 6 tablets in a blister pack. Dispensed according to prescription. Mebendazole tablets disrupt the process of glucose metabolism in the bodies of parasites, leading to their death. If significant colonies of helminth infections are suspected, the drug must be used in combination with Piperazine - this will prevent intestinal perforation, preventing the accumulation of parasites in the appendix and bile ducts.

Possible side effects

Like all medicines, Mebendazole can cause side effects, although not everyone gets them.

Stop using this medicine immediately if you notice or suspect any of the following serious side effects and tell your doctor right away - you may need urgent medical treatment.

• Sudden swelling of the face or throat. Hives, severe irritation, redness, or blistering of the skin.
• Blisters on the skin, around or in the mouth, eyes and genitals.
• Seizures (convulsions).

Tell your doctor or pharmacist if you experience the following side effects:

Common (1 in 10 people):

• Abdominal pain.

Uncommon (affects 1 in 100 people):

• Discomfort in the stomach
• Diarrhea
• Flatulence

Rare (affects 1 in 1000 people):

• Rash
• Liver inflammation
• Changes in liver enzyme map (determined by blood tests)
• Decreased white blood cells (determined by blood tests). You may become susceptible to other infections.
• Unexplained hair loss
• Dizziness

Side Effect Report:

If you notice any side effects, tell your doctor or pharmacist, including any side effects not listed in this leaflet. You can also report side effects to , by going to the website www.arpimed.com and filling out the appropriate form “Report a side effect or ineffectiveness of a drug,” as well as to the Scientific Center for Expertise of Medicines and Medical Technologies named after. Academician E. Gabrielyan by going to the website www.pharm.am to the “Report a side effect of a drug” section and filling out the form “Card for reporting a side effect of a drug.” Scientific center hotline phone number: +37410237665; +37498773368.

How to store Mebendazole

• Store out of the reach of children, at a temperature not exceeding 250C, in the original packaging.
• Do not use the drug after the expiration date stated on the label. The expiration date refers to the last day of that month.
• There are no special storage conditions.
• Shelf life: 3 years.

Medicines should not be disposed of in wastewater or sewer systems. Ask your pharmacist how to dispose of any medicine you no longer need. These measures are aimed at protecting the environment.

Package contents and additional information

What Mebendazole contains

Each 500 mg tablet contains:

Active substance: mebendazole – 500.0 mg.

Excipients: microcrystalline cellulose, sodium starch glycolate, corn starch, sodium lauryl sulfate, purified talc, magnesium stearate.

What Mebendazole looks like and contents of the pack.

500 mg tablets : round tablets with a flat end surface, white with a yellowish tint, beveled on both sides.

A labeled plastic bottle containing one tablet and a leaflet are placed in a cardboard package.

Vacation conditions

Dispensed by prescription.

Further recommendations regarding worms

Threadworms (pinworms) lay many tiny eggs. They can be present in house dust and also stick to clothes, carpets, towels and bedding. They can be picked up through contact with a person who is already infected with helminths. Because their eggs are very small, they are very easy to swallow. Then they enter the intestines, where they turn into sexually mature individuals. The female lays eggs overnight in the anus of an infected person. This is what causes anal itching and leads to the formation of scratches when scratching. The eggs, after being scratched through the fingers and nails, can then be transferred and enter the mouth through finger sucking or nail biting. The life cycle of a mature individual can last up to six weeks.

To prevent reinfection of yourself or others, you should follow these recommendations for at least 6 weeks:

• Keep your nails short
• Abstain yourself or try to prevent thumb sucking or nail biting
• Wear pajamas or underwear to bed
• Wash your anus thoroughly every morning
• Use a separate towel for each family member
• Change your clothes regularly
• Wash and iron your bed linen regularly
• Wash your hands and nails well after using the toilet and before eating.

Mebendazole price

The drug is not available for sale in Moscow; you cannot buy Mebendazole otherwise (order delivery by mail from St. Petersburg and other regions). It is possible to purchase analogues, of which it is better to choose between Vormin and Vermox. Medicinal anthelmintic drugs contain similar proportions of the mebendazole component and are characterized by the same effect on the structures of the helminth body, disrupting its metabolic processes. The treatment regimen with Vermox and Wormin is similar, prices may differ - promotions or discounts are possible.

Contraindications

Instructions for use recommend using Mebendazole with extreme caution when treating patients with diabetes mellitus - the active component is capable of making changes in the body's glucose metabolism - reducing the patient's need for insulin. For children under 2 years of age, an anthelmintic drug is prescribed solely based on vital signs and under the supervision of a specialist; otherwise, similar milder agents are used.

Absolute contraindications for Mebendazole, according to the instructions for use:

1. Intolerance to the active component or auxiliary components.
2. Pathological conditions of the liver.
3. Nonspecific ulcerative colitis, Crohn's disease.
4. Periods of pregnancy and breastfeeding.

Mebendazole is not recommended for use in combination with medications due to their negative interactions:

• vitamin E in the form of an oil solution;
• fat-soluble drugs;
• Cimetidine.

Mebendazole analogs

The drug has several analogues, which are characterized by a similar principle of action and composition:

• Vormin

1. The component is mebendazole, 100 mg/1 tablet.
2. Dispensed according to prescription.
3. The main advantage is accessibility. Average price in Russia (online pharmacy) – 30 rubles/6 tablets.

• Wormil

1. The active ingredient is albendazole.
2. Available in the form of tablets for chewing, powder for suspension and suspension.
3. It is characterized by a voluminous list of side effects, but has a more powerful effect compared to Mebendazole and mebendazole-containing medications.
4. Cost – from 250 rub.

• Vermox

1. Mebendazole-containing drug. Release form: tablets (100 mg/1 tablet) and suspension (100 mg/5 ml).
2. Prescription drug.
3. The main advantage is the shelf life of 5 years.
4. The average price in Moscow is 90 rubles.

• Mebex

1. Mebendazole-containing drug.
2. There is no way to find it in Moscow pharmacies - it is not on sale, pharmacists offer its substitutes.