Effect of the drug Nolitsin for urinary tract infections

Nolitsin is a drug aimed at destroying microbes in the urinary tract and preventing diarrhea. The tablets have a wide spectrum of action and are effective against bacterial lesions of the pelvic organs.

Nolitsin is a drug aimed at destroying microbes in the urinary tract and preventing diarrhea.

pharmachologic effect

Many people wonder: Is Nolitsin an antibiotic or not? The active substance has an antimicrobial effect against staphylococci, Klebsiella, Enterobacteriaceae, Neisseria, Escherichia coli, Chlamydia, Legionella, Salmonella, Shigella and other pathogens of infectious diseases. The mechanism of action of the drug is based on the interaction of norfloxacin with DNA gyrase (an enzyme of a microorganism), which leads to destabilization of the DNA chain and subsequent death of the microorganism. From this we can conclude that Nolitsin is an antibiotic, as it has a detrimental effect on bacteria.

The antimicrobial effect can last up to 12 hours. The antibiotic Nolitsin can be prescribed for diseases caused by mycobacteria and enterococci. Wikipedia contains a complete list of microorganisms that are sensitive to the action of the antibiotic.

Composition of the drug

The active ingredient of Nolitsin cystitis tablets is norfloxacin (NF), each containing 400 mg of the active ingredient

Acquired resistance to NF in clinical strains of bacteria develops relatively slowly, which is important when choosing this drug for the treatment of urinary tract diseases of an infectious nature.

The bactericidal and bacteriostatic activity of NF against a large number of microorganisms has been studied on tens of thousands of strains. The antibiotic quickly penetrates the microbial cell and is well tolerated when administered orally. It also remains highly effective against multiresistant strains of bacteria.

Composition of one Nolitsin tablet

Pharmacodynamics and pharmacokinetics

The active substance is absorbed quite quickly from the digestive system , peak concentrations in the blood are recorded within 1-2 hours after taking the medication. The biological availability of the drug reaches 30-40%. About 15% of the active substance binds to plasma proteins.

unchanged through the renal system In patients with severe pathology of the renal system, pharmacokinetic parameters are changed.

Release form and composition

The dosage form of Nolitsin is film-coated tablets: orange, round, somewhat biconvex, with a score on one side (10 pieces in blisters, 1 or 2 blisters in a cardboard box).

1 tablet contains:

• Active substance: norfloxacin – 400 mg;
• Additional components: povidone, sodium carboxymethyl starch, microcrystalline cellulose, colloidal anhydrous silicon dioxide, magnesium stearate, purified water;
• Shell: hypromellose, talc, titanium dioxide, propylene glycol, sunset yellow dye (E110) (yellow disperse dye, E110).

Indications for use of Nolicin

Nolicin tablets, what are they for? The drug is prescribed for the treatment of infectious and inflammatory diseases of the genitourinary system:

• chronic prostatitis of bacterial origin;
• endometritis;
• cervicitis;
• cystitis;
• pyelonephritis;
• urethritis;
• uncomplicated form of gonorrhea.

What else can Nolitsin be prescribed for: bacterial gastroenteritis, shigellosis , salmonellosis . Additional indications for the use of tablets: prevention of traveler's diarrhea and prevention of septic complications in patients with neutropenia .

Nolicin tablets

Some patients have heard about this drug, but do not know exactly what the antibiotic Nolitsin can be used for. This medication has a broad effect, so it is used in the treatment of many diseases.

Nolitsin's indications for use are as follows:

• urinary system infections;
• infectious diseases of the genital organs;
• infectious intestinal diseases;
• preventing recurrent infections.

The list of urinary tract infections for which Nolicin can be taken includes cystitis, urethritis and pyelonephritis.

The medicine is often used for salmonellosis and shigellosis.

It is recommended to use the drug only on the recommendation of a doctor.

The daily dose of medication is no more than 400 mg at a time. Drink twice a day (morning and evening), preferably at identical intervals.

The average duration of antibiotic treatment is 5 days. Only the treating specialist can increase the treatment period.

In case of uncomplicated diarrhea, take 2-4 tablets once or divide the dose over 3-7 days, 2 tablets per day.

An intestinal infection is treated with an antibiotic for no more than five days, taking the drug twice a day, 1 tablet.

For preventive purposes of recurrent infections, the drug is used at a dose of 200 mg once a day for six months or more.

The drug is antimicrobial. The antibiotic Nolitsin is prescribed for infectious and inflammatory diseases caused by bacteria sensitive to norfloxacin. Orange tablets. Each capsule contains 400 mg of norfloxacin. To avoid severe side effects, take the tablet with plenty of water or unsweetened tea.

Compound

The main active ingredient of Nolitsin is norfloxacin. It belongs to the group of broad-spectrum fluoroquinolones. Cellulose, magnesium stearate, povidone, and sodium carboxymethyl starch are added to the tablet to prevent premature destruction of the main active ingredient. The capsule shell contains dye, propylene glycol and talc. The full composition of the drug is listed in the table below.

Nolitsin is a broad-spectrum antimicrobial drug. The instructions for use say that it belongs to the group of fluoroquinolones. The bactericidal effect of the antibiotic is ensured by the destruction of DNA gyrase. This enzyme is necessary for the life of bacteria in the human body. The antibacterial effect of the drug Nolitsin is manifested against the following microorganisms:

• Staphylococcus aureus and Staphylococcus epidermidis;
• gonococcus, meningococcus;
• coli;
• Citrobacter, Enterobacter, Campylobacter jeuni;
• Klebsiella, hafnia;
• indole-positive and indole-negative proteins;
• Salmonella, Shigella, Aeromonas, Plesimonas;
• Yersinia enterocolitica;
• Vibrio cholerae, Vibrio parahaemolyticus;
• hemophilus influenzae;
• chlamydia, legionella.

The maximum concentration of norfloxacin will be observed 1-2 hours after administration, depending on the dose taken. Absorption of the drug is slowed down by food intake. The drug is highly soluble in lipids and quickly penetrates into organs and tissues. Norfloxacin will be able to cross the blood-brain and placental barrier. Metabolization of the drug in the liver is negligible. Norfloxacin is excreted by the kidneys 24 hours after taking the tablet.

The drug is prescribed for bacterial infections caused by microorganisms sensitive to norfloxacin. In the instructions for use, the manufacturer advises to first check the sensitivity of the pathogen to the drug in order to increase the effectiveness of treatment. Doctors often prescribe Nolicin for infectious and inflammatory diseases of the genitourinary system in women and men. According to the instructions, the indications for use of the medicine are as follows:

• bacterial prostatitis;
• prevention of diarrhea in travelers;
• treatment of acute and chronic cystitis;
• for chronic and acute diseases of the urinary tract (cystitis, pyelonephritis, renal abscess, etc.);
• prevention of sepsis in patients with neutropenia;
• prevention of urinary tract infections.

Contraindications

The summary of the drug contains the following absolute contraindications:

• intolerance to fluoroquinolones;
• carrying a pregnancy;
• congenital deficiency of the enzyme glucose-6-phosphate dehydrogenase.

The drug is not used in pediatrics.

Relative contraindications:

• allergic responses to acetylsalicylic acid;
• epileptic syndrome;
• disorders of cerebral blood supply;
• atherosclerotic changes in cerebral vessels;

Side effects of Nolicin

From the genitourinary system:

• hypercreatininemia;
• glomerulonephritis;
• polyuria;
• urethral bleeding;
• crystalluria;
• dysuria;
• albuminuria.

From the digestive tract:

• pseudomembranous enterocolitis;
• epigastric pain;
• appetite disorders;
• diarrhea syndrome;
• vomit;
• nausea;
• bitterness in the mouth;
• increase in ALT, AST.

The development of hallucinations, headaches, arrhythmia, tachycardia , vasculitis, itching, fainting, insomnia, swelling, urticaria, exudative erythema with a malignant course is possible. Candidiasis, decreased hematocrit, changes in blood counts, arthralgia , chemosis, and fear of light are rarely recorded.

Overdose

Symptoms of an overdose of Nolicin are: vomiting, nausea, loose stools, in severe cases - drowsiness, convulsions, dizziness, puffiness of the face without changes in hemodynamic parameters, cold sweat.

In case of intoxication with the drug, gastric lavage, forced diuresis with adequate hydration and other necessary symptomatic treatment are prescribed. There is no antidote. It is advisable to further examine and observe the patient in a hospital setting for several days.

Instructions for use of Nolicin (Method and dosage)

How to use Nolitsin correctly? Instructions for use instruct you to take the medication orally.

For infectious lesions of the genitourinary system: 400 mg twice a day, course 7-10 days.

Treatment of uncomplicated cystitis is carried out within 3-7 days.

Chronically recurrent infectious diseases of the urinary tract are treated within 12 weeks.

How to take Nolicin for acute gastroenteritis of bacterial origin : 400 mg twice a day for 5 days. For cervicitis, proctitis , urethritis and pharyngitis, 400 mg of norfloxacin is prescribed once.

Nolicin description of the drug

Nolitsin belongs to the second generation fluoroquinolones - a group of drugs that lead to the death of pathogens. It is based on the active antibacterial substance norfloxacin.

Release form and principle of operation

Nolitsin is produced in the form of tablets, each of which contains 400 mg of norfloxacin. One blister contains 10 tablets; the package contains one or two blisters. Norfloxacin, when it gets inside the bacteria, inhibits the DNA of microorganisms, thereby preventing their reproduction. The bactericidal effect of this medicine lasts for 12 hours after ingestion.

Each Nolicin tablet contains 400 mg of norfloxacin, a second-generation fluoroquinolone with antimicrobial activity

Doctors' opinions on the effectiveness of Nolitsin

Doctors note good penetration of Nolitsin into organs and tissues, as well as a wide range of antimicrobial activity - the drug is effective against most representatives of bacterial microflora. At the same time, its ability to penetrate the placenta, as well as into breast milk, makes it impossible to use this medication during pregnancy and breastfeeding.

Doctors also draw attention to the need for careful use of the drug when:

• atherosclerotic damage to cerebral vessels;
• epileptic seizures;
• allergic responses to taking Aspirin;
• renal and liver failure.

In addition, doctors warn about the need to maintain a full course of antibacterial therapy when using this drug - the therapeutic effect occurs quite quickly, but if you stop taking Nolitsin ahead of time, a relapse of the disease may soon occur.

Pros and cons of the drug, its cost

Those who took Nolitsin for cystitis paid attention to the rapid onset of the effect. Already on the second or third day after starting to take the drug, there was a decrease in pain, a decrease in the intensity of pain during urination and the urge to urinate

Among the negative aspects, some noted the large size of the tablets and the inconvenience of swallowing them, as well as the feeling of bitterness that remains in the mouth after using Nolitsin. With long-term use, stomach and intestinal disorders (nausea, vomiting, diarrhea) may occur, requiring the use of eubiotics (drugs that normalize intestinal microflora).

Nolitsin tablets are quite large in size and have a bitter taste, which is noted by some as a negative side of this drug

Interaction

The medication reduces the effectiveness of nitrofurans , increases the concentration of cyclosporine (mutual action) and indirect anticoagulants . Norfloxacin reduces the total clearance of theophylline by 1/4.

When treated simultaneously with medications that lower the epileptic threshold, epileptiform seizures . Antacids reduce the absorption of Nolicin. When taking antihypertensive drugs, a sharp drop in blood pressure is recorded. The use of medications for general anesthesia requires mandatory monitoring of heart rate, blood pressure, and heart function (ECG).

Causes of bladder inflammation

The inflammatory process in the bladder, often accompanied by infection of the mucous membrane, is called cystitis. This disease is more common in women due to the structural features of the genitourinary organs, in particular the urethra, which is shorter and wider than in the stronger sex. However, men also suffer from cystitis.

Pain in the lower abdomen may indicate the development of cystitis

Very often the cause of this disease is pathogenic microorganisms. There are other factors that can cause bladder inflammation in the absence of infection.

1. Hypothermia of the body, for example, when sitting for a long time on a cold surface.
2. Metabolic disease.
3. Poor nutrition with a predominance of salty and spicy foods in the menu.
4. Diabetes.
5. Chronic diseases of other organs that are inflammatory in nature.
6. Prolonged sitting, which leads to impaired blood flow in the walls of the bladder.
7. Menopause period.
8. Frequent and prolonged sex.
9. Wearing thick synthetic underwear that can cause irritation.
10. Depressive states and frequent stress.

Alas, cystitis is one of the ailments that many people try to fight on their own.

Only proper treatment prescribed by a specialist will help prevent complications with cystitis.

However, some home methods eliminate only the symptoms of the disease, but do not cure the disease completely. And then cystitis becomes a chronic disease, subsiding only for a while. And such a disease is more difficult to treat. But this is not the worst thing. Lack of proper drug treatment can lead to complications: the development of more serious diseases.

Treatment of cystitis: video

special instructions

Before prescribing an antibiotic, it is necessary to determine the sensitivity of the flora to norfloxacin. Why is this being done? Infectious agents may be sensitive to this drug, and the expected therapeutic effect will not be achieved in the required time frame.

For pyelonephritis, Nolitsin is recommended to be prescribed in combination with herbal medications (for example, Canephron ). When treating with norfloxacin, reviews for pyelonephritis are mostly positive. Monural is also used to treat diseases of the genitourinary system. Only the attending physician can decide what is best to prescribe.

Nolicin during breastfeeding

After childbirth, while hormonal changes occur and immunity decreases, the likelihood of infectious diseases of the abdominal and pelvic organs increases. Often, nursing mothers are diagnosed with cystitis of bacterial origin. This disease is manifested by frequent urination, which is accompanied by pain. Therefore, it is necessary to begin treatment as quickly as possible.

Nolicin is a modern antibacterial agent, which is a representative of fluoroquinolones. The drug demonstrates a pronounced bactericidal and anti-inflammatory effect and prevents complications. Many women are interested in the question of whether Nolitsin can be used for breastfeeding. This is exactly what will be discussed further.

Analogues of Nolitsin in Russia

Level 4 ATX code matches:
Siflox

Hyleflox

Leflobakt

Lefoccin

Gatifloxacin

Ofloxacin

Faktiv

Tigeron

Lebel

Zanotsin

Lomefloxacin

Eleflox

Lomflox

Pefloxacin

Tsiprobay

Sparflo

Tariwid

Zoflox

Abaktal

Moxifloxacin

Loxon-400, Sophasin, Norfatsin, Norilet, Norbactin , Renor.

Nolitsin price, where to buy

The price of tablets depends on the packaging. You can buy Nolitsin in Russia at a price of 10 pieces - 200 rubles, 20 pieces - 430 rubles. You can find out how much the medicine costs in your region by calling the pharmacy chain.

• Online pharmacies in RussiaRussia
• Online pharmacies in KazakhstanKazakhstan

ZdravCity

• Nolicin tablets p.p.o.
  400 mg 10 pcs. Krka-Rus LLC 209 rub. order
• Nolicin tablets p.p.o. 400 mg 20 pcs. Krka-Rus LLC

  RUB 390 order

Pharmacy Dialogue

• Nolicin tablets 400 mg No. 10KPKA

  RUB 235 order

• Nolicin tablets 400 mg No. 20KPKA

  RUR 464 order

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Reviews about Nolitsin

In my memory, I only had cystitis twice in my life. The first time I was saved by monural. And this time, a mother I knew at the playground, who is also a nurse at the clinic, recommended nolitsin. It is not expensive at all... Already on the second day of treatment I felt relief. I already went to the toilet painlessly, the pain and discomfort inside began to go away. I had no side effects from Nolitsin. So I'm happy with the drug. Of course, I am aware that cystitis is not something to joke about and self-medicate, but it is not always possible to go to the doctor to get tested and receive the appropriate prescriptions.

lana2309

https://citykey.net/review/nolitsin-izbavit-ot-tsistita

This spring cystitis struck again. Already accustomed to not taking the situation to an extreme, I went to the pharmacy for the usual “Furadonin”. And she left there with “Nolitsin”, which the pharmacist recommended to me, saying that “Nolitsin”:.. The result pleased me unexpectedly quickly: literally on the second day, all the characteristic signs of cystitis disappeared and did not recur. And it was great! No one has ever treated me in such a short time,

Falen84

Read also:  Instructions for use of the drug Fluanxol and reviews about it

https://citykey.net/review/a-ya-promenyala-furadonin-na-nolitsin

I took Nolicin for two years in a row during exacerbations and cystitis one fine day forgot the way to me. A friend also had the same problem - she advised Nolitsin, it helped her and the doctor approved it (he said it was a good modern remedy).

Natalisia

https://citykey.net/review/effektivno-izbavlyaet-ot-boli.

My wife came down with cystitis, at work I had to “endure”, and as a result - pain and burning in the area of ​​the bladder... I, like a good wife, bought “on the advice” (well, we rarely go to doctors in general) ordinary Furosemide, it seemed to help many I would, but my husband almost died from it. A terrible allergic reaction, after which he first became bloated, then became as thin as a mongrel, and I shook out all his underwear on the street every day (!) for a month - a T-shirt, sweatpants, even socks - that’s how his skin peeled off! Moreover, he followed a strict diet... And when my husband realized that he had CYSTITIS AGAIN, he panicked. We went to the pharmacy, the pharmacist admitted in good spirit that she often suffers from cystitis and is saved only by NOLICINE. Bought. They carried him home in silence... The next day, almost everything was gone, for another 3 days he drank 1 tablet and completely forgot about the torment (I emphasize that he drank 2 times less than the recommended dose, and the pain went away!).

rrraduga

https://otzovik.com/review_119421.html