Ofloxacin, 10 pcs., 400 mg, film-coated tablets

Release form and composition

Ofloxacin is available in the following forms:

• Film-coated tablets: biconvex, round, almost white; the cross-section layer is almost white (10 pieces in blister packs, 1 pack in a cardboard pack);
• Solution for infusion: transparent, greenish-yellow (100 ml in clear or dark glass bottles, 1 bottle in a cardboard box);
• Eye ointment 0.3%: white, white with a yellowish tint or yellow (5 g in aluminum tubes, 1 tube in a cardboard box).

Active ingredient: ofloxacin – 200 mg or 400 mg in 1 tablet; 2 mg in 1 ml solution; 3 mg per 1 g ointment.

Auxiliary components:

• Film-coated tablets: talc, corn starch, colloidal silicon dioxide, calcium stearate, microcrystalline cellulose, povidone; film shell: titanium dioxide, macrogol 4000, hypromellose, propylene glycol, talc;
• Solution for infusion: distilled water and sodium chloride;
• Eye ointment: propyl parahydroxybenzoate, methyl parahydroxybenzoate, petroleum jelly.

Price

How much does Ofloxacin cost? The price of the drug varies depending on the dosage form, the initial cost of the manufacturer and the marketing policy of the outlet. If this antibiotic is not on sale, you can order it from a catalog at a pharmacy or buy it inexpensively in an online store. The average price for the drug in pharmacies in the Moscow region:

Indications for use

Ofloxacin in the form of tablets and solution for infusion is used for the following diseases and conditions:

• Infectious and inflammatory diseases of the ENT organs (laryngitis, pharyngitis, sinusitis, otitis media);
• Infectious and inflammatory diseases of the respiratory system (pneumonia, bronchitis);
• Infectious and inflammatory diseases of the biliary tract and abdominal cavity (including infections of the gastrointestinal tract);
• Infectious and inflammatory diseases of the genital organs (orchitis, colpitis, epididymitis) and pelvic organs (oophoritis, parametritis, endometritis, prostatitis, salpingitis, cervicitis);
• Infectious and inflammatory diseases of the urinary tract (urethritis, cystitis) and kidneys (pyelonephritis);
• Infectious and inflammatory diseases of joints and bones;
• Infectious and inflammatory diseases of soft tissues and skin;
• Meningitis;
• Chlamydia;
• Gonorrhea;
• Prevention of infections in patients with impaired immune status (including neutropenia).

Ofloxacin ointment is used in ophthalmic practice for the following diseases and conditions:

• Chlamydial eye infections;
• Dacryocystitis, meibomitis (barley);
• Bacterial diseases of the cornea, conjunctiva and eyelids (conjunctivitis, blepharitis, blepharoconjunctivitis, bacterial keratitis and corneal ulcers);
• Prevention of infectious complications in the postoperative period after surgery for eye injury and removal of a foreign object.

Reviews from doctors

Igor, 36 years old, Moscow

I give preference to the Israeli manufacturer. Ofloxacin-Teva effectively eliminates inflammation of the paranasal sinuses when it comes to sinusitis. For patients with pathologies of the digestive tract, I recommend the product in ampoules for intravenous injection. In rare cases, side effects are observed, because the drug is not an antibiotic, so it does not disturb the bacterial balance in the intestines and vagina.

Igor, 54 years old, Perm

I prescribe the medication as a means to prevent infectious complications after surgical operations on the female internal genital organs. The product prevents the growth of bacteria and does not have a negative effect on a weakened body.

Contraindications

For oral and intravenous administration:

• Epilepsy (including history);
• Deficiency of the enzyme glucose-6phosphate dehydrogenase;
• Reducing the seizure threshold (including after a stroke, traumatic brain injury or inflammatory processes in the central nervous system);
• Pregnancy and breastfeeding period;
• Children and adolescents up to 18 years of age (since skeletal growth is not complete);
• Hypersensitivity to the components of Ofloxacin.

The drug is prescribed with caution for cerebral circulatory disorders (history), cerebral atherosclerosis, organic lesions of the central nervous system and chronic renal failure.

For external use:

• Chronic nonbacterial conjunctivitis;
• Pregnancy and breastfeeding period;
• Children under 15 years of age;
• Hypersensitivity to the components of Ofloxacin and other quinolone derivatives.

Ofloxacin during pregnancy

For women while expecting a child, the medicine is prescribed exclusively for local treatment (ointment), which is carried out under the strict supervision of a doctor. Taking the tablet form or injections of Ofloxacin during pregnancy and lactation is contraindicated. If it is necessary for a nursing woman to take medication, then stop breastfeeding the baby during the entire therapeutic course of the antibiotic.

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Directions for use and dosage

Doses of the drug are selected individually, based on the general condition of the patient, kidney and liver function, severity and localization of infection and sensitivity of microorganisms.

Film-coated tablets

The tablets are intended to be taken orally before or during meals. They should be swallowed whole, without chewing, with water.

The recommended dose for adults is 200-800 mg per day in 2 divided doses. The duration of treatment is 7-10 days. If the daily dose does not exceed 400 mg, it can be prescribed in one dose, preferably in the morning.

For acute gonorrhea, Ofloxacin is used in a dose of 400 mg once.

Solution for infusion

The solution is administered intravenously.

The initial dose of Ofloxacin is 200 mg intravenously (over 30-60 minutes). If the patient's condition improves, the patient is transferred to taking the drug orally at the same daily dose.

Recommended doses:

• Infections of the genital organs and kidneys – 100-200 mg 2 times a day;
• Urinary tract infections - 100 mg 1-2 times a day;
• Septic infections and infections of the ENT organs, respiratory tract, abdominal cavity, soft tissues and skin, joints and bones - 200 mg 2 times a day (if necessary, the dose can be increased to 400 mg 2 times a day);
• Prevention of infections in patients with impaired immune status - 400-600 mg per day.

If renal function is impaired (creatinine clearance 20-50 ml/min), the single dose should be reduced by 50% of the average dose (if the drug is taken 2 times a day) or the full single dose should be prescribed, but once a day. When creatinine clearance is less than 20 ml/min, a single dose is 200 mg, and then 100 mg per day every other day.

For peritoneal dialysis and hemodialysis, Ofloxacin is prescribed every 24 hours, 100 mg.

For liver failure, the maximum dose per day is 400 mg.

For children with severe infections, the drug is prescribed at an average daily dose of 7.5 mg/kg body weight, with a maximum dose of 15 mg/kg.

The duration of therapy depends on the sensitivity of the pathogen and the clinical picture of the disease. Treatment is continued for another 3 days after the symptoms of the infectious-inflammatory disease disappear and body temperature normalizes. For uncomplicated urinary tract infections, the course of treatment is 3-5 days, for salmonellosis - 7-8 days.

Ointment

Ofloxacin ointment is used topically. The drug is placed behind the lower eyelid of the affected eye (a strip of ointment 1 cm long, which corresponds to 0.12 mg of ofloxacin) 2-3 times a day. For chlamydial infections, the drug is used 5-6 times a day.

The course of treatment is no more than 2 weeks (chlamydial infections require longer treatment - from 4 to 5 weeks).

Side effects

Systemic side effects:

• Digestive system: abdominal pain (including gastralgia), vomiting, nausea, anorexia, flatulence, diarrhea, hyperbilirubinemia, pseudomembranous enterocolitis, increased activity of liver enzymes, cholestatic jaundice;
• Cardiovascular system: vasculitis, tachycardia, collapse, decreased blood pressure;
• Central nervous system: tremor, paresthesia and numbness of the extremities, headache, psychotic reactions, dizziness, nightmares, intense dreams, anxiety, uncertainty of movements, phobias, confusion, convulsions, hallucinations, increased excitability, depression, diplopia, impaired color vision, increased intracranial pressure, impairment of hearing, smell, taste and balance;
• Urinary system: impaired renal function, increased urea levels, acute interstitial nephritis, hypercreatininemia;
• Musculoskeletal system: arthralgia, myalgia, tendon rupture, tendonitis, tenosynovitis;
• Hematopoietic system: anemia, pancytopenia, leukopenia, aplastic and hemolytic anemia, thrombocytopenia, agranulocytosis;
• Allergic reactions: allergic pneumonitis, itching, skin rash, fever, eosinophilia, urticaria, bronchospasm, Quincke's edema, allergic nephritis, photosensitivity, Lyell's syndrome, erythema multiforme, Stevens-Johnson syndrome; rarely - anaphylactic shock;
• Dermatological reactions: bullous hemorrhagic dermatitis, pinpoint hemorrhages, papular rash;
• Other reactions: superinfection, vaginitis, dysbacteriosis, hypoglycemia (in patients with diabetes).

Local reactions:

• Thrombophlebitis, redness and pain at the injection site (for solution);
• Itching and dryness of the conjunctiva, lacrimation, discomfort and burning sensation in the eyes, photophobia, hyperemia (for ointment).

special instructions

Ofloxacin is not the drug of choice for pneumonia caused by pneumococci. Not intended for the treatment of acute tonsillitis.

During treatment, direct sunlight and exposure to UV rays (solarium, mercury-quartz lamps) should be avoided.

It is not recommended to use the drug for more than 2 months.

In case of allergic reactions and side effects from the central nervous system, Ofloxacin should be discontinued. For confirmed pseudomembranous colitis, oral metronidazole and vancomycin are recommended.

If symptoms of tendonitis occur, treatment should be stopped immediately, followed by immobilization of the Achilles tendon and consultation with an orthopedic physician.

Women are not recommended to use Tampax-type tampons during drug therapy, as there is a high risk of developing vaginal candidiasis.

When using Ofloxacin, false negative results are possible with the bacteriological method for diagnosing tuberculosis.

In predisposed patients, during treatment with the drug, there may be an increase in the frequency of attacks of porphyria and a worsening of the course of myasthenia gravis.

In patients with impaired renal or hepatic function, plasma concentrations of ofloxacin should be monitored. With severe liver or kidney failure, the risk of developing toxic effects is higher.

During treatment you should avoid drinking alcohol.

In childhood, Ofloxacin is used only in cases where there is a threat to life and it is impossible to use other, less toxic agents. In this case, the ratio of the expected benefit and the potential risk of side effects should be taken into account.

During the treatment period, it is necessary to refrain from engaging in potentially hazardous activities and driving vehicles.

Do not wear soft contact lenses while using Ofloxacin ointment. Due to the possible development of photophobia, it is recommended to use sunglasses and avoid prolonged exposure to bright sunlight.

The ointment is not injected into the anterior chamber of the eye or subconjunctivally.

Drug interactions

Ofloxacin increases the concentration of glibenclamide in the blood plasma and reduces the clearance of theophylline by 25%.

Drugs that block tubular secretion, furosemide, cimetidine and methotrexate increase the plasma concentration of ofloxacin.

When used simultaneously with methylxanthine and nitroimidazole derivatives and non-steroidal anti-inflammatory drugs, the likelihood of developing neurotoxic effects increases.

When combined with glucocorticosteroids, the risk of tendon development increases, especially in the elderly.

Citrates, carbonic anhydrase inhibitors, and sodium bicarbonate increase the risk of nephrotoxic effects and crystalluria.

When administered simultaneously with indirect anticoagulants-vitamin K antagonists, it is necessary to monitor the state of the blood coagulation system.

Ofloxacin solution is pharmaceutically compatible with Ringer's solution, 5% glucose (dextrose) solution, isotonic NaCl solution and 5% fructose solution.

When using the drug in ointment form simultaneously with other eye ointments/drops, an interval of at least 15 minutes should be maintained, with Ofloxacin being used last.

Pharmacological properties

The product has a bactericidal effect, disrupting the process of cell division and changing the structure of its wall.

Pharmacodynamics

The product stops the replication process of pathogens and is also active against strains that produce beta-lactamase.

Chlamydia, ureaplasma, and pathogens of bacterial vaginosis are sensitive to the action of ofloxacin.

Resistance to the active component develops slowly, which makes it possible to treat chronic forms of sexually transmitted infections in women and men for a long time.

Pharmacokinetics

The active component is absorbed from the rectum if the drug is taken orally. Within an hour, the maximum concentration of ofloxacin is observed in the blood plasma.

The largest part of the metabolites is excreted by the kidneys along with urine and, in a small amount, with bile.