Orgametril®

Pharmacodynamics and pharmacokinetics

Orgametril is a synthetic progestogen intended for internal use. Its active component is characterized by pharmacological properties similar to natural progesterone . When treated with this drug, a pronounced progestogenic effect on the endometrium is manifested. Continuous use helps suppress ovulation and menstruation. Therefore, the drug is prescribed when it is necessary to demonstrate its pronounced progestogenic effect.

Inside the body , linestrenol undergoes rapid absorption and is converted into active norethisterone . Metabolism occurs in the liver. The maximum concentration of norethisterone in the blood plasma is detected 2-4 hours after taking the drug. The substance is eliminated through the kidneys and intestines.

Pharmacological properties

Pharmacodynamics

The active ingredient of Orgametril is linestrenol, a synthetic progestogen with pharmacological characteristics that are similar to natural progesterone.

Orgametril has a pronounced progestogenic effect on the endometrium. When taken continuously, it can suppress menstruation and ovulation.

It is considered appropriate to prescribe the drug in cases where a pronounced progestogenic effect on the body is required.

Pharmacokinetics

Once in the gastrointestinal tract, linestrenol is quickly absorbed. In the liver it is biotransformed into the pharmacologically active metabolite norethisterone. The maximum plasma concentration is reached 2–4 hours after taking Orgametril.

Linestrenol and its metabolites are excreted from the body primarily by the kidneys, and to a lesser extent through the intestines.

The half-life of norethisterone is approximately 8–11 hours.

Indications for use

The medicine is recommended for use when:

• dysfunctional uterine bleeding;
• amenorrhea;
• oligomenorrhea;
• dysmenorrhea;
• premenstrual syndrome;
• endometriosis;
• endometrial carcinoma;
• benign breast tumor;
• delay of normal menstruation;
• hormone replacement therapy with estrogen - in complex treatment.

Side effects

When treated with Orgametril, various undesirable effects may develop, for example: nausea, weight gain, development of heavy bleeding and spotting.

In rare cases, the following may occur: headache, nervousness , dizziness, migraine, depression, jaundice, chest pain, changes in liver function. A decrease in glucose tolerance is also noted, acne, chloasma , rashes and skin itching , and hirsutism appear. After stopping treatment, swelling and amenorrhea may develop .

Side effects

Possible side effects (>10% – often, 1-10% – uncommon, <1% – rare):

• Digestive system: often – nausea, vomiting, abdominal pain, diarrhea, constipation; infrequently or rarely - jaundice, abnormal liver function tests (increased activity of liver enzymes);
• Blood coagulation system: rarely - hypercoagulation;
• Nervous system: infrequently or rarely - headache, migraine, dizziness;
• Reproductive system: often (with long-term therapy - more often, with cyclic use - less often; in most cases, controlled by a temporary increase in the dose of Orgametril) - metrorrhagia; infrequently – soreness of the mammary glands; infrequently or rarely - amenorrhea, vaginal discharge, cervical discharge;
• Immune system: infrequently or rarely - hypersensitivity;
• Psyche: often – change (increase or decrease) in libido; infrequently or rarely - increased nervous excitability, depression;
• Subcutaneous tissues and skin: infrequently or rarely - increased sweating, chloasma, itching, acne, seborrhea, rash, urticaria, hirsutism;
• Metabolism: often – weight gain; infrequently or rarely - fluid retention, incl. peripheral edema, decreased glucose tolerance, lipid metabolism disorders (increased LDL cholesterol and decreased HDL cholesterol).

Due to the lactose included in Orgametril (as an excipient), it should not be taken against the background of such rare hereditary disorders as galactose intolerance, glucose-galactose malabsorption or lapp lactase deficiency.

Instructions for use of Orgametril (Method and dosage)

This drug is intended for oral administration with liquid. If you miss another pill, you must take it immediately, unless the dose is delayed for more than 24 hours.

It should be noted that the first day of the cycle is the beginning of menstrual bleeding.

For polymenoria, a daily dosage of 5 mg or one tablet is prescribed, which should be taken 14-25 days during the menstrual cycle.

Treatment of menorrhagia and metrorrhagia requires taking two tablets per day for 10 days. As a rule, the bleeding stops after a few days. It is recommended to repeat the therapeutic course for the next three menstrual cycles at a dosage of 14-25 days. When treatment is ineffective, additional examination is prescribed and appropriate therapy is selected.

In any case, the drug is prescribed by the attending physician, who determines the dosage and treatment regimen. Diagnostics are carried out regularly to confirm the effectiveness of treatment. The use of the drug without a prescription from a specialist is contraindicated.

Dosage regimen

Take Orgametril strictly as prescribed by your doctor.

Carefully read the instructions for use of the drug. If you are not sure whether you are taking the drug correctly, consult your doctor.

The tablets should be taken preferably at approximately the same time each day with a small amount of water or other liquid.

How and when to take Orgametril

For menstrual irregularities and a number of other diseases, Orgametril taken one tablet per day from the 14th to the 25th day of the menstrual cycle (the first day is considered the first day of menstrual bleeding). For the treatment of severe or prolonged menstrual bleeding, Orgametril is usually taken 2 tablets per day for 10 days.

As an adjunct to estrogen replacement therapy, Orgametril is taken 0.5 - 1 tablet per day for 12-15 days every month, for example, Orgametril daily every first two weeks of each calendar month. For some other diseases, Orgametril is prescribed for daily use in a long-term continuous mode without monthly breaks in taking the drug.

If you forget to take Orgametril , and more than 24 hours have not passed since you took the drug, take the forgotten dose as soon as you remember. If more than 24 hours have passed, do not take the missed dose, but continue taking the drug.

Interaction

The simultaneous use of Orgametril with Rifamycin , Hydantoin derivatives, barbiturates, Carbamazepine and Aminogluthetimide , laxatives and Activated carbon significantly reduces its effect. However, Orgametril itself is capable of increasing the therapeutic, pharmacological or toxicological effects of Cyclosporine, Troleandomycin, Theophylline and beta-blockers.

Combination with macrolide antibiotics

It is noted that this drug reduces the properties of Insulin.

special instructions

The use of drugs with a high content of estrogen or progestogen can lead to the development of chloasma . Therefore, women who are predisposed to this need to protect themselves from exposure to UV rays on their skin.

Sex hormones influence specific laboratory parameters. As a result, it is possible that the level of LDL in the blood may increase or the level of HDL will decrease. There are some changes in liver function, carbohydrate metabolism and blood clotting.

During treatment, regular monitoring of the condition of patients with circulatory disorders is required, since hormonal substances can increase the risk of cardiovascular or cerebrovascular disorders.

You should also limit your intake of fats and carbohydrates, especially if women have a tendency to gain weight.

For patients with diabetes mellitus , monitoring of the glycemic profile is necessary in order to promptly adjust the insulin dose.

When dysfunctional uterine bleeding occurs in women of reproductive age, therapy is carried out only after therapeutic and diagnostic curettage of the uterine cavity.

If therapy is ineffective, manifested by recurrent bleeding and hyperplastic processes of the endometrium, an urgent clarification of the causes of bleeding is necessary.

Prolonged delay of menstruation during treatment requires examination to exclude the presence of an ectopic pregnancy.

It is known that Orgametril contains lactose . For this reason, the drug is contraindicated for use in patients suffering from hereditary disorders, such as galactose intolerance, lapp lactase deficiency, and glucose-galactose malabsorption.

Contraindications

Absolute:

• Bleeding from the vagina of unknown origin;
• Diabetes;
• Hepatoma, severe liver disease, including hepatitis or cholestatic jaundice (or history of severe liver disease in cases where liver function tests have not returned to normal);
• Severe depression;
• Congenital disorders of cholesterol metabolism;
• Thromboembolism/thrombosis (deep vein thrombosis, cerebrovascular disorders, pulmonary embolism, heart attack);
• Conditions that may be aggravated by the use of sex steroid hormones, such as gestational herpes, gestational jaundice, otosclerosis, chloasma of pregnancy, severe itching, porphyria (current or historical);
• Rotor, Gilbert and Dubin-Johnson syndromes;
• Bleeding disorders;
• Pregnancy (confirmed or suspected), ectopic pregnancy (anamnestic data) and the period of breastfeeding;
• Hypersensitivity to the components of the drug.

Relative (prescribing Orgametril requires caution and regular monitoring of the condition):

• Thromboembolism (anamnestic data);
• Arterial hypertension;
• Chronic heart failure;
• Depression (historical data).

Reviews about Orgametril

A variety of drugs intended for the treatment of disorders of the reproductive and reproductive systems in women are especially actively discussed on the Internet. At the same time, reviews about Orgametril on forums devoted to this problem are in most cases positive.

Treatment with this drug is prescribed to women of different ages, setting the dosage and therapeutic regimen, depending on the type and complexity of the gynecological disorder. Of course, for its effectiveness to manifest itself, it is necessary to undergo long-term therapy, lasting several months. It is also possible to prescribe additional medications and procedures.

In addition, women say that the drug is not only highly effective, but also does not cause side effects. As you know, some patients are concerned about the problem of excess weight, but if the treatment is chosen correctly, then body weight does not increase.

Organometril price, where to buy

The price of Orgametril in 5 mg tablets, for 30 pieces in a pack, varies between 1039-1100 rubles.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine

LuxPharma* special offer

• Organametril tab.
  5 mg No. 30 1980 rub. order

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Pharmacy24

• Organametril 5 mg No. 30 tablets N.V. Organon, Netherlands
  849 UAH. order