Gynepristone is a popular emergency contraceptive with a high effectiveness of 97%. The drug, in combination with other medications, is also used for medical abortion. Women are often interested in how to take gynepristone correctly and whether it is possible to perform a medical abortion with this drug at home.
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Release form, packaging and composition of Ginepristone
The analyzed product is available in flat-cylindrical tablets (1 tablet contains 10 mg of mifepristone), the color of which changes from light yellow to greenish.
The auxiliary components of Ginepristone include microcrystalline cellulose, calcium stearate, and sodium carboxymethyl starch.
In pharmacies it is sold in blister packs or cardboard boxes in quantities of 1-2 pcs. The drug is also sold in polymer jars, which also contain 1 or 2 tablets.
Analogue products
There are the following drugs that act on the body in a similar way to Ginepristone:
- "Ginestril";
- "Genale";
- "Esmiya";
- "Miropriston";
- "Mifegin";
- "Mifepristone";
- "Mifeprex";
- "Pencrofton";
- "Mytholian";
- "Myfotab";
- "Pharmatex";
- "Postinor";
- "Escapelle".
“Ginepristone” has a milder effect on the female body than, for example, “Postinor” or “Escapelle”, and is not only not inferior to them in effectiveness, but often surpasses them. It also causes very few side effects, so it is recommended by gynecologists as a safer remedy. At the same time, it is easy to use - you need to take one tablet at once, and not two with an interval of several hours.
Next, let's look at opinions about Gynepristone.
Pharmacological action of Ginepristone
The instructions for Ginepristone clearly indicate that this drug is intended for emergency prevention of pregnancy. The main active ingredient of this drug is mifepristone.
Mifepristone has a chemical structure that allows Ginepristone to be classified as a synthetic steroid (it should be noted that the adrenal glands are responsible for the production of steroid hormones found in the human body).
The action of Ginepristone is to block progesterone receptors (the main female hormone that is responsible for a successful and proper pregnancy). As a result of such processes, a poor environment for fertilization of the egg occurs in the uterus, as well as its impossible attachment to the walls of the uterus. The instructions for Ginepristone note that this drug also slows down the maturation of the egg (ovulation). To understand the pharmacological action of Ginepristone, it is necessary to remember what the ovulation process itself is. First of all, this is the release of an egg from a completely ready, mature ovarian follicle in order to prepare it for passage into the fallopian tube (oviduct). It is in the oviduct that fertilization occurs. Ovulation is a constant, monthly process that occurs every 19-45 days. Taking Ginepristone slows down the ovulation process. Also, unfavorable conditions for fertilization are created in the uterus, which are manifested in thickening of the mucus on the cervix, as well as changes in the functional layer of the uterus. Thus, Ginepristone for abortion is a very effective and reliable remedy.
How does gynepristone work?
The content of the article
The active ingredient of the drug is mifepristone, a synthetic steroid that inhibits the production of progesterone.
Progesterone is a hormone that is actively produced during ovulation, creating conditions for the implantation of a fertilized egg into the uterine cavity. Thanks to a special hormonal background, the uterus does not contract when a zygote enters there, and it quietly implants (attaches) to the walls of the organ, and then develops, forming an embryo.
Ginepristone creates unfavorable conditions for conception by slowing down ovulation. The result of suppressing progesterone production is that the endometrium (the inner layer of the uterus) remains underdeveloped, so the egg cannot implant.
If you are already pregnant, this synthetic progestogen enhances the effect of prostaglandins that stimulate labor. Prostaglandins are used during childbirth, but a similar effect has also been noticed in the early stages of pregnancy - in other words, when taking gynepristone, a miscarriage begins.
Mifepristone contained in the drug stimulates the sensitivity of receptors to prostaglandins and blocks the perception of progesterone. As a result, changes occur in the endometrial layer. The smooth muscles of the uterus begin to contract rhythmically under the influence of prostaglandins, pushing the fertilized egg out of the cavity.
Indications for use of Ginepristone
The instructions for Ginepristone contain detailed information that will tell you that this drug should be taken as a means of emergency contraception. Gynepristone will help protect a woman from unplanned pregnancy immediately after unprotected intercourse.
As stated in reviews of Ginepristone, in order to achieve the most positive result, you should take one tablet of the drug immediately after sexual intercourse or no later than 72 hours after it. Also in reviews of Ginepristone it is noted that the drug is best taken 2 hours before meals or 2 hours after it.
How does Gynepriston differ from analogues and why is it not suitable for medical abortion?
Ginepristone is an analogue of mifepristone and other drugs based on this active substance (Agesta, Zhenale, Ginestril, Escapelle). But it contains a small dose of the active substance - 0.01 g. Therefore, it is used as a means of emergency contraception when sexual intercourse has occurred, but conception (fusion of germ cells) has not yet occurred.
Tablets for medical abortion contain a dose tens of times higher than the content of mifepristone in gynepristone. If you take genipristone at home during pregnancy, in the form in which it is sold in pharmacies, there is a 99% chance that your pregnancy will continue. There are cases when, after taking the drug, menstruation begins, but the fetus still remains in the uterus. As a result, a woman discovers pregnancy when the fetus has already begun to move. It is no longer possible to talk about abortion at this stage, so childbirth is coming. But it is difficult to imagine how such experiments will affect a child.
At the same time, gynepristone can be chosen as emergency contraception. All drugs - analogues of gynepristone - act on the body according to the same principle, having the active substance mifepristone. But despite the large selection of contraceptives, Ginepriston is very popular and is characterized by positive reviews from gynecologists. This is due to the fact that the medicine does not affect ovulation and spares the ovaries.
This drug is also prescribed by gynecologists for the treatment of tumors and cysts. Naturally, the choice of medication should be made only after taking hormone tests and undergoing a gynecological ultrasound. This is due to the fact that the medicine is effective only up to a certain size of tumors; beyond this limit, on the contrary, it can provoke their growth.
Contraindications
The instructions for Ginepristone indicate a number of contraindications, which you should definitely read before you start using this product.
1. The drug should not be taken if a woman has insufficient function of the adrenal glands, kidneys and liver.
2. Reviews of Ginepristone indicate undesirable use of the drug for those who suffer from chronic diseases or have been taking prednisolone, hydrocortisone or dexamethosone for a long time.
3. If any serious diseases are detected, Ginepristone is also not recommended to be taken.
4. Additional consultation with a specialist is also necessary in cases where a woman has problems with heart rhythm, if heart failure or a blood clotting disorder is detected.
5. Gynepristone does not need to be taken to terminate pregnancy if the woman previously took medications whose active substance was aimed at the blood clotting process.
6. Ginepristone should not be taken together with non-steroidal drugs, the action of which is aimed at eliminating the inflammation process (indomethacin, analgin, paracetamol, aspirin, etc.).
Having finished taking Ginepristone, breastfeeding should be continued only after 14 days.
Overdose
Signs of overdose occur when taking a dose of the drug exceeding 2 g. In this case, the likelihood of unwanted side reactions increases. Also, in the case of taking a large dose of Gynepristone, disruption of the adrenal glands is possible, up to the development of adrenal insufficiency.
To treat side effects, symptomatic therapy is prescribed.
Taking the drug simultaneously with non-steroidal anti-inflammatory drugs is contraindicated, since NSAIDs significantly reduce the effectiveness.
Side effects of Gynepristone
The most common side effects after taking Ginepristone are nausea, pain in the lower abdomen, dizziness, headache, vomiting, bleeding, skin rashes, fever, weakness, and menstrual irregularities.
Reviews of Gynepristone indicate that after taking the drug, severe side effects almost never occur.
Before purchasing Gynepristone in pharmacies, you should additionally consult a qualified gynecologist.
Mechanism of action of the drug
The drug is a synthetic steroidal antigestagenic agent, that is, it blocks the action of progesterone at the receptor level.
Taking the drug causes an increase in the contractility of the myometrium, stimulates the release of substances that increase its sensitivity to certain types of hormones. The effect of the drug is determined by the phase of the menstrual cycle in which it was taken. Depending on this, the medication inhibits ovulation, changes the endometrium, or prevents an already fertilized egg from implanting.
What else does the instruction tell us about Ginepristone? According to reviews, it is very detailed.
special instructions
Gynepristone for abortion cannot be a permanent contraceptive.
The drug being analyzed will not protect a woman from AIDS and other sexually transmitted diseases.
Answer
50%.
Gynepristone - at your discretion.ReplyReply
Unlikely.Reply
Unlikely.
So, will you still have your period? Bloody discharge for the 3rd day, is this normal? Reply
Unlikely.
So, will you still have your period? I've been bleeding for 3 days now, is this normal?
Gynepristone can cause spotting and menstrual irregularities, which is one of its side effects, but it is unlikely to cause an early onset of menstruation. Not all bloody discharge from the genital tract is menstruation. They are also not the norm, but the powerful hormonal “shock” caused by this drug is not the norm for the body. Reply
Unlikely.
So, will you still have your period? I've been bleeding for 3 days now, is this normal?
Gynepristone can cause spotting and menstrual irregularities, which is one of its side effects, but it is unlikely to cause an early onset of menstruation. Not all bloody discharge from the genital tract is menstruation. They are also not the norm, but the powerful hormonal “shock” caused by this drug is not the norm for the body.
What is the normal number of days of bleeding? Reply
0ReplyReply
The tablets are quite effective if taken according to the instructions. In case of overdose, nausea and breakthrough bleeding can be expected. There is no antidote. Reply
So, am I saved from an unwanted pregnancy? Or is it not yet certain? Menstruation at the time of PA should occur in 5-6 daysReplyReply
Hello.
Nausea doesn't only happen during pregnancy. In your case, pregnancy most likely has nothing to do with it.ReplyReply
Unfortunately, definitely.ReplyReply
Interaction with alcohol
Gynepristone, like most medications, is not recommended to be taken with alcohol. Alcoholic drinks not only increase unwanted side reactions, but also significantly reduce the effectiveness of the product. At least five hours must pass between drinking any alcoholic drink and taking the drug.
Features of use and storage
The use of Gynepristone as postcoital contraception on an ongoing basis is strictly not recommended. Otherwise, the effectiveness of its action is reduced, initially amounting to 98.8%. In addition, the development of adrenal insufficiency and various liver and kidney dysfunctions may be a consequence.
Gynepristone is used only as a solution to the issue of unwanted pregnancy - it does not function as a barrier to sexually transmitted diseases.
Before using the medicine in the instructions, you must pay attention to the clause about its compatibility with other drugs. The simultaneous use of Ginepristone and non-steroidal anti-inflammatory drugs (NSAIDs - aspirin, ibuprofen, diclofenac) is not recommended. If such a “neighborhood” is necessary, the dose of NSAIDs must be adjusted.
Ginepristone belongs to list A. It should be stored in a dark, dry place, at a temperature not exceeding 30° C. The maximum shelf life is 36 months.
Marina, 27 years old: “The condom broke during intercourse. I counted the days of the cycle and it turned out that there was the most favorable time for conception - ovulation. It was necessary to urgently take action. I remembered only one remedy – Postinor. But the pharmacy didn’t have it and they recommended Ginepristone to me. I read the instructions and took the pill about 30 hours after intercourse. The first two days I felt pain in my lower abdomen. Nothing else bothered me. Two weeks later my period came as expected. In general, the drug performed its function 100%.”
Description of the drug and its benefits
Ginepristone is a synthetic steroid drug with a pronounced antigestagenic effect. Its essence is to block the interaction of the hormone progesterone and the receptors that capture it. Due to this, the fertilized egg cannot attach to the endometrium and is soon excreted from the body. If the period of ovulation has not yet occurred, the drug prevents its onset.
Compared to other contraceptives of this kind, the drug has clear advantages. The main thing is the non-hormonal nature of the drug, which avoids problems with the endocrine system when using it. That is, the drug has a milder, but no less effective effect, which has been confirmed by practice.
Another important detail is the absence of gestagenic activity, that is, the use of Gynepristone does not affect the ability to become pregnant in the future.
The instructions indicate that the pharmacokinetic characteristics of the contraceptive allow it to reach maximum concentrations in the blood serum within 2 hours when taking a single dose of 600 mg. At the same time, the connection with proteins is almost 100%. The half-life is about 18 hours. In particular, the concentration decreases by half between 12 and 72 hours after administration (depending on the organism). The remaining metabolites leave the body much faster - in 7-12 hours.
