Suspension for children Motilium belongs to the group of antiemetics that block dopamine receptors of central action. Stimulates gastrointestinal motility. The preferred dosage form for children is a suspension. The active ingredient is quickly absorbed from the gastrointestinal tract. The maximum concentration of the substance in the blood plasma is reached 1 hour after use.
The product is used to eliminate nausea and vomiting of organic and infectious origin. Used to eliminate regurgitation syndromes after eating in newborns. The product helps get rid of bloating. When using the drug for children, it is important to follow the dosages described in the instructions. Taking in large doses may cause side effects. Before using the product to treat children, you should consult a pediatrician; there are contraindications.
Compound
Regardless of the form of release, the medicine contains domperidone as an active substance.
Motilium suspension contains the following additional components: sodium saccharinate, sodium carboxymethylcellulose, methyl parahydroxybenzoate, sodium hydroxide, water, MCC, sorbitol , propyl parahydroxybenzoate, polysorbate.
Excipients of lozenges: gelatin, aspartame, poloxamer 188, mannitol, mint essence.
Coated Motilium tablets contain lactose, microcrystalline cellulose, polyvidone, hydrogenated vegetable oil, hypromelose, corn starch, gelatinized potato starch, magnesium stearate, sodium lauryl sulfate.
Dosage forms and composition
Motilium contains the active dose of the substance domperidone. It is a strong dopamine receptor blocker. Several types of the drug are available for oral administration:
- Regular film-coated tablets: white, convex, engraved “10M”. Each contains 10 mg of domperidone, lactose, MCC, hydrogenated vegetable fat, starch, polyvidone and other auxiliary components. The package contains 1–3 blisters.
- Lingual lozenges with a similar dosage, slightly minty taste. The active substance in them is supplemented with gelatin, menthol, aspartame and mannitol. Packed in 10–30 pieces.
- Suspension for children. White, syrupy, sweetish liquid containing 1 mg of domperidone per 100 ml. Packaged in dark glass bottles with a screw cap. The drug also contains sodium saccharinate, water, sorbitol, polysorbate and stabilizers. Each package of the product has a special syringe for precise dosing.
Pharmacodynamics and pharmacokinetics
The medicine inhibits dopamine receptors . This property, in combination with the gastrokinetic effect, determines the antiemetic effect of the drug.
When used internally, Motilium increases the pressure of the lower esophageal sphincter , accelerates gastric emptying and helps improve antroduodenal motility .
After taking on an empty stomach, the active substance of the drug is absorbed from the gastrointestinal tract in a short time. The degree of absorption of domperidone is reduced due to a decrease in the acidity of gastric juice. plasma concentration is observed after approximately 0.5-1 hour. In people with moderate liver dysfunction it can be 1.5 times higher than in healthy people.
Absolute bioavailability is about 15%. When using the medicine after meals, the maximum concentration is reached later. In healthy people, bioavailability increases when taken after meals. If you have problems with the gastrointestinal tract, you should use the drug 15-30 minutes before meals.
The degree of binding of the active substance to plasma proteins is 91-93%. Once in the body, it undergoes rapid and active biotransformation in the liver through hydroxylation and N-dealkylation.
The drug is excreted 31% in urine and 66% in feces. About 11% of the active substance is excreted unchanged.
The plasma half-life after a single dose is 7-9 hours. In people with severe renal impairment, the half-life increases to 20.8 hours and plasma concentrations decrease. Only about 1% is excreted unchanged through the kidneys. In people with impaired liver function, the half-life is 15-23 hours.
Indications for use of Motilium
Indications for the use of Motilium: vomiting, hiccups, nausea, atony and hypotension , cholecystitis , reflux esophagitis , peptic ulcers , the need to accelerate peristalsis before X-ray studies of the gastrointestinal tract, biliary dyskinesia cholangitis , flatulence .
As a component of complex treatment, the drug is taken for exacerbation of gastric and duodenal ulcers .
Indications for the use of Motilium for children: gastroesophageal reflux , cyclic vomiting, regurgitation syndrome .
Pharmadynamics
The antiemetic effect of Motilium is based on the property of domperidone to block the passage of signals from the vomiting center in the brain to the gastrointestinal tract. Without disturbing the blood-brain barrier as a whole, the substance penetrates only into the trigger zone, where it blocks dopamine receptors, reducing their activity.
The simultaneous effect on the vomiting center and nerve cells of the gastrointestinal tract allows you to effectively and quickly eliminate nausea and vomiting, regardless of the fullness of the stomach.
Recently, Motilium is often prescribed as a prokinetic agent to accelerate gastric emptying, strengthen the esophageal sphincter, and accelerate the movement of food masses in the intestines. The ability of the drug to improve gastrointestinal motility without changing gastric acidity has been experimentally proven.
The active substance does not penetrate the blood-brain barrier well, therefore, when dosed correctly, it does not cause neurological side effects typical of dopamine blockers. The effect of domperidone on the pituitary gland causes increased production of prolactin.
Contraindications
The medicine has the following contraindications:
- bleeding in the gastrointestinal tract, perforation , mechanical obstruction ;
- prolactinoma;
- negative reaction of the body to the components of the drug;
- severe or moderate liver dysfunction
The drug should be taken with caution in case of kidney dysfunction , as well as cardiac and disorders .
It is advisable to consult a specialist about possible contraindications to the use of the medicine.
Side effects
The following side effects are possible when taking this medicine:
- endocrine system: amenorrhea , hyperprolactinemia (in rare cases can cause galactorrhea ), gynecomastia ;
- Gastrointestinal tract: spasms in the intestines;
- allergies : urticaria , rash;
- nervous system: extrapyramidal disorders .
Negative effects are observed only in extremely rare cases.
Side effects
Most often, the drug is well tolerated, the described side effects are rare. Among the list of the most common symptoms are:
- neurological disorders in the form of prolonged depression, increased excitability;
- constant drowsiness and apathy;
- recurrent headaches;
- disorders of the gastrointestinal tract;
- feeling of dry mouth;
- deviations in the functioning of the endocrine system;
- allergic reactions.
If the described adverse reactions occur, you should consult a doctor and discuss the advisability of prescribing another composition with a similar effect.
Attention! It is prohibited to ignore the manifestation of an allergic reaction and continue taking the composition. Such actions can cause the development of anaphylactic shock.
Neurological disorders most often appear in children under one year of age, since the blood-brain barrier is not developed during this period.
Instructions for use of Motilium (Method and dosage)
The instructions for use of Motilium indicate that the dosage regimen may vary depending on whether the tablets or suspension are used in each specific case.
In case of chronic dyspepsia, adults need to take the medicine 10 mg (1 tablet) on an empty stomach 3 times a day. If necessary, you can use the drug before bedtime. For those who use Motilium suspension and tablets, the instructions for use do not recommend exceeding the daily dosage of 80 mg.
Children are given syrup in a dosage of 2.5 ml of medicine per 10 kg of weight. This should be done 3 times a day on an empty stomach. If necessary, take the medicine before bedtime.
Instructions for use of Motilium for children over 1 year of age also indicate that, if necessary, the dose can be increased by 2 times. The maximum dosage per day is 2.4 mg/kg, but not more than 80 mg.
In case of nausea and vomiting, take syrup in a dosage of 20 ml or 2 tablets. This should be done 3-4 times a day on an empty stomach and before bedtime. Daily dosage – no more than 80 mg.
Suspension for children is given at the rate of 5 ml of product per 10 kg of weight. The medicine is taken 3-4 times a day on an empty stomach and before bedtime. The maximum daily dosage is 2.4 mg/kg, but not more than 80 mg.
Tablets can only be given to adults and children weighing over 35 kg. If your body weight is less, you need to use the so-called children's Motilium in the form of syrup.
Before use, the bottle of suspension must be shaken well. To open it, you need to press on the plastic cover and turn it. Next, remove the cap containing the Motilium suspension; the instructions for use indicate that it should only be drawn up using a special pipette that comes with the drug.
Storage conditions and periods
Motilium, according to the instructions for use, has different shelf life depending on the form of release. The suspension for children can be used for 3 years from the date of production. Tablets that are swallowed whole retain their properties for up to 5 years. Soluble forms have a shelf life of no more than 24 months.
The indicated periods are valid provided that the drugs are stored in sealed pharmaceutical packaging in a dark, dry place. All forms of Motilium are stored at temperatures from +15 to +30 °C. The suspension, like the tablets, does not require refrigeration. The medicine should be stored out of the reach of children. Screw the bottle cap tightly after each use.
Overdose
Overdose symptoms: drowsiness , extrapyramidal reactions , disorientation .
special antidote . In case of overdose, it is advisable to rinse the patient’s stomach and give activated carbon . It is necessary to monitor the patient's condition and carry out supportive measures.
In case of extrapyramidal reactions, anticholinergic and antihistamine drugs may be effective
Interaction
Anticholinergics may block the action of Motilium. Antifungal drugs of the azole group, HIV protease inhibitors and antibiotics belonging to the macrolide group can inhibit the biotransformation of domperidone and increase its content in the blood plasma , so this combination should be prescribed with caution.
The simultaneous use of Motilium and Ketoconazole in oral form, as well as Erythromycin and strong inhibitors of the CYP3A4 isoenzyme , which cause prolongation of the QT interval .
Analogues of Motilium
Level 4 ATX code matches:
Passazhix
Motinorm
Domrid
Itomed
Metoclopramide
Domperidone
Motilak
Ganaton
Cerucal
The following analogues of Motilium are known:
- Domrid;
- Brulium Lingvatabs;
- Motinol;
- Gastropom-Apo;
- Motinorm;
- Domidon;
- Domperidone Hexal;
- Domperidone Sandoz;
- Domperidone-Credopharm;
- Domperidone-Ostoma;
- Domrid Sr;
- Motilak;
- Motoricum;
- Peridonium;
- Nausilium;
- Motorix;
- Peridon;
- Perilium.
Some analogues are cheaper than Motilium. These include, for example, Nausilium , Motorix , Motinorm , Domrid , Domidon .
Before taking Motilium analogues, you need to carefully study the instructions. Some of them are not suitable for children.
What is better - Motilium or Motilak?
find out which is better Motilium or Motilak only by experience. The active ingredient of both drugs is domperidone . Motilium is available in tablets and suspension form, while Motilak is available only in tablet form. The composition of the auxiliary components of the drugs is different, so if you have an individual intolerance to any of them, only one drug will do.
Both drugs normalize and prolong gastrointestinal motility , relieve vomiting and nausea. In addition, they help eliminate heartburn , flatulence and belching .
The difference between them is also the cost. Motilium costs 2-3 times more than Motilak . People who have taken both drugs claim that there is no qualitative difference between them.
Analogues of the drug
You can replace Motilium with the following medications:
- Motinorm is an Indian drug containing domperidone as an active ingredient. It is produced in a suspension, approved for children over one year of age, and in tablets, which are recommended for patients over 5 years old and weighing more than 20 kg.
- Passazhix is a complete analogue of Motilium. This is a domestic medicine, produced in chewable tablets, which can be used in patients over 5 years of age, pregnant women and breastfeeding women.
- Perinorm is a substitute for Motilium in the clinical and pharmacological group. This is an antiemetic drug that comes in tablets, ampoules and oral solution. The drug is contraindicated in children under 2 years of age in the first trimester and during breastfeeding.
- Cerucal contains metoclopramide as an active ingredient. The drug is available in tablets and injections. Can be used in children over 2 years of age, in the 2nd and 3rd trimester.
During pregnancy (and lactation)
data on the effect of the drug during pregnancy . There is no information about the risk to the fetus. However, it is advisable to allow the drug during pregnancy only if the benefit of treatment is greater than the potential threat to the fetus.
When breastfeeding, the concentration of the active substance of the drug is 10-50% of its level in the blood . It is not known whether the drug has negative effects on newborns. Taking the drug is also possible only if the benefit to the mother is greater than the possible risk to the baby.
pharmachologic effect
The drug has an antiemetic effect and stimulates peristalsis. The active component is a dopamine antagonist, but unlike its own analogues, it does not have the ability to penetrate the blood-brain barrier. It is precisely due to this condition that the relative safety of the composition is ensured and the risk of side effects is not high. The main effectiveness of the drug composition is achieved through inhibition of dopamine receptors along with peripheral action. The secretory function of the stomach does not change significantly under the influence of the drug.
Reviews about Motilium
Reviews of Motilium characterize the drug as a highly effective, fast-acting remedy. It is very popular among consumers. Reviews of Motilium for children are also mostly positive. This remedy is often recommended by pediatricians, but not for infants. In the latter case, the effect of the drug has not been studied. In addition, the medicine is rarely used by nursing mothers, since its harm to lactation has not been studied.
Among the negative aspects, those who took Motilium note only a slightly inflated cost.
Motilium price, where to buy
The price of Motilium suspension is on average 540 rubles. This form of release is mainly used for children. The average price of Motilium in lozenges is 530 rubles. You can buy the product in this form of release in many pharmacies; as a rule, it is purchased for adults. In addition, coated tablets are popular. The price of Motilium in this form of release is 620 rubles.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Motilium tablets p.p.o.
10 mg 30 pcs JANSSEN CILAG 695 RUR order - Motilium express tablets for rassas. 10 mg 10 pcs. Catalent UK Swindon Zaidis Limited/Jansen-Cilag S.p.A.
RUR 438 order
- Motilium Susp. for internal approx. 1mg/ml 100mlJanssen Pharmaceuticals N.V.
RUR 801 order
- Motilium express tablets for rassas. 10 mg 30 pcs. Catalent UK Swindon Zaidis Limited/Jansen-Cilag S.p.A.
RUR 736 order
Pharmacy Dialogue
- Motilium tablets 10 mg No. 30Janssen-Cilag
RUR 838 order
- Motilium Express lozenges No. 30Janssen-Cilag
RUB 852 order
- Motilium bottle 1mg/ml 100mlJanssen Pharmaceutica
958 RUR order
- Motilium Express lozenges No. 10Janssen-Cilag
540 rub. order
show more
Pharmacy24
- Motilium 10 mg No. 10 tablets Janssen-Cilag S.A., France
65 UAH. order - Motilium 10 mg No. 30 tablets Janssen-Cilag S.A., France
135 UAH order
PaniPharmacy
- Motilium tablets Motilium tablets. 10mg No. 30 France, Janssen-Cilag
163 UAH order
- Motilium tablets Motilium tablets. 10 mg No. 10 France, Janssen-Cilag
80 UAH order
show more
