Prajisan, capsules 200 mg, 10 pcs.

Compound

One tablet of Prajisan contains 100 or 200 mg of the active ingredient progesterone + excipients (soy lecithin, glycerol , peanut oil, water, sorbitol , gelatin, titanium dioxide).
Vaginal gel contains 80 mg of progesterone per 1 gram of the drug + sorbic acid, guar gum, liquid paraffin, hypromellose K100M, hydrogenated palm oil glyceride, water.

Pharmacological action of Prajisan

The active substance of Prajisan (progesterone) is a hormone of the corpus luteum that promotes the transition of the uterine mucosa into the secretory phase of proliferation.

The use of Prajisan promotes:

Reduced contractility and excitability of the uterine muscles;
Development of normal endometrium;
Increased aldosterone production and glucose utilization;
Accumulation of glycogen in the liver.

When Prajisan is applied topically in the form of a vaginal gel, progesterone penetrates the vagina, where it binds to the mucous membrane. In this case, the effect of the medication continues for at least 3 days, during which it is continuously released.

Pharmacodynamics and pharmacokinetics

The drug is a hormone of the corpus luteum . The hormone is able to penetrate into the nucleus of target organs and stimulate RNA and activate DNA .

Prajisan transfers the uterine mucosa to the secretion phase from the proliferative phase . Thus, specific conditions are created for the implantation of a fertilized egg to occur. The muscles of the uterus relax, the organ becomes less sensitive to the action of Oxytocin .

The active substance stimulates lipoprotein lipases , increases fat reserves, and activates the process of inducing Insulin Aldosterone production .

When the gel is applied to the mammary gland, there is a decrease in the proliferation and mitotic activity of the epithelium in the ducts. When taken orally, the permeability of the capillaries of the mammary gland tissue decreases, and the swelling of the connective stroma subsides.

The medicine is quickly and almost completely absorbed. Maximum concentration is achieved within two hours. The degree of binding of the hormone to blood plasma . The drug undergoes metabolic in liver tissue. The drug is excreted with bile and kidneys, with feces.

When using the drug vaginally, the active component accumulates in the uterus; an hour after administration, the maximum concentration of the substance is already blood

Use during pregnancy and breastfeeding

According to the instructions for use, Prajisan can only be used intravaginally during pregnancy. In addition, it is important to be as careful as possible in the second and third trimesters, since during this period the risk of developing cholestasis increases.

During lactation, treatment with the drug is prohibited, since progesterone can pass into breast milk.

Indications for use

The drug is prescribed for various disorders associated with a lack of the hormone progesterone in the body.

Capsules taken:

for premenstrual syndrome ;
if there is a disturbance in the menstrual cycle due to anovulation and ovulation ;
for fibrocystic myopathy ;
during perimenopause ;
when using hormone replacement therapy for perimenopause and postmenopause .

The medicine is prescribed locally:

as hormone replacement therapy for progesterone ;
during preparation for in vitro fertilization to prolong the luteal phase ;
upon the onset of early menopause ;
for the treatment of infertility due to failure to enter the luteal phase ;
to prevent abortion due to hormonal imbalance;
as a prophylactic for uterine fibroids or endometriosis .

Overdose

If the required doses of the drug are exceeded, patients may experience:

shortening of the menstrual cycle;
dysmenorrhea;
state of euphoria;
transient dizziness;
drowsiness.

The method of getting rid of overdose symptoms depends on their type. For example, in case of irregularities in the menstrual cycle or spotting, the use of the drug is postponed to several days later.

If you feel drowsy or dizzy, your doctor may recommend taking the drug before bed or reducing its dosage.

If necessary, symptomatic therapy can be performed.

Contraindications

The medicine is not prescribed:

patients with disturbances in the blood circulation of the brain, thromboembolic disorders, including a history;
with thrombophlebitis ;
patients with porphyria ;
persons suffering from liver or kidney diseases;
if you suspect or have malignant neoplasms of the mammary glands or genital organs;
persons with allergies to the components of the product;
with bleeding from the genitals of unknown origin;
after an incomplete abortion .

The solution in oil is not prescribed in the 2nd and 3rd trimester of pregnancy , as there is a tendency to form blood clots .

Dosage and course of treatment with gel

The required dosage and duration of treatment depend on the chosen form of the drug, the characteristics and nature of the disease.

Instructions for the use of "Prajisan" in the form of a gel provide the following dosages and course of treatment:

For replacement therapy in combination with estrogens during the postmenopausal period, 1 applicator of the drug (90 mg) twice a week.
For dysfunctional uterine bleeding and secondary amenorrhea - 1 applicator of the drug every other day, starting from the 15th and ending with the 25th day of the menstrual cycle. If necessary, the course of treatment can be adjusted up or down on an individual basis.
During ART, to maintain the luteal phase, the use of gel begins on the first day after embryo transfer. Dose – 1 applicator per day. After confirmation of pregnancy, therapy continues during the first trimester.
When treating infertility, therapy begins on the day of confirmed ovulation or between days 18 and 21 of the cycle and lasts 10 days. The dose remains the same as in all previous cases - 1 applicator per day.

Side effects

Of all the possible adverse reactions, the most common is allergies .

Adverse reactions from taking tablets and ointments:

tension and swelling of the mammary glands;
the onset of menstruation ahead of time;
drowsiness, dizziness, nausea;
headaches, jaundice , swelling and fluid retention in the body;
decreased performance, skin rashes, anaphylactic shock .

For a solution in oil, the following may additionally develop:

increased blood pressure , cholecystitis , hepatitis , visual impairment;
thromboembolism , decreased sexual activity;
pain at the injection site.

Instructions for use of Prajisan (Method and dosage)

The duration of administration and dosage should be determined by the attending physician, depending on the disease.

Instructions for Prajisan capsules

Inside, with plenty of liquid.

As a rule, 200 to 300 mg of the drug are prescribed, divided into 2 doses.

For premenstrual syndrome, dysmenorrhea, fibrocystic mastopathy , during premenopause , the recommended dosage is 200-400 mg per day. The course of treatment lasts from 10 to 12 days.

When introducing a capsule or cream via the vaginal route, they are inserted deep into the vagina.

During preparation for egg and women with removed testicles, 200 mg per day is prescribed, on days 13 and 14 of the menstrual cycle, from days 15 to 26 - 100 mg. In case of pregnancy, the dosage is increased by 100 mg per day every week; upon reaching the level of 600 mg per day, the dosage is divided into 3 doses. The maximum dosage of 600 mg can be taken for no more than 2 months.

In order to maintain the luteal phase in preparation for IVF , 200-600 mg per day is used during the first and second trimesters of pregnancy.

If there is a threat of abortion or for the purpose of preventing abortions due to a lack of the hormone progesterone in the body, 200-400 mg is prescribed every day, in 2 doses, in the 1st and 2nd trimester of pregnancy.

Instructions for the gel

Open the package with the applicator.
Remove the cap.
Place the applicator between your middle and thumb and press the plunger with your index finger.
The woman needs to take a “lying on her back” position, bend her knees slightly.
Slowly insert the applicator into the vagina and press the plunger.
Throw away the used applicator with any remaining gel.

Storage conditions

Prajisan belongs to a number of gestagenic prescription medications with a shelf life of up to 24 months, subject to standard storage conditions at a temperature of 15-25 degrees Celsius.

ReplyReply

This effect is not typical for this drug.ReplyReply

hello, this can be considered normal, my doctor warned me about this, don’t worry. Reply Reply

Hello. You can.ReplyReply

Good afternoon.

This is a question for your attending physician.ReplyReply

Hello.

As much as your attending physician prescribed.ReplyReply

Capsules are taken orally or intravaginally, but there is a difference - you need to take them in the way prescribed by your doctor.ReplyReply

Hello.

The drug is called Prajisan. They take it, strictly adhering to the doctor’s prescriptions for as long as required, so all instructions in this regard are given by the attending physician. About the fact that you can’t throw sharply - it’s wrong. Reply Reply Reply

Interaction

When combining the drug with Carbamazepine , Rifampicin , barbiturates or Hydantoin , the effectiveness of the drug may be reduced.

Also, Griseofulvin and enterosorbents may reduce the effectiveness of the drug.

The medicine is combined with caution with Troleandomycin , Theophylline and Cyclosporine .

When administered intravaginally, the drug cannot be combined with various suppositories and vaginal tablets.

special instructions

When taking the drug, caution should be exercised by persons suffering from cardiovascular diseases or with depression , including a history of depression.

The medicine should not be used to protect against unwanted pregnancy.

With long-term and systematic use of the drug, it is necessary to monitor blood counts, liver function and kidney function. chloasma increases ; sun exposure and exposure to ultraviolet radiation should be limited.

When using progesterone orally, you should be careful when driving.

Analogs

Matches by level 4 ATX code:
Iprozhin

Utrozhestan

Crinon

Progesterone

Progestogel

There are the following analogues of this drug: Krainon, Progesterone, Iprozhin, Prozhestogel, Utrozhestan .

Which is better: Prajisan or Utrozhestan

Prajeesan and Utrozhestan.
Photo: vchemraznica.ru Both drugs are analogues of each other. Release form: capsules. Prajisan is additionally available in the form of a gel for vaginal use. Capsules can be used in the vagina. The auxiliary components differ in peanut oil (Prajisan) and sunflower oil (Utrozhestan). The drugs are available with a doctor's prescription! It is he who chooses which medicine is best to prescribe.

The country of origin of Prajisan is India. The drug Utrozhestan is produced in Belgium. The cost of Utrozhestan is from 187 rubles.

Reviews about Prajisana

There are generally good reviews on the Internet about the medicine if you use it according to your doctor's recommendations.

Reviews of Prajisana on forums:

“I took the drug to get rid of pain before my period. The medicine significantly relieved all my pain. I advise you to buy...”
“After I took the first pill, I felt bad, dizzy, nauseous, and there was a vacuum in my ears, I felt unwell all day...”
“My sister took pills during pregnancy. I carried and gave birth, everything is fine...”

Prajisana price, where to buy

The price of Prajisan is about 250 rubles for 10 capsules with a dosage of 200 mg.

Online pharmacies in RussiaRussia

ZdravCity

Prajisan capsules 100 mg 30 pcs. SUN Pharmaceutikal Industries Ltd.
RUB 321 order
Prajisan capsules 200 mg 10 pcs. SUN Pharmaceutikal Industries Ltd.
RUB 225 order

Dosage form

Prajisan is available in 3 dosage forms - homogeneous gel, vaginal plastic applicators and capsules. A homogeneous white vaginal gel is characterized by the fact that 1 g of the drug contains 80 mg of the active component - progesterone. Vaginal applicators contain 1.35 g - they are disposable. The light yellow capsules contain a whitish suspension inside. Each capsule contains 100 or 200 mg of progesterone, depending on the dosage indicated on the pack. 1 blister contains 10 capsules.