Diseases of the cardiovascular system are in first place worldwide in terms of the frequency of fatal situations, leaving emergency neurological conditions and even cancer far behind. The level of technical development of the country and life does not play a big role.
During urgent periods, when the question of the patient’s possible death and further prognosis is at stake, the use of medications is required to normalize the nutrition and respiration of the muscle fibers of the heart - the myocardium in the first place.
And here medications like Nitroglycerin are usually used. And this is not a guarantee of a positive result, but the chances are good.
In Russian medical practice (the same feature was adopted by neighbors in the former Union), for some reason preference is given to more controversial drugs with already proven low effectiveness.
Moreover, it is not only patients and ordinary people who have nothing to do with medicine who “sin” like this, but also doctors and specialists.
Validol is a menthol-based medicine, perhaps the most popular remedy, which, as they say, “both in the feast and in the world.”
As the average person assumes, this is a panacea for heart attack, angina pectoris and much more. In fact, its beneficial effect is too small and its use is possible in a strictly limited number of cases.
Compound
According to Wikipedia, the INN (international nonproprietary name) of Validol is levomenthol solution in menthylisovalerate , chemical formula is C15H28O2.
Composition of Validol tablets: 60 mg of levomenthol solution in menthylisovalerate - the active ingredient. Additional components: calcium stearate, sucrose.
Composition of Validol in capsules: 50 mg or 100 mg of levomenthol solution in menthylisovalerate - the active ingredient. Additional ingredients: pharmaceutical gelatin, methyl parahydroxybenzoate, glycerol , propyl parahydroxybenzoate, purified water.
What does the medicine consist of?
The composition of Validol has remained unchanged for many years. The main component is menthol. It is dissolved in a special substance - menthyl ether. Then fine sugar, often powder, and calcium stearate are added. The last two play the role of auxiliary elements, they give the shape and appearance of the tablet, and also slightly soften the harsh taste of menthol. In the case of the capsule form, the top shell usually contains gelatin.
Pharmacodynamics and pharmacokinetics
Validol is a complex substance obtained during the process of dissolving menthol (levomenthol) in menthylisovalerate (menthyl ester of isovaleric acid). In the case of sublingual use of validol , for which tablets or capsules of the drug should be placed under the tongue, its pharmacological effect is manifested due to the influence of its two active ingredients - menthol and menthylisovalerate .
The action of menthol in the oral cavity is aimed at irritating the nerve endings located on the mucous membrane. It has been proven that such irritation leads to a reflex dilation of blood vessels (including coronary vessels).
The effect of menthylisovalerate is manifested due to its ability to stimulate in the central nervous system the production and further release of peptides ( dynorphin , endorphin , kinin , enkephalin ) and the mediator histamine , which are regulators of pain and vascular permeability . In this case, the combined effect of these substances acts as an analgesic and sedative compound.
As a result of the general effect of the active ingredients of validol, the observed pain sensations , peripheral blood circulation , and a calming (sedative) effect is manifested, from which validol helps with various painful conditions associated with the cardiovascular system.
Absorption of the active ingredients of the drug in the oral cavity occurs very quickly and within a few minutes their maximum concentrations circulate in the systemic bloodstream. The effect of validol , in the case of its sublingual use, is felt within 3-5 minutes.
Partial transformation of validol occurs in the liver with the formation of products ( glucuronides ) excreted in bile and urine, as well as in the air exhaled by a person.
Side effects and drug interactions
Validol should be taken in strictly prescribed doses prescribed by the doctor and in the instructions. With prolonged unreasonable use of the drug, side effects occur in the form of nausea, dizziness, fatigue, and lacrimation. They involve the abolition of validol, but do not require specific treatment. If you are allergic to the components of the drug, skin itching, rashes and even Quincke's edema are possible.
If the recommended dose is exceeded, symptoms of overdose appear: nausea, nervous overexcitation, hypotension, arrhythmia. In severe cases, brain depression occurs and there is a need for symptomatic treatment.
Overdose is more likely in young children or particularly “nervous” patients. The first ones can find pills poorly hidden by adults, taste their sweet taste and simply eat up like candy. The second ones lose control of themselves and swallow Validol tablet after tablet, not counting the amount of medicine taken.
Help for children (for whom validol is contraindicated) and adults in case of validol poisoning should be provided immediately. First, the stomach is washed out to remove the medicine. Secondly, sorbents (activated carbon) are used. Thirdly, the victim needs to drink more to speed up the filtration of validol in the urine and excretion from the body. In any case, you should not self-medicate; it is better to seek help from professionals.
Validol can be used with some other medications, but it is important to know about their compatibility. In particular, simultaneous use with nitroglycerin can reduce the severity of headaches against the background of cerebral vasodilation. This is a combination of drugs recommended by doctors. Validol increases the sedative effect of some psychotropic drugs, opiates, ethanol and anesthetics, and also contributes to a more pronounced hypotensive effect of drugs for hypertension.
During pregnancy and lactation, it is better to abstain from validol, since its possible effect on the fetus and baby is unknown. Validol is also not prescribed for children. Dosage forms containing sucrose can harm patients with diabetes, about which the latter should be warned by their doctor.
You should not drink validol on your own, despite its apparent harmlessness. Repeated pain in the heart can indicate a serious pathology, and trying to cure it with validol without examinations and consulting a doctor is unacceptable. A short-term dulling of pain can lead to a delayed diagnosis of myocardial infarction or severe angina, which is fraught with complications and very serious consequences.
Indications for use of Validol
Indications for use of Validol are:
- states of hysteria ;
- functional cardialgia ;
- various neuroses ;
- sensations of headaches ,
- arising during nitrate ;
- motion sickness syndrome (including symptoms of nausea / vomiting due to air and/or seasickness ).
Contraindications
Before taking Validol tablets or capsules, you must familiarize yourself with the contraindications to their use, which include personal hypersensitivity to the ingredients of the dosage form of the drug and the pathology of sugar intolerance (if they are present in the dosage form).
sucrose as an additional component , which is why Validol tablets should be taken with caution by people suffering from diabetes .
What causes nausea, nausea and vomiting?
The most common problems, causes that cause severe nausea, which is often replaced by vomiting, are bacterial infections, viral infections, various types of E. coli, entroviruses and hepatitis. Some common causes of nausea include drug overdose, excessive alcohol consumption, food poisoning and many other reasons. The causes of nausea often lie in serious diseases of the gastrointestinal tract, liver disease, pancreas and other problems.
If severe abdominal pain and nausea appear, then such problems may indicate the following diseases: cholecystitis, pancreatitis, the development of an inflammatory process in the abdomen. One of the common causes of nausea is intestinal obstruction, various types of disturbances in the functioning of the vestibular apparatus, when nausea and motion sickness occur. Pregnancy is often the cause of nausea in women, especially in the early stages of fetal development.
Side effects
allergic manifestations may occur , including itching / rash on the skin, Quincke's edema and urticaria .
The use of validol in large dosages and over a long period of time can lead to lacrimation , dizziness and nausea . These manifestations usually disappear when dosages are reduced or therapy is temporarily discontinued.
special instructions
Shelf life – 24-36 months (depending on the manufacturer). It should be stored in a dark place at a temperature of 9-16 degrees.
It is not recommended to take the drug in parallel with alcoholic beverages, since alcohol can have a suppressive effect on the central nervous system, which can lead to more severe adverse reactions.
If you use Validol together with psychotropic drugs, the effectiveness of the latter will increase.
After taking it, you should stop driving for a while.
Instructions for use of Validol
Before starting therapy with Validol, it is advised to establish the body’s personal sensitivity to its ingredients and, depending on their tolerance, determine how many tablets or capsules can be taken in 24 hours and whether taking large dosages is harmful in this particular case.
Capsules and tablets Validol, instructions for use
Instructions for use of Validol in capsules and tablets recommend their sublingual (under the tongue) use. Any form of the drug should be placed in the oral cavity under the tongue and kept there until it is completely absorbed. A single dose is considered to be one tablet (60 mg) or one capsule (50 mg or 100 mg). The average number of daily doses is 2-4 times, the maximum allowable dosage in 24 hours is 600 mg (10 tablets; 12 capsules of 50 mg or 6 capsules of 100 mg). It is better to limit the duration of alternating courses of therapy to 7 days. If the drug has zero or insufficient effectiveness 5-10 minutes after its complete absorption, the possibility of using other drugs should be considered.
Instructions for using Validol with glucose are identical to the above description.
Use for various pathological conditions
Various pathological processes in the body require certain adjustments to the general scheme. Let's consider how to use the drug for certain diseases.
For ischemic disease
An attack of angina develops due to spasm or blockage of the coronary vessels. At the same time, blood flow slows down, the heart does not have enough oxygen and nutrition to ensure its normal functioning. At the site of spasm (narrowing, blockage), a focus of ischemia occurs. The muscle tissue in that area dies or becomes damaged. This interferes with the functioning of the heart. During an attack, the patient feels squeezing pain behind the sternum.
Positive Action
Validol for angina pectoris is prescribed as a course of therapy or as a one-time dose during an attack. The use of the drug for mild symptoms of coronary heart disease reduces the intensity of pain in the heart region due to reflex vasodilation, as well as a distracting effect.
If an ischemic attack occurs, Validol should be taken as soon as possible. If the effect of the medicine does not occur after 5 minutes, you can take another one. If the measures are ineffective, you should call the ambulance service.
If the patient has a history of angina attacks, it is necessary to have the drug Nitroglycerin at home. It can be used in the same method (sublingually) as Validol, but its medicinal properties are much stronger than levomenthol. Patients with coronary heart disease should carry nitroglycerin with them everywhere.
For patients who have suffered a myocardial infarction, it is better to generally replace the medicine with Nitroglycerin, since the vasodilating effect of levomenthol is very weak. Nitroglycerin during a heart attack will help stop the attack and save the patient’s life. Validol here will work more as a sedative. Patient reviews also speak about this effect of the drugs:
Anastasia, 40 years old: “I have angina, I take Validol for severe anxiety and heart pain. I take it 3 times a day. Getting better".
Victor, 58 years old: “During the last attack of angina, I took Validol, but it didn’t help. I had to take Nitroglycerin. It does not hurt anymore. I don’t use Validol anymore.”
With VSD
What else do Validol tablets help with? Levomenthol is a sedative, so it is actively used for VSD.
Vegetative-vascular dystonia is manifested by cardiogenic pain, tachycardia, bradycardia, neuroses, increased sweating and excitability, headaches, extrasystole, increased or decreased blood pressure, as well as a feeling of palpitations, arrhythmias. All these manifestations occur against the background of vegetative disorders.
In the presence of vegetative-vascular dystonia, patients may experience severe pain in the heart against a background of anxiety and stress. They are not relieved by Nitroglycerin, but are well treated with Validol or other sedatives. In this case, Validol is prescribed under the tongue during an attack of cardialgia.
After pain relief, the medication should be continued, 1 tablet 3 times a day. During treatment, patients become calmer.
It is worth remembering that vegetative-vascular dystonia manifests itself in different forms. If low blood pressure is observed during VSD, then levomenthol can further reduce it, especially when using a large dosage. In this case, it is better not to use Validol.
With VSD against the background of stressful situations and excitement, a person experiences a rapid heartbeat (tachycardia) or a slowdown (bradycardia). For such symptoms, the doctor must prescribe Validol, which is a sedative. The dosage is selected individually. When taking the medicine sublingually, anxiety goes away, followed by heartbeat disturbances.
For bradycardia, Levomenthol can help if the cause of a pathologically slow pulse is a stressful situation. The medicine is prescribed during an attack. The patient must be laid down with his legs elevated on a pillow to increase blood flow to the head. If there is no effect, you should call a doctor to provide first aid.
For hypertension and hypotension?
Validol with high blood pressure will help alleviate a person’s condition by dilating blood vessels and having a sedative effect. There is a decrease in blood pressure inside the vascular bed, which improves the patient’s condition.
The drug should not be used continuously for blood pressure as a hypotonic medication. It is best used as part of complex therapy for arterial hypertension. The drug is good at lowering blood pressure and normalizing heart rate if all these effects are caused by stress.
When taking Levomenthol, patients with hypotension experience a further decrease in blood pressure, which can lead to fainting. Therefore, patients with low blood pressure should not use the drug. To raise the patient’s blood pressure, it is necessary to discontinue Validol, give medications containing caffeine, place him on the couch, and raise his legs on a pillow.
Overdose
Taking large doses of the drug leads to Validol lowering blood pressure or increasing the risk of side effects and their severity.
Overdose, that is, the use of an excessive number of tablets or capsules at a time, enhances both the positive and negative effects of the drug and can lead to a sharp decrease cardiac function , , the formation of severe headaches and severe nausea leading to vomiting , overexcitation and even depression functionality of the central nervous system.
In this case, depending on the observed manifestations and their intensity, symptomatic treatment .
What is the advantage of Validol?
Some experts argue that the composition of Validol is in no way capable of affecting the condition of the body. But it helped most patients. The advantage of the drug is that it practically cannot harm, and no one has yet canceled the placebo effect. In addition, the pricing policy for this drug is very loyal; you can buy Validol for less than 10 rubles.
The drug is available in all pharmacies without a prescription from a doctor. Therefore, in situations where it is not possible to contact a specialist, a person can help himself.
Validol is a sedative substance, it improves blood circulation in regional vessels and significantly reduces pain.
Interaction
Parallel use with opioid analgesics , psychotropic drugs , ethanol-containing drugs and anesthesia drugs increases their effects.
Combined use with nitrates reduces the feeling of headache that occurs during their use.
Combined use with antihypertensive drugs may potentiate their effectiveness.
Analogs
Level 4 ATC code matches:
Eltacin
Tonginal
Tricardin
Instenon
Pumpan
Barboval
Corvalment
If for some reason the use of Validol is impossible, doctors can recommend the following analogues:
- Advocard;
- Gulidol;
- Cardiolin;
- Dystonin;
- Cardiofit;
- Cormenthol;
- Kratal;
- Pumpan;
- Barboval;
- Tonginal;
- Instenon;
- Rhythmocore;
- Tricardin , etc.
Validol during pregnancy and lactation
The question of whether pregnant or breastfeeding women can take sedatives should be considered on a case-by-case basis, with the understanding that even when a single dose of a minimal dose of a sedative is completely normal, continued use may cause harm to the fetus, mother or breastfeeding child. to kid. In this regard, deciding whether Validol can be taken during pregnancy and breastfeeding should be left to the consideration of the attending physician.
How to use anti-nausea pills correctly during pregnancy?
Doctors are often divided on the use of anti-nausea pills during pregnancy. Because nausea during pregnancy is considered a completely natural symptom at certain stages of development and gestation. Many women suffer from nausea during pregnancy, which is why they wonder: is it possible to take anti-nausea pills during pregnancy? Is it possible to take pills for nausea and nausea in the early stages of pregnancy? Doctors, when they are asked for advice on which anti-nausea pills to choose during pregnancy, usually recommend regular mint tablets, because Many medications and anti-nausea medications can be harmful to a child's development. During pregnancy, you should definitely consult your doctor about which anti-nausea pills are best to choose. It should be remembered that many medications for nausea and vomiting are contraindicated for use in a woman’s first trimester of pregnancy. You can read about the causes of nausea and pain in the lower abdomen during pregnancy in the article: 40 weeks of pregnancy, why you feel nauseous, nauseous, why your lower abdomen pulls or aches.
Reviews about Validol
The vast majority of people leave purely positive reviews about Validol, especially when this drug is used occasionally to relieve various anxiety , stress or other similar conditions. Also, this medicine copes well with headaches nitrate therapy , and is a weak hypnotic and hypotonic .
Validol price, where to buy
The price of Validol, depending on the manufacturer and the number of tablets or capsules in secondary packaging, varies slightly, but still remains affordable for any consumer, since you can buy 10 tablets or capsules of the drug for 30-40 rubles.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Validol with glucose tablets 60 mg 10 pcs. JSC Pharmstandard (ICN) Leksredstva Kursk
26 rub. order - Validol Avexima sublingual tablets. 20 pcs. JSC Irbitsky Chemical Plant
60 rub. order
- Validol capsules roach. 50 mg 20 pcs. ZAO FP Meligen
31 rub. order
- Validol sublingual tablets 60 mg 10 pcs Usolye-Sibirsky chemical farm plant OJSC
49 RUR order
- Validol tab. sublingual 60 mg No. 20Ozon LLC
73 rub. order
Pharmacy Dialogue
- Validol with glucose (tab. 60 mg No. 10) FS.-Leksredstva
18 rub. order
- Validol (tab. 60 mg No. 10) Marbiopharm OJSC
27 RUR order
- Validol (tab. 60 mg No. 10) TCPP
22 RUR order
- Validol (caps. 100 mg No. 20)MinskIntercaps
32 RUR order
- Validol (caps. 100 mg No. 20) Marbiopharm OJSC
45 rub. order
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Pharmacy24
- Validol 0.06 g N10 tablets PAT "Lubnipharm", Ukraine
3 UAH. order - Validol Darnitsa No. 10 tablets PrAT” Pharmaceutical company “Darnitsa”, Ukraine
4 UAH order
- Validol 0.06 g No. 10 tablets PAT "Farmak", Ukraine
4 UAH order
- Validol Darnitsa No. 6 tablets PrAT” Pharmaceutical company “Darnitsa”, Ukraine
3 UAH order
PaniPharmacy
- Validol tablets Validol tablets. 0.06g No. 10 Ukraine, Darnitsa ChAO
5 UAH order
- Validol tablets 0.06g No. 10 Ukraine, Farmak
4 UAH order
- Validol tablets Validol tablets. 6mg No. 10 Ukraine, Lubnyfarm PJSC
4 UAH order
- Validol tablets Validol tablets. 0.06g No. 6 Ukraine, Darnitsa ChAO
3 UAH order
- Validol tablets Validol tablets. 0.06g No. 6 Ukraine, Lubnyfarm PJSC
2 UAH order
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