Mexiprim instructions for use, contraindications, side effects, reviews

Compound

There are two main forms of release of this drug - injections and tablets, the composition of which differs from each other in the amount of ethylmethylhydroxypyridine succinate .
One milliliter of Mexiprim solution contains 50 grams of the active drug compound, as well as about 1 milliliter of an excipient - water for injection.

One film-coated Mexiprim tablet contains 0.125 grams of ethylmethylhydroxypyridine succinate , as well as excipients such as talc, kaolin, povidone, sodium carboxymethyl starch, calcium stearate and MCC.

The shell of the tablet form of the drug contains compounds such as talc, hypromellose, titanium dioxide, and macrogol.

Release form

As mentioned earlier, the drug is produced in the form of round tablets, biconvex in shape and coated with a specialized white or cream-colored coating, as well as in the form of an injection solution, which is a transparent liquid of colorless or pale yellow color.

The nominal weight of one tablet is 125 mg. The tablets are packaged in blisters (cell-shaped made of aluminum foil and PVC) of 10 pcs. in everyone. One cardboard package can contain 1,2,3,4, 6 blisters.

The solution intended for the preparation of injections is packaged in ampoules of 2 or 5 ml. in each and placed in contour cells. One cardboard package may contain 20, 50 or 100 ampoules complete with a special knife for opening them.

Side effects

Side effects during treatment with Mexiprim are rare.

The most common side effects of the drug include the following:

• individual intolerance to Mexiprim in the form of redness, itching and swelling of the skin, dermatitis, urticaria and Quincke's edema, and in severe cases - bronchospasm and anaphylactic shock;
• nausea, dry mouth, bloating;
• increased sweating;
• headache, general weakness, vertigo, drowsiness, anxiety, impaired coordination of movements;
• arterial hypertension.

When a Mexiprim injection solution is quickly infused into a vein, patients also complain of a metallic taste in the mouth, a feeling of heat in the body, a sore throat, shortness of breath, redness of the facial skin, increased and rapid heartbeat. The listed phenomena are short-term in nature and disappear without a trace after stopping the administration of the drug.

Pharmacodynamics and pharmacokinetics

Since this drug belongs to the heteroaromatic antioxidant series , Mexiprim is distinguished by its wide range of applications. The medicine increases the body's resistance to stressful situations. When using the drug, its anxiolytic properties , without muscle relaxant effects or drowsiness .

In addition, the drug reduces and prevents the occurrence of memory and learning disorders , and has a nootropic and anticonvulsant effect on elderly patients. Thanks to its antihypoxic and antioxidant properties, Mexiprim helps improve performance and concentration, and in addition, minimizes the harmful toxic effects of alcoholic beverages.

Mexiprim has a positive effect on brain tissue, as well as the body’s circulatory system by stimulating blood microcirculation and platelet aggregation . The drug reduces cholesterol due to its pronounced lipid-lowering abilities . When the drug enters the human body, it is rapidly metabolized and transformed into glucurone-conjugated breakdown products .

Therapeutic effect

Taking Mexiprim is justified if a good antioxidant effect is needed. The medication helps cope with stress, fatigue of the body, exhibits a pronounced anxiolytic effect, but does not cause drowsiness and absent-mindedness, which is what other anxiolytics are famous for.

It has been proven that the drug Mexiprim has a nootropic, vasodilating effect. Taking it helps facilitate learning and reduces symptoms of age-related memory problems. The tablets are also known for their ability to have a positive effect on brain tissue by increasing blood flow in them.

Another property of the drug Mexiprim is hypolipidemic. Taking it helps reduce the level of platelets in the bloodstream.

Indications for use of Mexiprim

General indications for use for the two main forms of the drug are the following conditions and diseases:

• vegetative-vascular dystonia;
• withdrawal syndrome accompanied by vegetative-vascular and neurosis-like disorders in alcoholism ;
• nervous disorders;
• cognitive disorders in asthenic and psychoorganic syndrome caused by intoxication , circulatory disorders in the brain, neuroinfections, atrophic or senile processes ;
• exposure to stress ;
• disorders of intelligence and memory in elderly patients.

Mexiprim injection solution is also used for cerebral circulatory (acute forms), for cognitive disorders caused by atherosclerotic genesis , and in addition, for dyscirculatory encephalopathy.

Contraindications

General contraindications for both injections and Mexiprim tablets are:

• pregnancy;
• childhood;
• hypersensitivity;
• lactation period;
• disorders of the liver or kidneys (acute stages of the disease).

The tablet form of the drug is not recommended for use in case of renal or liver failure .

Comparison of drugs

Mexiprim and Mexidol - which drug is better

Drugs with the same main active ingredient, but Mexiprim has more auxiliary components. It is considered an analogue of Mexidol. It's cheaper than the original.

Both medications are produced in ampoules and tablets, they have the same direction of action. They treat brain disorders and have few contraindications. The effectiveness of one is not inferior to the other.

If intolerance to the components of Mexiprim occurs, you can switch to Mexidol. The drugs cannot be taken at the same time, as an overdose of the active substances occurs, which is dangerous for the patient’s health. The consequences cannot be foreseen.

Instructions for use of Mexiprim (Method and dosage)

The instructions for use of Mexiprim tablets prescribe taking them orally 2-3 times a day in a dosage individually determined by the doctor, for each individual patient, taking into account all physiological characteristics. It is recommended to start using the drug with a dosage of 0.25-0.5 grams. The maximum average daily dose of the drug should not exceed 0.8 grams.

The duration of the therapeutic course of treatment with the drug, depending on the type and severity of the patient’s disease/condition, can vary from 5 days to 6 weeks. It is recommended to reduce the dosage of the drug gradually over the last 2-3 days of the course of treatment.

Mexiprim injections are administered intramuscularly or intravenously (drip or jet) 1-3 times a day. The dosage of the drug is determined individually, taking into account the characteristics of each specific case. When administering an injection solution by infusion, the drug is diluted with sodium chloride. As a rule, the dosage of the first injections does not exceed 100 mg. Subsequently, the dose of the drug is gradually increased.

The duration of the therapeutic course of treatment with Mexiprim injection solution also depends on the patient’s condition and the severity of the disease; it can last from 7 to 30 days.

Mexiprim for blood pressure

"Mexiprim" belongs to the heteroaromatic antioxidant series. It increases the body's resistance to oxygen deficiency, slows down oxidation processes, and restores the membrane. It has a positive effect on cerebral cells, which contributes to an anticonvulsant and sedative effect. Used in stressful situations, high blood pressure, epilepsy, phobia, sclerosis. The drug acts on the body as a result of increasing the intensity of the enzyme superoxide oxidase, decreasing the plasticity of membrane structures, and influencing receptor complexes.

Composition and release form of "Mexiprim" for pressure

The main component of Mexiprim is an antioxidant, which inhibits the development of radical reactions, prevents the destruction of cell membranes, prevents oxygen starvation, and increases the energy potential of the body. After taking it, positive changes in blood flow indicators are observed, anabolism and catabolism in the brain are stabilized, and the risk of blood clots is reduced. Can only be used as prescribed by a doctor. This is especially true for people suffering from high blood pressure.

Mexiprim is produced in the form of tablets and ampoules for injection. The weight of the tablet is 125 mg. They are packaged in 10, 20, 30, 40, 60 pieces. packaged. Ampoules are intended for stationary use and are available in 5, 10, 100, 250 and 500 pcs. in packs of 2 and 5 ml. Composition of the drug:

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Directions for use and doses

The use of tablet or injection form of the medication depends on the diagnosis.

Tablets are taken 2-3 times a day, 1-2 pieces. during or after meals, with plenty of water. You can take a maximum of 6 tablets per day. The duration of treatment varies from 2 weeks to 1.5 months. The use of the medicine begins with a small dose. You need to stop using the medicine gradually, gradually reducing the dose over 3 days. Mexiprim ampoules are used in the hospital in the form of droppers or injections. For the dropper, use a sodium chloride solution in which the drug is diluted. The injections are administered intramuscularly over 5 minutes.

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Indications and contraindications

Depending on the diagnosis, a tablet or injection form of the drug is prescribed. The first option is prescribed in the case of:

• cognitive impairment as a result of neuroinfections, dementia, poor blood supply to the brain, traumatic brain injury, intoxication (accompanied by decreased memory and mental performance);
• neurocirculatory dystonia;
• blood pressure surges;
• memory impairment and mild mental impairment in older people;
• overstrain of the body as a result of stress;
• withdrawal symptoms after stopping alcohol consumption, which is accompanied by asthenia, obsession, hysteria;
• mental disorders caused by traumatic factors.

Injections are prescribed for:

Mexiprim is contraindicated for children, pregnant women, and during breastfeeding. The drug is not prescribed to patients:

• with individual intolerance to the components of the product;
• patients with liver failure, hepatitis, cirrhosis of the liver;
• with inflammatory kidney diseases.

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Side effects and overdose

The medicine is characterized by positive tolerability: it has practically no side effects. In rare cases, an allergic reaction to the components of Mexiprim, stomach discomfort, nausea, dry mouth, heartburn, diarrhea, and flatulence are observed. If the patient suffers from bronchial asthma or is prone to allergies, severe hypersensitivity may develop. The drug also inhibits a person’s reaction and attention, therefore it is not recommended to drive a vehicle.

In case of overdose, drowsiness is observed. It is necessary to take into account the fact that sometimes the drug raises blood pressure excessively, due to which emotional sensitivity occurs. If you are hypersensitive to Mexiprim substances, your blood pressure may drop, causing anaphylactic shock.

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Mexiprim's analogs

Level 4 ATC code matches:
Trigamma

Riluzole

Huato Boluses

Vitagamma

Vitaxon

Hypoxene

Glycine

Mexidol

Neurox

Glitsed

Cytoflavin

Among the analogues of Mexiprim, the following drugs can be distinguished: Medomexi, 2-ethyl-6-methyl-3-hydroxypyridine succinate, Armadin, 3-hydroxy-6-methyl-2-ethylpyridine succinate, Mexidant, Mexicor, Meksifin, Mexidol, Metostabil, Cerecard , Mexipridol and Ethylmethylhydroxypyridine succinate.

It is worth noting that quite often patients have the question of what is better: Mexiprim or Mexidol ? An unambiguous answer to this question can only be given by the attending physician, who, after a comprehensive medical examination, can correctly prescribe this or that drug, taking into account all the characteristics of a particular patient.

Mexiprim price, where to buy

The average price of Mexiprim tablets varies from 140 to 170 rubles.

The price of Mexiprim in ampoules averages 300-330 rubles.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine

ZdravCity

• Mexiprim tablets p.p.o.
  125 mg 30 pcs. ZAO OKFK 165 rub. order
• Mexiprim solution for intravenous and intramuscular injection. 50mg/ml 5ml 5 pcs. LLC NTFF POLYSAN

  RUB 345 order

• Mexiprim solution for intravenous and intramuscular injection. 50mg/ml 2ml 10 pcs. FSUE MEZ FSUE/Polisan NTFF

  280 rub. order

• Mexiprim tablets p.p.o. 125 mg 60 pcs. ZAO OKFK

  RUB 304 order

Pharmacy Dialogue

• Mexiprim (tab.p/vol. 125 mg No. 30) Obninsk Chemical-Pharmaceutical

  RUB 174 order

  Read also:  Teveten, 600 mg, film-coated tablets, 14 pcs.
• Mexiprim (amp. 50 mg/ml 5 ml No. 5) Polisan NTFF

  RUR 358 order

• Mexiprim (tablet p/o 125 mg No. 60) Obninsk Chemical-Pharmaceutical

  340 rub. order

• Mexiprim (amp. 50 mg/ml 2 ml No. 10) Moscow Endocrine Plant

  RUB 356 order

• Mexiprim (amp. 50 mg/ml 2 ml No. 10) Polisan NTFF

  RUB 356 order

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Pharmacy24

• Mexiprim 125 mg No. 30 tablets ZAT "OHFK", Russia
  130 UAH. order
• Mexiprim 50 mg/ml 2 ml No. 10 injection solution TOV "NTFF" Polisan", Russian Federation

  348 UAH order